检索结果-南通市图书馆

Management of gastric and duodenal neuroendocrine tumors

World Journal of Gastroenterology 2016年第30期22卷 6817-6828页

作者： Yuichi Sato Satoru Hashimoto ken-ichi mizuno Manabu Takeuchi Shuji Terai Department of Gastroenterology Niigata University Graduate School of Medical and Dental Sciences Division of Endoscopy Niigata University Medical and Dental Hospital

Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis. Type II G-NETs (5%-6%) are associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome (MEN1-ZES). Both type I and II G-NETs are related to hypergastrinemia, are small in size, occur in multiple numbers, and are generally benign. In contrast, type III G-NETs (10%-15%) are not associated with hypergastrinemia, are large-sized single tumors, and are usually malignant. Therefore, surgical resection and chemotherapy are generally necessary for type III G-NETs, while endoscopic resection and follow-up, which are acceptable for the treatment of most type I and II G-NETs, are only acceptable for small and well differentiated type III G-NETs. D-NETs include gastrinomas (50%-60%), somatostatin-producing tumors (15%), nonfunctional serotonin-containing tumors (20%), poorly differentiated neuroendocrine carcinomas (< 3%), and gangliocytic paragangliomas (< 2%). Most D-NETs are located in the first or second part of the duodenum, with 20% occurring in the periampullary region. Therapy for D-NETs is based on tumor size, location, histological grade, stage, and tumor type. While endoscopic resection may be considered for small nonfunctional D-NETs (G1) located in the higher papilla region, surgical resection is necessary for most other D-NETs. However, there is no consensus regarding the ideal treatment of D-NETs.

关键词： Gastric neuroendocrine tumors Duodenal neuroendocrine tumors Classification Endoscopic treatment Endoscopic submucosal dissection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices

引用

World Journal of Gastroenterology 2005年第47期11卷 7515-7519页

作者： Toru Ishikawa Takashi Ushiki ken-ichi mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Keiko Takeda Tomoteru Kamimura Department of Gastroenterology Saiseikai Niigata Second HospitalNiigataJapan Department of Radiology Saiseikai Niigata Second HospitalNiigataJapan

AIM： To evaluate the efficacy of CT-maximum intensity projection （CT-MIP） in the detection of gastric varices and their infiowing and outflowing vessels in patients with gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration （B-RTO）. METHODS： Sixteen patients with endoscopically confirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS： CT-MIP clearly depicted gastric varices in 16 patients （100%）, the left gastric vein in 6 （32.5%）, the posterior gastric vein in 12 （75.0%）, the short gastric veins in 13 （81.3%）, gastrorenal shunts in 16 （100%）, the hemiazygos vein （HAZV） in 4 （25.0%）, the pericardiophrenic vein （PCPV） in 9 （56.3%）, and the left inferior phrenic vein in 9 patients （56.3%）. Although flow direction itself cannot be determined from CT-MIP, this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP. CONCLUSION： We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO.

关键词： Gastric varices CT-MIP, Portal hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment

引用

World Journal of Gastroenterology 2019年第12期25卷 1457-1464页

作者： Hiroki Sato Manabu Takeuchi Satoru Hashimoto ken-ichi mizuno Koichi Furukawa Akito Sato Junji Yokoyama Shuji Terai Division of Gastroenterology Niigata University Medical and Dental Hospital Division of Gastroenterology Nagaoka Red Cross Hospital Division of Gastroenterology Niigata City General Hospital Division of Gastroenterology Nagaoka Chuo General Hospital

Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant,minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy(POEM). However,the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

关键词： Diverticulum Esophagus Epiphrenic diverticulum Zenker's diverticulum Rokitansky diverticulum Iatrogenic disease Esophageal achalasia Peroral endoscopic myotomy Diverticulectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case of severe alcoholic hepatitis treated with granulocytapheresis

引用

World Journal of Clinical Cases 2016年第11期4卷 369-374页

作者： Yukari Watanabe kenya Kamimura Tomohiro Iwasaki Hiroyuki Abe Shunsaku Takahashi ken-ichi mizuno Manabu Takeuchi Atsushi Eino ichiei Narita Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Japan Labor Health and Welfare Organization Tsubame Rosai Hospital Division of Clinical Nephrology and Rheumatology Graduate School of Medical and Dental SciencesNiigata University

