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Journal of Genetics and Genomics 2011年第8期38卷 351-355页

作者： Jung-Ha Kang ki hwan yu Jung-Youn Park Chul-Min An Je-Cheon Jun Sang-Jun Lee Biotechnology Research Division NFRDIBusan 619-705Republic of Korea Aquaculture Management Division NFRDIBusan 619-705Republic of Korea

Color variation is a well-known feature of sea cucumbers （Apostichopus japonicus）, which are classified into three groups based on their colors of red, green and black. It is also one of the most important traits related to how they taste, and it thereby affects their market price. Attempts were made to identify single-nucleotide polymorphisms （SNPs） and to analyze differences associated with SNP genotypes between green and red color variants using HSP70 as the target gene. The HSP70 gene, which is found universally in organisms from bacteria to humans, is one of the most evolutionarily conserved genes and the most widely studied biomarker of stress response. DNA fragments of 1074 bp covering a partial sequence of the sea cucumber HSP70 gene, were amplified from both red and green variants, and subsequently analyzed for the presence of SNPs. Twenty-seven polymorphic sites in total, including heterozygous sites, were observed. Of these, six sites were found to be significantly different SNP genotypes between green and red variants. Furthermore, PCR with an internal primer designed to include an allelespecific SNP at the 3＇ end （site 443） showed differentiation between the two variants, 100% and 4.2% amplification in green and red variants, respectively. The validated SNPs may serve as informative genetic markers that can be used to distinguish variants at the early developmental stage, prior to color differentiation.

关键词： Sea cucumber HSP70 SNP Color variant

Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-Micro Letters 2024年第12期16卷 468-514页

作者： Jung hwan Park Srinivas Pattipaka Geon-Tae hwang Minok Park yu Mi Woo Young Bin kim Han Eol Lee Chang Kyu Jeong Tiandong Zhang yuho Min Kwi-Il Park Keon Jae Lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(LMIs),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate LMI parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by LMI technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with LMIs,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices

Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-Micro Letters 2024年第12期 476-522页

作者： Jung hwan Park Srinivas Pattipaka Geon-Tae hwang Minok Park yu Mi Woo Young Bin kim Han Eol Lee Chang Kyu Jeong Tiandong Zhang yuho Min Kwi-Il Park Keon Jae Lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering) Kumoh National Institute of Technology Department of Materials Science and Engineering Pukyong National University Energy Technologies Area Lawrence Berkeley National Laboratory Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST) Division of Advanced Materials Engineering Jeonbuk National University School of Electrical and Electronic Engineering Harbin University of Science and Technology Key Laboratory of Engineering Dielectrics and Its Application Ministry of Education Harbin University of Science and Technology Department of Materials Science and Metallurgical Engineering Kyungpook National University School of Materials Science and Engineering Yeungnam University

This review provides a comprehensive overview of the progress in light-material interactions(LMIs), focusing on lasers and flash lights for energy conversion and storage applications. We discuss intricate LMI parameters such as light sources, interaction time, and fluence to elucidate their importance in material processing. In addition, this study covers various light-induced photothermal and photochemical processes ranging from melting, crystallization, and ablation to doping and synthesis, which are essential for developing energy materials and devices. Finally, we present extensive energy conversion and storage applications demonstrated by LMI technologies, including energy harvesters, sensors, capacitors, and batteries. Despite the several challenges associated with LMIs, such as complex mechanisms, and high-degrees of freedom, we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

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Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke

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Neural Regeneration Research 2017年第3期12卷 341-350页

作者： Jin hwan Lee James Zhang Shan Ping yu Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Veteran's Affair Medical Center Center for Visual and Neurocognitive RehabilitationAtlantaGAUSA

Stroke is a leading cause of disability and death,yet effective treatments for acute stroke has been very *** far,tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients,yet its application is only applicable to less than 4–5% of stroke patients due to the narrow therapeutic window（〈 4.5 hours after the onset of stroke） and the high risk of hemorrhagic *** evidence from basic and clinical studies has shown that therapeutic hypothermia,also known as targeted temperature management,can be a promising therapy for patients with different types of ***,the success in animal models using pharmacologically induced hypothermia（PIH） has gained increasing momentum for clinical translation of hypothermic *** review provides an updated overview of the mechanisms and protective effects of therapeutic hypothermia,as well as the recent development and findings behind PIH *** is expected that a safe and effective hypothermic therapy has a high translational potential for clinical treatment of patients with stroke and other CNS injuries.

