检索结果-南通市图书馆

Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

引用

Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.Illarionova Maria V.Zhukova elena V.Kiseleva Marina B.Sharapova Daniil S.Zuev konstantin e.kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Revisiting the stretch-induced force deficit:A systematic review with multilevel meta-analysis of acute effects

引用

Journal of Sport and Health Science 2024年第6期13卷 805-819页

作者： konstantin Warneke Lars Hubertus Lohmann Institute of Human Movement Science Sport and HealthUniversity of GrazGraz 8010Austria Institute of Sport Science Alpen-Adria University of KlagenfurtKlagenfurt am Worthersee 9020Austria Institute of Human Movement and exercise Physiology University of JenaJena 07749Germany

Background:When recommending avoidance of static stretching prior to athletic performance,authors and practitioners commonly refer to available systematic ***,effect sizes(eS)in previous reviews were extracted in major part from studies lacking control conditions and/or prepost testing ***,currently available reviews conducted calculations without accounting for multiple study outcomes,with eS:0.03 to 0.10,which would commonly be classified as ***:Since new meta-analytical software and controlled research articles have appeared since 2013,we revisited the available literatures and performed a multilevel meta-analysis using robust variance estimation of controlled prepost trials to provide updated ***,previous research described reduced electromyography activity—also attributable to fatiguing training routines—as being responsible for decreased subsequent *** second part of this study opposed stretching and alternative interventions sufficient to induce general fatigue to examine whether static stretching induces higher performance losses compared to other exercise ***:Including 83 studies with more than 400 eS from 2012 participants,our results indicate a significant,small eS for a static stretch-induced maximal strength loss(eS=0.21,p=0.003),with high magnitude eS(eS=0.84,p=0.004)for stretching durations≥60 s per bout when compared to passive *** opposed to active controls,the maximal strength loss ranges between eS:0.17 to0.28,petching did not negatively influence athletic performance in general(when compared to both passive and active controls);in fact,a positive effect on subsequent jumping performance(eS=0.15,p=0.006)was found in ***:Regarding strength testing of isolated muscles(e.g.,leg extensions or calf raises),our results confirm previous ***,since no(or even positive)e

关键词： Static stretching Maximal strength Athletic performance Performance testing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Systemic juvenile idiopathic arthritis–associated lung disease: A retrospective cohort study

引用

World Journal of Clinical Pediatrics 2024年第1期13卷 73-83页

作者： konstantin e Belozerov Natalia M Solomatina eugenia A Isupova Alla A Kuznetsova Mikhail M Kostik Department of Pediatric Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia St.Petersburg State Budgetary Institution of Health Care Children's City Polyclinic No.29 of the Kalininsky District of St.PetersburgSt.Petersburg 195274Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases World-Class Research Centre for Personalized MedicineAlmazov National Medical Research CentreSt.Petersburg 197341Russia

BACKGROUND Lung damage in systemic juvenile arthritis(sJIA)is one of the contemporary topics in pediatric *** previous studies showed the severe course and fatal outcomes in some *** information about interstitial lung disease(ILD)in the sJIA is scarce and limited to a total of 100 *** To describe the features of sJIA patients with ILD in *** In the present retrospective cohort study,information about 5 patients less than 18-years-old with sJIA and ILD were *** diagnosis of sJIA was made according to the current 2004 and new provisional International League of Associations for Rheumatology criteria *** was diagnosed with chest computed tomography with the exclusion of other possible reasons for concurrent lung *** activation syndrome(MAS)was diagnosed with HLH-2004 and 2016 eULAR/ACR/PRINTO Classification Criteria and hScores were calculated during the lung *** The onset age of sJIA ranged from 1 year to 10 *** time interval before ILD ranged from 1 mo to 3 *** disease course was characterized by the prevalence of the systemic features above articular involvement,intensive rash(100%),persistent and very active MAS(hScore range:194-220)with transaminitis(100%),and respiratory symptoms(100%).Only 3 patients(60%)developed a clubbing *** patients(100%)had pleural effusion and 4 patients(80%)had pericardial effusion at the disease *** patients(40%)developed pulmonary arterial ***-related reactions to tocilizumab were observed in 3(60%)of the *** patient with trisomy 21 had a fatal disease *** of the remaining patients had sJIA remission and 2 patients had *** disease improved in 3 patients(75%),but 1 of them had initial deterioration of lung *** patient who has not achieved the sJIA remission had the progressed course of *** cases of hyper-eosinophilia were *** patients(80%)received

关键词： Systemic juvenile arthritis Interstitial lung disease Canakinumab Tocilizumab Interleukin-6 Interleukin-1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of doping profiles on the formation of laser-active centers in bismuth-doped GeO_(2)–SiO_(2)glass fibers

