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Salt effect on MUCT system performance of nitrogen and phosphorus removal

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Green Energy & Environment 2021年第5期6卷 670-677页

作者： Huining Zhang Zhuowei Zhang kewei jiang Zhili Li Kefeng Zhang Jianqing Ma Yongxing Qian NingboTech University Ningbo315100China College of Water Sciences Beijing Normal UniversityBeijing100875China Ningbo Research Institute Zhejiang UniversityNingbo315100China Ningbo Key Laboratory of Urban and Rural Water Pollution Control Technology Ningbo315100China

The effect of salinity on biological nitrogen and denitrifying phosphorus removal was investigated in a Modified University of Cape Town(MUCT)*** rates of COD,NH_(4)^(+)-N,NO_(3)^(-)-N,NO_(2)^(-)-N,phosphorus and the sludge characteristics at salt concentrations(0.0,3.2,6.4,11.2 and 16.0 g L^(-1))were *** the salt concentration increasing,all the COD,NH_(4)^(+)-N,TN and TP removal rates exhibited a trend of decline,and exhibited an initial reduction and subsequent increase at every stage of salt ***_(4)^(+)-N,TN and TP removal rates were 92.7%,51.5%and 67.2%in 16 g L^(-1) salt concentration,*** they were outperformed the literature reported and acceptable in practical *** the salinity of wastewater changed from 0.0 to 16.0 g L^(-1),the biomass yield coefficients increased from 0.0794 to 0.126 g VSS/g *** salinity had a detrimental effect on phosphorus-accumulating organisms(PAOs)and denitrifying PAOs(DPAOs)(especially DPAOs).Therefore,phosphorus removal gradually depended on *** simultaneous nitrification and denitrification(SND)rate and nitrogen removal rate(including nitrification rate,denitrification rate,and total nitrogen removal rate)gradually decreased with the increased salinity.

关键词： Aquaculture wastewater Denitrifying phosphorus removal MUCT process TP SND rate

重视原发性甲状腺机能亢进患者合并甲状腺癌的规范化诊治

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西安交通大学学报（医学版） 2024年第1期45卷 35-38页

作者：王晨一贺晨宇姜可伟北京大学人民医院胃肠外科北京100442 北京大学人民医院外科肿瘤研究室、结直肠癌诊疗研究北京市重点实验室北京100442

原发性甲状腺机能亢进与甲状腺癌通常被视为相互独立的疾病,但近年来,越来越多的研究表明,这两种疾病可能存在共同的发病机制。本文旨在规范原发性甲状腺机能亢进患者合并甲状腺癌的诊治,通过综合分析国内外相关研究,为临床医师在面对... 详细信息

原发性甲状腺机能亢进与甲状腺癌通常被视为相互独立的疾病,但近年来,越来越多的研究表明,这两种疾病可能存在共同的发病机制。本文旨在规范原发性甲状腺机能亢进患者合并甲状腺癌的诊治,通过综合分析国内外相关研究,为临床医师在面对甲状腺机能亢进合并甲状腺癌患者时提供有益的参考和指导,进一步提高诊治水平。

关键词：甲状腺功能亢进症甲状腺肿瘤格雷夫斯病甲状腺疾病

Al_(2)(SO_(4))_(3)催化热解油转化生产酯类燃料

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河北科技大学学报 2024年第3期45卷 283-289页

作者：罗丹夏淑倩郭丽潇韩建荣蒋可为郝全爱李娇中国辐射防护研究院山西太原030000 天津大学化工学院天津300072 河北科技大学理学院河北石家庄050018

酸类、糖类等不稳定组分的存在是制约热解油直接用作生物燃料的主要因素。为了解决此问题,提出采用Al_(2)(SO_(4))_(3)催化剂将这些不稳定成分酯化为燃料类化合物的途径。首先,分别以单模型化合物左旋葡萄糖或乙酸为原料,考察各种金属... 详细信息

