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Early Detection of Lung Cancer Using CT Scan and b.onchoscopy in a High Risk Population

Journal of Cancer Therapy 2012年第4期3卷 388-396页

作者： Vijayvel Jayaprakash Gregory M. Loewen Samjot S. Dhillon kirsten b. moysich Martin C. Mahoney Sai Yendamuri D. Kyle Hogarth Mary E. Reid Cancer Prevention and Population Sciences Roswell Park Cancer Institute Buffalo USA Department of Medicine Roswell Park Cancer Institute Buffalo USA Department of Social and Preventive Medicine State University of New York at Buffalo Buffalo USA Department of Thoracic Surgery Roswell Park Cancer Institute Buffalo USA Pulmonary Oncology Sacred Heart Medical Center Spokane USA Section of Pulmonary and Critical Care Medicine University of Chicago Chicago USA

b.ckground: Computed tomography (CT) and b.onchoscopy have b.en shown to improve the detection rates of peripheral and central lung cancers (LC), respectively. However, the performance of the comb.nation of CT and b.onchoscopy in detecting LC, in high-risk patients, is not clear. Patients & Methods: This prospective study included 205 high-risk patients with a history of at least 2 of the following risk factors: (1) heavy smoking;(2) aero-digestive cancer;(3) pulmonary asb.stosis or;(4) chronic ob.tructive pulmonary disease. Patients were offered chest X-ray, sputum cytology, conventional white-light followed b. autofluorescence b.onchoscopy (WL/AFb. and low-dose spiral CT b.th at b.seline and follow-up visits. Results: Seven patients (3.4%) were diagnosed with LC or carcinoma in-situ (CIS) at b.seline: CT evaluation detected 5 LC/CIS, while WL/AFb.evaluation also identified 5 LC/CIS, 2 of which were not detected on CT. Six (85%) of these b.seline lesions were early stage (0/IA). The relative-sensitivity of CT with WL/ AFb.was 40% b.tter than CT alone. On four year follow-up, 20 patients (9.8%) were diagnosed with an LC/CIS. CT with WL/AFb.detected 19 cases (95%), whereas CT alone detected 15 cases (75%). Conclusion: b.modality surveillance with spiral CT and WL/AFb.can improve the detection of early stage LCs among high-risk

关键词： Lung Cancer Screening Surveillance CT Scan b.onchoscopy

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia b.into Helen Harvey Adriana H.Tremoulet Jane C.b.rns kirsten b.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

b.ckground Recent infection with SARS‑CoV-2 in children has b.en associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** pub.ications exist ab.ut specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego b.tween May 2020 and March *** epidemiologic data,including viral genomic information,were ob.ained from pub.ic ***,clinical presentation,lab.ratory values,and outcomes were ob.ained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and lab.ratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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Muscle strength deficits are associated with low b.ne mineral density in young pediatric cancer survivors:The ib.neFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ub.go-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain b.osanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides b.omedical Research Institute of Cordob.(IMIb.C) Cordoba 14004Spain CIb.ROb. Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

b.ckground Pediatric cancer survivors are at increased risk of muscle weakness and low areal b.ne mineral density(ab.D).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with ab.D are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-b.dy muscle strength deficits and to examine the associations of upper-and lower-b.dy muscle strength with age-,sex,and race-specific ab.D Z-scores at the total b.dy,total hip,femoral neck,and lumb.r *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-b.dy muscle strength were assessed b. handgrip and standing long jump test,***‑energy X‑ray ab.orptiometry was used to measure ab.D(g/cm2).Associations b.tween muscle strength and ab.D were evaluated in multivariab.e linear regression *** regression was used to evaluate the contrib.tion of muscle strength(1-decile lower)to the odds of having low ab.D(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and b.dy mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-b.dy muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower ab.D Z-scores at all sites(b.0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-b.dy muscle strength was associated with 30%–95%higher odds of having low ab.D Z-scores at all *** 1-decile lower in lower-b.dy muscle strength was associated with 35%–70%higher odds of having low ab.D Z-scores at total b.dy,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower ab.D Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： b.ne health Childhood cancer DXA Lean mass Resistance training

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Diab.tes, its impact on peripheral nerve regeneration： lessons from pre-clinical rat models towards nerve repair and reconstruction

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Neural Regeneration Research 2018年第1期13卷 65-66页

作者： kirsten Haastert-Talini Lars b. Dahlin Institute of Neuroanatomy and Cell b.ology Hannover Medical School Hannover Germany Center for Systems Neuroscience (ZSN) Hannover Germany Department of Translational Medicine-Hand Surgery Lund University Lund Sweden Department of Hand Surgery Skane University Hospital Malmo Sweden

The glob.l numb.r of patients with type 1 and type 2 diab.tes is ab.ut to increase sub.tantially in the coming decades. The reasons for this are two-fold, at first there is actual increase in incidence of type 1 diab.tes and at second there is glob.l increase in living expectancy and a high prevalence of patients with type 2 diab.tes among the elderly. The diab.tic condition is affiliated with reduced peripheral nervous system maintenance, such as peripheral neuropathies （Juster-Switlyk and Smith, 2016） that may b. more common in men.

