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A Rapid Evaluation Method of the Heat Removed by a VCS before Rise-to-Power Tests

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Journal of Thermal Science 2015年第3期24卷 295-301页

作者： KUNIYOSHI takamatsu Safety Design Group Nuclear Hydrogen and Heat Application Research Center Japan Atomic Energy Agency 4002 Narita-cho Oarai-machi Higashiibaraki-gun Ibaraki-ken 311-1393 Japan

Before rise-to-power tests, the actual measured value of heat released from the Reactor Pressure Vessel(RPV) or removed by the Vessel Cooling System(VCS) cannot be obtained. It is difficult for operators to evaluate the reactor outlet coolant temperature supplied from the High Temperature Engineering Test Reactor(HTTR) before rise-to-power tests. Therefore, when the actual measured value of heat released from the RPV or removed by the VCS are changed during rise-to-power tests, operators need to evaluate quickly, within a few minutes, the heat removed by the VCS and the reactor outlet coolant temperature of 30 MW, at 100% reactor power, before the temperature achieves 967℃ which is the maximum temperature limit generating the reactor scram. In this paper, a rapid evaluation method for use by operators is presented. The difference between the experimental and analytical results was within 30(k W) and it is appropriate that the presented evaluation method can be applied; therefore, operators can analyze the heat removed by the VCS quickly, within a few minutes, before and during Rise-to-Power Tests.

关键词： VCS HTTR RPV Rise-to-power test

Influence of Separated Vortex on Aerodynamic Noise of an Airfoil Blade

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Journal of Thermal Science 2010年第1期19卷 60-66页

作者： Soichi Sasaki Hajime takamatsu Masao Tsujino Haruhiro Tsubota Hidechito Hayashi Faculty of Engineering Nagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Graduate School of Science and Technology Nagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Research Division Komatsu Ltd.1200MandaHiratsuka-shiKanagawa 254-8567Japan

In order to clarify the mechanism by which aerodynamic noise is generated from separated flow around an airfoil blade,the relation between the attack angle and the aerodynamic noise of the blade was analyzed using a wind tunnel experiment and a CFD *** the case of rear surface separation,the separated vortex which has a large-scale structure in the direction of the blade chord is transformed into a structure that concentrates at the trailing edge with an increase in the attack *** aerodynamic noise level then becomes small according to the vortex scale in the blade *** the flow is separated at the leading edge,a separated vortex of low pressure is formed at the vicinity of the trailing *** pressure fluctuations on the blade surface at the vicinity of the trailing edge become large due to the vortex in the *** is considered that the aerodynamic noise level increases when the flow is separated at the leading edge because the separated vortex is causing the fluctuations due to wake vortex shedding.

关键词： Vortex Aerodynamic Noise Shear Flow Separation Airfoil

Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes

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World Journal of Gastroenterology 2015年第13期21卷 3876-3887页

作者： Naoko Terao Shinji takamatsu Tomomi Minehira Tomoaki Sobajima Kotarosumitomo Nakayama Yoshihiro Kamada Eiji Miyoshi Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of MedicineSuita 565-0871Japan

AIM: To evaluate/isolate cancer stem cells(CSCs) from tissue or cell lines according to various definitions and cell surface markers. METHODS: Lectin microarray analysis was conducted on CSC-like fractions of the human pancreatic cancer cell line Panc1 by establishing anti-cancer drug-resistant cells. Changes in glycan structure of CSC-like cells were also investigated in sphere-forming cells as well as in CSC fractions obtained from overexpression of CD24 and CD44. RESULTS: Several types of fucosylation were increased under these conditions, and the expression of fucosylation regulatory genes such as fucosyltransferases, GDP-fucose synthetic enzymes, and GDP-fucose transporters were dramatically enhanced in CSC-like cells. These changes were significant in gemcitabineresistant cells and sphere cells of a human pancreatic cancer cell line, Panc1. However, downregulation of cellular fucosylation by knockdown of the GDP-fucose transporter did not alter gemcitabine resistance, indicating that increased cellular fucosylation is a result of CSC-like transformation. CONCLUSION: Fucosylation might be a biomarker of CSC-like cells in pancreatic cancer.

关键词： Anti-cancer drug resistance Cancer stem cells Fuco

Regulation of immune cell responses by semaphorins and their receptors

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Cellular & Molecular Immunology 2010年第2期7卷 83-88页

作者： Hyota takamatsu Tatsusada Okuno Atsushi Kumanogoh Department of Immunopathology Research Institute for Microbial Diseases Osaka University Suita Osaka Japan World Premier International Immunology FrontierResearch Center Osaka University Suita Osaka Japan

Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called ＇immune semaphorins＇, are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses： their functions in cell-cell interactions and their involvement in immune cell trafficking.

