Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents:efficacy and mechanisms

作     者：Komal RAINA Rajesh AGARWAI 

作者机构：Department of Pharmaceutical SciencesSchool of PharmacyUniversity of Colorado Health Sciences CenterDenverCO 80262USA Department of Pharmaceutical SciencesSchool of PharmacyUniversity of Colorado Health Sciences CenterDenverCO 80262USA University of Colorado Cancer CenterUniversity of Colorado Health Sciences CenterDenverCO 80262USA 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2007年第28卷第9期

页      面：1466-1475页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Original studies in our silymarin/silibinin and cancer chemoprevention program are funded by NCI RO1 grants(№ CA64514,CA102514,CA104286,CA112304,and CA113876) DOD prostate cancer program funding,and a NCI RO3 grant(CA99079) 

主　　题：silibinin chemotherapeutic agents combined chemotherapy phytotherapeutic agents 

摘      要：In an effort to develop effective alternative strategies that increase the therapeu-tic efficacy and minimize the systemic toxicity of chemotherapeutic agents,moreefforts are being directed towards the investigation of dietary supplements andother phytotherapeutic agents for their synergistic efficacy in combination withanticancer *** such agent is silibinin,which has shown promisingchemopreventive and anticancer effects in various in vitro and in vivo *** present review summarizes the effects of the combination of silibinin andchemotherapeutic drugs on the growth inhibition,cell cycle regulation,andapoptosis induction in prostate,breast,and lung cancer ***,theresults indicate a synergistic effect of silibinin on growth inhibition,reversal ofchemoresistance,apoptosis induction,and a strong increase in G2-M checkpointarrest when given in combination with these *** results are highlysignificant with respect to the combined chemotherapy approach,wherein thecriteria for combination is that the response has to be synergistic and that thedrugs should not share common mechanisms of resistance and not overlap intheir major side-effects.