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Comparison of luminescent properties of helicene-like bibenzothiophenes with o-carborane and 5,6-dicarba-nidodecaborane

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Science China Chemistry 2018年第8期61卷 940-946页

作者： kenta nishino Kazushi Hashimoto Kazuo Tanaka Yasuhiro Morisaki Yoshiki Chujo Department of Polymer Chemistry Graduate School of Engineering Kyoto University Department of Applied Chemistry for Environment School of Science and Technology Kwansei Gakuin University

This article describes comparison of the anchoring effect on electronic properties of the helicene-like bibenzothiophene between o-carborane and 5,6-dicarba-nido-decaborane. The o-carborane and nido-decaborane-fused bibenzothiophenes were simultaneously obtained in the same reaction and successfully isolated. Initially, the X-ray single crystal analysis revealed that the helicene-like distorted structure was realized in the nido-decaborane-fused bibenzothiophene. From optical measurements in the solution state, distinct different characteristics depending on the type of anchors were observed. It was summarized that the absorption and luminescent properties originated from weak π-conjugation at the bibenzothiophene moiety in the o-carboranefused compound were obtained, whereas robust π-conjugation and significant emission from the intramolecular charge transfer state were detected from the nido-decaborane-fused compound. These data can be explained by the theoretical results that π-conjugation was restrictedly developed within the bibenzothiophene moiety in frontier orbitals of the o-carborane-fused compound. In contrast, π-conjugation can be constructed even through the distorted bibenzothiophene because of the nido-decaborane unit. Moreover, the intramolecular charge transfer state should be realized because of electronic interaction involving the nido-decaborane unit in the excited state. Furthermore, it was demonstrated that the nido-decaborane-fused compound possessed solid-state emission and mechanochromic luminescent properties. The π-conjugation on the distorted structure supported by the nido-decaborane anchor should play a significant role in suppressing aggregation-caused quenching followed by presenting solid-state emission with stimuli responsiveness.

关键词：光性质硼碳电子相互作用混合物电子性质状态抛锚

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Giant Brunner's gland hyperplasia of the duodenum successfully resected en bloc by endoscopic mucosal resection: A case report

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 368-375页

作者： Makomo Makazu Akiko Sasaki Chikamasa Ichita Chihiro Sumida Takashi nishino Miki Nagayama Shinichi Teshima Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533Japan Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Pathology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Duodenal Brunner's gland hyperplasia(BGH)is a therapeutic target when complications such as bleeding or gastrointestinal obstruction occur or when malignancy cannot be ruled ***,we present a case of large BGH treated with endoscopic mucosal resection(EMR).CASE SUMMARY An 83-year-old woman presented at our hospital with *** tests revealed severe anemia,esophagogastroduodenoscopy showed a 6.5 cm lesion protruding from the anterior wall of the duodenal bulb,and biopsy revealed the presence of glandular *** ultrasonography(EUS)demonstr-ated relatively high echogenicity with a cystic *** muscularis propria was slightly elevated at the base of the *** was performed without *** formalin-fixed lesion size was 6 cm×3.5 cm×3 cm,showing nodular proliferation of non-dysplastic Brunner's glands compartmentalized by fibrous septa,confirming the diagnosis of *** of EMR or hot snare polypectomy are rare for duodenal BGH>6 *** this case,the choice of EMR was made by obtaining information on the base of the lesion as well as on the internal characteristics through *** Large duodenal lesions with good endoscopic maneuverability and no evident muscular layer involvement on EUS may be resectable via EMR.

