Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke

作     者：Jin Hwan Lee James Zhang Shan Ping Yu 

作者机构：Department of AnesthesiologyEmory University School of MedicineAtlantaGAUSA Veteran's Affair Medical CenterCenter for Visual and Neurocognitive RehabilitationAtlantaGAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第3期

页      面：341-350页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by an American Heart Association(AHA)Postdoctoral Fellowship 15POST25680013(JHL) NIH grants NS085568(SPY) a VA Merit grant RX000666(SPY) 

主　　题：stroke therapeutic hypothermia drug-induced hypothermia ischemia cell death inflammation 

摘      要：Stroke is a leading cause of disability and death,yet effective treatments for acute stroke has been very *** far,tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients,yet its application is only applicable to less than 4–5% of stroke patients due to the narrow therapeutic window（〈 4.5 hours after the onset of stroke） and the high risk of hemorrhagic *** evidence from basic and clinical studies has shown that therapeutic hypothermia,also known as targeted temperature management,can be a promising therapy for patients with different types of ***,the success in animal models using pharmacologically induced hypothermia（PIH） has gained increasing momentum for clinical translation of hypothermic *** review provides an updated overview of the mechanisms and protective effects of therapeutic hypothermia,as well as the recent development and findings behind PIH *** is expected that a safe and effective hypothermic therapy has a high translational potential for clinical treatment of patients with stroke and other CNS injuries.