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Desmoid Tumor Mimicking Port Site Recurrence after Laparoscopic Retroperitoneal Lymph Node Dissection for Metastatic Testicular Tumor: A Case Report

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Case Reports in Clinical Medicine 2015年第5期4卷 179-183页

作者： Yujiro Hayashi Yu Ishizuya ken takeda Yuichiro Yamaguchi Masashi Nakayama Yasuyuki Arai ken-Ichi Kakimoto Yasuhiko Tomita Kazuo Nishimura Department of Urology Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan

Background: Desmoid tumor is a rare benign soft tissue tumor which commonly affects the trunk and extremities. Case presentation: We report a patient who presented with a tumor that slowly grew at the left lower abdominal port site 1 year after post-chemotherapy laparoscopic retroperitoneal lymph node dissection (RPLND) for metastatic testicular tumor. The enlarging mass mimicking port site recurrence after laparoscopic retroperitoneal lymph node dissection for metastatic testicular tumor was diagnosed as a desmoid tumor. Conclusion: To our knowledge, this is the first report of a desmoid tumor that developed after laparoscopic RPLND for a testicular tumor.

关键词： Testicular Tumor Retroperitoneal Lymph Node Dissection Desmoid Tumor CTNNB1

Feasibility of a Direct-Conversion Method from Magnetic Susceptibility to Relative Electron Density for Radiation Therapy Treatment Planning

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第3期6卷 252-265页

作者： kengo Ito Noriyuki Kadoya Yujiro Nakajima Masahide Saito Kiyokazu Sato Tatsuo Nagasaka Kazuomi Yamanaka Suguru Dobashi ken takeda Haruo Matsushita Keiichi Jingu Department of Radiation Oncology Tohoku University Graduate School of Medicine Sendai Japan Department of Radiology Tokyo Metropolitan Komagome Hospital Tokyo Japan Department of Radiology University of Yamanashi Chuo-shi Japan Department of Radiology Tohoku University Hospital Sendai Japan Department of Therapeutic Radiology Tohoku University School of Medicine Sendai Japan

Recently, several institutions have been developing magnetic resonance imaging (MRI)-guided radiotherapy treatment systems. In this study, we examine whether it is possible to perform radiation therapy planning (RTP) using a magnetic susceptibility map obtained using MRI. The head of a healthy volunteer was scanned using dual-energy computed tomography (CT) and MRI. A T2-star-weighted 3D gradient echo-based sequence (GRE) with images taken at four different echo times was acquired using the MRI scanner. The CT images were converted to relative electron density (rED) using a predefined ΔCT-rED conversion table. ΔCT was derived using the energy-subtraction method. The rED map was obtained from a single-linear relationship with the ΔCT-rED conversion table, whereas the magnetic susceptibility map was obtained from quantitative susceptibility mapping (QSM) via MRI. Subsequently, to obtain the relationship between the magnetic susceptibility and the rED, the rED map was rigidly aligned to the susceptibility map and resampled at the susceptibility map’s resolution. Finally, the magnetic susceptibility rED conversion table was obtained via voxel-by-voxel mapping between the two maps. No strong relationship between magnetic susceptibility and rED was obtained in the healthy volunteer’s head or in this study. The coefficient correlation between these parameters was 0.0145. Magnetic susceptibility values may be not able to convert to rED using our proposed method in healthy volunteer’s head. In contrast to the magnetic-susceptibility values obtained from the QSM algorithm, which were strongly affected by calcification and iron content, the rED or CT number was not considerably affected by such materials.

关键词： Magnetic Susceptibility Quantitative Susceptibility Mapping MRI-Based Radiation Therapy Planning

New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima ken Sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Exploring the novel role of oligodendrocyte precursor cells in phagocytosis:beyond myelinogenesis

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Neural Regeneration Research 2025年第2期20卷 473-474页

作者： Gen Hamanaka ken Arai Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA

Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-producing *** precursors,OPCs mature and differentiate into oligodendrocytes,which contribute significantly to the formation of myelin sheaths around *** myelination,which is critical for the conduction of salutatory nerve impulses in the cerebral white matter,underscores the classical role of oligodendrocytes in central nervous system(CNS)***,because oligodendrocytes are differentiated cells that cannot proliferate.

关键词： critical system conduction

Drug-induced entero-colitis due to interleukin-17 inhibitor use;capsule endoscopic findings and pathological characteristics:A case report

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World Journal of Gastroenterology 2023年第32期29卷 4912-4919页

作者： Keita Saito Kiichiro Yoza Shinichiro takeda Yoshihiro Shimoyama ken Takeuchi Department of Gastroenterology Tsujinaka Hospital Kashiwano-HaKashiwa 277-0871Japan

BACKGROUND Interleukin-17(IL-17)inhibitors are known to cause exacerbation or new onset of inflammatory bowel disease upon ***,few reports have described characteristic endoscopic and histopathologic findings,and no small intestinal lesions have been reported so *** SUMMARY A woman in her 60s with psoriasis was administered ixekizumab(IXE),an anti-IL-17A antibody,for the treatment of *** months after commencing treatment,the patient visited our hospital because of persistent *** tests performed at the time of the visit revealed severe inflammation,and colonoscopy revealed multiple round ulcers throughout the colon.A tissue biopsy of the ulcer revealed infiltration of inflammatory cells and granuloma-like findings in the submucosal *** endoscopy revealed multiple jejunal *** the withdrawal of IXE,the symptoms gradually improved,and ulcer reduction and scarring of the colon were endoscopically *** To the best of our knowledge,17 reports have documented IL-17 inhibitorinduced entero-colitis with endoscopic images,endoscopic findings,and pathological characteristics,including the present *** of these cases showed diffuse loss of vascular pattern,coarse mucosa/ulcer formation in the left colon,and endoscopic findings similar to those of ulcerative *** the remaining eight cases,discontinuous erosions and ulcerations from the terminal ileum to the rectum were seen,with endoscopic findings similar to those of Crohn’s *** this case,the findings were confirmed by capsule endoscopy,which has not been previously reported.

