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[H_(2)dab][GaB_(5)O_(10)]:an Acentric Galloborate with a 4-Connected Uninodal Framework

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Chemical Research in Chinese Universities 2024年第4期40卷 747-752页

作者： LIU Wenfang chen Chongan YANG Guoyu School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing102488P.R.China

A new acentric galloborate(GBO)[H_(2)dab][GaB_(5)O_(10)](1,1,4-dab:1,4-diaminobutane)has been synthesized under solvothermal *** alternation of 4,4-connected GaO4 and B5O10 cluster build up the 3D[GaB_(5)O_(10)]_(n)^(2n-)uninodal framework,which contains three pairs of helical channels with 8-member ring(MR)and 7-MR apertures,*** 1 exhibits a moderate second harmonic generation(SHG)response of 1.8 times that of KH_(2)pO_(4)(KDp),indicating its potential application in UV *** acentric uninodal framework in compound 1 represents a new type of zeolitic framework in the GBOs’family.

关键词： Galloborate Solvothermal synthesis Nonlinear optics Zeolitic framework

Towards Sustainable Grinding of Difficult-to-Cut Alloys-A Holistic Review and Trends

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 1-28页

作者： Ning Qian Jiajia chen Aqib Mashood Khan Biao Zhao Yurong chen Wenfeng Ding Yucan Fu Jiuhua Xu Jiangsu Key Laboratory of precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing 210037China JITRI Institute of precision Manufacturing Nanjing 211805China

Grinding,a critical precision machining process for difficult-to-cut alloys,has undergone continual technological advancements to improve machining ***,the sustainability of this process is gaining heightened attention due to significant challenges associated with the substantial specific grinding energy and the extensive heat generated when working with difficult-to-cut alloys,renowned for their exceptional physical and mechanical *** response to these challenges,the widespread application of massive coolant in manufacturing industries to dissipate grinding heat has led to complex post-cleaning and disposal ***,in turn,has resulted in issues such as large energy consumption,a considerable carbon footprint,and concerns related to worker health and safety,which have become the main factors that restrict the development of grinding *** paper provides a holistic review of sustainability in grinding difficult-to-cut alloys,encompassing current trends and future *** examination extends to developing grinding technologies explicitly tailored for these alloys,comprehensively evaluating their sustainability ***,the exploration delves into innovative sustainable technologies,such as heat pipe/oscillating heat pipe grinding wheels,minimum quantity lubrication,cryogenic cooling,and *** groundbreaking technologies aim to reduce dependence on hazardous coolants,minimizing energy and resource consumption and carbon emissions associated with coolant-related or subsequent disposal *** essence of these technologies lies in their potential to revolutionize traditional grinding practices,presenting environmentally friendly ***,future development trends and research directions are put forward to pursue the current limitation of sustainable grinding for difficult-to-cut *** paper can guide future research and development efforts toward more environmentally friendly

关键词： Grinding Sustainability Cooling Energy consumption Carbon footprint Difficult-to-cut alloys

Soil properties and not plant factors affect both abundant and rare microbial taxa after thinning in a mixed stand of Cunninghamia lanceolata and Sassafras tzumu

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Journal of Forestry Research 2024年第2期35卷 81-94页

作者： Wanxia peng Tongqing Song Hu Du Feng Wang Fuping Zeng Yang Wang Shulin chen Yinzhu chen Key Laboratory of Agro‑Ecological processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125People’s Republic of China Guangxi Industrial Technology Research Institute for Karst Desertification Control Nanning 530001People’s Republic of China Huanjiang Observation and Research Station for Karst Ecosystems Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125People’s Republic of China Hubei Ecology polytechnic College Wuhan 430200People’s Republic of China Hubei Tongshan Damushan State Forest Farm Tongshan 437652People’s Republic of China

Thinning is an effective management step for sustainable forest development,yet less attention is paid to the restoration of soil microbiota after *** this study,both abundant and rare soil microbial communities(i.e.,bacterial,fungal),were evaluated under various thinning treatments in a mixed stand of Cunninghamia lanceolata and Sassafras tzumu using Mi Seq *** did not significantly change either abundant or rare bacterial and fungal community composition,but affected their alpha *** Shannon–Wiener indexes of rare fungal taxa under medium thinning were significantly lower than in the light thinning(pprevalent rare fungal taxa under different *** addition,soil available nitrogen,total phosphorus,and p H had significant effects on rare bacterial ***,especially available phosphorus,but not nitrogen,affected abundant and rare soil *** results indicate that soil properties rather than plant factors affect abundant and rare microbial communities in soils of mixed ***,through mediating soil properties,influences both abundant and rare bacterial and fungal communities in the mixed *** and *** stand.

