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ZNf804A Variation May Affect Hippocampal-Prefrontal Resting-State functional Connectivity in Schizophrenic and Healthy Individuals

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Neuroscience Bulletin 2018年第3期34卷 507-516页

作者： Yuyanan zhang hao Yan Jinmin Liao hao Yu Sisi Jiang Qi Liu Dai zhang Weihua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191 China Key Laboratory of Mental Health Ministry of Health and National Clinical Research Center for Mental Disorders(Peking University) Beijing 100191 China Department of Psychiatry Jining Medical UniversityJining 272067 China Peking-Tsinglaua Joint Center for Life Sciences and PKUIDG/McGovern Institute for Brain Research Peking University Beijing 100871 China

The ZNf804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNf804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity（RSfC） between the hippocampus and the dorsolateral prefrontal cortex（DLPfC） in both schizophrenic patients and healthy controls. The homozygous ZNf804 A rs1344706 genotype（AA） conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPfC（f（2,165） = 13.43,P ／ 0.001）. The RSfC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNf804 A rs1344706 on hippocampalprefrontal RSfC associated with schizophrenia.

关键词： Schizophrenia ZNf804A Imaging genetics Hippocampus Dorsolateral prefrontal cortex

Surface-modified Zn_(0.5)Ti_(0.5)NbO_(4) particles filled polytetrafluoroethylene composite with extremely low dielectric loss and stable temperature dependence

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Journal of Advanced Ceramics 2020年第6期9卷 726-738页

作者： hao WANG fuming ZHOU Jianming GUO Yuanyuan zhang Hui YANG Qilong zhang School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou 310027China Jiaxing Glead Electronics Co. Ltd.Jiaxing 314003China

Polymer-ceramic composites are widely applied in microwave substrate materials due to the excellent dielectric properties and simple preparation process ***-based(PTfE)composites filled with Zn_(0.5)Ti_(0.5)NbO_(4)(ZTN)ceramic particles were fabricated by *** particles were modified by C_(14)H_(19)f_(13)O_(3)Si to enhance the interface compatibility between PTfE and ZTN powders,which was characterized by X-ray photoelectron spectroscopy(XPS)and contact *** surface characteristic of particles transformed into hydrophobicity and tight microstructure as well as better dielectric properties were obtained after the surface *** microstructure,dielectric,thermal,mechanical properties,and water absorption of the composites concerning ZTN content were *** ZTN/PTfE composites with 50 vol% ZTN particles exhibit excellent dielectric properties with a high dielectric constant of 8.3,an extremely low dielectric loss of 0.00055 at 7 GHz,and a stable temperature coefficient of the dielectric constant of-12.2 ppm/℃.All the properties show modified ZTN particles filled PTfE composite is the potential material for microwave substrate application.

关键词： composites dielectric properties niobium substrate

Case study of ionospheric fluctuation over mid-latitude region during one large magnetic storm

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Science China(Technological Sciences) 2012年第5期55卷 1198-1206页

作者： zhang DongHe MO XiaoHua A Ercha hao YongQiang Department of Geophysics Peking UniversityBeijing 100871China State Key Laboratory of Space Weather Chinese Academy of SciencesBeijing 100080China College of Physics and Electronic Engineering Guangxi University for NationalitiesNanning 530006China

from Nov. 6 to 10, 2004, a large number of solar events occurred, which triggered many solar flares and coronal mass ejections (CMEs). These CMEs caused two large geomagnetic storms and continuous energy proton events. During this period, one large positive ionospheric storm happened over the East-Asian region on Nov. 8, 2004. On Nov. 10, 2004, a strong spread-f was observed by the ionosonde located in the mid-latitude region of East China and Japan, and the ionospheric fluctuation over the ionosonde stations derived from GPS observation was also obvious. In this report, the characteristics of the spatial distribution of the ionosphere fluctuation and its temporal evolution are studied using the parameter of the rate of total electron content (ROT) derived from dual-frequency GPS measurement. Strong fluctuating activity of the ionosphere was found over the mid-latitude region in the southern and northern hemispheres between longitudes of 100°E and 180°E during the magnetic storm period on Nov. 10, 2004, and a regular movement of the disturbing region was observed. In the end, the reason of the ionospheric fluctuation during this magnetic storm is analyzed.

