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dysfunction of the adhesion G protein-coupled receptor latrophilin 1(AdGRL1/LPHN1)increases the risk of obesity

Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg Andrénguyen dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf diana Le duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for diabetes Research(dZd e.V.) Munich-NeuherbergGermany Cardiovascular degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARId) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(AdGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human AdGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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3d打印连续纤维增强树脂T型梁的弯曲性能

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材料导报 2024年第7期38卷 242-248页

作者：吴思远单忠德陈恳刘丰刘晓军严春晖中国机械科学研究总院集团有限公司先进成形技术与装备国家重点实验室北京100048 清华大学机械工程系北京100084 南京航空航天大学机电学院南京210016

1中国机械科学研究总院集团有限公司先进成形技术与装备国家重点实验室,北京1000482清华大学机械工程系,北京1000843南京航空航天大学机电学院,南京210016实现基梁于结熔构融的沉轻积量技化、术功的能连化续设纤计维和增制强造树。脂本3... 详细信息

1中国机械科学研究总院集团有限公司先进成形技术与装备国家重点实验室,北京1000482清华大学机械工程系,北京1000843南京航空航天大学机电学院,南京210016实现基梁于结熔构融的沉轻积量技化、术功的能连化续设纤计维和增制强造树。脂本3d工作打对印筋工高艺0为m梁m结与构5的m制m造的提T供型了梁一打种印新件的在途不径,同该打工印艺参具数有下快的速弯近曲净性成能型进、行可测设计试性实强验,等研优究势了,能打够印基于熔融沉积技术的连续纤维增强树脂3d打印工艺为梁结构的制造提供了一种新的途径,该工艺具有快速近净成型、可设计性强等优势,能够实现梁结构的轻量化、功能化设计和制造。本工作对筋高0 mm与5 mm的T型梁打印件在不同打印参数下的弯曲性能进行测试实验,研究了打印厚度分别为0.7 mm、0.8 mm、0.9 mm时与打印丝束间距分别为0.6 mm、0.7 mm、0.8 mm时T型梁对应的弯曲强度与模量。由于3d打印连续纤维增强树脂材料存在着复杂的破坏模式,本研究运用声发射技术对T型梁的弯曲破坏过程进行测试分析,采用主成分分析法与K-means++聚类算法对采集的过程信号进行损伤分类。结果表明,当打印层厚为0.7~0.9 mm时,随着打印层厚的增加,T型梁的弯曲强度与模量均降低。当打印丝束间距为0.6~0.8 mm时,随着打印丝束间距的增加,T型梁的弯曲强度与模量降低。在T型梁从弯曲载荷加载初始到破坏失效阶段,对应特征信号可以聚类为五类,分别对应五种破坏模式,即基体开裂、层间剥离、纤维与基体脱粘、纤维开裂及纤维断裂,分类结果能够很好地解释弯曲破坏过程。

关键词： 3d打印 T型梁弯曲性能声发射主成分分析 K-means++

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Influence of deviatoric stress on rockburst occurrence:An experimental study

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International Journal of Mining Science and Technology 2018年第5期28卷 763-766页

作者： Thomas Bruning Murat Karakus Selahattin Akdag Giang d.nguyen david Goodchild School of Civil Environmental and Mining EngineeringThe University of AdelaideAdelaide 5005Australia OZ Minerals 2 Hamra DriveAdelaide AirportSA5950Australia

As mining delves deeper into the crust, it is necessary to investigate the complex rock responses associated with higher stress gradients. Therefore, it is essential to better understand the mechanisms associated with the rockburst phenomenon. However, due to the large-scale and difficult monitoring of real mining excavations, laboratory scale tests must be utilised to determine the conditions conducive to burst. To this end, this research focuses on the implementation of a new rockburst testing apparatus to replicate the stress conditions of a rock mass excavation at the time of bursting. This apparatus allows the determination of rockburst stresses and a relationship between deviatoric stress and in-situ pressure/depth. Using this relationship it is then possible to estimate the standardised stress levels for a certain rock type which might lead to rockburst occurrence. Furthermore, it is demonstrated that with increasing in-situ pressure, the likelihood(measured as a lower differential stress) and the extent(indicated by the increasing range of deviatoric stress) of rockburst increases. These findings provide valuable information about the conditions necessary for bursting in deep mining.