酸类、糖类等不稳定组分的存在是制约热解油直接用作生物燃料的主要因素。为了解决此问题,提出采用Al_(2)(SO_(4))_(3)催化剂将这些不稳定成分酯化为燃料类化合物的途径。首先,分别以单模型化合物左旋葡萄糖或乙酸为原料,考察各种金属硫酸盐催化其转化制备乙酰丙酸乙酯或乙酸乙酯的能力,筛选出催化性能最好的催化剂;其次,以左旋葡萄糖和乙酸的模型混合物为原料,探究Al_(2)(SO_(4))_(3)催化同时转化制备酯类的最佳反应条件;最后,以真实热解油为原料,验证Al_(2)(SO_(4))_(3)在最佳反应条件下催化酯化的可行性。结果表明,酯化后热解油中大部分酸、糖、醛消失,同时产生大量的酯和缩醛,酯类和缩醛类占改性热解油总色谱面积的39.5%。Al_(2)(SO_(4))_(3)能有效将热解油中的酸类、糖类等不稳定组分酯化为燃料类化合物,可为热解油转化制备生物燃料提供借鉴。

关键词：催化化学热解油乙酰丙酸乙酯乙酸乙酯 Al_(2)(SO_(4))_(3)

MSH2 is required for cell proliferation,cell cycle control and cell invasiveness in colorectal cancer cells

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Chinese Science Bulletin 2012年第20期57卷 2580-2585页

作者： SHEN Kai YE Yingjiang jiang kewei LIANG Bin YANG XiaoDong WANG Shan Department of Gastroenterological Surgery Surgical Oncology Laboratory Peking UniversityPeople's HospitalBeijing 100044China

We have investigated the role of MSH2,a mismatch repair gene in cell proliferation,cell cycle control and cell invasiveness in the SW480 human colorectal cancer cell ***-mediated inhibition of MSH2 expression was achieved using MSH2 shRNA lentiviral expression *** knockdown of endogenous MSH2 expression was determined by real-time PCR *** most efficient MSH2 knockdown vector was selected for subsequent studies using SW480 *** MSH2 mRNA levels decreased after lentiviral delivery of the MSH2-RNAi,indicating efficient silencing of MSH2 expression in SW480 *** proliferation,cell cycle progression and cell invasiveness were quantified by MTT assays,flow cytometry and transwell assays,***-mediated inhibition of MSH2 expression in SW480 cells resulted in decreased cell proliferation,cell cycle arrest at the G0/G1 phase and decreased cell *** together,these results provide evidence that MSH2 stimulates cell proliferation,promotes cell cycle progression and positively regulates cell invasiveness.

关键词：错配修复基因细胞周期调控细胞增殖侵袭癌细胞大肠细胞周期阻滞 RNAi

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《正体类要》扑伤症治疗思路浅析及原理发挥

四川中医 2024年第6期42卷 29-32页

作者：程大鹏蒋科卫吴维真王文陈雨欣许东升北京中医药大学北京100029

目的:探究《正体类要》中对扑伤症的病因病机认识以及辨证论治思路,为临床诊治该疾病提供参考。方法:以《正体类要》中记载的扑伤症医案为主要研究对象,结合本书其他章节中的诊治思想,对其治疗思路进行归纳分析。结果:《正体类要》中的... 详细信息

目的:探究《正体类要》中对扑伤症的病因病机认识以及辨证论治思路,为临床诊治该疾病提供参考。方法:以《正体类要》中记载的扑伤症医案为主要研究对象,结合本书其他章节中的诊治思想,对其治疗思路进行归纳分析。结果:《正体类要》中的扑伤症医案,依据病因、主要病机可以为6种,即常证、变证、坏证、后遗证、破伤风类证及痉证。其论治思路包含了薛己对于“瘀血”作为核心病机在体内产生、转化、消除这一过程的理解,体现了薛己治疗扑伤症中以瘀血为核心、重视证型转化、重视体质的学术思想。结论:《正体类要》对扑伤症的病因病机、辨证论治认识深刻,能够为扑伤症的临床治疗提供参考。

关键词：正体类要扑伤症辨证论治病机转化

BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis

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Chinese Science Bulletin 2011年第23期56卷 2444-2449页

作者： DONG LingYi jiang kewei ZHANG YanBin ZHANG Hui ZHUO HongQing CUI ZhiRong YE Yingjiang WANG Shan Department of Gastroenterological Surgery Surgical Oncology Laboratory Peking University People's Hospital Peking University Beijing100044 China

