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Eight-year survival after advanced gastric cancer treated with S-1 followed by surgery

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World Journal of Gastroenterology 2010年第22期16卷 2824-2827页

作者： Susumu Hijioka Keisho Chin Yasuyuki Seto Noriko Yamamoto kiyohiko Hatake Department of Medical Oncology Cancer Institute Hospital of JFCR Department of Surgery Cancer Institute Hospital of JFCR Department of Pathology Cancer Institute Hospital of JFCR

We report a case of advanced gastric cancer, with cervical, axillary, and abdominal paraaortic lymph node metastases, that was successfully treated with chemotherapy and surgery. The disease was initially considered unresectable, and the patient was treated with orally administered S-1. Chemotherapy was effective, and all lymph node metastases disappeared after 6 courses. After 27 mo of chemotherapy, the patient underwent curative surgery, with subtotal gastrectomy and lymph node dissection. Histopathological examination revealed many viable poorly differentiated adenocarcinoma cells in the stomach, but no cancer cells in the lymph nodes. The patient is alive, without recurrence, 8 years later. This, therefore, is a case report of an 8-year survivor of advanced gastric cancer with distant lymph node metastasis.

关键词： S-1 Lymph node metastasis Gastric cancer Gastrectomy

Imaging biomarkers for the treatment of esophageal cancer

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World Journal of Gastroenterology 2019年第24期25卷 3021-3029页

作者： Koichi Hayano Gaku Ohira Atsushi Hirata Tomoyoshi Aoyagi Shunsuke Imanishi Toru Tochigi Toshiharu Hanaoka kiyohiko Shuto Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of MedicineChiba 260-8677Japan Department of Surgery Teikyo University Medical CenterChiba 299-0111Japan

Esophageal cancer is known as one of the malignant cancers with poor *** improve the outcome,combined multimodality treatment is *** the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”*** advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer *** this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer.

关键词： Esophageal cancer Computed tomography perfusion Dynamic-contrastenhanced magnetic resonance imaging Texture analysis Diffusion-weighted imaging Positron emission tomography

High-Efficiency Synthesis and Properties of Latent Pigment Red 272DPP-BOC by Microwave Irradiation

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Materials Sciences and Applications 2020年第3期11卷 195-203页

作者： Tomoji Ohishi Yu Kimura kiyohiko Nakajima Masayuki Watanabe Noboru Aoyagi Department of Applied Chemistry Faculty of Engineering Shibaura Institute of Technology Tokyo Japan Department of Chemistry Aichi University of Education Kariya Japan Nuclear Science and Engineering Center Sector of Nuclear Science Research Japan Atomic Energy Agency Naka-gun Ibaraki Japan

A high-efficiency synthesis method for a latent pigment of red pigment diketo-pyrrolo-pyrrole (Pig. Red 272:272DPP), which is important as a functional organic pigment, was investigated, and the investigation results revealed that irradiation of microwaves (MWs) for several seconds to 272 DPP in NMP (N-methyl-2-pyrrolidone) solvent yielded DPP latent pigment (272DPP-BOC) at a high yield of 86.2%. Two kinds of latent-pigment crystals, namely, red and yellow, were obtained by recrystallization, and it was found that the fluorescence-emission properties of the two kinds differ significantly. Single-crystal X-ray structural analysis showed that the difference in the fluorescence-emission properties of the two types is derived from the difference in their crystal structures.