关键词： stroke therapeutic hypothermia drug-induced hypothermia ischemia cell death inflammation

Polymeric micelle nanocarriers in cancer research

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Frontiers of Chemical Science and Engineering 2016年第3期10卷 348-359页

作者： Dae hwan Shin yu Tong Tam Glen S. Kwon School of Pharmacy University of Wisconsin Madison WI 53705 USA

Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention （EPR） effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous （IV） infusion, polymeric micelles that disas- semble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. Stable polymeric micelles are long- circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxi- city and targeting tumors by the EPR effect.

关键词： nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation

Impact of non-Hermitian mode interaction on inter-cavity light transfer

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Photonics Research 2022年第5期10卷 1232-1237页

作者： HYEON-HYE yu SUNJAE GWAK JINHYEOK Ryu HyuNDONG kiM JI-hwan kiM JUNG WAN Ryu CHIL-MIN kiM CHANG hwan YI Department of Emerging Materials Science DGISTDaegu 42988Republic of Korea Center for Theoretical Physics of Complex Systems Institute for Basic Science(IBS)Daejeon 34126Republic of Korea

Understanding inter-site mutual mode interaction in coupled physical systems is essential to comprehend large compound systems,as this local interaction determines the successive multiple inter-site energy transfer *** the present study,we demonstrate that only the non-Hermitian coupling can correctly account for the light transfer between two coupled optical *** also reveal that the non-Hermitian coupling effect becomes crucial as the system dimension *** results provide important insight for handling general-coupled devices in the subwavelength regime.

关键词： interaction transfer coupling

Hybridization of different types of exceptional points

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Photonics Research 2019年第12期7卷 1473-1478页

作者： JINHYEOK Ryu SUNJAE GWAK JAEWON kiM HYEON-HYE yu JI-hwan kiM JI-WON LEE CHANG-hwan YI CHIL-MIN kiM Department of Emerging Materials Science DGISTDaegu 42988South Korea Institut fur Physik Technische Universitat IlmenauD-98693 IlmenauGermany Samsung Electro-Mechanics Suwon 16674South Korea

A large number of different types of second-order non-Hermitian degeneracies called exceptional points(EPs)were found in various physical systems depending on the mechanism of coupling between *** show that these EPs can be hybridized to form higher-order EPs,which preserve the original properties of the initial EPs before *** a demonstration,we hybridize chiral and supermode second-order EPs,where the former and the latter are the results of intra-disk and inter-disk mode coupling in an optical system comprised of two Mie-scale microdisks and one Rayleigh-scale *** high sensitivity of the resulting third-order EP against external perturbations in our feasible system is emphasized.

关键词： exceptional coupling system

WRA-Net:Wide Receptive Field Attention Network for Motion Deblurring in Crop and Weed Image

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Plant Phenomics 2023年第2期5卷 174-194页

作者： Chaeyeong yun yu hwan kim Sung Jae Lee Su Jin Im Kang Ryoung Park Division of Electronics and Electrical Engineering Dongguk University30 Pildong-ro 1-gilJung-guSeoul 04620Republic of Korea

Automatically segmenting crops and weeds in the image input from cameras accurately is essential in various agricultural technology fields,such as herbicide spraying by farming robots based on crop and weed segmentation ***,crop and weed images taken with a camera have motion blur due to various causes(e.g.,vibration or shaking of a camera on farming robots,shaking of crops and weeds),which reduces the accuracy of crop and weed ***,robust crop and weed segmentation for motion-blurred images is ***,previous crop and weed segmentation studies were performed without considering motion-blurred *** solve this problem,this study proposed a new motion-blur image restoration method based on a wide receptive field attention network(WRA-Net),based on which we investigated improving crop and weed segmentation accuracy in motion-blurred ***-Net comprises a main block called a lite wide receptive field attention residual block,which comprises modified depthwise separable convolutional blocks,an attention gate,and a learnable skip *** conducted experiments using the proposed method with 3 open databases:BoniRob,crop/weed field image,and rice seedling and weed *** to the results,the crop and weed segmentation accuracy based on mean intersection over union was 0.7444,0.7741,and 0.7149,respectively,demonstrating that this method outperformed the state-of-the-art methods.

