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Does robot-assisted laparoscopic radical prostatectomy enable to obtain adequate oncological and functional outcomes during the learning curve?From the Korean experience

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Asian Journal of Andrology 2009年第2期11卷 167-175页

作者： Young Hwii Ko jeong Hyeon Ban Seok Ho Kang Hong Seok Park jeong Gu Lee Duck ki Yoon Je Jong kim Jun Cheon Vipul RPatel Department of Urology MIS&Robotic Urologic Surgery CenterKorea University School of MedicineSeoul 136705Korea Global Robotics Institute University of Central FloridaFlorida HospitalOrlandoFL 32803USA

To estimate the short-term results of robot-assisted laparoscopic radical prostatectomy(RALRP)during the learning curve,in terms of surgical,oncological and functional outcomes,we conducted a prospective survey on *** July 2007,a single surgeon performed 63 robotic prostatectomies using the same operative *** data,including pathological and early functional results of the patient,were collected prospectively and *** with the accumulation of the cases,the total operative time,setup time,console time and blood loss were significantly *** major complication was present in any *** was needed in six patients;all of them were within the initial 15 *** positive surgical margin rate was 9.8%(5/51)in pT2 *** most frequent location of positive margin in this stage was the lateral aspect(60%),but in pT3 disease multiple margins were the most frequent(41.7%).Overall,53(84.1%)patients had totally continent status and the median time to continence was 6.56 *** 17 patients who maintained preoperative sexual activity(Sexual Health Inventory for Men≥17),stage below pT2,followed up for>6 months with minimally one side of neurovascular bundle preservation procedure,12(70.6%)were capable of intercourse postoperatively,and the mean time for sexual intercourse after operation was 5.7 *** this series,robotic prostatectomy was a feasible and reproducible technique,with a short learning curve and low perioperative complication *** during the initial phase of the learning curve,satisfactory results were obtained with regard to functional and oncological outcome.

关键词： learning curve outcomes assessment radical prostatectomy robotics

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Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Phlebovirus in Domesticated Deer in South Korea

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Virologica Sinica 2019年第5期34卷 501-507页

作者： Min-Ah Yu Kwang-Min Yu Su-Jin Park Young-ll kim Norbert John Robles Young-Jae Si Eun-Ha kim Hyeok-ll Kwon Hye Won jeong Min-Suk Song Seok-Yong kim Young ki Choi Department of Microbiology College of Medicine and Medical Research InstituteChungbuk National UniversityCheongju 28644Republic of Korea Zoonotic Infectious Diseases Research Center Chungbuk National UniversityCheongju 28644Republic of Korea Department of Internal Medicine College of Medicine and Medical Research InstituteCheongju 28644Republic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Republic of Korea

Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV)has a wide host *** only has it been found in humans,but also in many wild and domesticated *** infection of breeding deer on farms is a particularly worrisome public health concern due to the large amount of human contact and the diverse use of deer products,including raw *** investigate the prevalence of breeding domesticated deer,we examined the SFTSV infection rate on deer farms in South Korea from 2015 to *** the 215 collected blood samples,0.9%(2/215)were found to be positive for viral RNA by PCR,and sequence analysis showed the highest homology with the KADGH human *** SFTSVspecific recombinant N and Gn protein-based ELIS As revealed that 14.0%(30/215)and 7.9%(17/215)of collected blood specimens were positive for SFTSV *** results demonstrate that the breeding farm deer are exposed to SFTSV and could be a potential infection source for humans through direct contact or consumption of byproducts.

关键词： Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV) Breeding deer•Seroprevalence South Korea

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Charge transfer in graphene/polymer interfaces for CO2 detection

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Nano Research 2018年第7期11卷 3529-3536页

作者： Myungwoo Son Yusin Pak Sang-Soo Chee Francis Malar Auxilia kihyeun kim Byung-Kee Lee Sungeun Lee Sun kil Kang Chaedeok Lee jeong Soo Lee ki Kang kim Yun Hee Jang Byoung Hun Lee Gun-Young Jung Moon-Ho Ham School of Materials Science and Engineering Research Institute for Solar and Sustainable Energies Gwangju Institute of Science & Technology 723 Cheomdangwagi-ro Buk-gu Gwangju 61005 Republic of Korea Materials & Devices Advanced Research Institute LG Electronics Woomyeon R&D Campus 38 Baumoe-ro Seocho-gu Seoul 06763 Republic of Korea Department of Energy and Materials Engineering Dongguk University Seoul 04620 Republic of Korea Energy Systems Engineering Daegu Gyeongbuk Institute of Science & Technology 333 Technojungang-daero Hyeonpung-myeon Dalseong-gun Daegu 42988 Republic of Korea

Understanding charge transfer processes between graphene and functional materials is crucial from the perspectives of fundamental sciences and potential applications, including electronic devices, photonic devices, and sensors. In this study, we present the charge transfer behavior of graphene and amine-rich polyethyleneimine （PEI） upon CO2 exposure, which was significantly improved after introduction of hygroscopic polyethylene glycol （PEG） in humid air. By blending PEI and PEG, the number of protonated amine groups in PEI was remarkably increased in the presence of water molecules, leading to a strong electron doping effect on graphene. The presence of CO2 gas resulted in a large change in the resistance of PEI/PEG-co-functionalized graphene because of the dramatic reduction of said doping effect, reaching a maximum sensitivity of 32% at 5,000 ppm CO2 and an applied bias of 0.1 V in air with 60% relative humidity at room temperature. This charge transfer correlation will facilitate the development of portable graphene-based sensors for real-time gas detection and the extension of the applications of graphene-based electronic and photonic devices.