关键词： semaphorin immune regulation immune cell trafficking tumorigenesis autoimmune diseases

Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

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Neural Regeneration Research 2023年第11期18卷 2466-2473页

作者： Kanae Murata Kenya Nozawa Mayumi Matsushita Aozora Yamashita Rintaro Fujii Yuji Awaga Aldric Hama Takahiro Natsume Go Yoshida Yukihiro Matsuyama Hiroyuki takamatsu Hamamatsu Pharma Research Inc.HamamatsuShizuokaJapan Department of Orthopedic Surgery Hamamatsu University School of MedicineHamamatsuShizuokaJapan

The lack of truly robust analgesics for chronic pain is owed,in part,to the lack of an animal model that reflects the clinical pain state and of a mechanismbased,objective neurological indicator of *** present study examined stimulus-evo ked brain activation with functional magnetic resonance imaging in male and female cynomolgus macaques following unilateral L7 spinal nerve ligation and the effects of clinical analgesics pregabalin,duloxetine,and morphine on brain activation in these macaques.A modified straight leg raise test was used to assess pain severity in awake animals and to evo ke regional brain activation in anesthetized *** potential effects of clinical analgesics on both awake pain behavior and regional brain activation were *** spinal nerve ligation,both male and female macaques showed significantly decreased ipsilateral straight leg raise thresholds,suggesting the presence of radicula rlike *** treatment increased straight leg raise thresholds in both males and females whereas duloxetine and pregabalin did *** male macaques,the ipsilateral straight leg raise activated contralateral insular and somatosensory cortex(Ins/SII),and *** female macaques,the ipsilateral leg raise activated cingulate cortex and contralateral insular and somatosensory *** leg raises of the contralateral,unligated leg did not evoke brain *** reduced activation in all brain regions in both male and female *** males,neither pregabalin nor duloxetine decreased brain activation compared with vehicle *** females,however,pregabalin and duloxetine decreased the activation of cingulate cortex compared with vehicle *** current findings suggest a diffe rential activation of brain areas depending on sex following a peripheral nerve *** rential brain activation observed in this study could underlie qualitative sexual dimorphism in clinical chronic pain perception and responses to

关键词： biomarkers functional magnetic resonance imaging lumbar radicular pain Macaca fascicularis neuroimaging neuropathic pain sciatica straight leg raise

Impact of changing our cannulation method on the incidenceof post-endoscopic retrograde cholangiopancreatography pancreatitis after pancreatic guidewire placement

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World Journal of Gastroenterology 2011年第48期17卷 5289-5294页

作者： Takeshi Hisa Ryusuke Matsumoto Masato takamatsu Masayuki Furutake Department of Internal Medicine Saku Central Hospital

AIM： To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography （ERCP） pancreatitis （PEP） after pancreatic guidewire placement （PGW） can be reduced by using a different cannulation method. METHODS： BebNeen April 2001 and October 2009, PGW was performed in 142 patients with native papilla to overcome difficult biliary cannulation. Our cannulation method for ERCP was changed from contrast injection （CI） using a single-lumen catheter （April 2001-May 2008） to wire-guided cannulation （WGC） using a double-lumen catheter （June 2008-October 2009）. The CI protocol was also changed during the study period： in the first period it was used for routine pancreatography for detecting small pancreatic cancer （April 2001-November 2002）, whereas in the second period it was not （December 2002-May 2008）. In PGW with CI using a single- lumen catheter, the contrast medium in the catheter lumen was injected into the pancreatic duct. The success rate of biliary cannulation, the incidence of PEP according to the cannulation method, and the impact of CI using a single-lumen catheter on PEP in comparison with WGC using a double-lumen catheter were ***： CI with routine pancreatography, CI without routine pancreatography, and WGC were performed in 27 patients, 77 patients and 38 patients, respectively. Routine pancreatography did not contribute to the early diagnosis of pancreatic cancer in our study period. In CI without routine pancreatography and WGC, diagnostic pancreatography was performed in 17 patients and no patients, respectively. The success rate of biliary cannulation by PGW alone was 69%, and the final success rate was increased to 80.3% by the addition of consecutive maneuvers or a second ERCP. PEP occurred in 22 patients （15.5%）, and the severity was mild in all cases. When analyzed according to cannulation method, the incidence of PEP was 37.0% （10/27） in the patients who underwent CI with routine pancreatography, 14.3% （11/77） in tho

