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Admission Motor Strength Grade Predicts Mortality in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy

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Neuroscience & Medicine 2013年第1期4卷 1-6页

作者： Vishnumurthy Shushrutha Hedna Aakash N. Bodhit Saeed Ansari Adam d Falchook Latha G. Stead Sharathchandra Bidari Brian L Hoh kenneth M Heilman Michael F Waters department of Emergency Medicine University of Florida Gainesville USA department of Neurology University of Florida Gainesville USA department of Neuroradiology University of Florida Gainesville USA department of Neurosciences University of Florida Gainesville USA. department of Neurosurgery University of Florida Gainesville USA

Background: The mortality due to mechanical thrombectomy (MT) in the acute treatment of intracranial arterial occlu- sions can be up to 45%. The SWIFT (Solitaire FR with the Intention for Thrombectomy) and Multi MERCI (mechani- cal embolus removal in cerebral ischemia) trials have evaluated the safety and efficacy of MT. It may be important to determine pre-procedural factors that help predict post-intervention prognosis. We sought to determine if admission medical research council (MRC) motor strength grade along with other factors can be used as predictor of mortality after MT for acute ischemic stroke. Methods: Retrospective analysis of stroke database assessing outcomes in all 62 patients who underwent MT as an intervention for acute ischemic stroke, with or without concurrent intravenous thrombolysis was done. Five baseline variables were included in univariate and multivariate analyses to define the in- dependent predictors of mortality during current hospitalization. The medical research council (MRC) motor grade (0 - 5);modified collateral flow (CS) grading (0 - 3);age;acute and chronic co-morbidities were used as the baseline vari- ables. If motor strength grade were different in upper and lower extremities, then the lower grade was used. Age was analyzed independently as well as dichotomized using 80 as cut-off value. Relevant stroke related acute and chronic co-morbidities were given 1 point each and mean calculated. Results: In the univariate analysis, low (0 - 1) motor strength grade (OR, 0.11;95% CI, 0.021 - 0.33;p = 0.001) and age (OR, 1.06;95% CI, 1.02 - 1.12;p = 0.011) was sig- nificantly associated with mortality. The presence of collateral flow, acute and chronic co-morbidities were not signifi- cantly associated with mortality. In the multivariate analysis, motor grade retained its statistical significance for morta- lity (OR, 0.09;95% CI, 0.01 - 0.32;p = 0.003) along with chronic co-morbidity (OR, 1.52;95% CI 1.05 - 2.43;

关键词： Motor Grade Collaterals Ischemic Stroke Endovascular Intervention Outcome after Stroke Mortality after Stroke Acute Stroke Endovascular Treatment Mechanical Thrombectomy

Primary 4-3-oxosteroid 5β-reductase deficiency:Two cases in China

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World Journal of Gastroenterology 2012年第47期18卷 7113-7117页

作者： Jing Zhao Ling-Juan Fang kenneth dR Setchell Rui Chen Li-Ting Li Jian-She Wang Center for Pediatric Liver diseases Children's Hospital of Fudan University department of Pathology and Laboratory Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States department of Pediatrics Jinshan Hospital of Fudan University

Aldo-keto reductase 1d1(AKR1d1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in ***,we describe the first two primary 4-3-oxosteroid 5β-reductase deficiency patients in China's Mainland diagnosed by fast atom bombardment-mass spectroscopy of urinary bile acids and confirmed by genetic analysis.A high proportion of atypical 3-oxo-4-bile acids in the urine indicated a deficiency in 4-3-oxosteroid 5β-*** of the coding exons and adjacent intronic sequence of the AKR1d1 gene were sequenced using peripheral lymphocyte genomic dNA of two patients and one of the patient's *** patient exhibited compound heterozygous mutations:c.396C>A and c.722A>T,while the other was heterozygous for the mutation c.797G>*** on these mutations,a diagnosis of primary 4-3-oxosteroid 5β-reductase deficiency could be *** ursodeoxycholic acid treatment and fat-soluble vitamin supplements,liver function tests normalized rapidly,and the degree of hepatomegaly was markedly reduced in both patients.