关键词： Diversity Abundant taxa Rare taxa Thinning Mixed stand

Elevational patterns of warming effects on plant community and topsoil properties: focus on subalpine meadows ecosystem

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Journal of Mountain Science 2024年第1期21卷 146-159页

作者： HAO Aihua LUO Zhengming chen Xiaojiang Department of Geography Xinzhou Normal UniversityXinzhou 034000China Department of Biological Sciences Xinzhou Normal UniversityXinzhou 034000China

Climate warming profoundly affects plant biodiversity, community productivity, and soil properties in alpine and subalpine grassland ecosystems. However, these effects are poorly understood across elevational gradients in subalpine meadow ecosystems. To reveal the elevational patterns of warming effects on plant biodiversity, community structure, productivity, and soil properties, we conducted a warming experiment using open-top chambers from August 2019 to August 2022 at high(2764 m a. s. l.), medium(2631 m a. s. l.), and low(2544 m a. s. l.) elevational gradients on a subalpine meadow slope of Mount Wutai, Northern China. Our results showed that three years of warming significantly increased topsoil temperature but significantly decreased topsoil moisture at all elevations(ppercentage of increasing temperature and decreasing moisture both gradually raised with elevation lifting. Warming-induced decreasing proportions of soil organic carbon(SOC, by 19.24%), and total nitrogen(TN, by 24.56%) were the greatest at high elevational gradients. Experimental warming did not affect topsoil C: N, p H, NO_(3)^(-)-N, or NH_(4)^(+)-N at the three elevational gradients. Warming significantly increased species richness(ppppth of 0–10 cm at three elevational gradients. Warming caused significant increases in the aboveground biomass in the three elevational plots. Warming significantly increased the aboveground biomass of graminoids in medium(by 92.47%) and low(by 98.25%) elevational gradients, that of sedges in high(by 72.44%) and medium(by 57.16%) elevational plots, and that of forbs in high(by 75.88%), medium(by 34.38%), and low(by 74.95%) elevational plots. Species richness had significant linear correlations with SOC, TN, and C: N(pponses to soil temperature and soil moisture in the warmed treatm

关键词： Warming effect plant diversity pattern Community structure change Elevation gradient Alpine meadow ecosystem Mount Wutai

Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 687-698页

作者： Juan Lin Zhu-Feng chen Guo-Dong Guo Xin chen Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of pathology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Internal Medicine Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND The Alcian blue(AB)and periodic acid Schiff(pAS)stains are representative mucus markers in gastric signet ring cell carcinoma(SRCC).They are low-cost special staining methods used to detect acidic mucus and neutral mucus,***,the clinical importance of the special combined AB and pAS stain is *** To investigate AB expression,pAS expression and the AB-to-pAS(A/p)ratio in gastric SRCC patients and to assess patient *** paraffin-embedded sections from 83 patients with gastric SRCC were stained with AB and pAS,and signet ring cell positivity was assessed ***-histochemical staining for Ki67,protein 53(p53)and human epidermal growth factor receptor 2(HER2)was performed *** cancer-specific survival(CSS)rate was estimated via Kaplan-Meier *** proportional hazards models were used for univariate and multivariate survival *** Kaplan-Meier survival analysis revealed that the 3-year CSS rate was significantly greater in the high-pAS-expression subgroup than in the low-pAS-expression subgroup(pp≤0.5 group was significantly greater than that in the A/p>0.5 group(p=0.042).Univariate Cox regression analysis revealed that the factors affecting prognosis included tumor diameter,lymph node metastasis,vessel carcinoma embolus,tumor stage,the A/p ratio and the expression of Ki67,p53 and the *** multivariate regression analysis confirmed that low pAS expression[hazard ratio(HR)=3.809,95%confidence interval(CI):1.563-9.283,p=0.003]and large tumor diameter(HR=2.761,95%CI:1.086-7.020,p=0.033)were independent risk factors for poor *** A/p>0.5 is potentially a risk factor for prognosis,and low pAS expression is an independent risk factor in the prognosis of gastric *** expression and the A/p ratio could help in predicting the clinical prognosis of patients with SRCC.

