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Hepatotoxicity induced by cyproterone acetate:A report of three cases

World Journal of Gastroenterology 2006年第46期12卷 7551-7555页

作者： Ioanna Savidou Melanie deutsch Aspasia S Soultati Dimitrios Koudouras Georgia Kafiri Spyridon P Dourakis 2nd Department of Medicine University of Athens Medical School Hippokration General Hospital 114 Vas Sofias Avenues 11527 Athens Greece Department of Pathology Hippokration General Hospital Greece

Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration. Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease. Clinical features compatible with mixed hepatocellular and cholestatic liver disease including jaundice, white stools and dark urine, manifested in all three cases whereas encephalopathy and ascites were present in two of the patients. Other primary causes of hepatotoxicity (alcohol consumption and viral hepatitis) were also verified in two cases, and in those patients biopsy findings revealed the presence of cirrhotic lesions in liver parenchyma. Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement. The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases. Three relevant cases are reported and a review of the published literature is made.

关键词： Cyproterone acetate Drug induced hepatotoxicity Prostate cancer Idiosyncratic drug reaction Hepatomitogen action

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激光在医学上的应用

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物理 1989年第7期18卷 413-414页

作者： T.F.deutsch 侯馥兴

近年来随着激光技术的发展和对激光与机体组织之间相互作用认识的深入,激光在医学方面的应用有迅速的发展.其中有不少只是简单地把激光作为高亮度的光源,光束经过聚焦可使机体产生强烈的局部变热.而当激光用于切割或穿刺细胞时,则要利... 详细信息

近年来随着激光技术的发展和对激光与机体组织之间相互作用认识的深入,激光在医学方面的应用有迅速的发展.其中有不少只是简单地把激光作为高亮度的光源,光束经过聚焦可使机体产生强烈的局部变热.而当激光用于切割或穿刺细胞时,则要利用激光的高度会聚性,以达到亚微米量级的精度.最初的兴趣多集中在利用聚焦的激光束凝结视网膜的血管以及切割机体组织等方面.纤维光学的发展使光纤维把激光的能量有效地传递到人体内的适当部位.光纤与内窥镜观察系统相配合,可以对休内多种器官施行激光手术.染料激光器提供了可调谐的波长输出,选取能被血液强烈…

关键词：激光医学应用

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Predicting utility of a model for end stage liver disease in alcoholic liver disease

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World Journal of Gastroenterology 2006年第25期12卷 4020-4025页

作者： Aspasia S Soultati Spyridon P Dourakis Alexandra Alexopoulou Melanie deutsch Larissa Vasilieva Athanasios J Archimandritis 2nd Department of Internal Medicine University of Athens Medical School Hippokration General Hospital114 Vas Sofias AvenuesAthens 11527Greece

AIM： To validate the statistic utility of both the Maddrey Discriminant Function score and the Model for End-Stage Liver Disease as predictors of short term （30 d and 90 d） mortality in patients with alcoholic hepatitis and to assess prognostic factors among clinical characteristics and laboratory variables of patients with alcoholic hepatitis. METHODS： Thirty-four patients with the diagnosis of alcoholic hepatitis admitted to Hippokration University Hospital of Athens from 2000 to 2005 were assessed in the current retrospective study and a statistical analysis was conducted. RESULTS： 30- and 90-d mortality rates were reported at 5.9% （2/34） and 14.7% （5/34）, respectively. Significant correlation was demonstrated for the Model for End- Stage Liver Disease （P30 = 0.094, P90 = 0.046） and the Maddrey Discriminant Function score （P30 = 0.033, P90 = 0.038） with 30- and 90-d mortality whereas a significant association was also established for alanine aminotrans- ferase （P = 0.057）, fibrin degradation products （P = 0.048） and C-reactive protein （P = 0.067） with 90-d mortality. For 30-d mortality the Area Under the Curve was 0.969 （95%CI： 0.902-1.036, P = 0.028） for the Model for End-Stage Liver Disease score and 0.984 （95%CI： 0.942-1.027, P = 0.023） for the Maddrey Discriminant Function score with the optimal cut off point of 30.5 （sensitivity 1, specificity 0.937） and 108.68 （sensitivity 1, specificity 0.969）, respectively. Accordingly, for 90-d mortality the Area Under the Curve was 0.762 （95%CI： 0.559-0.965, P = 0.065） for the Model for End-Stage Liver Disease score and 0.752 （95%CI： 0.465-1.038, P = 0.076） for the Maddrey Discriminant Function score with the optimal cut off point of 19 （sensitivity 0.6, specificity 0.6） and 92 （sensitivity 0.6, specificity 0.946）, respectively. The observed Kaplan Meier survival rates for different score-categories were compared with logrank tests and higher score values were correlated with a lower survival. CONCLUSION： Equivale