关键词： Primary 4-3-oxosteroid 5β-reductase gene Cholestasis Bile acid therapy Aldo-keto reductase 1d1 Bile acid synthetic defects

Spatial Accuracy of a Low Cost High Resolution 3d Surface Imaging device for Medical Applications

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2013年第2期2卷 45-51页

作者： Berthold Shin Rajkumar Venkatramani Priya Borker Arthur Olch John Grimm kenneth Wong Case Western Reserve University School of Medicine Cleveland USA department of Radiology Children’s Hospital Los Angeles Los Angeles USA division of Hematology/Oncology Children’s Hospital Los Angeles Los Angeles USA Radiation Oncology Program Center for Cancer and Blood Diseases Children’s Hospital Los Angeles Los Angeles USA Touro College of Osteopathic Medicine New York USA

The Kinect is a low-cost motion-sensing device designed for Microsoft’s Xbox 360. Software has been created that enables user to access data from the Kinect, enhancing its versatility. This study characterizes the spatial accuracy and precision of the Kinect for creating 3d images for use in medical applications. Measurements of distances between surface features on both flat and curved objects were made using 3d images created by the Kinect. These measurements were compared to control measurements made by a ruler, calipers or by a CT scan and using the ruler tools provided. Measurements on flat surfaces matched closely to control measurements, with average differences between the Kinect and control measurements of less than 2 mm and percent errors of less than 1%. Measurements on curved surfaces also matched control measurements but errors up to 3mm occurred when measuring protruding surface features or features along lateral boundaries of objects. The Kinect is an alternative to other 3d imaging devices such as CT scanners, laser scanners and photogrammetric devices. Alternative 3d meshing algorithms and combining images from multiple Kinects could resolve errors made when using the Kinect to measure features on curved surfaces. Medical applications include craniofacial anthropometry, radiotherapy patient positioning and surgical planning.

关键词： Kinect Anthropometric Craniofacial Measurement Surface Imaging

Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration

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Bioactive Materials 2021年第8期6卷 2315-2330页

作者： Zhengjie Lin danni Shen Weixiao Zhou Yufeng Zheng Tiantian Kong Xuanyong Liu Shuilin Wu Paul K.Chu Ying Zhao Jun Wu kenneth M.C.Cheung Kelvin W.K.Yeung College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen518060China department of Orthopaedics and Traumatology The University of Hong KongHong KongChina department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital1 Haiyuan 1st RoadFutian DistrictShenzhenChina Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical EngineeringSchool of MedicineShenzhen UniversityShenzhen518060China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin300072China department of Physics Department of Materials Science and EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Centre for Human Tissues and Organs degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

The design of orthopedic biomaterials has gradually shifted from“immune-friendly”to“immunomodulatory,”in which the biomaterials are able to modulate the inflammatory response via macrophage polarization in a local immune microenvironment that favors osteogenesis and implant-to-bone *** the well-known effects of bioactive metallic ions on osteogenesis,how extracellular metallic ions manipulate immune cells in bone tissue microenvironments toward osteogenesis and subsequent bone formation has rarely been ***,we investigate the osteoimmunomodulatory effect of an extracellular bioactive cation(Mg^(2+))in the bone tissue microenvironment using custom-made poly lactic-co-glycolic acid(PLGA)/MgO-alendronate microspheres that endow controllable release of magnesium *** results suggest that the Mg^(2+)-controlled tissue microenvironment can effectively induce macrophage polarization from the M0 to M2 phenotype via the enhancement of anti-inflammatory(IL-10)and pro-osteogenic(BMP-2 and TGF-β1)cytokines *** also generates a favorable osteoimmune microenvironment that facilitates the proliferation and osteogenic differentiation of bone marrow mesenchymal stem *** in vivo results further verify that a large amount of bony tissue,with comparable bone mineral density and mechanical properties,has been generated at an early post-surgical stage in rat intramedullary bone defect *** study demonstrates that the concept of in situ immunomodulated osteogenesis can be realized in a controlled magnesium tissue microenvironment.