Severe alcoholic hepatitis(AH) has a high mortality,and it is associated with encephalopathy,acute renal failure,sepsis,gastrointestinal bleeding,and *** 28-d mortality remains poor(34%-40%),because no effective treatment has been ***,corticosteroids(CS) have been considered effective for significantly improving the prognosis of those with AH,as it prevents the production of pro-inflammatory ***,CS are not always appropriate as an initial therapeutic option,such as in cases with an infection or resistance to *** describe a patient with severe AH complicated by a severe infection caused by the multidrug resistance bacteria(Pseudomonas aeruginosa),and was successfully treated with granulocytapheresis monotherapy without using *** experience of this case will provide understanding of the disease and information treating cases without using CS.

关键词： Apheresis Hepatitis Alcoholic Alcoholic hepatitis Case reports

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis

引用

World Journal of Gastroenterology 2017年第13期23卷 2414-2423页

作者： Hiroki Sato Nao Nakajima Kazuya Takahashi Go Hasegawa ken-ichi mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai Division of Gastroenterology and Hepatology Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Saiseikai Niigata Daini Hospital Division of Cellular and Molecular Pathology Department of Cellular FunctionNiigata University Graduate School of Medical and Dental Sciences

AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue *** In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo *** Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs.

关键词： Eosinophilic esophagitis Eosinophilic esophageal myositis Peroral endoscopic myotomy Jackhammer esophagus Achalasia Peroral esophageal muscle biopsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CRL4Wdr70 facilitates chromatin recruitment of Exo1 to promote long-range resection of double strand breaks

CRL4Wdr70 facilitates chromatin recruitment of Exo1 to promo...

引用

2014年第七届中国模式真菌研讨会

作者：曾鸣 Laifeng Ren ken'ichi mizuno Konstantinos Nestoras Haibin Wang Zizhi Tang Xiaobo Wang Liandi Guo Daochun Kong Qun He Lilin Du Antony M.Carr Cong Liu Sussex Centre for Genome Damage and Stability Centre School of Life SciencesUniversity of Sussex West China Second University Hospital Sichuan University

Homologous recombination(HR)is important for repairing potentially lethal DNA double strand breaks(DSBs)in the context of *** are resected by the combination action of the Mrell-Rad50-Nbsl(MRN),Ctpl,Exol and Rqhl-Top3-Dna2 factors to form the ssDNA substrates which initiate *** these DNA processing enzymes navigate nucleosome-packaged DNA remains poorly *** find that the fission yeast DCAF protein,Wdr70,is recruited to DSBs in complex with Ddbl and the Cullin4 ubiquitin ligase(CRL4).CRL4recruitment stimulates H2B lysine 119 mono-ubiquitination(uH2B)of chromatin both proximal

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Oral administration of Lactiplantibacillus plantarum 22A-3 exerts anti-allergic activity against intestinal food allergy mouse models sensitized and challenged with ovalbumin

引用

Food Bioscience 2022年第3期47卷 1294-1300页

作者： Mari Enokida ken-ichiro Minato Susumu Yoshino Nobuaki Ohto Hiroshige Kuwahara Masashi mizuno Department of Agrobioscience Graduate School of Agricultural ScienceKobe UniversityKobe657-8501Japan Department of Applied Biological Chemistry Graduate School of AgricultureMeijo UniversityNagoya468-8502Japan Research Center Maruzen Pharmaceuticals Co.Ltd.Fukuyama729-3102Japan

In recent years,researches on food components with anti-allergic effects have been gathering attention,because of the expectation for the establishment of a safe and effective treatment for food *** studies have reported that Lactiplantibacillus plantarum 22A-3 (LP22A3) inhibited degranulation of mast cells and reduced IgE *** have developed a gastrointestinal allergy system in which mice are sensitized by intraperitoneal and oral administration of OVA and then challenged by oral administration of high doses of *** a result,an increase in the amount of IgE in the blood and a decrease in the temperature of the colon were confirmed,and it was clarified that food allergy was induced by oral administration of high dose of OVA as the *** administration of LP22A3 ameliorated allergic responses significantly by reducing the amount of IgE in the blood and to recovered the decrease of rectal ***,LP22A3 did not affect the intestinal barrier *** LP22A3 significantly suppressed mRNA expression of OX40L and *** results suggested that LP22A3 suppressed Th2 differentiation and IL-4 production via downregulation of OX40L,and consequently suppressed IgE ***22A3 might provide a safe and effective treatment for allergic diseases due to ability modulating intestinal immune system.