关键词： Net shaking image

A facile one-step approach to hierarchically assembled core-shell-like MnO2@MnO2 nanoarchitectures on carbon fibers： An efficient and flexible electrode material to enhance energy storage

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Nano Research 2016年第5期9卷 1507-1522页

作者： Goli Nagaraju Yeong hwan Ko Sung Min Cha Sang Hyuk Im Jae Su yu Department of Electronics and Radio Engineering Institute for Wearable Convergence Electronics Kyung Hee University 1732 Deogyeong-daero Giheung-gu Yongin-si Gyeonggi-do 446-701 Republic of Korea Functional Crystallization Center (ERC) Department of Chemical Engineering Kyung Hee University 1732 Deogyeong-daeroGiheuncl-qu Yonqin-si Gyeonqqi-do 446-701 Republic of Korea

Hierarchical core-shell-like MnO2 nanostructures （NSs） were used to anchor MnO2 hexagonal nanoplate arrays （HNPAs） on carbon cloth （CC） fibers. The NSs were prepared by a novel one-step electrochemical deposition method. Under an external cathodic voltage of -2.0 V for 30 min, hierarchical core-shell-like MnO2-NS-decorated MnO2 HNPAs （MnO2 NSs@MnO2 HNPAs） were uniformly grown on CC with reliable adhesion. The phase purity and morphological properties of the samples were characterized by various physicochemical techniques. At a constant external cathodic voltage, growth of MnO2 NSs@MnO2 HNPAs on CC was carried for different time periods. When utilized as a flexible, robust, and binder-free electrode for pseudocapacitors, the hierarchical core-shell-like MnO2 NSs@MnO2 HNPAs on CC showed clearly enhanced electrochemical properties in 1 M Na2SO4 electrolyte solution. The results indicate that the MnO2 NSs@MnO2 HNPAs on CC have a maximum specific capacitance of 244.54 F/g at a current density of 0.5 A/g with excellent cycling stability compared to that of bare MnO2 HNPAs on CC （112.1 F/g at 0.5 A/g current density）. We believe that the superior charge storage performance of the pseudocapacitive electrode can be mainly attributed to the hierarchical MnO2 NSs@MnO2 HNPAs building blocks that have a large specific surface area, offering additional electroactive sites for efficient electrochemical reactions. The facile and single-step approach to growth of hierarchical pseudocapacitive materials on textile based electrodes opens up the possibility for the fabrication of high-performance flexible energy storage devices.

关键词： manganese oxide hierarchical structures carbon cloth electrochemical deposition energy storage properties

Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 909-914页

作者： Bo Hee kim In Boem Chang Hyeong Gon yu In hwan Hong Department of Ophthalmology Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181Republic of Korea Seoul On Eye Clinic Seoul 03355Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080Republic of Korea Retina Center Sky Eye InstituteSeoul 06536Republic of Korea Department of Ophthalmology Dongtan Sacred Heart HospitalHallym University Medical CenterHwaseong-siGyeonggido 18450Republic of Korea

·AIM:To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor(VEGF)injections to treat neovascular agerelated macular degeneration(n AMD)with subretinal fluid(SRF)and pigment epithelial detachment(PED).·METHODS:This prospective study included eyes with n AMD previously treated with as-needed anti-VEGF *** patients were treated with six monthly intravitreal injections of *** volumetric segmentation analyses of the SRF and PED were *** main outcome measures included best-corrected visual acuity(BCVA),and SRF and PED volumes.·RESULTS:Twenty eyes of 20 patients were included in this *** the 6-month follow-up,BCVA and PED volume did not change significantly(P=0.110 and 0.999,respectively)but the mean SRF volume decreased from 0.53±0.82 mm3 at baseline to 0.08±0.23 mm3(P=0.002).The absorption rate of the SRF volume was negatively correlated with the duration of previous antiVEGF treatment(P=0.029).Seven of the 20 eyes(35%)showed a fluid-free macula and significant improvement in BCVA(P=0.036)by month 6.·CONCLUSION:Quantifying the SRF can precisely determine the patient’s responsiveness to anti-VEGF treatment of n AMD.

关键词： neovascular age-related macular degeneration anti-vascular endothelial growth factor treatment drug tolerance persistent subretinal fluid volumetric fluid analysis