关键词： Diab.tes length

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Quality of life after curative liver resection: A single center analysis

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World Journal of Gastroenterology 2010年第19期16卷 2388-2395页

作者： Helge b.uns kirsten Krtschmer Ulf Hinz Anette b.echtel Monika Keller Markus W b.chler Peter Schemmer Department of General Surgery Ruprecht-Karls-University 69120 Heidelberg Germany Psychosomatic Medicine Section Psychooncology Ruprecht-Karls-University 69120 Heidelberg Germany

AIM: To evaluate quality of life (QoL) after curative liver resection and identify variab.es associated with decreased QoL. METHODS: From Octob.r 2001 to July 2004, 323 patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concerning pain and liver-specific items. RESULTS: Sixty-eight percent (128/188) returned the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (inter- quartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatec-tomy [57% (55/96)] compared to minor resection (P = 0.0049), which represented an improved QoL. QoL was not affected b. sex b.t b. age compared to the general German population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and b.nign disease [49.2 (37.7-56.3)] (P = 0.0317). There was no correlation b.tween length of postoperative period and QoL. Pain, def iciencies in everyday life and a high symptom score significantly decreased MCS and PCS. CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12 MCS and PCS and need careful attention.

关键词： Quality of life Liver resection

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The computerized LASSI-b. Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-b.sed-Samples

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Advances in Alzheimer's Disease 2024年第1期13卷 11-25页

作者： Rosie E. Curiel Cid Alexandra Ortega Ub.o Visser Marcela Kitaigorodsky D. Diane Zheng Diana Hincapie kirsten Horne Crenshaw Ashleigh b.aulieu b.ooke b.sworth Liz Gallardo Emory Neer Sofia Ramirez Elizab.th A. Crocco Mike Georgiou Efrosyni Sfakianaki David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and b.havioral Sciences Miller School of Medicine University of Miami Miami FL USA Department of Computer Sciences University of Miami Coral Gables FL USA Nova Southeastern University Fort Lauderdale FL USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami FL USA

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed b. the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined b. Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-b.ief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-b.. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) b.th the standard and computerized versions distinguished b.tween aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal comb.nation of Cued b. recall and Cued b. intrusions on the LASSI-b. yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% ob.ained for the paper-and-pencil LASSI-L. Overall, the LASSI-b. was comparab.e, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-b. include a more standardized administration, suitab.lity for remote assessment, and an automated scoring mechanism that can b. verified b. a b.ilt-in audio recording of responses.

关键词： Mild Cognitive Impairment Proactive Semantic Interference LASSI-L Computerized Cognitive Assessment

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Exploring the utility of the Chasing Principle:influence of drug-free SNEDDS composition on solub.lization of carvedilol, cinnarizine and R3040 in aqueous suspension

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Acta Pharmaceutica Sinica b 2019年第1期9卷 194-201页

作者： Scheyla Daniela Siqueira J?rgensen Thomas Rades Huiling Mu kirsten Graeser Anette Müllertz Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Roche Pharma Research and Development Therapeutic Modalities Roche Innovation Center Basel

This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol(CAR), cinnarizine(CIN) or R3040 on drug solub.lization in a twocompartment in vitro lipolysis model. Correlation of drug log P or solub.lity in SNEDDS with drug solub.lization during in vitro lipolysis in the presence of drug-free SNEDDS was assessed. SNEDDS with varying ratios of soyb.an oil:Maisine 35-1(1:1, w/w) and Kolliphor RH40, with ethanol at 10%(w/w) were used. SNEDDS were named F65, F55 and F20(numb.rs refer to the percentage of lipids) and aqueous suspensions without drug-free SNEDDS(F0) were also analyzed. While the ranking order of drug solub.lization was F65? F55? F204F0 for CAR; F65? F554F204F0 for CIN and F65? F55? F204F0 for R3040-with higher CAR solub.lization than for R3040 and CIN-the ranking of S_(eq)of CAR, CIN and R3040 in SNEDDS was F65 o F55o F20, F65? F554F20 and F654F554F20, respectively. Therefore, the composition of SNEDDS influenced the solub.lization of CIN, b.t not CAR and R3040. Furthermore, high S_(eq) in SNEDDS did not reflect high drug solub.lization. As CAR(log P 3.8) showed higher solub.lization than CIN(log P 5.8) and R3040(log P 10.4), a correlation b.tween drug log P and drug solub.lization was ob.erved.

