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肠壁囊样积气症的MSCT征象及其在临床诊治决策中作用的探讨

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中国医学计算机成像杂志 2024年第2期30卷 205-210页

作者：饶慧敏马梅香卢林沈云陈克敏陈大治宁夏回族自治区人民医院医学影像中心银川750002 GE中国CT研究中心上海交通大学附属瑞金医院

目的:通过比较采用不同临床治疗方案的肠壁囊样积气症(PCI)患者多层螺旋CT(MSCT)征象的差异,探讨MSCT征象在PCI临床诊治决策中的作用,从而为其临床应用提供参考依据。方法:回顾性分析宁夏回族自治区人民医院2016年1月至2022年8月期间治... 详细信息

目的:通过比较采用不同临床治疗方案的肠壁囊样积气症(PCI)患者多层螺旋CT(MSCT)征象的差异,探讨MSCT征象在PCI临床诊治决策中的作用,从而为其临床应用提供参考依据。方法:回顾性分析宁夏回族自治区人民医院2016年1月至2022年8月期间治疗的44例PCI患者资料,根据治疗方式分为保守组(34例)和手术组(10例),总结其MSCT征象特点,包括病变部位、气囊肿的大小、累计长度、在肠壁的分布、有无游离气体、门静脉积气、肠梗阻等,并比较两组间上述MSCT征象出现率的差异。结果:(1)MSCT征象:44例PCI肠壁囊样积气症气囊肿直径为0.1~3.7 cm,病变累计长度约为1.0~180 cm,1例为单发,其余为多发;浆膜下型13例(29.5%),黏膜下型15例(34.1%),混合型16例(36.4%);累及结直肠31例(70.5%),累及小肠19例(43.2%),累及胃壁、系膜处各1例(2.3%);伴有腹腔游离气体14例(31.8%);伴有肠梗阻14例(31.8%)。(2)两组间患者MSCT征象的差异:手术组与保守组之间病灶呈串珠样(90.0%vs 29.4%)、伴发门脉积气(60.0%vs 5.9%)、伴发肠梗阻(70.0%vs 20.6%)及伴发腹腔游离气体(70.0%vs 20.6%)等征象的出现率,差异均有统计学意义(P0.05)。结论:PCI患者在MSCT上具有特征性表现;MSCT的征象特点可为PCI的临床治疗方案选择提供参考依据,当病灶呈串珠样改变,伴发门脉积气、肠梗阻及腹腔游离气体时要结合临床表现考虑手术可能性。

关键词：肠壁囊样积气症多层螺旋CT 征象外科手术

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肺淋巴管平滑肌瘤病高分辨率CT分析

中国医学计算机成像杂志 2024年第1期30卷 33-38页

作者：董莱李慧王晗琦管鑫陈克敏上海市黄浦区香山中医医院放射科上海交通大学医学院附属瑞金医院放射科上海市黄浦区香山中医医院治未病科

目的:分析并总结肺淋巴管平滑肌瘤病(PLAM)的高分辨率CT(HRCT)影像特征,探讨胸部HRCT对该病的诊断价值。方法:回顾性分析50例于上海市黄浦区香山中医医院LAM中医特色专科门诊就诊的PLAM患者的HRCT资料,总结其典型的CT表现,包括弥漫囊样... 详细信息

目的:分析并总结肺淋巴管平滑肌瘤病(PLAM)的高分辨率CT(HRCT)影像特征,探讨胸部HRCT对该病的诊断价值。方法:回顾性分析50例于上海市黄浦区香山中医医院LAM中医特色专科门诊就诊的PLAM患者的HRCT资料,总结其典型的CT表现,包括弥漫囊样影及不同表现的肺间质病变等。结果:50例确诊的PLAM患者HRCT影像显示双肺弥漫性囊状影及肺间质病变的不同表现,部分病例出现胸腔积液、气胸病史、肺部感染及支气管扩张征象。结论:胸部HRCT检查所提供的影像学表现在PLAM干预中具有显著价值,可为疾病的后续诊治提供有效依据,提高疾病诊断准确性。

关键词：肺淋巴管平滑肌瘤病计算机体层成像

CT及MRI预测急性缺血性脑梗死出血性转化的价值研究进展

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诊断学理论与实践 2024年第1期23卷 83-89页

作者：李明陈克敏潘自来罗禹同济大学附属上海市第四人民医院放射科上海200434 上海交通大学医学院附属瑞金医院放射科上海200025

脑梗死是全球排名第二大致死原因,在中国已成为第一大致残及死亡原因。急性缺血性脑梗死(acute ischemic stroke,AIS)则是最常见的脑梗死类型,约占全部脑梗死的80%。出血性转化(hemorrhagic transformation,HT)是AIS患者的自然转归过程... 详细信息