关键词： graphene polyethyleneimine (PEI) polyethylene glycol carbon dioxide charge transfer

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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

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Cellular & Molecular Immunology 2022年第1期19卷 79-91页

作者： Seon-Yeong Lee Su-Jin Moon Young-Mee Moon Hyeon-Beom Seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-Som kim Yang-Mi Her jeong Won Choi Seung-ki Kwok Sung-Hwan Park Mi-La Cho The Rheumatism Research Center The Catholic University of KoreaSeoulSouth Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Medical Lifescience College of MedicineThe Catholic University of KoreaSeoulSouth Korea These author contributed equally:Seon-Yeong Lee Su-Jin MoonYoung-Mee Moon

OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or ***-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling ***,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune ***:The presence of the p40-EBI3 heterodimer was confirmed by ELISA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with ***:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with *** joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer *** vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent ***:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in *** propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.

关键词： cytokine p40-EBI3 Rheumatoid arthritis Autoimmune disease regulatory T cell

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Ophiobolin B inhibits proliferation of glioblastoma U87MG cells by inducing S phase arrest and caspase-dependent apoptosis

Ophiobolin B inhibits proliferation of glioblastoma U87MG ce...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： ki Seong Eom Gil-Saeng jeong Tae Young kim Department of Neurosurgery College of MedicineWonkwang University College of Pharmacy Wonkwang University

*** Human glioblastoma is the most common primary malignant brain tumor that only weakly responsive to the current therapeutic ***,new therapeutic agents for treat this devastating disease are urgently *** are secondary metabolites of certain fungi belonging to the genera Bipolaris,Drechslera,Cephalosporium and *** sesterterpene-type compounds（C25） are characterized by a unique tricyclic chemical *** B（OPB） is a minor member of a class of phytotoxic metabolites and acts as an inhibitor of calmodulin action in calcium *** has a wide range of biochemical and pharmacological effects,including antitumor activities,but its mechanism of action is not clearly *** this study,we investigated that the relationship between the antiproliferative activities of berberine and the apoptotic pathway associated with its molecular mechanism of action in human glioblastoma U87MG *** and mathods The effect of berberine on cell viability was quantified using MTT *** cytometric analysis was used to measure the cellular DNA *** blot analysis was performed using primary antibodies against p21,p27,cyclin-dependent kinase（CDK）2,CDK4,cyclin B,cyclin A,cyclin E,Bcl-2,Bax,caspase-9,caspase-3,poly（ADPribose） polymerase（PARP）,and *** nuclei of U87MG cells were stained with DAPI in order to assess the degree of *** data shown are a summary of the results from at least three experiments and statistical evaluation of the results was performed by One-way analysis of variance（ANOVA）.*** OPB significantly decreased the cell viability of U87MG cells in a dose-dependent *** cytometry showed a dose dependent increase of S phase arrested after treatment with OPB in U87MG *** blot analysis showed that the OPB-induced S phase arrest was mediated through the increased expression of cyclin-dependent kinase inhibitor（CDki） proteins（p21 and p27） a

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Control of onion fungal pathogen Botrytis aclada during postharvest low-temperature storage by thymol fumigation

Control of onion fungal pathogen Botrytis aclada during post...

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中国菌物学会2016年学术年会

作者： Sang Hye Ji Tae Kwang kim Mee Kyung Sang ki deok kim Se Chul Chun Department of Bioresource and Food Science Konkuk University Laboratory of Plant Disease and Biocontrol Department of Biosystems and BiotechnologyKorea University Institute of Life Science and Natural Resources Korea University

＜正＞The onion（Allium cepa L.）is considered as the most valuable crop of condiments in *** diseases of onion often develop rapidly due to the lack of proper storage *** control fungal pathogens that occurs during l...

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The Study on Sulfur and Nickel Distribution Behavior of Nickel between Fe-Ni alloy and MgO-FeO-SiO2 Slag System

The Study on Sulfur and Nickel Distribution Behavior of Nick...