We previously showed that B cell receptor associated protein 31(BAP31) was significantly upregulated in colorectal cancer compared with normal mucosa epithelia. However, its expression pattern and pathological role in colorectal cancer are not clearly understood. In this study, we investigated whether the expression of BAP31 was associated with the clinicopathological parameters of colorectal cancer. The expression pattern of BAP31 was detected by immunohistochemistry on a tissue microarray in both primary tumor and paired distant normal mucosa samples from 120 consecutive colorectal cancer patients. Furthermore, BAP31 protein expression was also determined in twenty colorectal adenomas and eight liver metastasis samples. There was positive expression of BAP31 in 64.17% of primary tumors and 6.67% in distant normal mucosa (P=0.000). Negative expression of BAP31 was correlated with distant metastasis (P=0.036) and lower tumor differentiation grade (P=0.001). Patients with BAP31-negative expression showed significantly lower overall survival rate (P=0.003) compared to patients with BAP31-positive expression. Our results demonstrate that BAP31 may serve as a candidate prognostic marker in colorectal cancer and negative BAP31 expression may lead to more aggressive invasion of colorectal cancer.

关键词：患者结直肠癌过度表达预后原发性受体相关蛋白免疫组化检测粘膜上皮

Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer

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Chinese Medical Journal 2014年第11期127卷 2021-2024页

作者： jiang kewei Lyu Liang Shen Zhanlong Zhang Jizhun Zhang Hui Dong Jianqiang Yan Yichao Liu Fangfang Wang Shan Department of Gastroenterological Surgery Peking University People's Hospital Beijing 100044 China Department of General Surgery Qingdao University Affiliated Hospital Qingdao Shandong 266000 China Central Laboratory Peking University People's Hospital Beijing 100044 China Department of Pathology Peking UniversityPeople's Hospital Beijing 100044 China

Background Sirtuin 1 （SIRT1） has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone ***,the correlations among SIRT1 protein expression,clinicopathological parameters,and survival of colorectal cancer patients remain *** SIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray,including 120 paired colorectal cancer and normal mucosa *** correlations among SIRT1 protein expression,clinicopathological features,and prognosis were *** All samples （100%） were positive for SIRT1,with variable staining in the cytoplasm rather than in the *** was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissue （P〈0.01,x2 test）.SIRT1 overexpression was more frequently observed in advanced-stage tumors （P=0.046,0.002,x2test）.SIRT1 overexpression was significantly correlated with poor overall survival （P=0.013,log-rank test） and diseasefree survival （P=0.012,log-rank test）.Conclusions SIRT1 overexpression correlated with advanced stage and poor ***1 may play an important role in the progression of colorectal cancer.

关键词： carcinogenesis colorectal cancer immunohistochemistry prognosis Sirtuin 1 (SIRT1)

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

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Chinese Journal of Cancer Research 2021年第2期33卷 271-288页

作者： Quan Wang Zhu Wang Zhen Zhang Wei Zhang Mengmeng Zhang Zhanlong Shen Yingjiang Ye kewei jiang Shan Wang Department of Gastroenterological Surgery Peking University People’s HospitalBeijing 100044China Laboratory of Surgical Oncology Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment ResearchPeking University People’s HospitalBeijing 100044China Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitisassociated cancer(CAC)and to reveal a potential evolutionary trajectory from ulcerative colitis(UC)to CAC at the single-cell ***:Fresh samples of tumor tissues and adjacent UC tissues from a CAC patient with pT3N1M0 stage cancer were examined by single-cell RNA sequencing(scRNA-seq).Data from The Cancer Genome Atlas(TCGA)and The Human Protein Atlas were used to confirm the different expression levels in normal and tumor tissues and to determine their relationships with patient ***:Ultimately,4,777 single-cell transcriptomes(1,220 genes per cell)were examined,of which 2,250(47%)and 2,527(53%)originated from tumor and adjacent UC tissues,*** defined the composition of cancer-associated stromal cells and identified six cell clusters,including myeloid,T and B cells,fibroblasts,endothelial and epithelial *** pathways and transcription factors involved in these cell clusters were analyzed and ***,the precise cellular composition and developmental trajectory from UC to UCassociated colon cancer were graphed,and it was predicted that CD74,CLCA1,and DPEP1 played a potential role in disease ***:scRNA-seq technology revealed intra-tumor cell heterogeneity in UC-associated colon cancer,and might provide a promising direction to identify novel potential therapeutic targets in the evolution from UC to CAC.