脑梗死是全球排名第二大致死原因,在中国已成为第一大致残及死亡原因。急性缺血性脑梗死(acute ischemic stroke,AIS)则是最常见的脑梗死类型,约占全部脑梗死的80%。出血性转化(hemorrhagic transformation,HT)是AIS患者的自然转归过程之一,也是静脉溶栓治疗(intravenous thrombolysis,IVT)或血管内取栓治疗等治疗后最严重的并发症,给患者及其家庭和社会都带来沉重的负担。精准预测、评估AIS的HT具有重要临床意义。近年影像学研究集中于CT和MRI评估HT的价值。CT平扫诊断HT价值有限,AIS治疗前,阿尔伯塔脑梗死计划早期诊断评分≤7分与HT发生相关(P=0.033),高密度大脑中动脉征是发生HT的独立危险因素(OR=10.334);AIS取栓治疗后24 h复查双能CT,预测2~7 d内发生HT风险的效能较高(灵敏度82.5%、特异度100%)。CT血管造影中,血栓负荷高的患者HT发生概率上升(OR=1.28);侧支循环良好的AIS患者HT发生率低。CT灌注成像参数包括表面渗透性、脑血容量、Tmax等,均有较好的HT预测价值。MRI平扫中,FLAIR上高信号可预测HT的发生;MRI弥散加权成像,高信号区域体积可预测HT(ROC曲线下面积0.78);MRI磁敏感率加权成像,刷状征、微出血灶提示HT的发生;MRI增强T1加权成像,脑实质强化与HT发生显著相关(P<0.05);MRI灌注加权成像中,梗死区脑血容量降低可预测HT。此外,CT及MRI图像后处理系统RAPID提升了评估HT的效能。建议根据各急救中心的硬件及当地医疗情况,设置个性化的影像学检测方式及流程,预测及管理HT。

关键词：计算机断层摄影核磁共振成像脑梗死出血性转化

Study on the effect of electrostatic interaction on core-shell nanoparticles preparation with microemulsion technique

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Chinese Science Bulletin 2005年第24期50卷 2821-2826页

作者： HE Xiaoxiao WANG kemin TAN Weihong chen Jiyun DUAN Jinghua YUAN Yin LIN Xia State Key Laboratory of Chemo/biosensing and Chemometrics Engineering Center for Biomedicine Institute of Life Science and Biological Technology Hunan University Engineering Research Center for Bio-Nanotechnology of Hunan Province Changsha 410082 China

The routine method for preparation of silica core-shell nanoparticles (NPs) is to carry out nucleation and shell coating through the hydrolysis of silane in water in oil (W/O) microemulsion to form three-dimensional netted silica shell. We found that electrostatic interaction of the core ma- terials with shell materials would determine whether the stable core-shell silica NPs formed or not. The traditional important factors such as molecular weight of core materials or the thickness of the shell have no obvious relationship with it. And the stability of the core-shell silica NPs can be im- proved after changing the electric charge polarity by regu- lating the experiment condition of relevant materials if some core materials cannot be doped inside to form the stable core-shell silica NPs based on the traditional method, which provided experimental and theoretic foundation for prepara- tion and application of the core-shell silica NPs.

关键词：硅纳米粒子静电相互作用稳定性微乳液法

Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 315-323页

作者： Weixia Li Ruokun Li Xiangtian Zhao Xiaozhu Lin Yixing Yu Jing Zhang kemin chen Weimin Chai Fuhua Yan Department of Radiology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Department of Nuclear Medicine Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic *** study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or ***:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and *** were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and *** CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from *** CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined ***:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH.