关键词： Pancreatic guidewire placement Wire-guidedcannulation Contrast injection Difficult biliary cannulation Post-endoscopic retrograde cholangiopancreatography pan-creatitis

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从祭祀来看殷商时代的数字观念

从祭祀来看殷商时代的数字观念

作者： takamatsu NAYORI 郑州大学

学位级别：硕士

殷商王朝的思想以“神祇”为主,“神祇”可分三大类:即自然神、宗主神以及至上神。殷人相信“神”统治这个世界,在世界上只有殷商王朝的“王”一人才能听神灵的吩咐。在王亲自举行的仪式中,“祭祀”是非常重要的环节。这些仪式承担着重... 详细信息

殷商王朝的思想以“神祇”为主,“神祇”可分三大类:即自然神、宗主神以及至上神。殷人相信“神”统治这个世界,在世界上只有殷商王朝的“王”一人才能听神灵的吩咐。在王亲自举行的仪式中,“祭祀”是非常重要的环节。这些仪式承担着重要作用,通过与神灵的思想沟通,能够向周围诸国显示王自身的权威,同时也能够保持殷商王朝国内的社会稳定。在记录祭祀内容的卜辞中,我们可知殷商王朝的各种数字观念以及与数字相关的思想等。当时的殷人在举行祭祀时,把各种动物、羌人、奴隶等作为祭品向神灵供奉,其中,动物的种类颇多,由卜辞可知当时“六畜”皆已齐备。除此之外,被作为“牺牲”的羌人也较多。商王或贵族族长在甲骨上刻辞时,也往往记录祭品的数量。通过把握祭品数量的一定规律性以及其与数字本意的关系,可以窥见殷商王朝对祭祀仪式的重视性和殷商王朝深刻而久远的数字观念。殷商王朝的祭祀中使用频度较高的数字为“一”、“二”、“三”、“五”和“十”。这五个数字使用频率高的原因与数字本义以及殷商王朝如何看待数字、对数字赋予何种意义有关系。但需要注意的是卜辞、甲骨上的刻辞并不是为了把当时的历史记录下来,或者把当时的思想、文化传授给下一代人,而是为了听取神灵吩咐而作成的卜辞,因此,由卜辞上记录的内容无法知道殷商王朝所有的东西。因为缺文严重,无法解读或无法判定甲骨文内容的卜辞也很多,所以,本论同时也通过参考文献古籍《尚书》中的数字用法的进行分析,由文献记载可知,《尚书》中经常使用的数字为“三”、“四”、“五”、“八”,含有具体意义的数字中最大的数字为“九”。再探寻隐藏在断离了与神之关系的场合下,其数字观念是否有变化。

关键词：殷商王朝卜辞数字观念《尚书》

Preoperative detection and localization of small bowel hemangioma: Two case reports

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World Journal of Gastroenterology 2017年第20期23卷 3752-3757页

作者： Nobuhisa Takase Keisuke Fukui Takafumi Tani Tohru Nishimura Tomohiro Tanaka Naoki Harada Kimihiko Ueno Manabu takamatsu Akihiko Nishizawa Akiharu Okamura Kunihiko Kaneda Department of Surgery Kakogawa Central City Hospital Department of Internal Medicine Kakogawa Central City Hospital Department of Diagnostic Pathology Kakogawa Central City Hospital

Among the various diagnostic modalities for small bowel hemangioma, video capsule endoscopy (VCE) and double-balloon enteroscopy (DBE) can be recommended as part of the work-up in patients with obscure gastrointestinal bleeding (OGIB). DBE is superior to VCE in the accuracy of diagnosis and therapeutic potential, while in most cases total enteroscopy cannot be achieved through only the antegrade or retrograde DBE procedures. As treatment for small bowel bleeding, especially spout bleeding, localization of the lesion for the decision of DBE insertion facilitates early treatment, such as endoscopic hemostatic clipping, allowing patients to avoid useless transfusion and the worsening of their disease into life-threatening status. Applying endoscopic India ink marking prior to laparoscopic surgical resection is a particularly useful technique for more minimally invasive treatment. We report two cases of small bowel hemangioma found in examinations for OGIB that were treated with combination of laparoscopic and endoscopic modalities.

关键词： Laparoscopic surgery India ink marking Small bowel hemangioma Obscure gastrointestinal bleeding Minimally invasive

Iron-making Technology Progress in Japan

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Iron-making Technology Progress in Japan