关键词： Duodenum Brunner’s gland hyperplasia Brunner’s gland hamartoma Brunner’s gland adenoma Endoscopic mucosal resection Case report

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Update on gut microbiota in gastrointestinal diseases

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World Journal of Clinical Cases 2022年第22期10卷 7653-7664页

作者： Atsushi Nishida Kyohei nishino Masashi Ohno Keitaro Sakai Yuji Owaki Yoshika Noda Hirotsugu Imaeda Department of Gastroenterology and Hepatology Nagahama City HospitalNagahama 526-8580Japan

The human gut is a complex microbial ecosystem comprising approximately 100 trillion microbes collectively known as the“gut microbiota”.At a rough estimate,the human gut microbiome contains almost 3.3 million genes,which are about 150 times more than the total human genes present in the human *** vast amount of genetic information produces various enzymes and physiologically active ***,the gut microbiota contributes to the maintenance of host health;however,when healthy microbial composition is perturbed,a condition termed“dysbiosis”,the altered gut microbiota can trigger the development of various gastrointestinal *** gut microbiota has consequently become an extremely important research area in *** is also expected that the results of research into the gut microbiota will be applied to the prevention and treatment of human gastrointestinal diseases.A randomized controlled trial conducted by a Dutch research group in 2013 showed the positive effect of fecal microbiota transplantation(FMT)on recurrent Clostridioides difficile infection(CDI).These findings have led to the development of treatments targeting the gut microbiota,such as probiotics and FMT for inflammatory bowel diseases(IBD)and other *** review focuses on the association of the gut microbiota with human gastrointestinal diseases,including CDI,IBD,and irritable bowel *** also summarize the therapeutic options for targeting the altered gut microbiota,such as probiotics and FMT.

关键词： Inflammatory bowel disease Clostridioides difficile(Clostridium)infection Irritable bowel syndrome Probiotics Fecal microbiota transplantation

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Hepatitis B:Who should be treated?-managing patients with chronic hepatitis B during the immune-tolerant and immunoactive phases

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World Journal of Gastroenterology 2021年第43期27卷 7497-7508页

作者： Miwa Kawanaka Ken nishino Hirofumi Kawamoto Ken Haruma Department of General Internal Medicine 2 General Medical CenterKawasaki Medical SchoolOkayama 700-8505Japan

New hepatitis B virus(HBV)infections are decreasing owing to improved antiviral therapy and increased HBV vaccination worldwide;however,the number of HBV infections remains a major cause of liver *** triggers cytotoxic immunity to eliminate HBV-infected ***,the HBV pathophysiology changes in persistently infected individuals depending on host immune responses and HBV DNA proliferation *** prevent liver cirrhosis and carcinogenesis caused by HBV,it is important to treat HBV infection at an early *** treatment is recommended for the immunoactive hepatitis B surface-antigen-positive and-negative phase,but not during the immune-inactive phase or immune-tolerant phase;instead,follow-up is ***,these patients should be monitored through regular blood tests to accurately diagnose the immune-inactive or-tolerant *** treatment regimen should be determined based on the age,sex,family history of liver cancer,and liver fibrosis status of *** treatment is often recommended due to various problems during the immune-tolerant *** review compares the four major international practice guidelines,including those from the Japanese Society of Hepatology,and discusses strategies for chronic hepatitis B treatment during the immune-tolerant,immune-inactive,and resolved ***,recommended hepatitis B antiviral therapy and follow-up protocols are discussed.

关键词： Hepatitis B Immune tolerance Immune-inactive Anti-viral therapy Hepatocellular carcinoma Cirrhosis

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Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor

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World Journal of Gastroenterology 2023年第12期29卷 1863-1874页

作者： Sakue Masuda Kazuya Koizumi Kento Shionoya Ryuhei Jinushi Makomo Makazu Takashi nishino Karen Kimura Chihiro Sumida Jun Kubota Chikamasa Ichita Akiko Sasaki Masahiro Kobayashi Makoto Kako Uojima Haruki Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Gastroenterology Internal MedicineKitasato University School of MedicineKanagawa 252-0375Japan

Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030,a high mortality rate considering the number of *** and chemotherapy are the main treatment options,but they are burdensome for patients.A clear histological diagnosis is needed to determine a treatment plan,and endoscopic ultrasound(EUS)-guided tissue acquisition(TA)is a suitable technique that does not worsen the cancer-specific prognosis even for lesions at risk of needle tract *** the development of personalized medicine and precision treatment,there has been an increasing demand to increase cell counts and collect specimens while preserving tissue structure,leading to the development of the fine-needle biopsy(FNB)***-FNB is rapidly replacing EUS-guided fine-needle aspiration(FNA)as the procedure of choice for EUS-TA of pancreatic ***,EUS-FNA is sometimes necessary where the FNB needle cannot penetrate small hard lesions,so it is important clinicians are familiar with *** these recent developments,we present an up-to-date review of the role of EUS-TA in pancreatic ***,technical aspects,such as needle caliber,negative pressure,and puncture methods,for obtaining an adequate specimen in EUS-TA are discussed.

