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Development of Mental Health Literacy Scale for Depression Affecting the Help-Seeking Process in Health Professional Students

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International Journal of Mental Health Promotion 2021年第3期23卷 331-352页

作者： Soshi Kodama Koichi shido Nozomu Ikeda School of Rehabilitation Sciences Health Sciences University of HokkaidoHokkaido061-0293Japan School of Nursing and Social Services Health Sciences University of HokkaidoHokkaido061-0293Japan School of Health Sciences Sapporo Medical UniversityHokkaido060-8556Japan

Despite depression being a global mental health disorder,many people with depression do not seek psychiatric *** particular,it has been reported that only 15.7%of medical students seek treatment.A longer duration of untreated illness(DUI)leads to clinically poor *** shorten the DUI,the mental health literacy(MHL)with regard to depression needs to be improved,although it is unclear which MHL components will improve the help-seeking ***,the existing MHL scale for depression is poorly validated for structural ***,the purpose of this study was to develop an MHL scale for depression with verified reliability and validity(particularly structural validity)and verify its relationship with the help-seeking *** this purpose,we adapted the mixed research ***,we conducted a systematic literature review on MHL scales for depression to prepare a draft scale with content ***,we conducted semi-structured interviews on MHL with outpatients with ***,78 questions on MHL for depression were ***,to develop our scale,we verified the reliability and validity of these questions with 782 health professional *** sample size was 780 and data collection was performed by collective survey *** was conducted in 2018 in *** verify the factor structure,exploratory and confirmatory factor analyses were *** also examined the internal consistency,test-retest reliability,and criterion-related *** exploratory factor analysis revealed a three-factor structure(recognition of depression symptoms,helpseeking preferences,and depression onset possibility)with 10 *** to the confirmatory factor analysis results,the goodness of fit indicators had a good *** internal consistency,test-retest reliability,and criterion-related validity had good ***,the relationship between the MHL of depression and other factors affecting the help-seeking process was

关键词： Depression health literacy psychometrics secondary prevention

Evaluation of the inhibitory effect of docosahexaenoic acid and arachidonic acid on the initial stage of amyloid β1-42 polymerization by fluorescence correlation spectroscopy

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Advances in Alzheimer's Disease 2013年第2期2卷 66-72页

作者： koji Miwa Michio Hashimoto Shahdat Hossain Masanori Katakura Osamu shido Department of Environmental Physiology Shimane University Faculty of Medicine Shimane Japan

Amyloid β(Aβ)1-42 fibrillation is a crucial step in the development of pathological hallmarks, such as neuritic plaques and neurofibrillary tangles, of Alzheimer’s disease (AD). In this study, we evaluated the effects of free docosahexaenoic acid (DHA), an essential brain polyunsaturated fatty acid (PUFA), on the inhibition of Aβ1-42 fibrillation by fluorescence correlation spectroscopy (FCS), a technique capable of detecting molecular movements and interactions in solution. We also examined whether free arachidonic acid (AA), eicosapentaenoic acid (EPA), and metabolites of DHA, including neuroprotectin D1 (NPD1, 10S, 17S-dihydroxy-DHA), resolvin D1 (RvD1, 7S, 8R, 17S-trihydroxy-DHA), and didocosahexaenoyl glycerol (diDHA), affect Aβ1-42 polymerization. The results of the FCS study reveal that DHA and AA significantly reduced the diffusion time of TAMRA (5-carboxytetramethylrhoda-mine)-Aβ1-42 by 28% and 31%, respectively, while EPA, NPD1, RvD1, and diDHA had no effects on diffusion time. These results indicate that DHA and AA inhibited Aβ1-42 polymerization and that their inhibitory effects occurred at the initial stage of Aβ1-42 polymerization. This study will advance the research on PUFAs in preventing AD progression.

关键词： Docosahexaenoic Acid Arachidonic Acid Fluorescence Correlation Spectroscopy Amyloid β Peptide Fibrillation

SYNTHESIS AND CHARACTERIZATION OF[Ru_(6)(CO)_(18)]_(2-) IN NaX ZEOLITE CAGES AND ITS CATALYTIC BEHAVIOR FOR n-C_(4)H_(10) HYDROGENOLYSIS

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Chinese Chemical Letters 1995年第2期6卷 163-164页

作者： An Ming LIU Lin HUANG Yi De XU Takafumi shido Macaru ICHIKAWA State Key Laboratory for Catalysis Dalian Institute of Chemical PhysicsDalian 116023 Catalysis Research Center Hokkaido University.Sapporo 060JAPAN

Ru111(NH3)6 in the cages of NaX zeolite was converted in the presence of CO+H2 into [Ru6(CO)18]2-, which was characterized by in-situ FTIR, UV-VIS and EXAFS spectroscopies. The material derived from [Ru6(CO)18]2-/NaX ... 详细信息

关键词： ?

Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentation

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Regenerative Biomaterials 2021年第2期8卷 34-42页

作者： Rena shido Yoshinori Sumita Masahito Hara Mayumi Iwatake Shun Narahara Mayumi Umebayashi Kei-ichiro Miura Yukinobu Kodama Izumi Asahina Department of Regenerative Oral Surgery Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Basic&Translational Research Center for Hard Tissue Disease Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Laboratory of Craniofacial Tissue Engineering and Stem Cells Faculty of DentistryMcGill University3640 University StreetM43MontrealQuebec H3A 2B2Canada Department of Hospital Pharmacy Nagasaki University Hospital1-7-1 SakamotoNagasaki 852-8501Japan

Gene-activated matrix(GAM)has a potential usefulness in bone engineering as an alternate strategy for the lasting release of osteogenic proteins but efficient methods to generate non-viral GAM remain to be *** this study,we investigated whether an atelocollagen-based GAM containing naked-plasmid(p)DNAs encoding microRNA(miR)20a,which may promote osteogenesis in vivo via multiple pathways associated with the osteogenic differentiation of mesenchymal stem/progenitor cells(MSCs),facilitates rat cranial bone ***,we confirmed the osteoblastic differentiation functions of generated pDNA encoding miR20a(pmiR20a)in vitro,and its transfection regulated the expression of several of target genes,such as Bambi1 and PPARc,in rat bone marrow MSCs and induced the increased expression of ***,when GAMs fabricated by mixing 100 ll of 2%bovine atelocollagen,20mg b-TCP granules and 0.5mg(3.3 lg/ll)AcGFP plasmid-vectors encoding miR20a were transplanted to rat cranial bone surface,the promoted vertical bone augmentation was clearly recognized up to 8 weeks after transplantation,as were upregulation of VEGFs and BMP4 expressions at the early stages of ***,GAM-based miR delivery may provide an alternative non-viral approach by improving transgene efficacy via a small sequence that can regulate the multiple pathways.

关键词： gene-activated matrix in vivo gene transfer bone augmentation atelocollagen mir20a

Visualization of decreased docosahexaenoic acid in the hippocampus of rats fed an n – 3 fatty acid-deficient diet by imaging mass spectrometry

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Journal of Biophysical Chemistry 2012年第3期3卷 221-226页

作者： Shu Taira Michio Hashimoto Kazunori Saito Osamu shido Bruker Daltonics K.K. Kanagawa Japan Japan Advanced Institute of Science and Technology Ishikawa Japan Shimane University Haculty of Medicine Shimane Japan

The present study employed an imaging mass spectrometry (IMS) method to evaluate the effect of dietary n – 3 fatty acids on the fatty acid composition in rat brain. Rats were divided into two groups and fed either an n – 3 fatty acid-deficient or adequate diet. We determined the decreased n – 3 fatty acids in the hippocampus of rats fed an n – 3 fatty acid-deficient diet compared to the control. IMS visualization was achieved at a resolution of 100 m in rat brain, and showed decreased docosahexaenoic acid (DHA)-containing phosphatidyl choline (PC) or phosphatidyl ethanolamine (PE) in the hippocampus of rats fed an n – 3 fatty acid-deficient diet.

关键词： Docosahexaenoic Acid Imaging Mass Spectrometry Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry Hippocampus

固定时间热暴露对大鼠胸主动脉血管收缩性的影响

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第二军医大学学报 2013年第3期34卷 291-294页

作者：李光华赵楠杨敏赵志芳罗彦 Osamu shido 宁夏医科大学基础医学院生理学系银川750004 岛根大学医学部环境生理教研室

目的探讨固定时间热暴露对大鼠胸主动脉血管收缩特性的影响及机制。方法选用雄性Wistar大鼠,随机分为对照组、随意时间热暴露组和固定时间热暴露组,环境温度24℃,热暴露温度为36℃,每天热暴露6h。经7d热暴露后,采用体温遥感技术监测大... 详细信息

目的探讨固定时间热暴露对大鼠胸主动脉血管收缩特性的影响及机制。方法选用雄性Wistar大鼠,随机分为对照组、随意时间热暴露组和固定时间热暴露组,环境温度24℃,热暴露温度为36℃,每天热暴露6h。经7d热暴露后,采用体温遥感技术监测大鼠体核温度变化;器官浴槽法测定大鼠胸主动脉对去甲肾上腺素(NA)的反应性;RT-PCR检测动脉血管内皮型一氧化氮合酶(eNOS)mRNA的表达水平及用试剂盒测定血浆中一氧化氮等离子体(NOx)NO2-和NO3-的含量变化。结果热暴露对大鼠的体核温度变化影响不大(P>0.05);与对照组相比,固定时间热暴露组大鼠胸主动脉血管对NA的反应性降低(P<0.01);与对照组和随意时间热暴露组相比,固定时间热暴露组eNOS mRNA相对表达水平及血浆中NOx的含量增加(P<0.05)。结论固定时间热暴露可改变大鼠胸主动脉血管的反应性,内皮细胞源性的NOS通路可能参与并诱导了血管舒张作用。

关键词：热体温血管收缩胸主动脉

Computational Analyses of Docosahexaenoic Acid (DHA, C22:6, n-3) with Alzheimer’s Disease-Causing Amyloid Peptide Aβ_1-42 Reassures Its Therapeutic Utility

