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千禧桥与伦敦眼

建筑实践 2008年第4期 70-75页

作者： nomura shin

五月的伦敦天气多变,乌云在霎那间占据了太阳的领地,没有阳光,暖风骤然变得沁凉,几分钟前的风和日丽是那么的不真实。云朵的层次让天空变得无比立体,是那样的美丽。穿梭在天空的飞机一瞬间被乌云吞没,消失在无际的云朵中,好比刚才明媚... 详细信息

五月的伦敦天气多变,乌云在霎那间占据了太阳的领地,没有阳光,暖风骤然变得沁凉,几分钟前的风和日丽是那么的不真实。云朵的层次让天空变得无比立体,是那样的美丽。穿梭在天空的飞机一瞬间被乌云吞没,消失在无际的云朵中,好比刚才明媚的阳光,怀疑它是否真正存在过。而又在另一个瞬间,飞机穿越云间,恍然一切的真实。

关键词：天空伦敦避震摩天轮

Effects of Bofutsushosan and Gardeniae Fructus on Diabetic Serum Parameters in Streptozotocin-Induced Diabetic Mice

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Chinese Medicine 2011年第4期2卷 130-137页

作者： Qing Yu Mai Yasuda Tatsuo Takahashi Masaaki nomura Nobuyoshi Hagino Shinjiro Kobayashi 不详

Streptozotocin (STZ)-induced diabetic mice increased levels of serum glucose, triglyceride and cholesterol, and decreased level of serum insulin. Effects of Bofutsushosan (BOF: Pulvis ledebouriellae compositae: 防風通聖散) and its composed crude drug, gardeniae fructus (GF: 山梔子) were investigated on levels of these diabetic parameters (serum glucose, insulin, triglyceride and cholesterol) in STZ-diabetic mice. BOF and GF were extracted in 10 volumes of distilled water with an automatic extractor “Torobi”. STZ-induced diabetic mice with serum glucose level of over 600 mg/dl at 3 - 4 weeks after intravenous injection of 150 mg/kg STZ were used for experiments. BOF extract, GF extract, geniposide (a main constituent of GF), and glibenclamide were administered intraperitoneally into 3-hour-fasted STZ-diabetic mice. At 6 hours after administration, BOF extract (100 - 300 mg/kg) decreased high levels of serum glucose, triglyceride and cholesterol, and also increased low level of serum insulin in STZ-diabetic mice in a dose-dependent manner, respectively. Anti-diabetic drug glibenclamide (0.3 - 1 mg/kg) as positive control significantly decreased serum glucose and cholesterol levels, and increased serum insulin level in the diabetic mice. GF extract (30 - 300 mg/kg) decreased serum glucose, triglyceride and cholesterol levels but did not affect serum insulin level in the diabetic mice. Geniposide (10 - 100 mg/kg), decreased serum glucose level but did not affect serum insulin and triglyceride levels in the diabetic mice. These results demonstrated that intraperitoneally administrated BOF extract improved abnormal levels of serum glucose, insulin, triglyceride and cholesterol in the STZ-diabetic mice as being similar to glibenclamide. GF extract has an important role in a part of improving actions of BOF in the diabetic mice. The action of GF extract on serum glucose was parallel with the action of geniposide in the diabetic mice, supporting roles of geniposide in anti-hyperglyc

关键词： Bofutsushosan (Pulvis Ledebouriellae Compositae: 防風通聖散) Gardeniae Fructus (山梔子) Geniposide Streptozotocin-Induced Diabetic Mice Anti-Hyperglycemic Action An-ti-Hyperlipidemic Action

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回转式压缩机效率的提高

制冷技术 1985年第4期 44-54页

作者： Teruo nomura

本文介绍如何提高回转式压缩机的效率。首先估算压缩机的功率损失,分析轴承的运转状态,並计算压缩机的性能。其次,为了测得压缩机内部的状态数据,在实际压缩机中测量机壳内的温度和气缸内的压力,但是用一个实际压缩机来测量是不够充分的... 详细信息