关键词： Hepatocellular carcinoma Hepatic hemangioma Focal nodular hyperplasia Computed tomography spectral imaging Spectral curve

Structural changes in the gray matter of unmedicated patients with obsessive-compulsive disorder: a voxel-based morphometric study

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Neuroscience Bulletin 2013年第5期29卷 642-648页

作者： Ling Tan Qing Fan Chao You Jijun Wang Zhao Dong Xuemei Wang kemin chen Zeping Xiao Kaida Jiang Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine School of Pharmacy Shanghai University of Traditional Chinese Medicine

The aim of the current study was to use whole brain voxel-based morphometry（VBM）to assess the gray matter（GM）changes in unmedicated patients with obsessive-compulsive disorder（OCD）compared with normal *** compared the GM volumes in28 patients with 22 matched healthy controls using a1.5T ***-dimensional T1-weighted magnetic resonance images were obtained from all *** was performed to detect GM volume differences between the two *** detected increased regional GM volumes in the bilateral middle temporal gyri,bilateral middle occipital gyri,bilateral globus pallidus,right inferior parietal gyrus,left superior parietal gyrus,right parahippocampus,right supramarginal gyrus,right medial superior frontal gyrus,and left inferior frontal opercular cortex in the OCD patients relative to controls（P〈0.001,uncorrected,cluster size〉100 voxels）.No decreased GM volume was found in the OCD group compared with normal *** findings suggest that structural changes in the GM are not limited to fronto-striato-thalamic circuits in the pathogenesis of ***-parietal cortex may also play an important role.

关键词： obsessive-compulsive disorder magnetic resonance imaging voxel-based morphometry gray matter

Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： Yu chen Yu Guo Jiaoli Wang Ruiting Liu Xiaohai Yang kemin Wang Ying Pu Hui Shi Jin Huang Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical Research Center for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

基于功能磁共振的织物触压舒适度脑感知研究进展

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纺织学报 2017年第10期38卷 146-152页

作者：苑洁于伟东陈克敏东华大学纺织学院上海201620 东华大学纺织面料技术教育部重点实验室上海201620 上海交通大学医学院附属瑞金医院上海200025

针对织物接触人体皮肤所产生的压、挤、摩擦等作用在人体中的综合表征问题,通过对比国内外织物接触压力舒适性评价方法的优劣,并结合现代先进医学影像技术功能磁共振成像(f MRI)技术,从时空分辨率和织物感知神经环路2个方面,证明了f MR... 详细信息

针对织物接触人体皮肤所产生的压、挤、摩擦等作用在人体中的综合表征问题,通过对比国内外织物接触压力舒适性评价方法的优劣,并结合现代先进医学影像技术功能磁共振成像(f MRI)技术,从时空分辨率和织物感知神经环路2个方面,证明了f MRI大脑皮层评价对皮肤触觉真实感知可视化表达的唯一性。结合国内外相关案例,指出与舒适性有关的脑区可能位于对侧次级感觉皮层脑区,而不舒适感可能是在杏仁核区域。在可行性问题上,通过合理控制环境、人体因素、刺激时间以及引入呼气末二氧化碳回归量可将实验可信度由0.4以下成功提高至0.82。结果证明f MRI将成为纺织材料与工程领域中认知解答穿着中的接触舒适性的客观表征与机理认知的新的实践性方法。

关键词：触觉织物接触压力舒适度大脑感知功能磁共振成像

原发性高血压肾脏血流的多层螺旋CT灌注研究

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临床放射学杂志 2007年第9期26卷 891-894页

作者：王晓琰陈克敏第二军医大学附属东方肝胆外科医院放射科上海200438 上海交通大学附属瑞金医院放射科

目的利用多层螺旋CT(MSCT)灌注扫描研究原发性高血压病肾脏血流变化,探讨其在诊断高血压病早期肾损害的价值。资料与方法将原发性高血压病患者分为两组:无早期肾损害组和早期肾损害组。应用MSCT灌注扫描检查,测量血流量(BF)、血容量(BV... 详细信息

目的利用多层螺旋CT(MSCT)灌注扫描研究原发性高血压病肾脏血流变化,探讨其在诊断高血压病早期肾损害的价值。资料与方法将原发性高血压病患者分为两组:无早期肾损害组和早期肾损害组。应用MSCT灌注扫描检查,测量血流量(BF)、血容量(BV)和平均通过时间(MTT)等,并与核医学肾脏有效血浆流量(ERPF)进行比较。结果高血压组整肾、皮质和髓质的BF值均低于对照组,其中高血压有早期肾损害组下降明显,3组间差异均有统计学意义。高血压病组整肾BV下降,与正常组比较,高血压有早期肾损害组差异有统计学意义(P0.05)。高血压病组MTT延长,与正常组比较差异无统计学意义。高血压病组整肾BF与ERPF线性相关。结论MSCT可对原发性高血压病患者组织血流变化进行动态观察,早期诊断和预测高血压病肾脏损害。

关键词：原发性高血压体层摄影术,X线计算机肾灌注图