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World Journal of Hepatology 2014年第10期6卷 745-751页

作者： Masayuki Ishii Toru Mizuguchi kohei harada Shigenori Ota Makoto Meguro Tomomi Ueki Toshihiko Nishidate Kenji Okita Koichi Hirata Department of Surgery Surgical Oncology and ScienceSapporo Medical University Postgraduate School of Medicine

Liver resection is the gold standard treatment for certain liver tumors such as hepatocellular carcinoma and metastatic liver tumors. Some patients with such tumors already have reduced liver function due to chronic hepatitis, liver cirrhosis, or chemotherapy-associated steatohepatitis before surgery. Therefore, complications due to poor liver function are inevitable after liver resection. Although the mortality rate of liver resection has been reduced to a few percent in recent case series, its overall morbidity rate is reported to range from 4.1% to 47.7%. The large degree of variation in the post-liver resection morbidity rates reported in previous studies might be due to the lack of consen-sus regarding the definitions and classification of postliver resection complications. The Clavien-Dindo(CD) classification of post-operative complications is widely accepted internationally. However, it is hard to apply to some major post-liver resection complications because the consensus definitions and grading systems for posthepatectomy liver failure and bile leakage established by the International Study Group of Liver Surgery are incompatible with the CD classification. Therefore, a unified classification of post-liver resection complications has to be established to allow comparisons between academic reports.

关键词： Complication Liver failure Bile leakage Renal failure Ascites Coagulation disorder Surgical site infection

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月幔底部黏弹性结构研究现状

中国科学：物理学、力学、天文学 2024年第3期54卷 19-29页

作者：肖驰叶茂李斐鄢建国 Yuji harada 郝卫峰邓青云中国地震局地震研究所地震大地测量重点实验室武汉430071 武汉引力与固体潮国家野外科学观测研究站武汉430071 武汉大学测绘遥感信息工程国家重点实验室武汉430079 武汉大学中国南极测绘研究中心武汉430079 澳门科技大学创新工程学院中国澳门999078

长期以来,月球幔层底部是否存在一个部分熔融的S波衰减层一直存在着争议.针对这一争议,本文首先回顾了国内外对月幔底部黏弹性结构的研究成果,梳理总结了争议的提出和发展历程,接着分析这一争议产生的主要原因.本文认为,虽然越来越多的... 详细信息

长期以来,月球幔层底部是否存在一个部分熔融的S波衰减层一直存在着争议.针对这一争议,本文首先回顾了国内外对月幔底部黏弹性结构的研究成果,梳理总结了争议的提出和发展历程,接着分析这一争议产生的主要原因.本文认为,虽然越来越多的研究支持月幔底部存在一个部分熔融的低黏性、低S波波速的转换层,但目前仍缺乏决定性的证据作为支撑.因此,本文进一步讨论了现有研究存在的不足,对未来研究方向进行了展望.

关键词：月球固体潮潮汐勒夫数黏弹性模型内部结构

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规制战略理论的现状及其课题

南大法学 2024年第1期 183-192页

作者： [日]原田大树朱芒(译) 日本京都大学法学院上海交通大学凯原法学院

规制战略理论是行政法学中制度设计方向发展的最前沿成果。其在行政法学方法论近半个世纪的讨论过程中,从传统公法的“权力”“主体”和“利益”定义要素中发展出了新的内容。如突破对“权力”性行政活动的限制,分别在行为形式、行政活... 详细信息

规制战略理论是行政法学中制度设计方向发展的最前沿成果。其在行政法学方法论近半个世纪的讨论过程中,从传统公法的“权力”“主体”和“利益”定义要素中发展出了新的内容。如突破对“权力”性行政活动的限制,分别在行为形式、行政活动复合构成的行政过程以及诉讼之外的立法和制度设计三个方面获得新的开拓。再如在主体要素方面,突破了国行政组织的范围,将民间主体本身、民间主体与行政之间的协作以及法政策的动态形成过程归入了研究对象范围之内。与此同时,规制战略理论本身也在主体与权力方面开拓出新的理论空间,如在组织方面,关注公益实现的意思形成过程中未必明确且分散的行动者和国家立法者的作用;如在权力方面,除了行政固有的权力性外,从作为股东的国家和作为所有权人的国家的角度关注民事法律关系中的国家作用。未来,规制战略理论还需要刑事法学、信息技术之间的联系方面的课题。