关键词： Latent Pigment Diketopyrrolopyrrol Pigment Red 272 High Efficiency Synthesis Microwave Irradiation Single-Crystal X-Ray Analysis

Pancreaticoduodenectomy after neoadjuvant chemotherapy for gastric cancer invading the pancreatic head:A case report

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World Journal of Gastroenterology 2021年第6期27卷 534-544页

作者： Masahiro Yura Kiminori Takano kiyohiko Adachi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Yoichiro Ikoma Hiroto Fujisaki Akira Hirata Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Kazuo Koyanagi Motohito Nakagawa Department of Surgery Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Surgical Pathology Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259193KanagawaJapan

BACKGROUND Pancreaticoduodenectomy(PD)for advanced gastric cancer is rarely performed because of the high morbidity and mortality rates and low survival ***,neoadjuvant chemotherapy for advanced gastric cancer has improved,and chemotherapy combined with trastuzumab may have a preoperative tumorreducing effect,especially for human epidermal growth factor receptor 2(HER2)-positive *** SUMMARY We report a case of successful radical resection with PD after neoadjuvant S-1 plus oxaliplatin(SOX)and trastuzumab in a patient(66-year-old male)with advanced gastric cancer invading the pancreatic *** esophagogastroduodenoscopy detected a type 3 advanced lesion located on the lower part of the stomach obstructing the pyloric *** tomography detected lymph node metastasis and tumor invasion to the pancreatic head without distant *** findings revealed adenocarcinoma and HER2 positivity(immunohistochemical score of 3+).We performed staging laparoscopy and confirmed no liver metastasis,no dissemination,negative lavage cytological findings,and immobility of the distal side of the stomach due to invasion to the *** gastrojejunostomy was performed at that *** course of SOX and three courses of SOX plus trastuzumab were *** computed tomography showed partial response;therefore,PD was performed after neoadjuvant chemotherapy,and pathological radical resection was *** We suggest that radical resection with PD after neoadjuvant chemotherapy plus trastuzumab is an option for locally advanced HER2-positive gastric cancer invading the pancreatic head in the absence of non-curative factors.

关键词： Pancreaticoduodenectomy Gastric cancer Neoadjuvant chemotherapy Trastuzumab Human epidermal growth factor receptor 2 Case report

Characteristics of Postoperative Bleeding after Neck Surgery

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Surgical Science 2013年第3期4卷 192-195页

作者： Junko Nambu Keizo Sugino Koichi Oishi Masatsugu Yano Masahiro Nishihara kiyohiko Dohi Department of Surgery Tsuchiya General Hospital Hiroshima Japan

Objective: To review the characteristics of and the procedure for preventing postoperative bleeding after neck surgery. Materials and Methods: A retrospective review of 9 patients (9/893;1.0%) with postoperative bleeding who required reoperation was performed to analyze clinical findings. Results: There was no significant difference in the incidence of bleeding between types of surgical procedures. Postoperative bleeding occurred within 24 hours in all cases except 2, in which it occurred 7 days or more after the operation. Seven cases showed bleeding from the cut surface of the muscle. Other bleeding points included vessels and the Berry ligament. There were no additional complications after reoperation. Conclusion: When separating the muscles in neck surgery, it is important to sufficiently ligate vessels and induce coagulation with an ultrasonically activated scalpel to prevent postoperative bleeding.

关键词： Postoperative Bleeding Neck Surgery Reoperation

Distal gastric tube resection with vascular preservation for gastric tube cancer:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2020年第9期12卷 397-406页

作者： Masahiro Yura Kazuo Koyanagi kiyohiko Adachi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Survival rates in patients with esophageal cancer undergoing esophagectomy have improved,but the prevalence of gastric tube cancer(GTC)has also *** resection of the gastric tube with lymph node dissection is considered a radical treatment,but GTC surgery is more invasive and involves a higher risk of severe complications or death,particularly in elderly *** SUMMARY We report an elderly patient with early GTC that had invaded the duodenum who was successfully treated with resection of the distal gastric tube and Roux-en-Y(R-Y)*** tumor was a type 0-IIc lesion with ulcer scars surrounding the pyloric *** submucosal resection was not indicated because the primary lesion was submucosally invasive,was undifferentiated type,surrounded the pyloric ring,and had invaded the *** of distal gastric tube with R-Y reconstruction was safely performed,with preservation of the right gastroepiploic artery(RGEA)and right gastric artery(RGA).CONCLUSION Distal resection of the gastric tube with preservation of the RGEA and RGA is a good treatment option for elderly patients with cT1bN0 GTC in the lower part of the gastric tube.

