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Food Bioscience 2022年第3期47卷 1294-1300页

作者： Mari Enokida ken-ichiro minato Susumu Yoshino Nobuaki Ohto Hiroshige Kuwahara Masashi Mizuno Department of Agrobioscience Graduate School of Agricultural ScienceKobe UniversityKobe657-8501Japan Department of Applied Biological Chemistry Graduate School of AgricultureMeijo UniversityNagoya468-8502Japan Research Center Maruzen Pharmaceuticals Co.Ltd.Fukuyama729-3102Japan

In recent years,researches on food components with anti-allergic effects have been gathering attention,because of the expectation for the establishment of a safe and effective treatment for food *** studies have reported that Lactiplantibacillus plantarum 22A-3 (LP22A3) inhibited degranulation of mast cells and reduced IgE *** have developed a gastrointestinal allergy system in which mice are sensitized by intraperitoneal and oral administration of OVA and then challenged by oral administration of high doses of *** a result,an increase in the amount of IgE in the blood and a decrease in the temperature of the colon were confirmed,and it was clarified that food allergy was induced by oral administration of high dose of OVA as the *** administration of LP22A3 ameliorated allergic responses significantly by reducing the amount of IgE in the blood and to recovered the decrease of rectal ***,LP22A3 did not affect the intestinal barrier *** LP22A3 significantly suppressed mRNA expression of OX40L and *** results suggested that LP22A3 suppressed Th2 differentiation and IL-4 production via downregulation of OX40L,and consequently suppressed IgE ***22A3 might provide a safe and effective treatment for allergic diseases due to ability modulating intestinal immune system.

关键词： Anti-allergic activity Food allergy Lactiplantibacillus plantarum 22A-3 Ovalbumin OX40L

New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima ken Sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Exploring the novel role of oligodendrocyte precursor cells in phagocytosis:beyond myelinogenesis

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Neural Regeneration Research 2025年第2期20卷 473-474页

作者： Gen Hamanaka ken Arai Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA

Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-producing *** precursors,OPCs mature and differentiate into oligodendrocytes,which contribute significantly to the formation of myelin sheaths around *** myelination,which is critical for the conduction of salutatory nerve impulses in the cerebral white matter,underscores the classical role of oligodendrocytes in central nervous system(CNS)***,because oligodendrocytes are differentiated cells that cannot proliferate.

关键词： critical system conduction

Inhibition of blue-light- dependent binding of 14-3-3 proteins to phototropins by hydrogen peroxide

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Science Bulletin 2005年第11期50卷 1166-1168页

作者： SHIMAZAKI ken-ichiro Faculty of Sciences Department of Biology Japan Fu- kuoka 810-8560 Kyushu University

Phototropins, following the discovery of phyto-chromes and cryptochromes, arethe most recently characterized blue-light (BL) receptors in plants. The N-terminal regions of theproteins contain two light oxygen and voltage (LOV) — LOV1 and LOV2, which belong to PAS domaininvolved in protein-protein interaction and ligand binding, possessing non-covalent binding sitesfor the chromophore FMN. The C-terminal regions contain Ser/Thr kinase domains. Increasing lines ofevidence have shown that phototropins function as photoreceptors for stomotal opening, hypocotylsphototropism, chloroplast relocation, and plant growth under low light environment of higher plantsin response to BL. Phototropins, the autophosphorylation receptor Ser/Thr kinases, are activated viaphosphorylation with concomitant binding of a 14-3-3 protein, leading to special BL signal ***, the details about the signaling remain unknown.

关键词： dependent binding of 14-3-3 proteins to phototropins by hydrogen peroxide blue

Deformation behaviors of magnesium alloy AZ31 sheet in cold deep drawing

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中国有色金属学会会刊：英文版 2008年第1期18卷 86-91页

作者：杨连发 MORI ken-ichiro TSUJI Hirokazu School of Electromechnical Engineering Guilin University of Electronic Technology Department of Production Systems Engineering Toyohashi University of Technology

To investigate how the popular magnesium alloy AZ31 sheet(aluminum 3%,zinc 1%)behaves in cold working,deep drawing experiments at room temperature,along with finite element(FE)simulation,were performed on the cold forming sheet of the AZ31 alloy after being annealed under various *** activities were focused on the fracture pattern,limit drawing ratio(LDR),deformation load,thickness distribution,anisotropic effect,as well as the influences of the annealing conditions and tool configuration on *** results display that punch shoulder radius instead of die clearance,has much influence on the thickness *** anisotropy is remarkable in cold working,which adversely impacts the *** fracture often happens on the side wall at an angle to axis of the deformed *** results also imply that the LDR for the material under present experimental conditions is 1.72,and annealing the material at 450 ℃ for 1 h may be preferable for the cold deep drawing.

关键词： AZ31镁合金冷压制各向异性有限元素模拟

Effects of selenium-containing compounds on Cu^(2+)/Zn^(2+)-induced neuronal cell death and potential application as therapeutic agents for neurological diseases

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Neural Regeneration Research 2022年第2期17卷 311-312页

作者： ken-ichiro Tanaka Mikako Shimoda Masahiro Kawahara Department of Bio-Analytical Chemistry Faculty of PharmacyMusashino UniversityShinmachiNishitokyoTokyoJapan

In many tissues, trace metals such as iron(Fe), zinc(Zn), and copper(Cu) are important for various physiological functions such as immune function, cell division, and enzyme function. However, it has been shown in humans and experimental animal models that excessive amounts of these trace metals in the body can induce various diseases in the central nervous system, liver.