关键词： Alcian blue periodic acid-Schiff prognosis Gastric Signet ring cell carcinoma

Clinical and socioeconomic determinants of survival in biliary tract adenocarcinomas

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1374-1383页

作者： Laura Sahyoun Kay chen Cynthia Tsay George chen petr protiva Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10065United States Gastroenterology Section Jennifer Moreno VA San Diego Healthcare SystemSan DiegoCA 92161United States Division of Gastroenterology Department of MedicineUniversity of California San DiegoLa JollaCA 92093United States Department of Gastroenterology and Hepatology John Hopkins HospitalBaltimoreMD 21287United States Department of Digestive Diseases Yale New Haven HospitalNew HavenCT 06520United States Department of Gastroenterology VA Connecticut Health Care SystemWest HavenCT 06516United States

BACKGROUND Despite advances in detection and treatments,biliary tract cancers continue to have poor survival ***,there is limited data investigating the significance of socioeconomic status,race/ethnicity,and environmental factors in biliary tract cancer *** from the Surveillance,Epidemiology,and End Results database for biliary and gallbladder adenocarcinomas were extracted from 1975 to ***-conomic data included smoking,poverty level,education,adjusted household income,and percentage of foreign-born persons and urban *** was calculated with Cox proportional hazards models for death in the 5-year period following *** Our study included 15883 gallbladder,11466 intrahepatic biliary,12869 extrahepatic biliary and 7268 ampulla of Vater adenocarcinoma *** analyzing county-specific demographics,patients from counties with higher incomes were associated with higher survival rates[hazard ratio(HR)=0.97,ppercentage of patients with a college level education and counties with a higher urban population had higher 5-year survival rates(HR=0.96,p=0.002 and HR=0.97,p=0.004,respectively).CONCLUSION Worse survival outcomes were observed in lower income counties while higher income and education level were associated with higher 5-year overall survival among gallbladder and biliary malignancies.

关键词： Biliary tract cancers Survival Outcomes research Socioeconomic factors Healthcare disparities

MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by pI3K/AKT signaling pathway

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Oncology Research 2024年第3期32卷 517-528页

作者： YUANYUAN XU XIAOKE chen Department of Oncology Surgery Shanghai Lung Cancer CenterShanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Background:The aberrant intraellular expression of a mitochondrial aspartyl tRNA synthetase 2(DARS2)has been reported in human *** its critical role and detailed mechanism in lung adenocarcinoma(LUAD)remain ***:Initially,The Cancer Genome Atlas(TCGA)based Gene Expression profiling Interactive Analysis(GEpIA)database (http:/***/)was used to analyze the prognostic relevance of DARS2 expression in ***,cell counting kit(CCK)8,immunostaining,and transwell invasion assays in LUAD cell lines in vitro,as well as DARS2 silence on LUAD by tumorigenicity experiments in wivo in nude mice,were ***,we analyzed the expression levels of p-pI3K(phosphorylated phosphotylinosital3 kinase),pI3K,AKT(protein Kinase B),p-AKT(phosphorylated protein Kinase B),pCNA(proliferating cell nudear antigen),cleaved-caspase 3,E cadherin,and N-cadherin proteins using the Westem blot ***:LUAD tissues showed higher DARS2 expression compared to normal *** of DARS2 could be related to Tumor-Node-Metastasis(TNM)stage,high lymph node metastasis,and inferior ***2 silence decreased the proliferation,migration,and invasion abilities of LUAD *** addition,the DARS2 downregulation decreased the pCNA and N-cadherin expression and increased cleaved:caspase 3 and E cadherin expressions in LUAD cells,coupled with the inactivation of the pI3K/AKT signaling ***,DARS2 silence impaired the tumonigenicity of LUAD in ***,let:7b-5p could recognize DARS2 through a complementary ***,the increased let 7b 5p expression attenuated the promo oncogenic action of DARS2 during LUAD progression,which were inversely correlated to each other in the LUAD tssues Conclusion:In summary,let 7b-5p,downregulated DARS2 expression,regulating the progression of LUAD cells by the pI3K/AKT signaling pathway.