关键词：行政规制制度设计行政主体行政权力组织公共利益

Scoring criteria for determining the safety of liver resection for malignant liver tumors

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World Journal of Meta-Analysis 2019年第5期7卷 234-248页

作者： kohei harada Minoru Nagayama Yoshiya Ohashi Ayaka Chiba Kanako Numasawa Makoto Meguro Yasutoshi Kimura Hiroshi Yamaguchi Masahiro Kobayashi Koji Miyanishi Junji Kato Toru Mizuguchi Departments of Surgery Surgical Scienceand OncologySapporo Medical UniversitySapporoHokkaido 060-8556Japan Division of Radiology Sapporo Medical University HospitalSapporoHokkaido 060-8556Japan Sapporo Medical University Postgraduate School of Health Science and Medicine Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Research and Education Center for Clinical Pharmacy Kitasato University School of PharmacyTokyo 108-8641Japan Department of Internal Medicine IV Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Department of Nursing and Surgical Science Sapporo Medical UniversitySapporo 0608543Japan

BACKGROUND Liver resection has become safer as it has become less ***,the minimum residual liver volume(RLV)required to maintain homeostasis is ***,the formulae used to calculate standard liver volume(SLV)are *** To review previously reported SLV formulae and the methods used to evaluate the minimum RLV,and explore the association between liver volume and *** A systematic review of Medline,PubMed,and grey literature was *** in the retrieved articles were cross-checked manually to obtain further *** last search was conducted on January 20,*** developed an SLV formula using data for 86 consecutive patients who underwent hepatectomy at our institution between July 2009 and August *** Linear regression analysis revealed the following formula:SLV(mL)=822.7×body surface area(BSA)?183.2(R2=0.419 and R=0.644,P<0.001).We retrieved 25 studies relating to SLV formulae and 12 studies about the RLV required for safe liver *** the previously reported formulae included various coefficient and constant values,a simplified version of the SLV,the common SLV(cSLV),can be calculated as follows:cSLV(mL)=710 or 770×*** minimum RLV for normal and damaged livers ranged from 20%-40%and 30%-50%,*** Sapporo score indicated that the minimum RLV ranges from 35%-95%depending on liver *** We reviewed SLV formulae and the minimum RLV required for safe liver *** Sapporo score is the only liver function-based method for determining the minimum RLV.

关键词： Standard liver volume Residual liver volume Hepatectomy Mortality Liver failure Liver function

Torque control strategy with V2X information for HEVs to minimize fuel consumption

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Control Theory and Technology 2022年第2期20卷 197-209页

作者： Yasutaka Okada Shunki Nishii Akihiro Takeshita Kazuki harada Yudai Yamasaki Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Today,much information from traffic infrastructures and sensors of ego vehicle is *** such information has a potential for internal combustion engine vehicle to reduce fuel consumption in real *** this paper,a powertrain controller for a hybrid electric vehicle aiming to reduce fuel consumption is introduced,which uses information from traffic signals,the global positioning system and sensors,and the preceding *** study was carried out as a benchmark problem of engine and powertrain control simulation and modeling 2021(E-COSM 2021).The developed controller firstly decides reference acceleration of the ego vehicle using the traffic signal and the position information and the preceding vehicle *** acceleration and deceleration leading to increase in unnecessary fuel consumption is ***,the reference engine,generator,and motor torques are decided to achieve the reference acceleration and minimize fuel *** addition,the reference engine,generator and motor torques were decided by the given fuel consumption map for the engine,and by the virtual fuel consumption maps for the generator and the *** virtual fuel consumption is derived from the efficiency maps of the generator and the motor using a given equivalent factor,which converts electricity consumption to fuel for the generator and the *** this study,a controller was designed through the benchmark problem of E-COSM 2021 for minimizing total fuel consumption of the engine,the generator,and the *** developed controller was evaluated in driving *** result shows that operating the powertrain in efficient area is a key factor in reducing total fuel consumption.