关键词： Rockburst test Hollow cylinder Hard rock In-situ stress

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Approximate graphical method of solving Fermi level and majority carrier density of semiconductors with multiple donors and multiple acceptors

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Journal of Semiconductors 2011年第6期32卷 1-6页

作者： ken K.Chin department of Physics and Apollo CdTe Solar Energy Research Center New Jersey Institute of Technology

We present a generic approximate graphical method for determining the equilibrium Fermi level and majority carrier density of a semiconductor with multiple donors and multiple acceptors compensating each other. Simple and easy-to-follow procedures of the graphical method are *** graphically plotting two wrapping step functions facing each other,one for the positive hole-ionized donor and one for the negative electron-ionized acceptor,we have the crossing point that renders the Fermi level and majority carrier *** the graphical method,new equations are derived,such as the carrier compensation proportional to N;/N;,not the widely quoted N;-N;.Visual insight is offered to view not only the result of graphic determination of Fermi level and majority carrier density but also the dominant and critical pair of donors and acceptors in *** graphical method presented in this work will help to guide the design,adjustment,and improvement of the multiply doped *** of this approximate graphical method with previous work on compensation,and with some experimental results,is *** work in the field is proposed.

关键词： doping compensation Fermi level carrier density graphical method ionization

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Multiscale analysis of composite material reinforced by randomly-dispersed particles

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International Journal of Smart and Nano Materials 2012年第1期3卷 2-13页

作者： Jiaoyan Li James d.Lee ken P.Chong The George Washington University WashingtonDC 20052USA National Institute of Standards and Technology GaithersburgMD 20899USA

A multiscale analysis method is presented in which detailed information on the microscopic level is incorporated into macroscopic models capable of simulating damage evolution and ultimate *** composite considered is reinforced by randomly-dispersed particles,which reflects the statistical characteristics of real materials,such as cement-based ***,a three-dimensional material body is decomposed into many unit *** unit cell is reinforced by a cylindrical particle,the orientation of which is characterized by three Euler angles generated by the random number *** on a detailed finite element analysis,the material properties of the representative volume element are *** verification,the properties of the cylindrical particles are set equal to those of the matrix and the computed‘composite’properties reduce exactly to those of the‘isotropic’material,as *** coordinate transformation,the effective material properties of each unit cell are *** assembly of stiffness matrices of all unit cells leads to the stiffness matrix of the whole *** the simple tension loading condition,the initial damaged unit cell can be identified according to the vonMises yield *** stiffness of the damaged unit cell will then be reduced to zero and it will cause stress redistribution and trigger further *** was found that the reinforcement is effective to mitigate and arrest the damage propagation,and therefore prolongs the material’s *** results suggest that the hierarchical coupling approaches used here may be useful for material design and failure protection in composites.

关键词： multiscale analysis random response finite element method representative volume element Euler angle damage propagation

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A new formula for screening metabolic syndrome in Asians:skin fold thickness at A8 point on Erdheim diagram and waist circumference

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Journal of Geriatric Cardiology 2007年第1期4卷 32-41页

作者： Toan C nguyen Thai Q Ngo Khoa TA Pham Son V nguyen Hieu T Luong Cong d nguyen Vietnam Military Medical University Ha Dong Town Ha Tay Province Vietnam department of Cardiology Hospital 103 Vietnam

Background and objectives Recent studies have shown that abdominal obesity is an important component for the diagnosis of metabolic syndrome (MS) and MS is a high risk factor for cardiovascular disease and diabetes mellitus. The aim of this study was to develop a new formula for screening and diagnosis of MS using the waist circumference (WC) and skin fold thickness at the point A8 (SFA8) on the Erdheim diagram. Methods A total of 358 essential hypertensive patients (189 male and 169 female) with a mean age of 59.0±9.7 years were included; 151 healthy people (79 male, 72 female) with a mean age of 57.3±12.1 years (similar to hypertensive patients) who were non-hypertensive and non-diabetic served as a control group. All subjects had no evidence of hepatic, renal, or endocrine disease as determined by history, physical examination and screening blood tests. Height, weight, WC, SFA8, blood pressure (BP), fasting plasma glucose, HdL-cholesterol and triglyceride levels were measured in all subjects. Abdominal obesity measured by WC using the Asia-Pacific criteria (IdFA) was applied for meeting the MS definition. The normal value of SFA8 was measured in the non- MS group. Relationships between SFA8 and systolic BP, diastolic BP, fasting plasma glucose, HdL-cholesterol and triglyceride levels were calculated in the control group. A new formula was developed according to high SFA8 and high WC. Results The normal value of SFA8 in non-MS group was 23.6±7.2 mm in male and 26.5±4.6 mm in female, respectively. The value of SFA8 in MS group was 36.7± 7.4 mm in male and 38.9 ± 8.1 mm in female, respectively. The value of WC in MS group and non-MS group were 92.5±3.0 cm and 79.4±6. 1 cm in male and 86.3±6.4 cm and 74.7±5.4 cm in female, respectively. There was a correlation between SFA8 and systolic BP, diastolic BP, fasting plasma glucose, HdL-cholesterol and triglyceride in control group (the correlation coefficients were 0.29, 0.23, 0.25, -0.31 and 0.46, respectively, P < 0.01)

关键词： waist circumference skin fold thickness metabolic syndrome

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Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference

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Journal of Geriatric Cardiology 2006年第2期3卷 85-92页