关键词： Bone regeneration Osteoimmunomodulatory property Osteoimmune environment Macrophage polarization Magnesium ions

Stepwise 3d-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu kenneth M.C.Cheung Kelvin W.K.Yeung department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite Magnesium ion Microenvironment 3d scaffold Bone tissue regeneration

Identification and molecular characterization of two novel mutations in COL1A2 in two Chinese families with osteogenesis imperfecta

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Journal of Genetics and Genomics 2011年第4期38卷 149-156页

作者： Zhenping Xu Yulei Li Xiangyang Zhang Fanming Zeng Mingxiong Yuan Mugen Liu Qing kenneth Wang Jing Yu Liu Key Laboratory of Molecular Biophysics of the Ministry of Education Center for Human Genome ResearchCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Key Open Laboratory for Tissue Regeneration of Henan Universities Department of Life Science and TechniqueXinxiang Medical UniversityXinxiang 453003China department of Molecular Cardiology Cleveland ClinicClevelandOH 44195USA

Osteogenesis imperfecta（OI,also known as brittle bone disease）is caused mostly by mutations in two type I collagen genes,COL1A1 and COLIA2 encoding the pro-α1（I）and pro-α2（I）chains of type I collagen,*** Chinese families with autosomal dominant OI were identified and *** analysis revealed linkage of both families to COL1A2 on chromosome *** analysis was carried out using direct dNA sequence *** novel missense mutations,c.3350AG and c.3305GC,were identified in exon 49 of COL1A2 in the two families,*** c.3305GC mutation resulted in substitution of a glycine residue（G）by an alanine residue（A）at codon 1102（p.G1102A）,which was found to be mutated into serine（S）,argine（R）,aspartic acid（d）,or valine（V）in other *** c.3350AG variant may be a de novo mutation resulting in *** mutations co-segregated with OI in respective families,and were not found in 100 normal *** G1102 and Y1117 residues were evolutionarily highly conserved from zebrafish to *** analysis did not identify any mutation in the COX-2 gene（a modifier gene of OI）.This study identifies two novel mutations p.G1102A and p.Y1117C that cause OI,significantly expands the spectrum of COL1A2 mutations causing OI,and has a significant implication in prenatal diagnosis of OI.

关键词： Osteogenesis imperfecta Mutation COL1A2 COX-2

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CT骨矿密度测定的方法研究

上海医学影像 2002年第1期11卷 13-15页

作者：王鸣鹏 kenneth d.Hopper Allen Kunselman 张国桢上海华东医院放射科 department of Radiology University HospitalPenn state UniversityPA 17033USA

目的作者对临床上常用的CT检查部位,腹部和盆腔作了临床应用性实验,以期能获得测量骨矿密度的简便方法。方法 26例患者(男13例,女13例),分别作了CT平扫和增强腹部检查,随后作无专用体模的QCT定量骨密度测定,QCT测量部位为L1-L3椎体。结... 详细信息

目的作者对临床上常用的CT检查部位,腹部和盆腔作了临床应用性实验,以期能获得测量骨矿密度的简便方法。方法 26例患者(男13例,女13例),分别作了CT平扫和增强腹部检查,随后作无专用体模的QCT定量骨密度测定,QCT测量部位为L1-L3椎体。结果平扫CT和QCT的平均骨矿密度分别是96.54和87.70(平均差为8.85,p=0.0005;95％自信区间4.32～13.38)。平扫和增强CT扫描之间QCT测量平均差无统计学意义(P=0.17)。结论根据本文作出的换算公式,可在常规CT平扫和增强扫描的方法中作QCT骨矿密度测量,无需作专门的QCT扫描测量。换算公式为d_(平均值)=C-8.45×0.995,式中“d”和“C”分别表示QCT骨矿密度测量和常规CT扫描检查。

关键词：骨质疏松症骨密度 X线计算机体层摄影定量CT 骨矿含量测定方法

Authentication of Video Evidence for Forensic Investigation: A Case of Nigeria

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Journal of Information Security 2021年第2期12卷 163-176页