关键词： Anti-allergic activity Food allergy Lactiplantibacillus plantarum 22A-3 Ovalbumin OX40L

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virtual Reconstruction of Long Bone Fracture in Car-to-pedestrian Collisions Using Multi-body System and Finite Element Method

引用

Chinese Journal of Mechanical Engineering 2011年第6期24卷 1045-1055页

作者： HAN Yong YANG Jikuang mizuno Koji State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China Department of Applied Mechanics Chalmers University of TechnologyGothenburg 41296Sweden Department of Mechanical Science and Engineering Nagoya UniversityNagoya 464-8601JapanState

Lower limb injures are frequently observed in passenger car traffic *** studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinematics,which lack in-depth study on the fractures in stress *** paper aims to investigate lower limb impact biomechanics in real-world car to pedestrian accidents and to predict fractures of long bones in term of stress parameter for femur,tibia,and *** the above purposes,a 3D finite element(FE) model of human body lower limb(HBM-LL) is developed based on human *** model consists of the pelvis,femur,tibia,fibula,patella,foot bones,primary tendons,knee joint capsule,meniscus,and *** FE model is validated by comparing the results from a lateral impact between simulations and tests with cadaver lower limb *** real-world accidents are selected from an in-depth accident database with detailed information about the accident scene,car impact speed,damage to the car,and pedestrian ***-body system(MBS) models are used to reconstruct the kinematics of the pedestrians in the two accidents and the impact conditions are calculated for initial impact velocity and orientations of the car and pedestrian during the *** FE model is used to perform injury reconstructions and predict the fractures by using physical parameters,such as von Mises stress of long *** calculated failure level of the long bones is correlated with the injury outcomes observed from the two accident *** reconstruction result shows that the HBM-LL FE model has acceptable biofidelity and can be applied to predict the risk of long bone *** study provides an efficient methodology to investigate the long bone fracture suffered from vehicle traffic collisions.

关键词： passenger car pedestrian accident lower limb FE model long bone fracture impact biomechanics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Sterilization Method Using Pulsed Discharge Plasma

引用

Chinese Physics Letters 1998年第1期15卷 41-42页

作者： WANG Xi-lu Akira mizuno Shijin Katsura Department of Ecological Engineering Toyohashi University of TechnologyTempaku-choToyohashi441Japan Institute of Electrostatics Northeast Normal UniversityChangchun 130024

Pulsed discharge plasma(PDP)has been used to kill bacteria and the curves of the survival rate of bacteria against treatment time are *** structural change in the cell membrane is caused by PDP and the cell is thus **... 详细信息

关键词： PDP Plasma treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Novel Estimating Method for Steering Efficiency of the Driver with Electromyography Signals

引用

Chinese Journal of Mechanical Engineering 2014年第3期27卷 460-467页

作者： LIU Yahui JI Xuewu HAYAMA Ryouhei mizuno Takahiro State Key Laboratory of Automotive Safety and Energy Tsinghua University Research and Development Center jtekt co.ltd.

The existing research of steering efficiency mainly focuses on the mechanism efficiency of steering system, aiming at designing and optimizing the mechanism of steering system. In the development of assist steering system especially the evaluation of its comfort, the steering efficiency of driver physiological output usually are not considered, because this physiological output is difficult to measure or to estimate, and the objective evaluation of steering comfort therefore cannot be conducted with movement efficiency perspective. In order to take a further step to the objective evaluation of steering comfort, an estimating method for the steering efficiency of the driver was developed based on the research of the relationship between the steering force and muscle activity. First, the steering forces in the steering wheel plane and the electromyography （EMG） signals of the primary muscles were measured. These primary muscles are the muscles in shoulder and upper ann which mainly produced the steering torque, and their functions in steering maneuver were identified previously. Next, based on the multiple regressions of the steering force and EMG signals, both the effective steering force and the total force capacity of driver in steering maneuver were calculated. Finally, the steering efficiency of driver was estimated by means of the estimated effective force and the total force capacity, which represented the information of driver physiological output of the primary muscles. This research develops a novel estimating method for driver steering efficiency of driver physiological output, including the estimation of both steering force and the force capacity of primary muscles with EMG signals, and will benefit to evaluate the steering comfort with an objective perspective.

关键词： electromyography muscle activity steering efficiency estimating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：