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Bone morphogenetic protein 2 improves patellar tendon healing by promoting migration and proliferation of tenocytes

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Chinese Science Bulletin 2011年第13期56卷 1361-1369页

作者： TANG MeiKuen LEE kenneth K Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University Joint Laboratory for Regenerative Medicine the Chinese University of Hong Kong-Jinan University School of Biomedical Sciences the Chinese University of Hong Kong International Base of Collaboration for Science and Technology (JNU) the Ministry of Science and Technology & Guangdong Province School of Biomedical Sciences the Chinese University of Hong Kong

The repair of injured tendons remains a great challenge because of the poor intrinsic healing capacity of tendons. In this study, we examined the spatiotemporal expression pattern of the bone morphogenetic protein 2 (bmp-2) gene in normal and experimentally injured rat patellar tendons. We also investigated the ability of exogenously applied BMP-2 to promote patellar tendon healing. In situ hybridization with bmp-2 and alk-6 (bmp-2 receptor) antisense riboprobes revealed that both genes were normally expressed at low levels in intact rat tendons. However, bmp-2 expression was significantly upregulated in tenocytes found in the wound site at 7 d and later following tendon injury. In addition, it was found that bmp-2 was expressed in cultured patellar tenocytes. Appli- cation of exogenous BMP-2 to the tendon wound site significantly enhanced tendon repair. Moreover, in vitro and in vivo studies further demonstrated that BMP-2 enhanced tenocyte proliferation and migration to the wound site. The detectable amount of BMP-2 in normal tendons suggests that a basal level of bmp-2 expression was likely present to maintain the normal functions of the patellar tendon. Injury to the tendon induced increased bmp-2 expression intrinsically, but the expression level was insufficient for proper tendon repair. Our findings indicate that it is possible to significantly improve tendon healing by applying exogenous BMP-2 to the wound site, inferring that this protein could be developed as a potential therapeutic reagent for the treatment of damaged tendons.

关键词：骨形态发生蛋白肌腱细胞愈合能力迁移扩散 BMP 表达模式原位杂交

Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans

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World Journal of Gastroenterology 2009年第42期15卷 5274-5278页

作者： M Mazen Jamal Eugene J Yoon kenneth J Vega Mehrtash Hashemzadeh kenneth J Chang Division of Gastroenterology Veterans Affairs(VA) Medical CenterLong BeachCA 90822United States Division of Gastroenterology Department of Internal MedicineCollege of MedicineUniversity of CaliforniaIrvine Medical CenterOrangeCA 92868United States Division of Gastroenterology University of Florida/JacksonvilleJacksonvilleFL 32207United States

AIM:To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus(DM) .METHODS:Eligibility for this study included patients with type 2 DM(ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and ***-matched control patients without DM were selected from the same patient treatment files during the same *** information included age,sex and *** diagnoses included known risk factors based on their ICD-9 *** multivariate logistic regression,the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without ***:A total of 1172496 case and control subjects were *** mean age for study and control subjects was 65.8 ± 11.3 and 64.8 ± 12.6 years,*** frequency of pancreatic cancer in subjects with DM was increased(0.9%) in comparison to control subjects(0.3%) with an OR of 3.22(95% CI:3.03-3.42) .The incidence of gallbladder andextrahepatic biliary cancers was increased by twofold in diabetic patients when compared to *** OR and 95% CI were 2.20(1.56-3.00) and 2.10(1.61-2.53) ,***:Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer.

关键词： Diabetes mellitus Pancreatic neoplasms Adenocarcinoma Gallbladder neoplasms

China–Africa Education Cooperation: From FOCAC to Belt and Road

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ECNU Review of Education 2020年第2期3卷 221-234页

作者： kenneth King University of Edinburgh Easter Saltoun HallPencaitlandEast Lothian EH345DSScotlandUK

Purpose:The article discusses the relationship between the human resource traditions of the Forum on China–Africa Cooperation(FOCAC)and those supported by the Belt and Road Initiative(BRI),and in particular by the Education Action Plan for the Belt and Road Initiative,issued by the Chinese Ministry of Education(MOE)in ***/Approach/Methods:The article draws upon discourse analysis of both the FOCAC Ⅵ and Ⅶ documents and the key MOE 2016 Action ***:Given the trans-continental coverage of the BRI,it is suggested that its ambitious pledges in respect of education and human resource development(HRD)actually complement or even exceed the commitments made by FOCAC Ⅵ and Ⅶ.Originality/Value:This is the first article explicitly to compare the HRD pledges of FOCAC with those associated with BRI’s Education Action Plan.