关键词： Alcoholic liver disease Alcoholic hepatitis Maddrey discriminant function score Model for end-stage liver disease score

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GSLIB Version 2.0; 2nd ed.

GSLIB

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1998年

作者： deutsch Clayton V.

来源：畅想之星图书光盘版（南... 评论

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The XX International Congress of Zoology, 26-29 August 2008, Paris

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Integrative Zoology 2009年第3期4卷 257-257页

作者： JEAN-MARC JALLON Rene LAFONT Jean-Loup dHONDT Jean deutsch University of Paris-Sud 11 OrsayFrance University Pierre and Marie Curie 6 ParisFrance and National Museum of Natural History ParisFrance

International Congresses of Zoology(ICZ)provide an opportunity for zoologists working in different fields of zoology to meet and exchange their research and *** is also a venue where topical issues facing the science of zoology,such as the biodiversity crisis,the teaching of zoology and ethics can be *** Congresses were resurrected in 2000 in Athens and held again in Beijing in *** an age of increasing reductionism and complex information management,having a general meeting of zoologists to discuss the whole animal is of vital service to our science.

关键词： biodiversity Congress teaching

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“No Need to Get Salty” Or Is There? Sodium Functionality as a Consideration in Nutrition Public Health Policy

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Food and Nutrition Sciences 2021年第2期12卷 138-146页

作者： Molly Riordan Brandy-Joe Milliron Rachel Sherman Lauren Miller Jennifer Aquilante Jonathan deutsch Division of Chronic Disease & Injury Prevention Philadelphia Department of Public Health Philadelphia PA USA Department of Nutrition Sciences College of Nursing and Health Professions Drexel University Philadelphia USA Drexel Food Core Lab College of Nursing and Health Professions Drexel University Philadelphia USA Division of Chronic Disease & Injury Prevention Philadelphia Department of Public Health Philadelphia PA USA Drexel Food Core Lab Department of Food and Hospitality Management College of Nursing and Health Professions Drexel University Philadelphia USA

Aim: Public health professionals focus on both downstream (individual) and upstream (population-level) interventions to reduce sodium consumption and prevent sodium-related chronic diseases. Effective upstream interventions specifically aimed at reducing dietary sodium intake include the implementation of comprehensive nutrition standards that restrict the amount of sodium contained in foods available for purchase. The aim of this work was to identify sought-after foods that did not meet the Philadelphia Nutrition Standards’ sodium limits and reformulate those foods to be standards-compliant and consumer-acceptable. Subject and Methods: Two foods were reformulated for compliancy with the Philadelphia Nutrition Standards’ sodium limits and consumer acceptability: the hoagie roll and soft pretzel. Reformulation included sensory testing and engaging potential manufacturing partners to investigate products’ commercial potential. Results: While hoagie roll reformulation led to a local company manufacturing and selling the reformulated product, soft pretzel reformulation stalled due to lack of consumer acceptability of the reformulated product. Salt contributes desirable characteristics in the texture, taste, and appearance of the soft pretzel, the absence of which consumers found unacceptable. Conclusion: Product reformulation holds great potential to create lower-sodium foods that otherwise have all of the characteristics of the higher-sodium “original” products but requires an understanding of the role of salt in product recipes. Reducing salt without considering its multiple functions in food may result in a product that is unacceptable or even unsafe. A simple four-step tool can help public health practitioners evaluate the extent to which products are suitable for reformulation.