关键词： Ulcerative colitis-associated colon cancer single-cell RNA sequencing cell heterogeneity evolutionary trajectory

半环形外固定支架治疗C型桡骨远端骨折的稳定性有限元分析

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中医正骨 2024年第6期36卷 1-9,36页

作者：王文蒋科卫成永忠林晴尹晓冬钱秀清刘广伟北京中医药大学研究生院北京100029 中国中医科学院望京医院北京100102 首都医科大学生物医学工程学院北京100069 中医正骨技术北京市重点实验室北京100102

目的:探讨半环形外固定支架治疗C型桡骨远端骨折的稳定性。方法:选取1名健康成年男性志愿者,分别采用CT和MRI扫描腕关节。基于CT和MRI扫描数据,建立正常腕关节的三维有限元模型,并对模型有效性进行验证。基于正常腕关节的三维有限元模型... 详细信息

目的:探讨半环形外固定支架治疗C型桡骨远端骨折的稳定性。方法:选取1名健康成年男性志愿者,分别采用CT和MRI扫描腕关节。基于CT和MRI扫描数据,建立正常腕关节的三维有限元模型,并对模型有效性进行验证。基于正常腕关节的三维有限元模型,建立C1、C2、C3型桡骨远端骨折有限元模型,制作并装配半环形外固定支架。分别在装配半环形外固定支架的C1、C2、C3型桡骨远端骨折有限元模型上施加轴向、旋前及掌屈载荷,记录不同载荷下3种桡骨远端骨折有限元模型桡腕关节面的轴向最大相对位移及骨折块的最大应力和最大位移。结果:(1)正常腕关节有限元模型构建和验证结果。本研究建立的正常腕关节有限元模型涉及1 094 717个单元,387 763个节点。在尺骨近端施加完全约束后,对模型施加100 N的轴向载荷,桡腕关节面最大应力为10.7 MPa;桡骨远端关节面主要应力分布于桡舟关节面和桡月关节面,且桡舟关节面所承受的应力较大;该结果与文献中尸体实验结果一致,提示正常腕关节有限元模型构建成功。(2)3种桡骨远端骨折有限元模型桡腕关节面的轴向最大相对位移。在轴向载荷下,C1、C2、C3型桡骨远端骨折有限元模型桡腕关节面的轴向最大相对位移依次为0.27 mm、0.14 mm、0.64 mm;在旋前载荷下,C1、C2、C3型桡骨远端骨折有限元模型桡腕关节面的轴向最大相对位移依次为0.21 mm、0.29 mm、0.36 mm;在掌屈载荷下,C1、C2、C3型桡骨远端骨折有限元模型桡腕关节面的轴向最大相对位移依次为0.11 mm、0.08 mm、0.24 mm。(3)3种桡骨远端骨折有限元模型骨折块的最大应力。在轴向载荷下,C1、C2、C3型桡骨远端骨折有限元模型骨折块的最大应力依次为5.58 MPa、20.93 MPa、40.91 MPa;在旋前载荷下,C1、C2、C3型桡骨远端骨折有限元模型骨折块的最大应力依次为1.45 MPa、11.31 MPa、11.89 MPa;在掌屈载荷下,C1、C2、C3型桡骨远端骨折有限元模型骨折块的最大应力依次为0.78 MPa、19.94 MPa、4.66 MPa。(4)3种桡骨远端骨折有限元模型骨折块的最大位移。在轴向载荷下,C1、C2、C3型桡骨远端骨折有限元模型骨折块的最大位移依次为0.63 mm、1.4 mm、1.5 mm;在旋前载荷下,C1、C2、C3型桡骨远端骨折有限元模型骨折块的最大位移依次为0.10 mm、0.16 mm、0.16 mm;在掌屈载荷下,C1、C2、C3型桡骨远端骨折有限元模型骨折块的最大位移依次为1.24 mm、1.15 mm、1.05 mm。结论:半环形外固定支架治疗C型桡骨远端骨折具有较好的稳定性。

关键词：桡骨骨折骨折固定术外固定器限定因素分析生物力学现象