CYP3A5 and MDR1 Polymorphisms are Associated with Calcineurin Inhibitor-related Neurotoxicity after Allogenic Stem Cell Transplantation in Children

作     者：Masakatsu Yanagimachi Takuya Naruto Reo Tanoshima Hiromi Kato Tomoko Yokosuka Hisaki Fujii Hiroaki Goto Tatsuhiko Yagihashi Kenjiro Kosaki Shumpei Yokota 

作者单位：Department of PediatricsYokohama City University School of Medicine 

会议名称：《第五届亚洲儿科研究大会》

会议日期：2009年

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

摘      要：正Calcineurin inhibitors such as cyclosporine（CsA） and tacrolimus（FK506） are widely used as prophylactics and for treatment of graft-versus-host disease（GVHD） after hematopoietic stem cell transplantation（HSCT）.One severe side effect of these calcineurin inhibitors is *** substances are substrates for CYP3A5 and P-glycoprotein,the product of multidrug resistance gene （MDR1）.The effect of the polymorphisms,such as CYP3A5 6986GA,MDR1 1236CT,2677GA/T and