关键词： Sodium Chloride Dietary/Administration & Dosage Health Promotion/Methods Nutrition Policy Food/Standards Food Technology

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会计师事务所目前关注的四大优先事项

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新理财（公司理财） 2023年第11期 86-87页

作者： Sophie deutsch 不详

会计师事务所对其优先关注的事项进行了排名,按照顺序分别是效率、客户服务、业务增长和人才。本文阐述了小型、中型和大型会计师事务所分别采取的做法。根据汤森路透(Thomson Reuters)研究所发布的《税务专业人员状况报告》(以下简称... 详细信息

会计师事务所对其优先关注的事项进行了排名,按照顺序分别是效率、客户服务、业务增长和人才。本文阐述了小型、中型和大型会计师事务所分别采取的做法。根据汤森路透(Thomson Reuters)研究所发布的《税务专业人员状况报告》(以下简称《报告》),会计师事务所将效率列为今年最重要的优先事项,其次是客户服务、业务增长和人才。

关键词：会计师事务所客户服务优先事项税务专业汤森路透《报告》

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着手创办企业的五个步骤

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新理财（公司理财） 2023年第9期 79-80页

作者： Sophie deutsch 不详

开始经营企业的确是一个令人兴奋的时刻,但也可能使人望而生畏,特别是当你还不太能驾驭创建企业的每个复杂步骤时。从建立强大的客户基础、获得正确的技术解决方案以促进增长,到制定政策以减少洗钱风险,都有大量的因素需要考虑,以下五... 详细信息

开始经营企业的确是一个令人兴奋的时刻,但也可能使人望而生畏,特别是当你还不太能驾驭创建企业的每个复杂步骤时。从建立强大的客户基础、获得正确的技术解决方案以促进增长,到制定政策以减少洗钱风险,都有大量的因素需要考虑,以下五个方面介绍了在创立新企业时需要考虑的一些关键点。

关键词：洗钱风险五个方面五个步骤关键点技术解决方案

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Matter and Radiation at Extremes 2019年第3期4卷 1-17页

作者： C.deutsch Laboratoire de Physique des Gaz et Plasmas CNRSUniversite Paris-SudUniversite Paris-Saclay91405 OrsayFrance

Correlated ion stopping arising from an intense cluster ion beam(CIB)interacting with an ultradense plasma target of relevance to inertial confinement fusion(ICF)is first investigated in a two-body approximation in an arbitrarily degenerate electron fluid *** specific advantages of CIB-driven ICF are first demonstrated through 1D simulations,highlighting the very fine focusing of the ion beam on the target ***,theN-body configurations of ion debris resulting from the impact of heavy cluster ions are determined in terms of their specific *** validities of the usual assumptions of equal ion fragment charge and negligible coupling between stopping and Coulomb explosion are assessed.

关键词： cluster negligible debris

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在钻孔条件下试验金刚石切削具

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探矿工程 1987年第5期 55-57页

作者： U.deutsch 联邦德国

本文作者***先生系联邦德国克劳斯塔尔工业大学深钻和采油技术研究所博士研究生。今年6月应本刊编委会副主任委员、北京地质教育中心李世忠教授邀请来华讲学，介绍了联邦德国深孔水平钻进、岩石破碎研究和将在联邦德国实施14000m超深孔... 详细信息

本文作者***先生系联邦德国克劳斯塔尔工业大学深钻和采油技术研究所博士研究生。今年6月应本刊编委会副主任委员、北京地质教育中心李世忠教授邀请来华讲学，介绍了联邦德国深孔水平钻进、岩石破碎研究和将在联邦德国实施14000m超深孔的技术准备等情况。并访问了勘探技术研究所、探矿工程研究所和长春地质学院等单位。作者应本刊编辑部邀请为纪念本刊创刊30周年而热心撰写此文。

关键词：编委会副主任金刚石切削探矿工程勘探技术研究所长春地质学院地质教育博士研究生岩石破碎采油技术复合片

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