关键词： Powertrain optimization Fuel consumption minimization Hybrid electric vehicle Speed following system

Niche Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization

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Engineering 2022年第2期8卷 61-66页

作者： Kengo Kubota Kei Igarashi Masayoshi Yamada Yasuyuki Takemura Yu-You Li Hideki harada Department of Civil and Environmental Engineering Tohoku UniversitySendai 980-8579Japan Department of Urban Environmental Design and Engineering National Institute of TechnologyKagoshima CollegeKirishima 899-5193Japan New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan

A microbial community structure of granules harvested from an anaerobic sludge blanket reactor treating phenolic wastewater was investigated using fluorescence in situ hybridization(FISH)and clone library *** of Syntrophorhabdaceae and Cryptanaerobacter were observed to be responsible for phenol *** accurate taxonomic assignment of Cryptanaerobacter clones,phylogenetic analysis using nearly full-length 16S ribosomal RNA(rRNA)gene sequences was *** oligonucleotide probes were designed to detect the following three taxonomic groups:Syntrophorhabdaceae,Cryptanaerobacter,and *** analysis of thin sections of anaerobic granules showed a random distribution of bacteria and ***,a well-defined distribution of Syntrophorhabdaceae,Cryptanaerobacter,and Syntrophus was *** and Syntrophus were found on the outer layer of the granules and were closely associated with each other,while Syntrophorhabdaceae was located in the deeper part of the *** specific distribution of the bacteria is most likely due to their metabolic association and affinity for the *** degradation in the granular sludge was observed to be carried out in the following ***,Cryptanaerobacter converts phenol to benzoate,which is then degraded by Syntrophus into *** syntrophic degradation of phenol occurs near the surface of the granule,where the phenol concen-tration is *** the deeper part of the granule,where the phenol concentration is lower,Syntrophorhabdaceae degrades phenol into *** observed that Syntrophorhabdaceae is less likely to produce benzoate as an intermediate to feed the neighboring organisms,which contradicts the theo-ries presented by previous studies.

关键词： Cryptanaerobacter Fluorescence in situ hybridization Anaerobic phenol degradation Syntrophorhabdaceae Syntrophus UASB granular sludge

Effects of alginate and laminaran on the microbiota and antioxidant properties of human faecal cultures

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Food Bioscience 2022年第3期47卷 1244-1251页

作者： Gayang Lee Mika harada Yuko Midorikawa Mahiro Yamamoto Ayaka Nakamura Hajime Takahashi Takashi Kuda Department of Food Science and Technology Tokyo University of Marine Science and Technology4-5-7 KonanMinato-kuTokyo108-8477Japan

Alginate and laminaran are water soluble dietary fibres in brown *** a previous study,pure cultures of Bacteroides xylanisolvens,Bacteroides uniformis,and Erysipelaclostridium ramosum increased antioxidant capacities in the broth with alginate and/or laminaran *** study was conducted to evaluate the presence of the alginate-and laminaran-responsive human gut indigenous bacteria(RIB)and their ***,human stool samples were cultured in media without(control),or with 1%(w/v)alginate or laminaran at 37℃ for 24 h under anaerobic *** showed that during incubation,the pH of the culture reduced with the *** production was clearly suppressed via laminaran supplementation in the faecal sample *** 16S rRNA(V4)gene amplicon sequencing confirmed that ***-,*** and ***-like bacteria were alginate-and/or laminaran-RIB in human gut,although their read numbers differed among ***,some butyrate-producers,such as Faecalibacterium and Roseburia,were also detected as the RIB in alginate and laminaran cultures,*** increased 1,1-diphenyl-2-picrylhydrazyl and superoxide anion radical-scavenging capacities and the Fe-reducing power of the culture ***,the fermented cultures increased the nitric oxide secretion in macrophage like RAW 264.7 cells *** results suggest that the interaction of alginate and laminaran with their RIB may have desirable effects on the host as next generation prebiotics when brown algae are ingested.

关键词： Alginate Laminaran Human gut microbiota Antioxidant capacity Faecal culture

Neonatal feeding of an estrogen receptor β agonist induces external adenomyosis-like lesions in ICR mouse

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Reproductive and Developmental Medicine 2022年第3期6卷 144-151页

作者： Yun-Lei Cao Xi Wang Xi-Shi Liu Tasuku harada Sun-Wei Guo Shanghai Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases Fudan UniversityShanghai 200011China Department of Obstetrics and Gynecology Tottori University Faculty of MedicineYonagoTottori 683-8504Japan