关键词： Lung adenocarcinoma prognosis pI3K/AKT pathway Mitochondrial asparty-tRNA synthetase MicroRNAs

Dietary supplementation with Neolamarckia cadamba leaf extract improves broiler meat quality by enhancing antioxidant capacity and regulating metabolites

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Animal Nutrition 2024年第2期17卷 358-372页

作者： cheng Wang Dandan chen Shou Wu Wei Zhou Xiaoyang chen Qing Zhang Li Wang State Key Laboratory of Swine and poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureInstitute of Animal ScienceGuangdong Academy of Agricultural Sciences College of Forestry and Landscape Architecture Guangdong Province Research Center of Woody Forage Engineering TechnologyGuangdong Research and Development Center of Modern Agriculture (Woody Forage) Industrial TechnologyGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresourcesSouth China Agricultural University

This study was to evaluate the effect of supplementing the diet of broilers with Neolamarckia cadamba leaf extract(NCLE) on meat quality by evaluating antioxidant parameters and the expression of genes in the p38 mitogen-activated protein kinase/nuclear factor-erythroid 2-related factor 2/antioxidant responsive element(p38 MApK/Nrf2/ARE) signaling pathway, coupled with LC-MS-based metabolomic analysis. A total of 480 one-day-old male broilers were randomly allocated to four treatment groups—a control(CON)group, which was fed a basal diet, and three NCLE treatment groups, which were fed the basal diet supplemented with 100, 200, or 400 mg/kg NCLE(N1, N2, and N3 groups, respectively) for 42 d. Compared with the CON group, meat quality was improved in the N2 and N3 groups, as evidenced by the higher p H45min(p p p loss at48 h(p pacity was significantly enhanced in the N3group, characterized by an increase in the total antioxidant capacity(T-AOC), the concentrations of glutathione peroxidase(GSH-px) and catalase(CAT), and the relative mRNA expression of p38 MApK,extracellular-signal regulated kinase 1/2(ERK1/2), c-Jun N-terminal kinase(JNK), Nrf2, CAT, and GSH-px(p p displayed higher T-AOC, increased GSH-px and CAT concentrations,reduced malonaldehyde contents(p pregulation of the relative mRNA levels of JNK, Nrf2,heme oxygenase, CAT, and superoxide dismutase(SOD)(p pAF C-16-d4 were negatively correlated with shear force and cooking loss(p played increased abundance in BM of the N3 group. L-Serine levels were upregulated while D-fructose 1,6-diphosphate contents were downregulated in the three NCLE groups. Finally, the differential metabolites in both BM and LM were involved in amino acid metabolism pathwa

关键词： Neolamarckia cadamba leaf extract Broiler Meat quality Antioxidant capacity Metabolomics

Well posedness analysis of a parabolic-hyperbolic free boundary problem for necrotic tumors growth

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International Journal of Biomathematics 2024年第5期17卷 257-283页

作者： Wei chen Xuemei Wei School of Mathematics and Statistics Guangdong University of Technology Guangzhou 510520 P.R.China

In this paper,we study a free boundary problem of tumor growth with necrotic *** model is a parabolic-hyperbolic partial differential equations,which is composed of three first-order nonlinear hyperbolic equations,a parabolic equation and an ordinary differential ***,we obtained the approximation model by polishing the Heaviside function,and then proved the existence and uniqueness of the solution of the approximation *** addition,we improved the regularity of solution of the approximate problem by using the characteristic curves method,and finally proved the global existence of the weak solution of the original problem by the convergence.

关键词： Existence and uniqueness parabolic-hyperbolic free boundary Heaviside