关键词： Belt and Road Initiative(BRI) China-Africa Cooperation Forum on China-Africa Cooperation(FOCAC) human resource development(HRD) people-to-people exchanges South-South Cooperation(SSC)

Should patients with erectile dysfunction be evaluated for cardiovascular disease？

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Asian Journal of Andrology 2012年第1期14卷 138-144,179页

作者： kenneth A Ewane Hao-Cheng Lin Run Wang Division of Urology University of Texas Medical School at Houston Houston TX 77030 USA Department of Urology Affiliated Drum Tower Hospital Nanjing University School of Medicine Nanjing 210008 China Department of Urology University of Texas M D Anderson Cancer Center Houston TX 77030 USA

The landmark Massachusetts Male Ageing Study shed new light on the prevalence of erectile dysfunction （ED） and drew attention to ED as a disease of ageing. Over the years, ED has been linked to the development of cardiovascular disease （CVD） in some patients. There is clear evidence that ED and CVD share and have a similar risk factor profile. CVD is one of the most recognizable causes of mortality and early detection coupled with prevention of mortality from CVD has been the prime interest of many researchers. Consequently, there has been a multidisciplinary curiosity regarding the proposal to use ED as a marker for future CVD. I n fact, there have been several proposals to use ED as a screening tool for future CVD. We performed a comprehensive Search of two main databases--PubMed and Cochrane Library using a combination of keywords such as acute myocardial infarction, coronary artery disease （CAD） and ED. Journal articles from January 2000 to June 2011 were reviewed. We included all articles discussing the relationship between ED and CVD in the English language. All the relevant randomized controlled trials, cohort and retrospective studies, and review articles were included in our overall analysis in an attempt to answer the question whether all patients with ED should be clinically evaluated for CVD. The results showed a link between ED and the development of future CVD in some patients, but ED was not shown to be an independent risk predictor that is any better than the traditional Framingham risk factors. Screening for CVD may, however, be rewarding in younger patients with severe ED and in patients with concurrent CVD risk factors.

关键词： atherosclerotic disease cardiovascular disease coronary artery disease erectile dysfunction

A review of CPT based axial pile design in the Netherlands

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Underground Space 2021年第1期6卷 85-99页

作者： kenneth Gavin Meho Sasa Kovacevic David Igoe TU Delft Geo-Engineering SectionFaculty of Civil Engineering and GeosciencesDelft University of TechnologyBuilding 23Stevinweg 1PO-Box 50482628 CN Delft/2600 GA DelftNetherlands University of Zagreb Croatia Trinity College Dublin Ireland

Because of the deltaic nature of the Netherlands,deep soft soil deposits are *** to the population density exploitation of underground space is vital for commercial developments and transport *** are used as primary support elements in deep excavations,cut and cover tunnels,quay walls,flood defences and to provide uplift resistance to the base of tunnels and *** paper examines empirical correlations linking the Cone Penetration Test(CPT)end resistance qc and the resistance of deep foundations in *** is found that correlations between qc and pile end resistance are independent of pile ***,the impact of installation method,residual load,plugging and sand creep should be *** the case of shaft resistance,constant correlation factors between qc and average shaft resistance are possible for non-displacement *** the case of displacement piles,correlations that include the effects of friction fatigue and pile plugging during installation are recommended.