关键词： metals potential copper

Blue-light-induced rapid chloroplast de-anchoring in Vallisneria epidermal cells

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Journal of Integrative Plant Biology 2015年第1期57卷 93-105页

作者： Yuuki Sakai Shin-ichiro Inoue Akiko Harada ken-ichiro Shimazaki Shingo Takagi Department of Biological Sciences Graduate School of Science Osaka University Division of Biological Science Graduate School of Science Nagoya University Department of Biology Osaka Medical College Department of Biology Faculty of Science Kyushu University

In the outer periclinal cytoplasm of leaf epidermal cells of an aquatic angiosperm Vallisneria, blue light induces ＂chloroplast de-anchoring＂, a rapid decline in the resistance of chloroplasts against centrifugal force. Chloroplast de- anchoring is known induced within lmin of irradiation with high-fluence-rate blue light specifically, preceding the com- mencement of chloroplasts migration toward the anticlinal cytoplasm. However, its regulatory mechanism has remained elusive, although pharmacological analysis suggested that a calcium release from intracellular calcium stores is necessary for the response, in search of the responsible photoreceptors, immunoblotting analysis using antibodies against phototropins demonstrated that cross-reactive polypeptides of 120-kDa exist in the plasma-membrane fraction prepared from the leaves. In vitro phosphorylation analysis revealed that 120-kDa polypeptides were phosphorylated by exposure to blue light in a fluence-dependent manner. The blue-light-induced phosphorylation activity was sensitive to a Ser/Thr kinase inhibitor, staurosporine, and unusually was retained at a high level for a long time in darkness. Furthermore, phototropin gene homologs （Vallisneria PHOTOTROPINI and PHOTOTROPIN2） expressed in leaves were isolated. We propose that calcium- regulated chloroplast de-anchoring, possibly mediated by phototropins, is an initial process of the blue-light-induced avoidance response of chloroplasts in Vallisneria.

关键词： Avoidance response of chloroplasts blue-light response chloroplast de-anchoring cytoplasmic calcium phototropin

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新型超高强度钢零件热冲压技术(英文)

中国有色金属学会会刊：英文版 2012年第S2期22卷 496-503页

作者： ken-ichiro MORI Department of Mechanical Engineering Toyohashi University of Technology

为克服现今热冲压的难题,开发了一种高强度钢零件的新型热冲压技术。利用快速电阻加热,该热冲压技术所需的设备比电炉加热的设备更简单。与传统液压加工相比,该工艺采用机械伺服高速冲压可以提高成形性。通过具有局部旁路电阻加热的剪... 详细信息

为克服现今热冲压的难题,开发了一种高强度钢零件的新型热冲压技术。利用快速电阻加热,该热冲压技术所需的设备比电炉加热的设备更简单。与传统液压加工相比,该工艺采用机械伺服高速冲压可以提高成形性。通过具有局部旁路电阻加热的剪切模具,制备了具有不同强度分布的零件。局部电阻加热使得剪切区的流变应力减小,从而使模具淬火钢零件和超高强钢板的剪切更容易。通过对杯壁进行电阻加热,利用热齿键成型技术制备了超高强度钢齿轮盖。同时,还通过热冲压成型制备了汽车用中空导流槽。一次热压成形工艺包括电阻加热、成形、剪切和模具冷却等流程,该工艺适用于相对较小的高强度钢零件。

关键词：热冲压超高强度钢模具淬火剪切模淬火齿键成型管成型一次成型

Low toxic nitromethane based monopropellant for gas generator cycle air turbo ramjet engine

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Propulsion and Power Research 2022年第3期11卷 311-324页

作者： Ryojiro minato Department of Engineering Muroran Institute of TechnologyMuroranHokkaido050-8585Japan

The present study proposes ethanol-nitromethane mixture as a safe, storable, andlow toxic monopropellant for a gas generator cycle air turbo ramjet engine and evaluates itspropulsion performance. The present study proposes that nitromethane is mixed with ethanolto adjust gas generator combustion temperature. The author developed the computational codefor the present analysis and verified its accuracy. The specific thrust of ethanol-nitromethane isnearly identical to that of ethanol-liquified oxygen and is higher than methanol-hydroxylammonium nitrate aqueous solution and hydrazine. Hydrazine has the highest Ispamong the propellants in the present analysis. However, Isp of ethanol-nitromethane is nearlyequal to that of ethanol-liquified oxygen and higher than those of methanol-hydroxylammonium nitrate aqueous solution, and hydroxyl terminated polybutadiene-ammonium perchlorate. With the propellant-to-air ratio range in the present study, ethanol-nitromethane has the stoichiometric condition at the ram combustor around the propellant-to-air ratio range from 0.2 to 0.25 and can obtain high ram combustion temperature. This resultis favorable for ethanol-nitromethane because it improves the specific thrust and the specificimpulse. Therefore, ethanol-nitromethane can be a promising low-toxic liquid monopropellantfor the air turbo ramjet engine.

关键词： Air turbo ramjet Monopropellant Nitromethane Low toxicity Ethanol

Renal amyloidosis as a late complication of Crohn's disease:a case report and review of the literature from Japan

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World Journal of Gastroenterology 2000年第3期6卷 461-464页

作者： Osamu Saitoh Keishi Kojima Tsutomu Teranishi ken Nakagawa Masanobu Kayazawa Masashi Nanri Yutaro Egashira ichiro Hirata ken-ichi Katsu Second Department of Internal Medicine Osaka Medical CollegeTakatsukiJapan First Department of Pathology Osaka Medical CollegeTakatsukiJapan

INTRODUCTION Secondary amyloidosis is a rare but seriouscomplication of Crohn’s disease(CD).Theincidence of the association of secondaryamyloidosis in patients with CD has been reportedto be 0.5%-8% in Western ***,in Japan,the number of patients with CDcomplicated by amyloidosis is *** of their clinical manifestations andthe incidence of association are ***,we report herein a patient with

关键词： Crohn’s disease/complication renal amyloidosis amyloid deposits