关键词： ionospheric irregularities ionospheric scintillation TEC GPS rate of TEC

奶牛乳房炎5种致病菌多重PCR检测方法的建立与应用

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动物医学进展 2025年第1期46卷 48-55页

作者：王雪容张宇张海森杨王浩靳亚平陈华涛西北农林科技大学动物医学院/农业农村部动物生物技术重点实验室陕西杨凌712100

为建立一种能快速检测奶牛乳房炎主要病原菌(大肠埃希氏菌、无乳链球菌、肺炎克雷伯氏菌、金黄色葡萄球菌和肠炎沙门氏菌)的多重PCR检测方法,根据大肠埃希氏菌phoA基因、无乳链球菌ef-tu基因、肺炎克雷伯氏菌Khe基因、金黄色葡萄球菌Nu... 详细信息

为建立一种能快速检测奶牛乳房炎主要病原菌(大肠埃希氏菌、无乳链球菌、肺炎克雷伯氏菌、金黄色葡萄球菌和肠炎沙门氏菌)的多重PCR检测方法,根据大肠埃希氏菌phoA基因、无乳链球菌ef-tu基因、肺炎克雷伯氏菌Khe基因、金黄色葡萄球菌Nuc基因和肠炎沙门氏菌invA基因设计特异性引物,优化PCR反应体系与反应程序并进行特异性试验,同时分别构建含病原菌基因的pMD-19T重组质粒进行灵敏性试验。结果显示,多重PCR反应的最适引物工作浓度为0.8μmol/L,最适退火温度为59.6℃,最佳延伸时间为40 s,最合适的循环数为30次;优化后的多重PCR反应体系可扩增出5种目标病原菌的特异性条带;5种病原菌PCR检测灵敏度可达到5 copies/μL。进一步利用该多重PCR反应体系对采集的108份乳房炎乳样进行检测,检测结果显示,108份样本的阳性检出率为77.8%,大肠埃希氏菌、无乳链球菌、金黄色葡萄球菌、肺炎克雷伯氏菌和肠炎沙门氏菌的检出率分别为23.1%、8.3%、34.3%、8.3%、5.6%。结果表明,建立了一种具有良好特异性和灵敏性的多重PCR检测方法,在临床生产实践中可用于快速鉴定奶牛乳房炎的致病菌,为奶牛乳房炎的诊断、防控与流行病学调查提供了方法基础。

关键词：奶牛乳房炎病原菌多重PCR

A guide to shortening the time from submission to publication in frontiers of Environmental Science & Engineering

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frontiers of Environmental Science & Engineering 2020年第2期14卷 5-7页

作者： Jiao zhang Xia Huang Jiming hao John CCrittenden School of Environment Tsinghua UniversityBeijing 100084China Brook Byers Institute for Sustainable Systems Georgia Institute of TechnologyAtlantaGA 30332USA

Authors want to publish their work as soon as ***,the manuscript processing time increases if the manuscript does not meet the journal *** analysis of manuscripts submitted to frontiers o f Environmental Science&Engineering from November 2018 to July 2019 shows that the processing time was increased up to 33 days because the manuscripts:(1)had inconsistent formatting of citations,references,and units,(2)exceeded the word limit,(3)were missing information such as the graphical abstract,(4)plagiarized other papers,and(5)had too many tables and ***,we explain how authors can avoid these issues and decrease the manuscript processing time.

关键词： Manuscript Technical evaluation Technical review Return Time Reason Journal

Propagation of local spatial solitons in power-law nonlinear PT-symmetric potentials based on finite difference

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Communications in Theoretical Physics 2021年第12期73卷 14-24页

作者： hao Ji Yinghong Xu Chaoqing Dai Lipu zhang Department of Mathematics Zhejiang Sci-Tech UniversityHangzhou310018China Department of Physics Zhejiang A&F UniversityHangzhou311300China College of Media Engineering Communication University of ZhejiangHangzhou310018China

We consider the(2+1)-dimensional nonlinear Schrodinger equation with power-law nonlinearity under the parity-time-symmetry potential by using the Crank-Nicolson alternating direction implicit difference scheme,which can also be used to solve general boundary problems under the premise of ensuring *** use linear fourier analysis to verify the unconditional stability of the *** demonstrate the effectiveness of the scheme,we compare the numerical results with the exact soliton ***,by using the scheme,we test the stability of the solitons under the small environmental disturbances.

关键词： nonlinear Schrodinger equation localized spatial solitons PT-symmetric potential ADI difference scheme stability

The mobility of two-dimensional electron gas in AlGaN/GaN heterostructures with varied Al content

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Science in China(Series f) 2008年第6期51卷 780-789页

作者： zhang Jinfeng hao Yue zhang JinCheng NI JinYu Key Laboratory of the Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of Microelectronics Xidian University Xi'an 710071 China

The mobility of the two-dimensional electron gas （2DEG） in AIGaN/GaN hetero-structures changes significantly with AI content in the AIGaN barrier layer, while few mechanism analyses focus on it. Theoretical calculation and analysis of the 2DEG mobility in AIGaN/GaN heterostructures with varied AI content are carried out based on the recently reported experimental data. The 2DEG mobility is modeled analytically as the total effects of the scattering mechanisms including acoustic deformation-potential, piezoelectric, polar optic phonon, alloy disorder, interface roughness, dislocation and remote modulation doping scattering. We show that the increase of the 2DEG density, caused by the ascension of the AI content in the barrier layer, is a dominant factor that leads to the changes of the individual scat- tering processes. The change of the 2DEG mobility with AI content are mainly determined by the interface roughness scattering and the alloy disorder scattering at 77 K, and the polar optic phonon scattering and the interface roughness scattering at the room temperature. The calculated function of the interface roughness pa- rameters on the AI content shows that the stress caused AIGaN/GaN interface degradation at higher AI content is an important factor in the limitation of the in- terface roughness scattering on the 2DEG mobility in AIGaN/GaN heterostructures with high AI content.