Objective:Despite the fact that adenomyosis is a fairly common gynecological disorder,its pathogenesis remains *** theories on the pathogenesis of adenomyosis have been proposed,but none of them has been proven *** far,the most used one is the neonatal feeding of tamoxifen(TAM)in Institute of Cancer Research/cryopreserved(ICR/CD-1)***,its underlying mechanism of action is *** further delineate the mechanism of TAM-induced adenomyosis in ICR/CD-1 mouse with regard to specific estrogen receptor(ER),we conducted an experiment that neonatal mice were fed with either TAM,or 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol(PPT;an ERαagonist),or 2,3-bis(4-hydroxyphenyl)-propionitrile(DPN;an ERβagonist),or G-1(a G-protein coupled receptor 30 agonist),or just vehicle,in an attempt to tease out which specific receptor plays a dominant role in the genesis of adenomyosis induced by neonatal feeding of ***:Forty female neonatal mice were randomly divided into 5 equal-sized groups:CTL(control),TAM,PPT,DPN,and *** months later,all mice were sacrificed and their uterine horns were harvested,weighed,and processed for histological ***:All mice in the TAM group developed adenomyosis,so did 4 mice(50%)in the DPN group,a result that should be considered significant given that mice in the CTL group would not develop *** mouse in the PPT or G-1 group developed ***,all lesions in the DPN group were seen exclusively near the uterine serosa,which are dramatically different from that of TAM mice and reminiscent of extrinsic or external adenomyosis in ***:Neonatal feeding of DPN induces adenomyosis,but the adenomyotic lesions appear to be different from those induced by ***,the cause of TAM-induced adenomyosis in ICR/CD-1 mouse cannot be attributable to one specific ER *** suggests that the extrinsic/external adenomyosis may have a pathogenesis that is differen

关键词： Adenomyosis Estrogen receptor a agonist Estrogen receptorβagonist Mouse model Neonatal Tamoxifen

Massive low-grade myxoid liposarcoma of the floor of the mouth:A case report and review of literature

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World Journal of Clinical Cases 2022年第34期10卷 12742-12749页

作者： Takuma Kugimoto Yuko Yamagata Toshimitsu Ohsako Hideaki Hirai Naoto Nishii Kou Kayamori Tohru Ikeda Hiroyuki harada Department of Oral and Maxillofacial Surgical Oncology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan Department of Oral Pathology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan

BACKGROUND Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign tumor due to its asymptomatic and indolent clinical ***,we report a case of massive low-grade myxoid liposarcoma(MLS)of the floor of the *** SUMMARY A 71-year-old man presented with a huge mass in the left floor of the mouth.A biopsy was performed,and a diagnosis of a myxoid tumor suspicious for lowgrade MLS or myxoma was ***-enhanced T1-weighted magnetic resonance imaging showed an intensely enhanced tumor lesion that occupies the left sublingual space and extends to the submandibular *** dissection,tumor resection,and reconstruction with a radial forearm flap were *** surgical specimen exhibited histologically low-grade *** in sarcoma(FUS,also known as TLS)and DNA damage-inducible transcript 3(DDIT3,also known as CHOP)break-apart was not detected in the fluorescence in situ hybridization *** tumor was completely encapsulated and did not require additional ***,no recurrence was reported 40 mo after *** We experienced an extremely rare,massive,low-grade MLS emerging from the floor of the ***,an MLS of the floor of the mouth lacks significant clinical findings and is often *** no FUS-DDIT3 fusion gene was detected,a low-grade MLS was ultimately diagnosed based on the histological findings.

关键词： Myxoid liposarcoma Floor of mouth Surgery Fluorescence in situ hybridization Sublingual space Case report

Sinistral portal hypertension and distal splenorenal shunt during pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 73-75页

作者： Tomohide Hori Ryuhei Aoyama Hidekazu Yamamoto Hideki harada Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Masazumi Zaima Department of Surgery Shiga General Hospital5-4-30 MoriyamaMoriyama CityShiga Prefecture524-8524Japan

Locally advanced pancreatic cancer located in the head or un-cinate process(i.e.,uncus)often invades the confluence of the superior mesenteric vein(SMV),portal vein(PV),and splenic vein(SV)[1,2].Additionally,chronic pancreatitis easily occludes drainage flow via the SV[3].These pancreatic diseases force sur-geons to perform en bloc resection of the *** ligation of the remnant SV without venous resection results in sinistral por-tal hypertension(PH)(i.e.,left-sided PH),gastrointestinal bleeding,splenic congestion,and hypersplenism over the long term[1,2].

关键词： hypertension shunt diseases