关键词： Gastric tube cancer Distal resection Preservation of right gastroepiploic artery and right gastric artery Elderly patients Duodenal invasion Case report Posterior mediastinal reconstruction

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澳洲坚果干燥特性的研究

世界热带农业信息 1993年第6期 44-47页

作者： kiyohiko Toyoda 陈里林

澳洲坚果风味佳,果质松脆。为了避免这些品质的变劣,澳洲坚果采后要经过几道工序进行细致地干燥。

关键词：澳洲坚果干燥特性干燥试验果壳初始含水量含水量控制电子天平秤空气湿度自然杂交种高含水量

日本京都府立医科大学疼痛与姑息医学科应用内脏神经阻滞术治疗上腹部癌痛的现状

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实用疼痛学杂志 2018年第1期14卷 9-13页

作者： kiyohiko Hatano Toyoshi Hosokawa Keita Fukazawa 姚军日本国京都府立医科大学疼痛与姑息治疗学科河北大学附属医院疼痛科保定市071000

目的本文报告在锥束CT下接受内脏神经阻滞术(SNB)治疗的上腹部恶性肿瘤疼痛患者24例的疼痛缓解效果,并讨论CT成像在两例患者中的应用.方法癌症相关的上腹部疼痛患者24例,从2015年6月起6个月内接受SNB治疗.分别对他们在治疗前和治疗后... 详细信息

目的本文报告在锥束CT下接受内脏神经阻滞术(SNB)治疗的上腹部恶性肿瘤疼痛患者24例的疼痛缓解效果,并讨论CT成像在两例患者中的应用.方法癌症相关的上腹部疼痛患者24例,从2015年6月起6个月内接受SNB治疗.分别对他们在治疗前和治疗后1周的疼痛数字评分量表(NRS)变化、阿片类药物使用剂量变化(等效剂量吗啡转换)及治疗引起的并发症发生率进行回顾性研究.SNB经T12～L1或L1-2椎间盘入路进行,应用阻力消失法将造影剂注入膈脚后间隙,并使用锥束CT以及透视法确认造影剂的扩散.神经阻滞剂使用99.5％脱水乙醇10～20 ml.结果受试者24例,男15例,女9例,平均年龄63.8岁.NRS从治疗前的5/10下降至治疗后1周的0.86/10(P＜0.01),阿片类药物使用剂量(等效剂量吗啡转换)从治疗前86.6 mg/d降至治疗后1周的58 mg/d(P＜0.01).仅观察到以下轻度不良反应:一过性低血压(8例)、恶心(5例)和腹泻(3例),未观察到严重不良反应.结论 SNB是治疗癌症诱发的腹部疼痛的有效方法,联合应用锥束CT可提高疼痛缓解效果.

关键词：内脏神经阻滞(SNB) 锥束CT (cone-beam CT)

Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer

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World Journal of Gastroenterology 2014年第46期20卷 17345-17351页

作者： Koichi Hayano Takeshi Fujishiro Dushyant V Sahani Asami Satoh Tomoyoshi Aoyagi Gaku Ohira Toru Tochigi Hisahiro Matsubara kiyohiko Shuto Division of Abdominal Imaging and Intervention Department of RadiologyMassachusetts General HospitalBostonMA 02114United States Department of Frontier surgery Chiba university Graduate School of MedicineChiba 260-8677Japan Department of Surgery Teikyo University Medical CenterIchiharaChiba 299-0111Japan

Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer(CRC),and the importance of angiogenesis in cancer progression has been *** tomography(CT)perfusion(CTP)based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer *** has been reported to characterize tumor angiogenesis,and to be a sensitive marker for predicting recurrence or survival in *** this review,we will discuss the biomarker value of CTP in the management of CRC patients.

关键词： Colorectal cancer Angiogenesis Computed tomography