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Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents:efficacy and mechanisms

Acta Pharmacologica Sinica 2007年第9期28卷 1466-1475页

作者： komal raina Rajesh AGARWAI Department of Pharmaceutical Sciences School of PharmacyUniversity of Colorado Health Sciences CenterDenverCO 80262USA Department of Pharmaceutical Sciences School of PharmacyUniversity of Colorado Health Sciences CenterDenverCO 80262USA University of Colorado Cancer CenterUniversity of Colorado Health Sciences CenterDenverCO 80262USA

In an effort to develop effective alternative strategies that increase the therapeu-tic efficacy and minimize the systemic toxicity of chemotherapeutic agents,moreefforts are being directed towards the investigation of dietary supplements andother phytotherapeutic agents for their synergistic efficacy in combination withanticancer *** such agent is silibinin,which has shown promisingchemopreventive and anticancer effects in various in vitro and in vivo *** present review summarizes the effects of the combination of silibinin andchemotherapeutic drugs on the growth inhibition,cell cycle regulation,andapoptosis induction in prostate,breast,and lung cancer ***,theresults indicate a synergistic effect of silibinin on growth inhibition,reversal ofchemoresistance,apoptosis induction,and a strong increase in G2-M checkpointarrest when given in combination with these *** results are highlysignificant with respect to the combined chemotherapy approach,wherein thecriteria for combination is that the response has to be synergistic and that thedrugs should not share common mechanisms of resistance and not overlap intheir major side-effects.

关键词： silibinin chemotherapeutic agents combined chemotherapy phytotherapeutic agents

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Silibinin and colorectal cancer chemoprevention:a comprehensive review on mechanisms and efficacy

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The Journal of Biomedical Research 2016年第6期30卷 452-465页

作者： komal raina Sushil Kumar Deepanshi Dhar Rajesh Agarwal Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Cancer Center University of Colorado Anschutz Medical Campus

Globally,the risk of colorectal cancer（CRC） as well as the incidence of mortality associated with CRC is ***,it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents,for the prevention of *** ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC,and use these natural agents as a safe intervention strategy during the clinical course of this deadly *** the years,pre-clinical studies have shown that silibinin（a flavonolignan isolated from the seeds of milk thistle,Silybum marianum） has strong preventive and therapeutic efficacy against various epithelial cancers,including *** focus of the present review is to provide a comprehensive tabular summary,categorically for an easy accessibility and referencing,pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression.

关键词： colorectal cancer silibinin cancer chemoprevention milk thistle

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