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Luminescent cyclometalated iridium(Ⅲ) dipyridoquinoxaline indole complexes as biological probes

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Science China Chemistry 2010年第10期53卷 2091-2098页

作者： LO kenneth Kam-Wing LEUNG Arthur Ho-Hon Department of biology and Chemistry City University of Hong Kong

Four luminescent cyclometalated iridium(Ⅲ) dipyridoquinoxaline complexes appended with an indole moiety [Ir(N^C)2(N^N)] (PF6) (HN^C = 2-phenylpyridine, Hppy; N^N = 2-(N-(2-(indole-3-acetamido)ethyl)aminocarbonyl)dipyrido[3,2-f:2′,3′-h]quinox- aline, dpqC2indole (1a), N^N = 2-(N-(6-(indole-3-acetamido)hexyl)aminocarbonyl)dipyrido[3,2-f:2′,3′-h]quinoxaline, dpqC6indole (1b); HN^C = 7,8-benzoquinoline, Hbzq, N^N = dpqC2indole (2a), N^N = dpqC6indole (2b)) have been synthesized and characterized. Upon irradiation, all the complexes displayed moderately intense and long-lived luminescence under ambient condi-tions and in 77 K glass. On the basis of the photophysical data, the emission of the complexes has been assigned to an excited state of triplet metal-to-ligand charge-transfer (3MLCT) ((dπ(Ir)→π*(N^N)) character. Cyclic voltammetric studies revealed indole-based and iridium-based oxidations at ca. +1.10 V and +1.24 V vs. SCE, respectively, and ligand-based reductions at ca. -1.07 to-2.29 V vs. SCE. The interactions of the complexes with an indole-binding protein, bovine serum albumin (bSA), have been examined by emission titrations.

关键词： binding indole iridium luminescence probes

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慢性阻塞性肺疾病中黏液高分泌的潜在疗法

中华医学杂志 2006年第41期86卷 2890-2892页

作者： Jin-Ah Park kenneth b Adler 美国北卡罗来那州大学兽医学院分子生物医学系

虽然黏液在黏膜屏障中起清除和辅助作用,但黏液高分泌是慢性支气管炎的一个主要的病理生理学特点,持续的黏液高分泌导致气道阻塞,影响了慢性阻塞性肺疾病(COPD)患者气道对吸入细菌和颗粒的清除。尽管对黏液高分泌的机制还不甚清楚,但其... 详细信息

虽然黏液在黏膜屏障中起清除和辅助作用,但黏液高分泌是慢性支气管炎的一个主要的病理生理学特点,持续的黏液高分泌导致气道阻塞,影响了慢性阻塞性肺疾病(COPD)患者气道对吸入细菌和颗粒的清除。尽管对黏液高分泌的机制还不甚清楚,但其仍是一个主要的治疗目标。研究表明,人中性粒细胞弹性蛋白酶是与慢性支气管炎患者气道黏液高分泌有关的刺激物,在体外能刺激人气道上皮细胞分泌黏蛋白(黏液的糖蛋白组成部分)。人中性粒细胞弹性蛋白酶诱导的黏液高分泌相关的信号分子包括蛋白激酶C,[第一段]

关键词：慢性阻塞性肺疾病黏液高分泌粒细胞弹性蛋白酶人中性粒细胞气道阻塞疗法潜在慢性支气管炎

Levels of Agricultural Pesticides in Sediments and Irrigation Water from Tono and Vea in the Upper East of Ghana

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Journal of Environmental Protection 2011年第6期2卷 761-768页

作者： kenneth b. Pelig-ba 不详

Water and sediment samples were taken from selected irrigation dams located at Tono and Vea in the Upper East Region of Ghana and analyzed for organic pesticides using gas chromatography. Sixteen organic residues were identified of which thirteen had at least some trace concentrations ranging from 0.001 to 25.4 μg/L. It was found in the laboratory that the concentrations of DDT, bHC and heptachlor were above the upper limited recommended by WHO and the concentrations of DDT in both reservoirs were higher than 20 times the recommended limits. High concentrations of DDT were found in the water samples while the other two residues were identified in the sediments. The high DDT concentration in water was due to 1) the initial amount of DDT applied and the period in the reservoirs, 2) a half-life of 350 days suggested that much of the DDT originally used was not destroyed if applied less than this period, 3) its low solubility in water did not allow for dissolution and subsequent dispersal in water;4) the indiscriminate uses of DDT for fishing as confirmed by the local people The high DDT level suggested that the water is not safe for many aquatic organisms and even humans. Generally the levels of these organic residues suggested that the dams have been polluted due to human activities such as farming and the unorthodox method of fishing. Therefore, steps should be taken to reduce the levels of DDT concentrations to preserve the aquatic life in the dams.