引用

Photonics Research 2024年第2期12卷 260-270页

作者： SeRGeY ALYSHeV ALeXANDeR VAKHRUSHeV ALeKSANDR KHeGAI eLeNA FIRSTOVA konstantin RIUMKIN MIKHAIL MeLKUMOV LYUDMILA ISKHAKOVA ANDReY UMNIKOV SeRGeI FIRSTOV Prokhorov General Physics Institute of the Russian Academy of Sciences Dianov Fiber Optics Research Center119333 MoscowRussia Devyatykh Institute of Chemistry of High-Purity Substances of the Russian Academy of Sciences 603951 Nizhny NovgorodRussia

Multi-wavelength-band transmission technology based on the exploitation of the extended spectral region is considered as a potential approach to increase the transmission capacity in the deployed fiber-optic communication *** development of optical amplifiers operating in the O-,e-,S-,and U-telecom bands is an extremely important challenge for the successful implementation of this ***-doped fibers are of increasing interest as gain materials,which can be used to provide broadband amplification in the mentioned telecom *** is due to the ability of Bi ions incorporated into glass network to form bismuth active centers(BACs)with specific optical properties,which are primarily determined by the glass *** this work,the impact of the doping profiles of both Ge atoms as glass modifiers and Bi ions on the BACs formation is studied using a series of bismuth-doped fibers fabricated by the modified chemical vapor deposition(MCVD)*** Bi-to-BACs conversion efficiency in various spatial regions of the studied samples is *** is turned out that for high-Bi concentration regions,the conversion efficiency is very low(less than 10%).In addition,the relationship of the conversion efficiency to the distribution of Bi ions and/or Ge atoms is ***,a continuous-wave laser at 1.46μm with a record slope efficiency of 80%is demonstrated using a Bi-doped fiber with confined doping profile,where the Bi-to-BACs conversion efficiency is 35%.This paper provides new information which might help to facilitate understanding of the features of Bi-doped fibers and their potentially achievable characteristics.

关键词： fiber fibers bismuth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear interferometers with correlated photons:toward spectroscopy and imaging with quantum light

引用

Light(Science & Applications) 2020年第1期9卷 840-841页

作者： konstantin e.Dorfman State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China

A nonlinear optical interferometer based on crystal superlattices has been demonstrated for the first time in a cascade of up to five *** enhanced sensitivity due to quantum interference and correlations makes it a pr... 详细信息

关键词： spectroscopy quantum Nonlinear

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ni catalyzed ethylene copolymerization with polar monomers

引用

Science China Chemistry 2019年第6期62卷 653-654页

作者： Igor e.Soshnikov Changle Chen konstantin P.Bryliakov Boreskov Institute of Catalysis Novosibirsk State University Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China

Introduction of polar comonomers into polyethylene is highly challenging,paving the way to tuning the copolymers'mechanical properties,adhesion/compatibility,and ***-group tolerant single-site palladium and,more tempting,nickel-based catalysts have demon-strated promising reactivities in the ethylene copolymerization with polar comonomers via coordination/insertion mechanism。

关键词： Introduction polyethylene mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CO_(2)-Free Calcium Carbide Manufacturing: Demanded Strategy in the Carbon-Neutral Chemical Industry

引用

Chinese Journal of Chemistry 2023年第24期41卷 3611-3617页

作者： Dmitriy e.Samoylenko konstantin S.Rodygin Valentine P.Ananikov Institute of Chemistry Saint Petersburg State University7/9 Universitetskaya nabSt.Petersburg199034 Russia Zelinsky Institute of Organic Chemistry Russian Academy of SciencesLeninsky pr.47Moscow119991 Russia

Calcium carbide is considered a possible key component in the sustainable carbon cycle,including convenient recycling of carbon wastes to industrial ***,currently employed CaC2 manufacturing process produces significant amounts of CO_(2).One of the main factors of its appearance is the formation of carbon oxide during the *** reaction of lime ore with coal inevitably results in the formation of CO and the loss of one carbon *** is usually burnt,forming CO_(2) to maintain the required high temperature during synthesis – 2200 ℃.In the present study,we discuss that the use of calcium metal instead of lime represents a good opportunity to prevent CO_(2) emission since the reaction of Ca with carbon occurs in an atom-efficient manner and results in only CaC_(2) at a much lower temperature of 1100 ℃.Here,the reaction of Ca with carbon was successfully tested to synthesize CaC_(2).The desired product was isolated in gram-scale amounts in 97.2% yield and 99% *** environmental friendliness of the proposed method originates from the calculations of the *** is provided concerning the cost factor of Ca within the considered process.

