Clinical factors influencing the resting and stimulated salivary flow

作     者：Shigeo Yamachika Ken Yamamoto Yoshiaki Nomura Hiroyuki Yamada Ichiro Saito Yoichi Nakagawa 

作者机构：Department of Clinical PathophysiologySchool of Dental MedicineTsurumi UniversityYokohamaJapan Department of Oral Medicine and StomatologySchool of Dental MedicineTsurumi UniversityYokohamaJapan Department of Geriatric DentistrySchool of Dental MedicineTsurumi UniversityYokohamaJapan Department of Translational ResearchSchool of Dental MedicineTsurumi UniversityYokohamaJapan Department of Oral and Maxillofacial SurgerySchool of Dental MedicineTsurumi UniversityYokohamaJapan Department of PathologySchool of Dental MedicineTsurumi UniversityYokohamaJapan 

出 版 物：《Open Journal of Stomatology》 (口腔学期刊（英文）)

年 卷 期：2012年第2卷第2期

页      面：103-109页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This investigation was supported in part by a grant-in-aid from the Ministry of Education Culture Sports Science and Technology 

主　　题：Xerostomia Sialometry Sialography Labial Minor Salivary Gland Biopsy Sjogren’s Syndrome 

摘      要：Objective: The objective of this study was to examine the clinical and immunological factors influ encing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative con-tributions of clinical and immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = -0.244), grade of lip biopsy (-0.189), and anti-SS-B antibody (-0.171), were significantly associated with the RSF. The stage of sialography (?0.423) and age (-0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.