作者： Beatrice O. Akumba Aamo Iorliam Selumun Agber Emmanuel Odeh Okube kenneth dekera Kwaghtyo department of Mathematics & Computer Science BSU Makurdi Nigeria

Video shreds of evidence are usually admissible in the court of law all over the world. However, individuals manipulate these videos to either defame or incriminate innocent people. Others indulge in video tampering to falsely escape the wrath of the law against misconducts. One way impostors can forge these videos is through inter-frame video forgery. Thus, the integrity of such videos is under threat. This is because these digital forgeries seriously debase the credibility of video contents as being definite records of events. This leads to an increasing concern about the trustworthiness of video contents. Hence, it continues to affect the social and legal system, forensic investigations, intelligence services, and security and surveillance systems as the case may be. The problem of inter-frame video forgery is increasingly spontaneous as more video-editing software continues to emerge. These video editing tools can easily manipulate videos without leaving obvious traces and these tampered videos become viral. Alarmingly, even the beginner users of these editing tools can alter the contents of digital videos in a manner that renders them practically indistinguishable from the original content by mere observations. dana;">This paper, however, leveraged on the concept of correlation coefficients to produce a more elaborate and reliable inter-frame video detection to aid forensic investigations, especially in Nigeria. The model employed the use of the idea of a threshold to efficiently distinguish forged videos from authentic videos. A benchmark and locally manipulated video datasets were used to evaluate the proposed model. Experimentally, our approach performed better than the existing methods. The overall accuracy for all the evaluation metrics such as accuracy, recall, precision and F1-score was 100%. The proposed method implemented in the MATLAB programming language has proven to effectively d

关键词： Inter-Frame Video Forgery Correlation Coefficients Forensic Investigation Threshold

金属有机框架材料在电化学/电化学发光免疫分析中的应用

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电化学 2023年第6期29卷 4-18页

作者：覃晓丽詹子颖 Sara Jahanghiri kenneth Chu 张丛洋丁志峰湖南农业大学化学与材料科学学院湖南长沙410128 department of Chemistry Western UniversityLondonONN6A 5B7Canada

设计和研制具有超灵敏、高精度、选择性好的免疫传感器对于疾病的早期诊断和筛查以及疾病治疗过程的监测具有十分重要的意义。其中,电化学免疫分析法和电化学发光(ECL)免疫分析法,由于具有稳定性好、灵敏度高、线性范围宽、可控性好等... 详细信息

设计和研制具有超灵敏、高精度、选择性好的免疫传感器对于疾病的早期诊断和筛查以及疾病治疗过程的监测具有十分重要的意义。其中,电化学免疫分析法和电化学发光(ECL)免疫分析法,由于具有稳定性好、灵敏度高、线性范围宽、可控性好等优点而备受关注,已成为当前的研究热点之一。金属有机框架(MOFs)作为一类新型的多孔晶体材料,由于其具有比表面积大、化学稳定性好、孔径和纳米级骨架结构可调节等优点,在电化学和ECL免疫传感器的制备中得到了广泛的应用。MOFs不仅可以作为固定生物识别分子的敏感平台,还可以用于富集痕量分析物和信号分子来放大分析信号,提高电化学或ECL免疫分析的灵敏度。目前,科研人员已合成各种各样具有不同性能和形貌的MOFs纳米材料,并用于开发高性能的电化学免疫传感器和ECL免疫传感器。本文综述了不同类型的基于MOFs纳米材料的电化学/ECL免疫传感器的制备及其在免疫分析中的检测应用。研究表明,MOFs不仅可以作为电极表面修饰的基底、信号探针(包括电活性标记分子和电化学发光发光标记探针)、催化活性标记物,还可以作为负载各种生物分子、纳米材料的载体,最终可用于灵敏的电化学和ECL检测。此外,本综述还讨论了未来发展功能化MOFs纳米材料的挑战和机遇,并为未来设计和制造基于MOFs的高性能免疫传感器提出了一些指导性意见。

关键词：金属有机框架电化学免疫传感器电化学发光法免疫传感器免疫分析