作者： Toan C nguyen Thai Q Ngo Son V nguyen Hieu T Luong Khoa TA Pham Cong d nguyen Vietnam Military Medical University Ha ToyVietnam

Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NdM group) and 58 patients with diabetes (dM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or dBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HdL-cholesterol (＜ 1.03 mmol/L in men, ＜1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed dM. Metabolic Syndrome by the National Cholesterol Education Program and International diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IdFA). Results The percentage of MetS as defined by NCEPA, IdFA and MetSSFA8 in NdM group was lower than that of NCEPA, IdFA and MetSSFA8 in dM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IdFA and MetSSFA8 in males in NdM group was lower than the percentage of MetS by NCEPA, IdFA and MetSSFA8 in females in NdM group (50.8% and 77.9%, P＜ 0.0

关键词： skin fold thickness metabolic syndrome hypertension

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Hardy factorization in terms of fractional commutators in Lorentz spaces

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Frontiers of Mathematics in China 2022年第5期17卷 853-873页

作者： nguyen Anh dAO Institute of Applied Mathematics University of Economics Ho Chi Minh CityHo Chi Minh CityVietnam

We provide a constructive proof of H^(1)(R^(d))(the classical Hardy space)factorization in terms of fractional commutators in Lorentz *** a direct application,we obtain a characterization of functions in BMO ***,we al... 详细信息

关键词： BMO CMO Lorentz space commutator Hardy space Riesz potentia

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Mathematical modeling and numerical computation of the effective interfacial conditions for Stokes flow on an arbitrarily rough solid surface

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Applied Mathematics and Mechanics(English Edition) 2021年第5期42卷 721-746页

作者： A.T.TRAN H.LE QUANG Q.C.HE d.H.nguyen Research and Application Center for Technology in Civil Engineering University of Transport and CommunicationsHanoi 10000Vietnam Laboratoire Modelisation et Simulation Multi-Echelle Unite Mixte de Recherche 8208Centre National de la Recherche ScientifiqueUniversite Gustave EiffelMarne-la-Vallee F-77454France School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China

The present work is concerned with a two-dimensional(2d)Stokes flow through a channel bounded by two parallel solid *** distance between the walls may be arbitrary,and the surface of one of the walls can be arbitrarily *** main objective of this work consists in homogenizing the heterogeneous interface between the rough wall and fluid so as to obtain an equivalent smooth slippery fluid/solid interface characterized by an effective slip *** solve the corresponding problem,two efficient numerical approaches are elaborated on the basis of the method of fundamental solution(MFS)and the boundary element methods(BEMs).They are applied to different cases where the fluid/solid interface is periodically or randomly *** results obtained by the proposed two methods are compared with those given by the finite element method and some relevant ones reported in the *** comparison shows that the two proposed methods are particularly efficient and accurate.

关键词： effective slip length method of fundamental solution(MFS) boundary element method(BEM) Stokeslet micro-channel fluid/solid interface

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differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway

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Journal of Animal Science and Biotechnology 2012年第1期3卷 32-41页

作者： Agus Suryawan Hanh V nguyen Rosemarie d Almonaci Teresa A davis department of Pediatrics Baylor College of Medicine United States Department of Agriculture/Agriculture Research Service Children's Nutrition Research Center 1100 Bates Street Houston TX 77030 USA

Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the postprandial rise in insulin and amino acids, especially leucine. The mechanism of leucine＇s action in vivo is not well understood. In this study, we investigated the effect of leucine infusion on protein synthesis in skeletal muscle and liver of neonatal pigs. To evaluate the mode of action of leucine, we used rapamycin, an inhibitor of mammalian target of rapamycin （mTOR） complex-1 （mTORC1）. Overnight-fasted 7-day-old piglets were treated with rapamycin for 1 hour and then infused with leucine （400 μmol·kg^-1·h^-1） for 1 hour. Leucine infusion increased the rate of protein synthesis, and ribosomal protein S6 kinase 1 （S6K1） and eukaryotic initiation factor （elF） 4E-binding protein-1 （4E-BP1） phosphorylation in gastrocnemius and masseter muscles （P 〈 0.05）, but not in the liver. The leucine-induced stimulation of protein synthesis and S6K1 and 4E-BP1 phosphorylation were completely blocked by rapamycin, suggesting that leucine action is by an mTORC1-dependent mechanism. Neither leucine nor rapamycin had any effect on the activation of the upstream mTQRC1 regulators, AMP-activated protein kinase and protein kinase B, in skeletal muscle or liver. The activation of elF2α and elongation factor 2 was not affected by leucine or rapamycin, indicating that these two pathways are not limiting steps of leucine-induced protein synthesis. These results suggest that leucine stimulates muscle protein synthesis in neonatal pigs by inducing the activation of mTORC1 and its downstream pathway leading to mRNA translation.

关键词： leucine mTORC1 neonatal pigs rapamycin skeletal muscle

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