关键词： Piles Sand CPT based methods Design codes

OTX2 signaling in retinal dysfunction,degeneration and regeneration

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Neural Regeneration Research 2021年第10期16卷 2002-2003页

作者： kenneth.L.Moya Raoul Torero Ibad Centre for Interdisciplinary Research in Biology(CIRB) Collège de FranceCNRS UMR 7241INSERM U1050Labex MemoLifePSL Research UniversityParisFrance(Moya KLIbad RT)Univ.LilleCNRSUMR 8523-PhLAM-Physique des Lasers Atomes et MoléculesF-59000 LilleFrance(Ibad RT)

The protein OTX2 in the retina is necessary for the maintenance of normal physiologic processes,and may be a promising therapeutic agent for some ophthalmic *** this Perspective,we first shortly introduce the organization of the retina and the importance of OTX2 *** then present an example of reduced OTX2 activity in the developed retina associated with structural and functional *** next show that homeoproteins can have neuroprotective *** finally review several clear examples of OTX2 non-cell autonomous activity in the retina and the effects of diminishing or providing extracellular OTX2.

关键词： expression. functions. agent

Rethinking the Histories of War in Modern China

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Frontiers of History in China 2018年第1期13卷 2-27页

作者： kenneth Pomeranz Department of History University of Chicago Chicago IL 60637 USA

War creates intense experiences, and can be a powerful engine of social transformation. Yet it can also epitomize ＂sound and fury, signifying nothing＂： Either pure destruction that contributed to no large project, or a stage which merely displayed the inevitable outcome of a balance of forces already determined by social, economic, or political processes unfolding elsewhere.

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Large-scale distribution of elements in Chinese aerosol

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China Particuology 2007年第6期5卷 395-400页

作者： Jinghua Guo kenneth A. Rahn Guoshun Zhuang Shuifeng Wang Analysis and Testing Center Beijing Normal University Beijing 100875 China Center for Atmospheric Chemistry Studies Graduate School of Oceanography University of Rhode Island Narragansett R1 02882-1197 USA The Center for Atmospheric Chemistry Study Department of Environmental Science & Engineering Fudan University Shanghai 200433 China

In spite of increasing attention on Chinese aerosol, there has never been a country-wide survey of its general characteristics. This paper presents elemental data for aerosol at 23 sites in and around China, mostly drawn from the literature, and shows some of the large-scale patterns. Al, Na, and Se are used to represent the crustal, marine, and pollution components, respectively. Most of the patterns are aligned in SW-NE. Al and Na are highest to the NW and the SE, respectively, and their ratio changes rapidly near the coast. Se has a broad maximum over Central China, and the Se/Al ratio （an indicator of pollution vs. crustal aerosol） increases progressively from the NW to the SE. A simple index for simulating pollution aerosol, which uses population density, annual precipitation, and mean wind speed, adequately reproduces the large-scale pattern of pollution aerosol and shows how crustal Al in the NW gradually gives way to flyash Al toward the SE.

关键词： Chinese aerosol Elemental concentration Distribution Pollution index

Dendritic cells in cancer immunology

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Cellular & Molecular Immunology 2022年第1期19卷 3-13页

作者： Theresa L.Murphy kenneth M.Murphy Department of Pathology and Immunology Washington University in St.LouisSchool of MedicineSt.LouisMO 63110USA

The clinical success of immune checkpoint therapy(ICT)has produced explosive growth in tumor immunology research because ICT was discovered through basic studies of immune *** of the current translational efforts are aimed at enhancing ICT by identifying therapeutic targets that synergize with CTLA4 or PD1/PD-L1 blockade and are solidly developed on the basis of currently accepted *** these principles through continuous basic research may help broaden translational *** this mindset,we focused this review on three threads of basic research directly relating to mechanisms underlying ***,this review covers three aspects of dendritic cell(DC)biology connected with antitumor immune responses but are not specifically oriented toward therapeutic ***,we review recent advances in the development of the cDC1 subset of DCs,identifying important features distinguishing these cells from other types of ***,we review the antigen-processing pathway called cross-presentation,which was discovered in the mid-1970s and remains an *** pathway serves an essential in vivo function unique to cDC1s and may be both a physiologic bottleneck and therapeutic ***,we review the longstanding field of helper cells and the related area of DC licensing,in which CD4 T cells influence the strength or quality of CD8 T cell *** topic is connected with ICT in some manner but is also a fundamental aspect of cell-mediated immunity directed toward intracellular pathogens.

关键词： Dendritic cells transcription factors cross-presentation tumor rejection CD4 help