Visualization of decreased docosahexaenoic acid in the hippocampus of rats fed an n – 3 fatty acid-deficient diet by imaging mass spectrometry
Visualization of decreased docosahexaenoic acid in the hippocampus of rats fed an n – 3 fatty acid-deficient diet by imaging mass spectrometry作者机构：Bruker Daltonics K.K. Kanagawa Japan Japan Advanced Institute of Science and Technology Ishikawa Japan Shimane University Haculty of Medicine Shimane Japan
出 版 物：《Journal of Biophysical Chemistry》 (生物物理化学（英文）)
年 卷 期：2012年第3卷第3期
页 面：221-226页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Docosahexaenoic Acid Imaging Mass Spectrometry Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry Hippocampus
摘 要：The present study employed an imaging mass spectrometry (IMS) method to evaluate the effect of dietary n – 3 fatty acids on the fatty acid composition in rat brain. Rats were divided into two groups and fed either an n – 3 fatty acid-deficient or adequate diet. We determined the decreased n – 3 fatty acids in the hippocampus of rats fed an n – 3 fatty acid-deficient diet compared to the control. IMS visualization was achieved at a resolution of 100 m in rat brain, and showed decreased docosahexaenoic acid (DHA)-containing phosphatidyl choline (PC) or phosphatidyl ethanolamine (PE) in the hippocampus of rats fed an n – 3 fatty acid-deficient diet.
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