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Ninth International Conference on Molten Slags,Fluxes and Salts(MOLTEN12)

作者： ki deok kim Hyung Sub Eom Eun Jin Jung Wan Wook Huh Dong Joon Min Department of Materials Science and Engineering Yonsei UniversitySeoul 120-749Korea RIST(Research Institute of Industrial Science & Technology) Gangwon Province210-340Korea

The dissolution behavior of nickel in the MgO-SiO 2-FeO slag system was investigated by using the thermodynamic equilibrium *** distribution ratio between molten MgO-SiO 2-FeO slag and molten Fe-Ni alloy at 1773 K and 1873 K was measured to understand the dissolution mechanism of nickel into the *** dependence of oxygen partial pressure and basicity on the distribution of nickel was *** distribution behavior between slag and Fe-Ni alloy increased with higher oxygen partial pressure showing a dependence of 1/*** basic slag systems near the olivine saturated composition,the nickel distribution ratio increased with higher basicity showing a slope of 1 and for acidic slag systems near the cristobalite saturated composition,the nickel distribution ratio decreased with higher basicity showing a slope *** dissolution behavior of nickel in the MgO-SiO 2-FeO slag system showed two independent mechanisms similar to that found in the CaO-SiO 2-CaF 2 *** distribution ratio of sulfur between the（CaO）-MgO-FeO-SiO 2 slag and Fe-Ni alloy at high temperature was also investigated to understand the refining ability of Ferronickel smelting slag by chemical equilibrating *** experimental results indicated that sulfide capacity in terms of the slag composition of MgO-FeO-SiO 2 slag and temperature was increased with increasing FeO and CaO contents as well as *** FeO is considered to work as relatively basic component in this slag system that has low *** the effect of components of slag on sulfide capacity,CaO and FeO is considered to be more effective basic oxide than MgO in MgO-FeO-SiO 2 slag system while the effect of FeO on sulfide capacity was gradually retarded with increasing *** effect of CaO on MgO solubility of slag and the relationship between sulfide and Ni oxide capacities was also discussed.

关键词： nickel distribution ratio basicity amphoteric behavior sulfide capacity

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Combined Sciatic, Femoral, and Obturator Nerve Blocks for Ankle Surgery in a Patient with Severe Pulmonary Hypertension—A Case Report

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Open Journal of Anesthesiology 2017年第8期7卷 203-209页

作者： Ju Hyun Lee Hyun Su Shin ki Yoon kim Ji Seon jeong Justin Sangwook Ko Department of Anesthesiology and Pain Medicine Samsung Medical Center School of Medicine Sungkyunkwan University Seoul Korea

We report a patient with severe pulmonary arterial hypertension (PAH) undergoing tibio-talo-calcaneal fusion due to Charcot joint. Despite the advancement in the management of PAH, the risks of anesthesia, surgery, and postoperative morbidity and mortality still remain high. A 46-year-old female was presented with severe PAH and end stage renal disease requiring hemodialysis three times a week. Ultrasound-guided sciatic, femoral, and obturator nerve blocks were performed with 0.5% levobupivacaine 15 ml, 10 ml, and 5 ml, respectively. All the blocks were successful, and the patient underwent uneventful anesthesia and surgery. In addition, the postoperative pain control lasted for 15 h and the patient was discharged on POD 5 without any complications. Therefore, ultrasound-guided sciatic, femoral, and obturator nerve blocks are valuable alternative to the general or neuraxial anesthesia in patients with severe pulmonary hypertension.

关键词： Femoral Nerve Block Obturator Nerve Block Sciatic Nerve Block Severe Pulmonary Hypertension Ultrasound-Guided

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Recent advances in controlled modification of the size and morphology of metal-organic frameworks

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Nano Research 2018年第9期11卷 4441-4467页

作者： Botao Liu Kowsalya Vellingiri Sang-Hee Jo Pawao Kumar Yong Sik Ok ki-Hyun kim Department of Civil & Environmental Engineering Hanyang University 222 Wangsimni-Ro Seou104763 Republic of Korea Environmental and Water Resources Engineering Division Department of Civil Engineering IITMadras Chennoi 600 036 India Department of Nano Science and Materials Central University ofJammu Jammu J & K- 180011 India Korea Biochar Research Center O-Jeong Eco-Resilience Institute (OJERI) & Division of Environmental Science and Ecological Engineering Korea University Seou102841 Republic of Korea

Advances in metal-organic frameworks （lVIOFs） resulted in significant contributions to diverse applications such as carbon capture, gas storage, heat transformation and separation along with emerging applications toward catalysis, medical imaging, drug deliver~ and sensing. The unique in situ and ex situ structural features of MOFs can be tailored by conceptual selection of the organic （e.g., ligand） and inorganic （e.g., metal） components. Here, we provide a comprehensive review on the synthesis and characterization of MOFs, particularly with respect to controlling their size and morphology. A better understanding of the specific size and morphological parameters of MOFs will help initiate a new era for their real-world applications. Most importantly, this assessment will help develop novel synthesis methods for MOFs and their hybrid/porous materials counterparts with considerably improved properties in targeted applications.

关键词： metal-organic frameworks smart materials novel synthesis advanced materials composite materials green chemistry

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Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin kim Young Uk Cho Jaejin Park Jung-Hoon Hong Kyubeen kim Jongwoon Shin jeong Eun Ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee Jung Huanyu Cheng Il-Joo Cho ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-kiST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-kiST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

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