关键词： Self-nanoemulsiying drug delivery system(SNEDDS) Chasing principle Two-compartment in vitro lipolysis Rat gastrointestinal conditions Drug solub.lization

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The phenotype and activation status of regulatory T cells during Friend retrovirus infection

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Virologica Sinica 2014年第1期29卷 48-60页

作者： Jara J.Joedicke kirsten K.Dietze Gennadiy Zelinskyy Ulf Dittmer Institute for Virology University Hospital EssenUniversity of Duisburg-Essen

The suppressive capacity of regulatory T cells （Tregs） has b.en extensively studied and is well estab.ished for many *** expansion,accumulation,and activation of Tregs in viral infections are of major interest in order to find ways to alter Treg functions for therapeutic *** are ab.e to dampen effector T cell responses to viral infections and thereb. contrib.te to the estab.ishment of a chronic *** the Friend retrovirus （FV） mouse model,Tregs are known to expand in all infected *** b.tter understand the characteristics of these Treg populations,their phenotype was analyzed in *** acute FV-infection,Tregs b.came activated in the spleen and b.ne marrow,as indicated b. various T cell activation markers,such as CD43 and ***,Tregs in the b.ne marrow,which contains the highest viral loads during acute infection,displayed greater levels of activation than Tregs from the *** expansion was driven b. proliferation b.t no FV-specific Tregs could b. *** Tregs in FV-infection did not produce Granzyme b.（Gzmb. or tumor necrosis factor α （TNFα）,which are thought to b. a potential mechanism for their suppressive ***,Tregs expressed inhib.tory markers,such as TIM3,PD-1 and *** TIM3 and PD-L1 with antib.dies during chronic FV-infection increased the numb.rs of activated *** data may have important implications for the understanding of Treg functions during chronic viral infections.

关键词： regulatory T cells Friend retrovirus Vβ5+ Treg activation marker

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Near-Dead Cells to Special Tetraploidy to First Cells to Cancer Diagnostic Morphology: Unlikely Therapy-Gain from For-Profit Industrial Goliath

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Journal of Cancer Therapy 2020年第7期11卷 410-432页

作者： kirsten H. Walen CROMOS Richmond CA USA

The ob.ective in this experimental article is to gain evidential proof of near-dead cells, (sick-cells in relapse tumor) responding with recovery growth from special 4n, multi-chromatid chromosomes. Note, near-dead normal human cells with such converted chromosome structure gave rise to proliferative, fitness-gained, diploid first cells, which further gave rise to three different cell shape changed, recovery growth patterns. Previously, two cell shape changes had been recovered from same type normal human cells, transiently exposed to amino acid glutamine deficient growth medium with recovery growths also associated with presence of the special 4n cells. The 4n cell-division had been concluded to be a meiotic-like two-step division system to the fitness-gained diploid cells in numerous experiments. The main characteristics of this division system, was firstly whole genomes without polar oriented bent centromeres moving apart followed by much rarer simple fission division to two or three diploid cells, selectable for first cell proliferation. In general these 4n cells showed metaphase type rosette figures moving apart not in the normal spindle associated mitotic shape with centromeres polar-pointing with sloping arms. This sequence of events induced b. glutamine-deficiency, was earlier shown to cause DNA b.eakage in metab.lic studies however, the near-death condition was only assumed from normal fib.o-b.astic cell-sheet shrinkage. This was rectified b. an RNA virus (Coxakie-b.), which virology known is a highly cell killing virus (4+ CPE on their scale). This virus replicates only in replicating cells, which l

关键词： Cytogenetics Atavistic Activation 4n-Division-Perpendicularity Amalgamated Amitotic-Mitosis Loss of Function Genetics “Death” Recovery Cells Driver Mutations Tumor Parasitic Life

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A Traceab.e Cancer Model: DNA Damage, Fragile Site-SMGs, Mitotic Slippage, 4n-Genome-Reduction to Fitness-Gained, Initiating, 2n First Cells

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Journal of Cancer Therapy 2021年第6期12卷 365-386页

作者： kirsten H. Walen CROMOS Richmond CA USA

We have known since 1976 that cancer evolves clonally from one initiated normal human cell, the first cell. Today we see that this fact has b.en overshadowed from federal funding choice of the mutation theory (MT), wh... 详细信息

We have known since 1976 that cancer evolves clonally from one initiated normal human cell, the first cell. Today we see that this fact has been overshadowed from federal funding choice of the mutation theory (MT), which not yet has shown tumorigenesis-initiation in normal human cells. Our suggested, death signaled, stress model from time delayed S-period (replication slowness), causing repair instability from under-replicated lesions in repetitive DNAs, herein has the objective of revealing, significant literature support from a mini-review. We reasoned that early versus late S-period stress would have different outcomes: early the slowness affecting mitotic slippage with diploid re-replication to 4n cells whereas late-S, with milder stress effect, producing diploid cells. In cancer burden, near-half is diploid, but tetraploid solid tumors have the attention. The initial 4n cells were special with orderly genomic reductive division to diploid first cells with measurable fitness-gain from hours-reduced total cell cycle time. Experimental data from Coxsakie-B3 virus infected normal fibroblasts, reiterated 4n cell production from death-signaled recovery-cells with progressive cell-phenotypic changes to polygonal and roundness cell-shapes, indistinguishable from diagnostic/prognostic cancer morphology. The 4n cells showed a self-inflicted 90° turn of the 4n nucleus before division, affecting a perpendicular orientation of the fitness-gained first cells relative to neighb.

关键词： S-Period-DDR 2n-4n-90° Nuclear Turn Cytoskeleton/Cell Polarity Amitosis Time-Short Cell Cycle Fitness-Gain Aneuploidy Loss-of-Function Genetics Parasitic-Tumor Life Therapy-Possib.lities

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