关键词： Endoscopic ultrasound-guided fine needle biopsy Endoscopic ultrasoundguided tissue acquisition Personalized medicine Genomic profiling test Pancreatic cancer Puncture procedure

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Clinical features and progress of ischemic gastritis with high fatalities: Seven case reports

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World Journal of Clinical Cases 2022年第24期10卷 8686-8694页

作者： Kento Shionoya Akiko Sasaki Hidekazu Moriya Karen Kimura Takashi nishino Jun Kubota Chihiro Sumida Junichi Tasaki Chikamasa Ichita Makomo Makazu Sakue Masuda Kazuya Koizumi Jun Kawachi ToshitakaTsukiyama Makoto Kako Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of General Internal Medicine Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of General Surgery Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Radiology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Ischemic gastritis is a clinically rare and highly fatal disease that occurs when the hemodynamics of a patient with vascular risk is *** diagnosis and treatment are possible only with upper endoscopy after symptom *** report seven cases of ischemic gastritis and its clinical features,prognosis,and indicators that may help in early *** SUMMARY Of the seven patients,six had vascular risk and five died within 2 wk of *** symptoms included hematemesis and *** surgery is a choice for radical treatment,not all patients were *** such patients,conservative treatment was selected,but all of them *** contrast,patients who underwent repeat endoscopy showed improved mucosal findings,suggesting that this improvement may not affect *** ischemic changes such as wall thickening,mural emphysema,and fluid retention in the stomach were observed before diagnosis through endoscopy and computed tomography(CT).The CT scan can be effective for early detection,and improvement in circulatory failure and aggressive treatment may save the lives of patients with this *** The characteristic CT findings enable early detection of ischemic *** diagnosis increases the chance of survival if early therapeutic intervention and improvement of circulatory dynamics can be achieved in this highly fatal disease.

关键词： Celiac artery Gastrointestinal bleeding Ischemic gastritis Superior mesenteric artery Vascular risk Case report

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Comprehensive review on small common bile duct stones

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World Journal of Gastroenterology 2023年第13期29卷 1955-1968页

作者： Sakue Masuda Kazuya Koizumi Kento Shionoya Ryuhei Jinushi Makomo Makazu Takashi nishino Karen Kimura Chihiro Sumida Jun Kubota Chikamasa Ichita Akiko Sasaki Masahiro Kobayashi Makoto Kako Uojima Haruki Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Gastroenterology Kitasato University School of MedicineKanagawa 252-0375Japan

Common bile duct stones are among the most common conditions encountered by ***,it is well researched;however,some items,such as indications for endoscopic papillary balloon dilatation(EPBD),safety of EPBD and endoscopic sphincterotomy in patients receiving dual antiplatelet therapy or direct oral anticoagulant,selection strategy for retrieval balloons and baskets,lack adequate ***,the guidelines have been updated with new research,while others remain unchanged due to weak *** this review,we comprehensively summarize the standard methods in guidelines and new findings from recent studies on papillary dilation,stone retrieval devices,difficult-to-treat cases,troubleshooting during the procedure,and complicated cases of cholangitis,cholecystolithiasis,or distal biliary stricture.

