检索结果-南通市图书馆

Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2022年第7期34卷 305-314页

作者： Yukako Komaki koki Suganuma Yuko Ibuki Graduate Division of Nutritional and Environmental Sciences University of ShizuokaShizuoka 422-8526Japan

Dibromoacetonitrile(DBAN) is a disinfection byproduct(DBP) and linked with cancer in rodents, but the mechanism of its carcinogenicity has not been fully elucidated. We recently reported that DBAN induced inhibition of nucleotide excision repair(NER). In this study, we investigated if glutathione(GSH) is involved in the DBAN-induced inhibition of NER. Human keratinocytes Ha Ca T were pretreated with L-buthionine-(S,R)-sulfoximine(BSO) to deplete intracellular GSH. BSO treatment markedly potentiated the DBAN-induced NER inhibition as well as intracellular oxidation. The recruitment of NER proteins(transcription factor IIH, and xeroderma pigmentosum complementation group G) to DNA damage sites was inhibited by DBAN, which was further exacerbated by BSO treatment. Our results suggest that intracellular GSH protects cells from DBAN-induced genotoxicity including inhibition of DNA damage repair.

关键词： Disinfection byproducts Haloacetonitriles Pyrimidine dimers Glutathione DNA damage repair

Prostate-specific antigen-based population screening for prostatecancer： current status in Japan and future perspective in Asia

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第3期17卷 475-480页

作者： Yasuhide kitagawa Mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan

In Western countries, clinical trials on prostate cancer screening demonstrated a limited benefit for patient survival. In the Asia-Pacific region, including Japan, the rate of prostate-specific antigen （PSA） testing remains very low compared with Western countries, and the benefits of population-based screening remain unclear. This review describes the current status of population screening and diagnosis for prostate cancer in Japan and discusses the efficacy of population screening for the Asian population. Since the 1990s, screening systems have been administered by each municipal government in Japan, and decreases in the prostate cancer mortality rate are expected in some regions where the exposure rate to PSA screening has increased markedly. A population-based screening cohort revealed that the proportion of metastatic disease in cancer detected by screening gradually decreased according to the increased exposure rate, and a decreasing trend in the proportion of cancer with high serum PSA levels after population screening was started. The prognosis of the prostate cancer detected by population screening was demonstrated to be more favorable than those diagnosed outside of the population screening. Recent results in screening cohorts demonstrated the efficacy of PSA. These recent evidences regarding population-based screening in Japan may contribute to establishing the optimal prostate cancer screeninK system in Asian individuals.

关键词： free prostate-specific antigen pro-prostate-specific antigen prostate cancer prostate cancer gene 3 prostate-specificantigen-based population screening serum prostate-specific antigen distribution

Communication Scheduling with Diversity for Unmanned Aircraft Systems Using Local 5G

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Communications and Information Networks 2020年第1期5卷 50-61页

作者： Takeru kitagawa Yuichi Kawamoto Nei Kato Graduate School of Information Sciences Tohoku University Aramaki-Aoba 6-3-09Aoba-kuSendai980-8579Japan

The use of unmanned aircraft systems(UAS)for critical public service missions by public organizations,local governments,and social users is *** radio transmission by unmanned aerial vehicles(UAVs)is indispensable in these *** of the standards suitable for UAV wireless communications is local ***,to introduce local 5G into a UAS,several problems specific to UASes must be *** include the deterioration of the signal-to-noise ratio due to topography and obstacles,the uncertainty of the communication environment due to the movement of multiple UAVs,and the limitation of the frequency *** address these problems and to introduce local 5G into the UAS,we propose a novel communication scheduling *** method incorporates transmission modes with *** evaluations shows that total data volumes increase by 1.9~3 times with the proposed scheduling method compared with transmission without diversity or efficient scheduling.

关键词： unmanned aircraft system(UAS) unmanned aerial vehicle(UAV) local 5G diversity scheduling LTE sidelink time division multiple access(TDMA)

Top-k Outlier Detection from Uncertain Data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2014年第2期11卷 128-142页

作者： Salman Ahmed Shaikh Hiroyuki kitagawa Graduate School of Systems and Information Engineering University of Tsukuba

Uncertain data are common due to the increasing usage of sensors, radio frequency identification(RFID), GPS and similar devices for data collection. The causes of uncertainty include limitations of measurements, inclusion of noise, inconsistent supply voltage and delay or loss of data in transfer. In order to manage, query or mine such data, data uncertainty needs to be considered. Hence,this paper studies the problem of top-k distance-based outlier detection from uncertain data objects. In this work, an uncertain object is modelled by a probability density function of a Gaussian distribution. The naive approach of distance-based outlier detection makes use of nested loop. This approach is very costly due to the expensive distance function between two uncertain objects. Therefore,a populated-cells list(PC-list) approach of outlier detection is proposed. Using the PC-list, the proposed top-k outlier detection algorithm needs to consider only a fraction of dataset objects and hence quickly identifies candidate objects for top-k outliers. Two approximate top-k outlier detection algorithms are presented to further increase the efficiency of the top-k outlier detection *** extensive empirical study on synthetic and real datasets is also presented to prove the accuracy, efficiency and scalability of the proposed algorithms.

关键词： Top-k distance-based outlier detection uncertain data Gaussian uncertainty cell-based approach PC-list based approach

Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第22期25卷 2743-2751页

作者： koki Nakanishi Mitsuro Kanda Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of Medicine

Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis.