关键词： Pesticides Sediments Irrigation Dams Tono Vea

Diurnal variation in fecal concentrations of acid-detergent insoluble ash and alkaline-peroxide lignin from cattle fed bermudagrass hays of varying nutrient content

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Journal of Animal Science and biotechnology 2015年第4期6卷 410-415页

作者： Juvenal Kanani Dirk Philipp kenneth P Coffey Elizabeth b Kegley Charles P West Shane Gadberry John Jennings Ashley N Young Robert T Rhein Division of Agriculture University of Arkansas Department of Plant and Soil Science Texas Tech University

background： The effect of time of fecal sampling on the accuracy of acid-detergent insoluble ash （ADIA） and alkaline-peroxide lignin （APL） for the prediction of fecal output （FO） in cattle was evaluated. Eight ruminally cannulated cows （594 _＋ 35.5 kg） were allocated randomly to 4 bermudagrass [Cynodon dactylon （L.） Pers.] hay diets markedly different in crude protein concentration （79-164 g/kg） with 2 replicates per diet for 3 periods. Cows were offered hay individually at 20 g DM/kg of body weight daily in equal feedings at 08：00 and 16：00 h for a 10-d adaptation period followed by 5-d of total fecal collection. Fecal grab samples also were taken each day during the fecal collection period at 06：00, 12：00, 18：00, and 24：00 h either directly from the rectum or from freshly voided feces. Samples were composited within cow and time across the 5 d total fecal collection period. Additionally, forage, ort, and fecal samples were analyzed for concentrations of APL and ADIA. Results： Fecal concentrations of ADIA and APL were not affected by sampling time （P 〉 0.22）, even though diet affected （P 〈 0.01） fecal ADIA and APL concentrations. There were no diet x sampling time interactions （P ≥ 0.60）. Estimates of FO and dry matter digestibility （DMD） from ADIA and APL were not affected （P 〉 0.16） by sampling time or the diet x sampling time interaction （P 〉 0.74）. Estimates of FO and DMD from markers from different sampling times or all different combinations of sampling time were not different （P 〉 0.72） from those of total collection among internal markers. Conclusion： Little variation in concentrations of ADIA and APL in daily fecal excretion across time increases flexibility in fecal grab sampling schedules for predicting FO and DMD.

关键词： Digestibility Fecal sampling time Internal markers bermudagrass Cattle

Light field on a chip: metasurface-based multicolor holograms

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Advanced Photonics 2021年第2期3卷 1-14页

作者： Dandan Wen Jasper J.Cadusch Jiajun Meng kenneth b.Crozier University of Melbourne Department of Electrical and Electronic EngineeringVictoriaAustralia University of Melbourne School of PhysicsVictoriaAustralia University of Melbourne Australian Research CouncilCentre of Excellence for Transformative Meta-Optical SystemsVictoriaAustralia

Multicolor holography can faithfully record the color,depth,parallax,and other properties of scenes and have thus found numerous applications,for example,in optical document security,nonvolatile data storage,and virtual or augmented reality *** metasurfaces present multiple degrees of freedom to manipulate the properties of optical fields at visible *** in turn provide opportunities for metasurface-based multicolor *** describe recent developments in multicolor metasurface *** are categorized based on their color-separating mechanisms rather than their structural properties,such as whether they are plasmonic or *** hope this review will provide readers with new insights and thus help extend applications of metasurface-based multicolor holography to other fields.

关键词： multicolor hologram metasurface

Expression of Shiga Toxin b Subunit at Cell Surface in E. coli K-12

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Science China Chemistry 1993年第11期36卷 1352-1360页

作者：苏国富 Himanshu N.brahmbhatt kenneth N.Timmis Institute of biotechnology Academy of Military Medical Sciences CPLA Beijing 100850 PRC National Research Centre for biotechnology Germany

The three parts(Stx17b, Stx27b and Stxb) of Shiga toxin b subunit have been fused into a cell surface exposed loop of the Lamb protein at a bamH I site between residues 153 and 154. Western blotting revealed that the three parts of Shiga toxin b subunit could be expressed as the Lamb fusion proteins in E. coli. Indirect immunofluorescence and immunoelectron microscopy analyses showed fusion proteins Lamb/Stx17b and Lamb/Stx27b could be expressed at cell surface in E. coli, but fusion protein Lamb/Stxb could not be expressed at cell surface; it was aggregated in cytoplasm and was toxic to host. This expression system provided a new way to construct an oral live vaccine against Shigella dysenteriae 1.

关键词： Shiga toxin b subunit Lamb gene E. coli K-12 cell surface expression.