关键词： GaN heterostructures 2DEG mobility

Energy transfer process of Nd^(3+)/Ho3+co-doped fluoride halide glasses with anion substituted multi-wavelength tunable mid-infrared luminescence

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Journal of Rare Earths 2021年第11期39卷 1344-1352,I0002页

作者： hao Yin Xiaosong zhang Lan Li Jiajia zhang Zhaowei zhang Xin Liu Xiaokai Gong Rukun Ding Key Laboratory of Display Materials and Photoelectric Devices Ministry of EducationTianjin Key Laboratory for Photoelectric Materials and DevicesNational Demonstration Center for Experimental Function Materials EducationInstitute of Material PhysicsSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Ho^(3+)doped ZBLAN glass with 2.0 and 2.9μm emission was *** order to further improve the luminescence of Ho^(3+),halogen ions(Cl,Br,1)were introduced to reduce the maximum phonon energy and phonon state density of the *** the same time,Nd^(3+)was introduced to transfer the energy to Ho^(3+)pumped with a 793 nm laser(Nd^(3+):4 f5/2,4 f3/2→Ho^(3+):5 I6).The effect of different halogen ion on the luminescent properties of the fluoride halide glass was *** results show that the luminescent intensity of infrared increases with the introduction of different halogen *** comparison,it is found that the sample with I-has the strongest luminescence of 1064 nm,2.0μm and 2.9μ*** is consistent with the calculated J-O intensity *** addition,the 2.0 and 2.9μm emission of Ho^(3+)pumped with a 450 nm laser will not disappear.A mid-infrared sample with multi-wavelength excitation and multi-wavelength emission can be ***^(3+)/Ho^(3+)co-doped fluoride halide glasses with 1064 nm,2.0μm and 2.9μm luminescence were prepared by melt quenching *** luminescent mechanism and the energy transfer process between the two ions of Nd^(3+)/Ho^(3+)co-doped fluoride halide glass were *** J-O parameters,luminescence lifetime and absorption emission cross-sectional area of Ho^(3+)and Nd^(3+)were calculated,*** is found that the value ofΩ2 in the glass matrix increases with the introduction of different halogen ions,whileΩ4 andΩ6 do not change obviously in different glass *** is because the environment of the crystal field around the rare earth ions *** crystal phase and phonon energy of the sample were analyzed by X-ray diffraction pattern and a fourier transform infrared spectrometer,*** on the above spectra and data(phonon energy is 634.71 cm-1),it can be predicted that Nd^(3+)/Ho^(3+)co-doped fluoride halide glass is a potential mid-infrared luminescent material.

关键词： Halogen ion substitution Rare earth ion Multi-wavelength tunable Energy transfer mechanism Mid-infrared emission

Selenium vacancy-rich and heteroatom-doped CoSe/Mo_(2)CTx MXene prepared using ionic liquid dopants for pH-universal hydrogen evolution and flexible supercapacitors

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Journal of Energy Chemistry 2022年第9期31卷 453-464,I0013页

作者： Mingjie Yi Shunyou Hu Na Li hao Wang Jiaheng zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyShenzhen 518055GuangdongChina Research Centre of Printed flexible Electronics School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055GuangdongChina

Vacancy engineering is a useful methodology in the development of catalysts and electrode ***,we report the introduction of Se-vacancy pairs in heteroatom-doped(N,B,and f)CoSe/Mo_(2)CT_(x) MXene(NBf-CoSe/Mo_(2)CT_(x))to enhance the hydrogen evolution reaction(HER)and supercapacitor activities via an ionic liquid-mediated *** vacancy pairs and heteroatom doping enable the reallocation of local electron states and add active sites,improving the electrochemical activity of NBf-CoSe/Mo_(2)CT_(x) with high HER activities over a broad range of *** a current density of 10 mA cm^(-2),overvoltages of 70 and 81 mV are respectively produced in 0.5 M H_(2)SO_(4)and 1 M *** optimal structure also exhibits outstanding electrochemical performance in an asymmetric supercapacitor with an energy density of 34.2 Wh kg^(-1)at a power density of 15989.6Wkg^(-1).This study opens new avenues for the introduction of Se vacancies and heteroatom doping to improve the application performance.

关键词： flexible supercapacitors,Heteroatom-doped CoSe Hydrogen evolution reaction Ionic liquids Selenium vacancy