BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis

作     者：DONG LingYi JIANG KeWei ZHANG YanBin ZHANG Hui ZHUO HongQing CUI ZhiRong YE YingJiang WANG Shan 

作者机构：Department of Gastroenterological Surgery Surgical Oncology Laboratory Peking University People's Hospital Peking University Beijing100044 China 

出 版 物：《Chinese Science Bulletin》 (Chinese Science Bulletin)

年 卷 期：2011年第56卷第23期

页      面：2444-2449页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (30872470, 81072018) the Research Fund for the Doctoral Program of Higher Education of China (New Teacher, 20090001120082) 

主　　题：患者 结直肠癌 过度表达 预后 原发性 受体相关蛋白 免疫组化检测 粘膜上皮 

摘      要：We previously showed that B cell receptor associated protein 31(BAP31) was significantly upregulated in colorectal cancer compared with normal mucosa epithelia. However, its expression pattern and pathological role in colorectal cancer are not clearly understood. In this study, we investigated whether the expression of BAP31 was associated with the clinicopathological parameters of colorectal cancer. The expression pattern of BAP31 was detected by immunohistochemistry on a tissue microarray in both primary tumor and paired distant normal mucosa samples from 120 consecutive colorectal cancer patients. Furthermore, BAP31 protein expression was also determined in twenty colorectal adenomas and eight liver metastasis samples. There was positive expression of BAP31 in 64.17% of primary tumors and 6.67% in distant normal mucosa (P=0.000). Negative expression of BAP31 was correlated with distant metastasis (P=0.036) and lower tumor differentiation grade (P=0.001). Patients with BAP31-negative expression showed significantly lower overall survival rate (P=0.003) compared to patients with BAP31-positive expression. Our results demonstrate that BAP31 may serve as a candidate prognostic marker in colorectal cancer and negative BAP31 expression may lead to more aggressive invasion of colorectal cancer.