Comparison of acid-detergent lignin,alkaline-peroxide lignin,and acid-detergent insoluble ash as internal markers for predicting fecal output and digestibility by cattle offered bermudagrass hays of varying nutrient composition

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Journal of Animal Science and biotechnology 2014年第3期5卷 310-317页

background： The potential for acid-detergent insoluble ash （ADIA）, alkaline-peroxide lignin （APL）, and acid-detergent lignin （ADL） to predict fecal output （FO） and dry matter digestibility （DMD） by cattle offered bermudagrass [Cynodon doctylon （L） Pers.] hays of different qualities was evaluated. Eight ruminally cannulated cows （594 ± 35.5 kg） were allocated randomly to 4 hay diets： low （L）, medium low （ML）, medium high （MH）, and high （H） crude protein （CP） concentration （79, 111,131, and 164 g CP/kg on a DM basis, respectively）. Diets were offered in 3 periods with 2 diet replicates per period and were rotated across cows between periods. Cows were individually fed 20 g DM/kg of body weight in equal feedings at 08：00 and 16：00 h for a 10-d adaptation followed by a 5-d total fecal collection. Actual DM intake （DMI）, DMD, and FO were determined based on hay offered, ort, and feces excreted. These components were then analyzed for ADL, APL, and ADIA concentration to determine marker recovery and marker-based estimates of FO and DMD. Results： Forage DMI was affected by diet （P = 0.02）, and DMI from MH and H was greater （P 〈 0.05） than from L. Apparent DMD tended （P = 0.08） to differ among diets while FO （P = 0.20） was not affected by diet treatments. Average ADL recovery （1.16） was greater （P 〈 0.05） than that of ADIA （1.03） and APL （1.06）, but ADIA and APL did not differ （P = 0.42）. Estimates of FO and DMD derived using APL and ADIA were not different （P≥0.05） from total fecal collection while those using ADL differed （P 〈 0.05）. There was no diet by marker interaction （P≥ 0.22） for either FO or DMD. Conclusion： Acid-detergent insoluble ash and APL accurately predicted FO and DMD of cattle fed bermudagrass hay of varying nutrient composition. These internal markers may facilitate studies involving large numbers of animals and forages. Results from such studies may be used to develop improved equations to predict energy values of forages based on the relationship of di

关键词： Acid-detergent insoluble ash Alkaline-peroxide lignin bermudagrass Cattle Digestibility Marker

Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR

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Neural Regeneration Research 2016年第3期11卷 372-385页

作者： kenneth Maiese Cellular and Molecular Signaling Newark NJ USA

Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this *** impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic *** mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase b（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth *** a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this *** studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.

关键词： Akt AMP activated protein kinase(AMPK) apoptosis Alzheimer’s disease autophagy β-cell cancer cardiovascular disease caspase CCN family diabetes mellitus epidermal growth factor erythropoietin fibroblast growth factor forkhead transcription factors Fox O FRAP1 hamartin(tuberous sclerosis 1)/tuberin(tuberous sclerosis 2)(TSC1/TSC2) insulin mechanistic target of rapamycin(mTOR) m TOR Complex 1(m T ORC1) m TOR Complex 2(m TORC2) nicotinamide nicotinamide adenine dinucleotide(NAD+) non-communicable diseases oxidative stress phosphoinositide 3-kinase(PI 3-K) programmed cell death silent mating type information regulation 2 homolog 1(Saccharomyces cerevisiae)(SIRT1) sirtuin stem cells wingless Wnt Wnt1 inducible signaling pathway protein 1(WISP1)

STRONG COMPACTNESS OF APPROXIMATE SOLUTIONS TO DEGENERATE ELLIPTIC-HYPERbOLIC EQUATIONS WITH DISCONTINUOUS FLUX FUNCTION

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Acta Mathematica Scientia 2009年第6期29卷 1573-1612页

作者： Helge Holden kenneth H. Karlsen Darko Mitrovic Evgueni Yu. Panov Department of Mathematical Sciences Norwegian University of Science and TechnologyNO–7491 Trondheim Norway Centre of Mathematics for Applications University of Oslo P.O. Box 1053 BlindernNO–0316 Oslo Norway Centre of Mathematics for Applications University of OsloP.O. Box 1053 Blindern N–0316 Oslo Norway Faculty of Mathematics University of Montenegro 81000 Podgorica Montenegro Mathematical Analysis Department Novgorod State Universityul. B. St. Peterburgskaya 41 173003 Veliky Novgorod Russia

Under a non-degeneracy condition on the nonlinearities we show that sequences of approximate entropy solutions of mixed elliptic-hyperbolic equations are strongly precompact in the general case of a Caratheodory flux vector. The proofs are based on deriving localization principles for H-measures associated to sequences of measurevalued functions. This main result implies existence of solutions to degenerate parabolic convection-diffusion equations with discontinuous flux. Moreover, it provides a framework in which one can prove convergence of various types of approximate solutions, such as those generated by the vanishing viscosity method and numerical schemes.

关键词： degenerate hyperbolic-elliptic equation degenerate convection-diffusion equation conservation law discontinuous flux approximate solutions compactness