关键词： CO_(2)emission CaC_(2) Carbon cycle Sustainable chemistry Green chemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

引用

Genes & Diseases 2024年第5期11卷 40-43页

作者： konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif el Desoky Jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.eid Hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt egypt Center for Research and Regenerative Medicine(eCRRM) Cairo 11511Egypt Medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

experimental study of a low-pressure hybrid RF discharge

引用

Plasma Science and Technology 2020年第5期22卷 70-82页

作者： elena KRALKINA Polina NeKLIUDOVA Vladimir PAVLOV konstantin VAVILIN Ilya ZADIRIeV and Chen ZHAO Physical electronics Department Faculty of PhysicsLomonosov Moscow State University119991 MoscowRussia

experimental study of the low-pressure hybrid RF discharge with both inductive and capacitive channels was carried out. The RF power unit consists of inductor(antenna) and capacitor plates connected in parallel to the same RF power source. A separating capacitor Csepis included into the circuit between the antenna ends and the lead connected to the discharge capacitor plate in order to prevent the closing of the capacitive circuit through direct current by inductor and to control the contribution of capacitive channel to discharge sustaining. It is shown that at low power of the RF power source, power coupling to the discharge mainly occurs through the capacitive channel. Increasing the power of the RF power source increases the power coupled in the inductive channel, electron density, and current flowing through the capacitive channel. This leads to increasing voltage drop on the separating capacitor and partial cutoff of the capacitive channel. At separating capacitance values below certain value(below 50 pF in the present experiments), the self-bias of the loaded plate of the discharge capacitor becomes positive indicating that the thickness of the electrode sheath of the loaded electrode decreases compared to thickness of the sheath of the grounded electrode. The thickness of the space-charge sheath of the grounded electrode decreases with increasing power coupled to the plasma. At separating capacitance below 50 pF, higher harmonics of the RF voltage and current are actively generated in the capacitive discharge channel. Increasing the separating capacitance leads to decreasing electron density, increasing effective electron temperature and more effective RF energy coupling to plasma due to increasing relative importance of the capacitive discharge channel.

关键词： radio-frequency discharge plasma e-mode H-mode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Change in carbonate budget and composition during subduction below metal saturation boundary

引用

Geoscience Frontiers 2023年第1期14卷 79-100页

作者： Anton Shatskiy Anton V.Arefiev konstantin D.Litasov Vernadsky Institute of Geochemistry and Analytical Chemistry Russian Academy of SciencesMoscow 119991Russia Vereshchagin Institute for High Pressure Physics Russian Academy of SciencesTroitskMoscow 108840Russia

It is generally accepted that carbonates can be subducted to the mantle depths,where they are reduced with iron metal to produce a *** this work,we found that this is not always the *** mantle carbonates from inclusions in diamonds show a wide range of cation compositions(Mg,Fe,Ca,Na,and K).Here we studied the reaction kinetics of these carbonates with iron metal at 6-6.5 GPa and 1000-1500℃.We found that the reduction of carbonate with Fe produces C-bearing species(Fe,Fe-C melt,Fe_(3)C,F e_(7)C_(3),C)and wüistite containing Na_(2)O,CaO,and *** reaction rate constants(k=△x^(2)/2t)are log-linear relative to 1/T and their temperature dependences are determined to be k_(MgcO_(3))(m^(2)/s)=4.37×10^(-3)exp[-251(kJ/mol)/RT]k_(caMg(CO_(3))2)(m^(2)/s)=1.48×10^(-3)exp[-264(kJ/mol)/RT]k_(cacO_(3))(m^(2)/s)=3.06×10^(-5)exp[-245(kJ/mol)/RT]and k_(Na_(2)cO_(3))(m^(2)/s)=1.88×10^(-10)exp[-155(kJ/mol)/RT].According to obtained results at least,45-70 vol%of carbonates preserve during subduction down to the 660-km discontinuity if no melting *** slab stagnation and warming,subsequent carbonate melting,and infiltration into the mantle saturated with iron metal are accompanied by a reduction of carbonate melt with *** established sequence of reactivity of carbonates:FeCO_(3)≥MgCO_(3)>CaMg(CO_(3))2>CaCO_(3)>>Na_(2)CO_(3),where K_(2)CO_(3)does not react at all with iron metal,implies that during reduction carbonate melt with Fe evolves toward *** above conclusions are consistent with the findings of carbonates in inclusions in diamonds from the lower mantle and high concentrations of alkalis,particularly K,in mantle carbonatite melts entrapped by diamonds from kimberlites and placers worldwide.

关键词： Carbonate Reduction of carbonate with Fe Reaction kinetics Carbonatite melt High-pressure experiment earth's mantle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：