关键词： Gastric cancer Blood loss Prognosis Transfusion Adverse effect Immunosuppression Mortality Recurrence Complication

Partial sine wave tracking dual mode control topology for a single-phase transformerless photovoltaic system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2018年第6期6卷 1338-1343页

作者： koki OGURA Mohan Lal KOLHE Mutsuo NAKAOKA Kyushu Sangyo University University of Agder University of Malaya

A unique high efficiency photovoltaic(PV)system is presented. It uses partial sine wave tracking for a pulse-width modulation(PWM) boost converter as well as a full-bridge inverter. The boost converter and full-bridge inverter are connected via a compact intermediate film capacitor(i.e. non-smoothing DC link stage). PWM switching is activated by a dual mode control technique. In the proposed topology, simultaneous switching of both power conversion stages is avoided and therefore this increases the power conversion efficiency. The distinctive operating principles of these two power processing stages are discussed and analyzed with the experimental results for single-phase loading of the PV system.

关键词： Partial sine wave instantaneous tracking pulsewidth modulation(PWM) boost converter Bypass diode Dual mode control High efficiency power conversion

Magneto-Optical Properties of Wider Gap Semiconductors ZnMnTe and ZnMnSe Films Prepared by MBE

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2020年第3期18卷 201-211页

作者： Masaaki Imamura Daisuke Tashima Jiro kitagawa Hironori Asada Department of Electrical Engineering Fukuoka Institute of TechnologyFukuoka 811-0295 Graduate School of Sciences and Technology of Innovation Yamaguchi UniversityUbe 755-8611

TheⅡ-Ⅵbased magnetic semiconductors with a direct and wide optical bandgap are expected to show high potential for optical applications utilizing short wavelength laser diodes(LDs),such as 532-nm green and475-nm blue *** have confirmed that the Faraday rotationθ_F in the ZnMnTe and ZnMnSe films deposited on quartz glass(QG)and sapphire(SA)substrates by using molecular beam epitaxy(MBE)is large near the absorption *** paper reports the magneto-optical properties of ZnMnTe and ZnMnSe films synthesized on the QG and SA substrates,and shows the result of a direct Faraday rotation observation successfully made for the ZnMnTe films under 1.28-kHz alternating magnetic *** optical absorption characteristics of the ZnMnTe films grown on the SA substrates by MBE are discussed by comparing them with the optical absorption properties and photoluminescence spectra of theⅡ-ⅥZnTe parent single crystals.

关键词： Magnetic semiconductors magneto-optical effects wide bandgap ZnMnTe and ZnMnSe films

Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第5期15卷 1980-1995页

作者： koki Nishihara Clothilde Villot Lautaro Cangiano Le Luo Guan Michael Steele Department of Animal Biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Faculty of Land and Food Systems The University of British ColumbiaVancouverBC V6T 1Z4Canada Present Address:Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life,understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal *** probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune *** objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune *** Twenty Holstein bull calves received no supplementation(CON)or Saccharomyces cerevisiae boulardii(SCB)from birth to 5 d of *** tissue biopsies were taken within 2 h of life(D0)before the first colostrum feeding and 3 h after the morning feeding at d 5 of age(D5)to analyze mucosa-attached bacteria and colon *** sequencing showed that there was no difference inαandβdiversity of mucosa-attached bacteria between day and treatment,but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to *** addition,q PCR indicated that the absolute abundance of Escherichia coli(***)decreased in the colon mucosa on D5 compared to D0;however,that of Bifidobacterium,Lactobacillus,and Faecalibacterium prausnitzii,which could competitively exclude ***,increased in the colon mucosa on D5 compared to ***-sequencing showed that there were no differentially expressed genes between CON and SCB,but suggested that pathways related to viral infection such as“Interferon Signaling”were activated in the colon mucosa of D5 compared to *** Growth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB *** early life,opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune *** activation

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第14期26卷 1594-1600页

作者： koki Nakanishi Mitsuro Kanda Junichi Sakamoto Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of MedicineNagoya 466-8550Japan Tokai Central Hospital Kakamigahara 504-8601Japan

Many studies investigating postoperative pancreatic fistula(POPF)after gastrectomy,including studies measuring drain amylase content(D-AMY)as a predictive factor have been *** article reviews previous studies and looks to the future of measuring D-AMY in patients after *** causes of pancreatic fluid leakage are;the parenchymal and/or thermal injury to the pancreas,and blunt injury to the pancreas by compression and *** of D-AMY to predict POPF has become common in clinical practice after pancreatic surgery and was later extended to the gastric *** studies have reported associations between D-AMY and POPF after gastrectomy,and the high value of D-AMY on postoperative day(POD)1 was an independent risk *** improve both sensitivity and specificity,attempts have been made to enhance the predictive accuracy of factors on POD 1 as well as on POD 3 as combined *** several studies have shown a high predictive ability of POPF,it has not necessarily been exploited in clinical *** problems remain unresolved;ideal timing for measurement,optimal cut-off value,and means of intervention after *** clinical trial could be imperative in order to develop D-AMY measurement in common clinical practice for gastric surgery.

关键词： Gastric cancer Drain amylase Postoperative pancreatic fistula Pancreasrelated complications Gastrectomy Early prediction