关键词： Choledocholithotomy Choledocholithiasis Common bile duct stones Endoscopic papillary balloon dilation Endoscopic sphincterotomy Small common bile duct stones

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Effectiveness of early colonoscopy in patients with colonic diverticular hemorrhage:A single-center retrospective cohort study

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World Journal of Gastrointestinal Endoscopy 2022年第12期14卷 759-768页

作者： Chikamasa Ichita Sayuri Shimizu Akiko Sasaki Chihiro Sumida Takashi nishino Karen Kimura Department of Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan

BACKGROUND Current guidelines recommend colonoscopy within 24 h for acute lower gastrointestinal bleeding;however,the evidence in support for colonic diverticular hemorrhage(CDH)indications remains *** To investigate the effectiveness of early colonoscopy on the length of hospital stay for CDH *** We conducted a single-center retrospective cohort *** who underwent colonoscopy within 24 h of presentation(early group)were compared with those who underwent colonoscopy beyond 24 h of presentation(elective group).The primary outcome was the length of hospital stay,and secondary outcomes were the identification of stigmata of recent hemorrhage(SRH),rebleeding,red blood cell transfusion more than 4 units,and interventional radiology and abdominal surgery after *** We identified 574 CDH *** were divided into the early(n=328)and elective(n=226)*** propensity score matching,191 pairs were *** length of hospital stay did not significantly differ between the two groups(early group vs elective group;median,7 vs 8 d;P=0.10).The early group had a significantly high identification of SRH(risk difference,11.6%;95%CI:2.7 to 20.3;P=0.02).No significant differences were found in the rebleeding(risk difference,4.7%;95%CI:-4.1 to 13.5;P=0.35),red blood cell transfusion more than 4 units(risk difference,1.6%;95%CI:-7.5 to 10.6;P=0.82),and interventional radiology and abdominal surgery rate after colonoscopy(risk difference,0.5%;95%CI:-2.2 to 3.2;P=1.00).CONCLUSION Early colonoscopy within 24 h,on arrival for CDH,could not improve the length of hospital stay.

关键词： Colonic diverticular hemorrhage Colonic diverticular bleeding Diverticular hemorrhage Diverticular bleeding Early colonoscopy Colonoscopy

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Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?

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World Journal of Gastroenterology 2021年第23期27卷 3317-3326页

作者： Atsushi Nishida Kyohei nishino Keitaro Sakai Yuji Owaki Yoshika Noda Hirotsugu Imaeda Department of Gastroenterology and Hepatology Nagahama City HospitalNagahama 5268580ShigaJapan

Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities,Crohn’s disease and ulcerative *** evidence indicates that an aberrant immune activation caused by the interplay of genetic susceptibility and environmental impact on the gut microbiota may be involved in the pathogenesis of *** advances in next-generation sequencing technology have enabled a number of studies to identify the alteration of the gut microbiota,termed dysbiosis,in ***,the alteration in the metabolites derived from the gut microbiota in IBD has also been described in many ***,microbiota-based interventions such as fecal microbiota transplantation(FMT)have attracted attention as a novel therapeutic option in ***,in clinical trials,the efficacy of FMT for IBD remains *** basic and clinical studies are required to validate whether FMT can assume a complementary role in the treatment of *** present review provides a synopsis on dysbiosis in IBD and on the association between the gut microbiota and the pathogenesis of *** addition,we summarize the use of probiotics in IBD and the results of current clinical trials of FMT for IBD.

关键词： Inflammatory bowel disease Dysbiosis Fecal microbiota transplantation Short chain fatty acid Probiotics

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Mass screening-based case-control study of diet and prostate cancer in Changchun, China

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Asian Journal of Andrology 2008年第4期10卷 551-560页

作者： Xiao-Meng Li Jiang Li Ichiro Tsuji Naoki Nakaya Yoshikazu nishino Xue-Jian Zhao School of Life Sciences Northeast Normal University Changchun 130024 China School of Basic Medical Sciences Changchun 130041 China Dental Hospital Jilin University Changchun 130041 China Department of Public Health Tohoku University Sendai 980-8576 Japan

Aim： To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods： We carded out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value （〈 4.1 ng/mL） by 1：10 according to age and place of employment. A case-control study of diet and prostate cancer was then carded out. Results： After adjustment for education, body mass index （BMI）, smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio （OR） of 0.38 （95% confidence interval [CI], 0.13-1.12）. In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 （95% CI, 0.11-0.79） compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion： Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.

关键词： soybean prostate cancer case-control study diet

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