本文介绍如何提高回转式压缩机的效率。首先估算压缩机的功率损失,分析轴承的运转状态,並计算压缩机的性能。其次,为了测得压缩机内部的状态数据,在实际压缩机中测量机壳内的温度和气缸内的压力,但是用一个实际压缩机来测量是不够充分的,故利用模拟实际压缩机的泄漏状态及润滑状态的试验装置来进行模型试验。然后在上述分析与测量的基础上,计算减少损失的各种的效果,通过采用最有效的措施。使效率提高12％,並在容量调节装置工作时,使效率的降低减小到最小。

关键词：回转式压缩机轴承机械损失液体润滑气体压缩机功率损失

A Greener Approach for Synthesis of Functionalized Polyolefins by Introducing Reactive Functionality into Ethylene Copolymers

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Green and Sustainable Chemistry 2014年第3期4卷 133-143页

作者： Wannida Apisuk Ken Tsutsumi Hyun Joon Kim Dong Hyun Kim Kotohiro nomura Department of Chemistry Tokyo Metropolitan University Tokyo Japan Korea Institute of Industrial Technology Ansan Republic of Korea

Recent successful examples for synthesis of new polyolefins containing (polar) functionalities by adopting the approaches by controlled incorporation of reactive functionalities (and the subsequent introduction of polar functionalities under mild conditions) by coordination polymerization in the presence of transition metal complex catalysts have been described. Related methods (such as direct copolymerization of olefin with polar monomer using living radical or coordination insertion methods) have also been demonstrated for comparison. Our recent efforts for precise synthesis of polyolefins containing polar functionalities by efficient incorporation of reactive functionality by copolymerization of ethylene with nonconjugateddiene (1,7-octadiene, vinylcyclohexene etc.) or divinyl-biphenyl using nonbridged half-titanocene [ex. Cp’TiCl2(O-2,6-iPr2C6H3), Cp’ = C5Me5, tBuC5H4 etc.] catalysts have been introduced.

关键词： Fine Polyolefin Incorporation of Reactive Functionality Copolymerization

DFT Study on Reaction Mechanism of DNA Base Pair with Hydroxyl Radical

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Journal of Modern Physics 2013年第3期4卷 442-451页

作者： Eisuke Shimizu Ryota Hoshino Kazuya nomura Victor I. Danilov Noriyuki Kurita Department of Computer Science and Engineering Toyohashi University of Technology Toyohashi Japan Department of Molecular and Quantum Biophysics Institute of Molecular Biology and Genetics National Academy of Sciences of Ukraine Kyiv Ukraine

In order to elucidate the indirect effect by radiation on DNA base pairs, we investigate the mechanism for the attacking reaction of a hydroxyl radical (·OH-radical) to the G-C and A-T base pairs, by the density functional theory (DFT) calculations. The effect of solvation on the mechanism is also revealed by performing the same DFT calculations under the continuum solvation approximation. We find the stable structures for the dehydrogenated G-C and A-T base pairs, in which the hydrogen atom of NH2 group of G or A base is abstracted by the ·OH-radical. The solvation around the base pairs stabilizes the dehydrogenated structures significantly, indicating the acceleration of the attacking reaction by ·OH-radical to the base pairs in water. Therefore, we conclude that the hydrogen atom of the NH2 group of G or A base in the G-C and A-T base pairs is the most preferably abstracted by the ·OH-radical in living cells.

关键词： Density Functional Theory DNA Hydroxyl Radical Base Pair Reaction Mechanism Dehydrogenation

Fundamental Study on the Production of ＂Hyper Wood Pellet＂——Effect of Torrefaction Condition on Grinding and Pelletizing Properties

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Journal of Energy and Power Engineering 2013年第4期7卷 705-710页

作者： Takahiro Yoshida Tetsuya Sano Takashi nomura Hideki Gensai Hiroki Watada Seiji Ohara Forestry and Forest Products Research Institute Tsukuba 305-8687 Japan Fukui Prefectural Green Center Sakai 910-0336 Japan

In order to upgrade the conventional wood pellet, Japanese softwood and hardwood chips were torrefied at around 200-350℃, and pelletized. The characteristics of the torrefied material/pellets such as their calorific value, grinding energy, pelletizing energy and elemental composition, were also evaluated in this study. The calorific value rose with increasing torrefaction temperature and exceeded 25 MJ/kg （an increase of nearly 40% compared to the untreated state） for torrefaction at around 350℃. The grinding energy greatly decreased with increasing torrefaction temperature, and the reduction was larger for Japanese oak hardwood chips. The pelletization energy for the torrefied material tended to be slightly smaller than in the untreated case. People named such torrefied pellet as ＂hyper wood pellet＂.