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Advances in Alzheimer's Disease 2016年第2期5卷 73-86页

作者： Michio Hashimoto Shahdat Hossain Kentaro Matsuzaki Abdullah Al Mamun Hiroyuki Arai Osamu shido Department of Environmental Physiology Faculty of Medicine Shimane University Izumoshi Japan Laboratory of Alternative Medicine and Behavioral Neurosciences Department of Biochemistry and Molecular Biology Jahangirnagar University Dhaka Bangladesh Department of Geriatrics and Gerontology Division of Brain Sciences Institute of Development Aging and Cancer Tohoku University Sendai Japan

The accumulation of amyloid β peptide1-42 (Aβ1-42) masses in the brains of Alzheimer’s Disease (AD) patients is associated with neuronal loss and memory deficits. We have previously reported that oral administration of docosahexaenoic acid (DHA, C22:6, n-3) significantly decreases Aβ burden in the brains of AD model rats and that direct in vitro incubation of DHA with Aβ1-42 curbs the progression of amyloid fibrillation. In the present in silico study, we investigated whether DHA computationally binds with amyloid peptides. The NMR solution structures of Aβ1-42 were downloaded from the Protein Data Bank (PDB IDs: 1Z0Q and 2BEG). The binding of DHA to Aβ peptides was assessed by molecular docking using both a flexible and rigid docking system. Thioflavin T (ThT) was used as positive control. The chemical structures of ThT and DHA were modeled and converted to the PDB format using PRODRUG. Drug-like properties of DHA were evaluated by ADME (Absorption, Distribution, Metabolism, and Excretion). DHA was found to successfully dock with Aβ1-42. Computational analyses of the binding of DHA to Aβ1-42, as evaluated by docking studies, further corroborated the inhibitory effect of DHA on in vitro Aβ1-42 fibrillogenesis and might explain the in vivo reduction of amyloid burden observed in the brains of DHA-administered AD model rats demonstrated in our previous study. These computational data suggest the potential utility of DHA as a preventive medication in Aβ-induced neurodegenerative diseases, including AD.

关键词： Docosahexaenoic Acid Alzheimer’s Disease Amyloid Beta Peptide Molecular Docking In Silico Drug Design Protein Data Bank

Confirmation of the Experimentally-Proven Therapeutic Utility of Madecassoside in an Aβ<sub>1-42</sub>Infusion Rat Model of Alzheimer’s Disease by in Silico Analyses

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Advances in Alzheimer's Disease 2015年第2期4卷 37-44页

作者： Abdullah Al Mamun Michio Hashimoto Shahdat Hossain Masanori Katakura Hiroyuki Arai Osamu shido Department of Environmental Physiology Shimane University Faculty of Medicine Izumoshi Japan Laboratory of Alternative Medicine and Behavioral Neurosciences Department of Biochemistry and Molecular Biology Jahangirnagar University Dhaka Bangladesh Department of Geriatrics and Gerontology Division of Brain Sciences Institute of Development Aging and Cancer Tohoku University Sendai Japan

The accumulation of amyloid β peptide 1 - 42 (Aβ1-42) in the brain of Alzheimer’s disease (AD) patients is known to be associated with neurodegeneration and memory impairment. More recently, we reported that madecassoside, an active component of Centella asiatica, improved memory impairment in an Aβ1-42 infusion rat model of AD, ameliorated neurotoxicity in SH-SY5Y cells, and inhibited in vitro Aβ1-42 fibril formation. In the present study, we investigated the utility of in silico analyses in corroborating observed in vivo and in vitro effects of madecassoside in AD to further assess the therapeutic benefits of madecassoside. The 3D structure of Aβ1-42 was downloaded from the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB). The binding of madecassoside to Aβ1-42 was assessed by molecular docking. The chemical structure of madecassoside was modeled and converted to the PDB format. Madecassoside was found to successfully dock with Aβ1-42. Computational demonstration of the binding of madecassoside to Aβ1-42 further corroborated the inhibitory effect of madecassoside on Aβ1-42 fibrillogenesis which was demonstrated in our previous study. These data showed the potential utility of madecassoside as a preventive medication in Aβ1-42-induced neurodegenerative diseases such as AD.

关键词： Alzheimer’s Disease Centella asiatica Madecassoside Ayurveda in Silico Drug Designing

SHIP－IN－BOTTLE　SYNTHESIS　AND　CHARACTERIZATION　OF　Ru_4H_4（CO）_（12）ENTRAPPED　WITHIN　NaY　ZEOLITE

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Chinese Chemical Letters 1994年第11期5卷 999-1000页

作者： An Ming LIU Yi De Xu Takafumi shido Masaru ICHIKAWA (Catalysis Research Center.Hokkaido University, Sapporo 060.Japan State Key Laboratory for Catalysis, Dalian Institute of Chemical Physics.Dalian 116023)

The ruthenium hydrido-carbonyl cluster in NaY zeolite,synthesized by the reaction of Ru3(CO)(12)/NaY with hydrogen,was characterized by FTIR,UV-VIS and EXAFS spectroscopies.

关键词： Ru4H4 OF ZEOLITE WITHIN NaY SHIP CO