关键词： Interleukin-17 inhibitor Ixekizumab Drug-induced entero-colitis Capsule endoscopy Case report

CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices

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World Journal of Gastroenterology 2005年第47期11卷 7515-7519页

作者： Toru Ishikawa Takashi Ushiki ken-ichi Mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Keiko takeda Tomoteru Kamimura Department of Gastroenterology Saiseikai Niigata Second HospitalNiigataJapan Department of Radiology Saiseikai Niigata Second HospitalNiigataJapan

AIM： To evaluate the efficacy of CT-maximum intensity projection （CT-MIP） in the detection of gastric varices and their infiowing and outflowing vessels in patients with gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration （B-RTO）. METHODS： Sixteen patients with endoscopically confirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS： CT-MIP clearly depicted gastric varices in 16 patients （100%）, the left gastric vein in 6 （32.5%）, the posterior gastric vein in 12 （75.0%）, the short gastric veins in 13 （81.3%）, gastrorenal shunts in 16 （100%）, the hemiazygos vein （HAZV） in 4 （25.0%）, the pericardiophrenic vein （PCPV） in 9 （56.3%）, and the left inferior phrenic vein in 9 patients （56.3%）. Although flow direction itself cannot be determined from CT-MIP, this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP. CONCLUSION： We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO.

关键词： Gastric varices CT-MIP, Portal hypertension

Local charge neutrality condition,Fermi level and majority carrier density of a semiconductor with multiple localized multi-level intrinsic/impurity defects

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Journal of Semiconductors 2011年第11期32卷 1-8页

作者： ken K.Chin Department of Physics and Apollo CdTe Solar Energy Research Center New Jersey Institute of Technology Department of Photonic and Information Engineering School of Electronic and Information EngineeringBeihang University

For semiconductors with localized intrinsic/impurity defects, intentionally doped or unintentionally incorporated, that have multiple transition energy levels among charge states, the general formulation of the local charge neutrality condition is given for the determination of the Fermi level and the majority carrier density. A graphical method is used to illustrate the solution of the problem. Relations among the transition energy levels of the multi-level defect are derived using the graphical method. Numerical examples are given for p-doping of the CdTe thin film used in solar panels and semi-insulating Si to illustrate the relevance and importance of the issues discussed in this work.

关键词： multi-level defects defect complex intrinsic impurity semiconductor Fermi level majority carrier density

Approximate graphical method of solving Fermi level and majority carrier density of semiconductors with multiple donors and multiple acceptors

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Journal of Semiconductors 2011年第6期32卷 1-6页

作者： ken K.Chin Department of Physics and Apollo CdTe Solar Energy Research Center New Jersey Institute of Technology

We present a generic approximate graphical method for determining the equilibrium Fermi level and majority carrier density of a semiconductor with multiple donors and multiple acceptors compensating each other. Simple and easy-to-follow procedures of the graphical method are *** graphically plotting two wrapping step functions facing each other,one for the positive hole-ionized donor and one for the negative electron-ionized acceptor,we have the crossing point that renders the Fermi level and majority carrier *** the graphical method,new equations are derived,such as the carrier compensation proportional to N;/N;,not the widely quoted N;-N;.Visual insight is offered to view not only the result of graphic determination of Fermi level and majority carrier density but also the dominant and critical pair of donors and acceptors in *** graphical method presented in this work will help to guide the design,adjustment,and improvement of the multiply doped *** of this approximate graphical method with previous work on compensation,and with some experimental results,is *** work in the field is proposed.

关键词： doping compensation Fermi level carrier density graphical method ionization

The Structure and Mechanical Properties of Cr4Mo4V Steel Treated by PIII Carbonitriding

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稀有金属材料与工程 2012年第S1期41卷 176-179页

作者： ken Yukimura Harbin Institute of Technology Harbin 150001China

The composition and structure of PIII(plasma immersion ion implantation)carbonitrided Cr4Mo4V steel were analyzed using X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),optical microscopy(OM)and *** results indicate that the nitride and carbide are dispersion phase precipitation and except formation of compound other implantation atoms dissolve into martensite *** total concentration of carbon and nitrogen is about 30 at%near the surface,and still keeps at about 20 at%even at the depth of 8μ*** effect of treatment temperature,implantation time and ratio of N2 to CH4 on the hardness and wear resistance of carbonitrided layer are *** is found that the hardness of Cr4Mo4V steel increases after *** highest hardness of samples is 22.3 GPa,which is about 1.8 times than initial *** dry-wear resistance of the samples is also improved after treatment,and the sample with higher hardness shows the better wear resistance.

关键词： Cr4Mo4V steel PBII carbonitriding hardness wear resistance