关键词： Wood pellets torrefaction calorific value.

Vancomycin Resistant Enterococci(VRE) and the highly efficiently conjugative plasmids

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Vancomycin Resistant Enterococci(VRE) and the highly efficie...

Clinical factors influencing the resting and stimulated salivary flow

第8届全国抗菌药物临床药理学术会议暨北京大学临床药理研究所成立三十周年

作者： Yasuyoshi Ike Takahiro nomura Koichi Tanimoto Haruyoshi Tomita Department of Bacteriology Gunma University Graduate School of Medicine MaebashiGunmaJapan Laboratory of Bacterial Drug Resistance Gunma University Graduate School of MedicineMaebashiGunmaJapan

Multiple-drug-resistant enterococci and vancomycin-resistant enterococci(VRE),in particular,are opportunistic pathogens and major causes of nosocomial infections in immuno-compromised *** isolation of VRE(VanA type)was first reported in 1988 in the United Kingdom and France,and shortly thereafter it was reported in the United *** then,VRE have been identified in many *** have caused an increasing

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Open Journal of Stomatology 2012年第2期2卷 103-109页

作者： Shigeo Yamachika Ken Yamamoto Yoshiaki nomura Hiroyuki Yamada Ichiro Saito Yoichi Nakagawa Department of Clinical Pathophysiology School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Oral Medicine and Stomatology School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Geriatric Dentistry School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Translational Research School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Oral and Maxillofacial Surgery School of Dental MedicineTsurumi UniversityYokohamaJapan Department of Pathology School of Dental MedicineTsurumi UniversityYokohamaJapan

Objective: The objective of this study was to examine the clinical and immunological factors influ encing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative con-tributions of clinical and immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = -0.244), grade of lip biopsy (-0.189), and anti-SS-B antibody (-0.171), were significantly associated with the RSF. The stage of sialography (?0.423) and age (-0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.

关键词： Xerostomia Sialometry Sialography Labial Minor Salivary Gland Biopsy Sjogren’s Syndrome

Inhibitory Actions of Tetrandrine on Tumor Necrosis Factor α-Induced NF-κB Activation in Neovascularization of Cultured Choroidal Explants

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Chinese Medicine 2010年第3期1卷 75-83页

作者： Minoru Kikuchi Shusuke Kamimura Masaaki nomura Tatsuo Takahashi Nobuyoshi Hagino Shinjiro Kobayashi 不详

Tetrandrine (1 μM), a bis-benzylisoquinoline alkaloid isolated from Stephania tetrandra S Moore, signifi-cantly decreased tumor necrosis factor alpha (TNFα;10 ng/ml)-induced increase in the number of micro vessels that budded from cultured rat choroidal explants. Tetrandrine also decreased the TNFα-induced in-crease in the number of cells composing the microvessels. Ammonium pyrrolidine dithiocarbamate (APDC;0.1-0.3 μM), an inhibitor of nuclear factor-κB (NF-κB), decreased the TNFα-induced increase in the number of microvessels in a concentration-dependent manner. TNFα increased the phosphorylation and degradation of inhibitor of NF-κB (IκBα), as well as increasing the DNA-binding activity of NF-κB in choroidal explants. TNF? induced an increase of vascular endothelial growth factor (VEGF)-A mRNA, but not VEGF-C mRNA or VEGF-D mRNA. TNFα-induced angiogenic action was inhibited by treatment of VEGF-A antibody in cultured choroidal capillaries. Tetrandrine inhibited the TNFα-induced increases of phosphorylation and degradation of IκBα, and reduced the TNFα-induced increase of DNA-binding activity of NF-κB in chor-oidal explants. In conclusion, tetrandrine inhibits TNFα-induced activation of NF-κB in the choroidal capil-laries via inhibition of TNFα-induced phosphorylation of IκBα.

关键词： Choroidal Neovascularization Anti-angiogenesis Tetrandrine Tumor Necrosis Factor α NF-κB Activity Phosphorylation of IκBα