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Synapsin Polymorphisms Could Be Correlated with Stroop Simple Reaction Time Scores

American Journal of Molecular Biology 2016年第1期6卷 25-32页

作者： Ahmet Buber Burge Kabukcu Basay Omer Basay Onder Ozturk Huseyin Alacam kemal utku yazici Ali Bacanli Mustafa Ertan Ay Mehmet Emin Erdal Hasan Herken Eyup Sabri Ercan Child and Adolescent Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Child and Adolescent Psychiatry Department Firat University Medical Faculty Elazig Turkey Child and Adolescent Psychiatry Department Gaziantep Children Hospital Gaziantep Turkey Medical Biology and Genetics Department Mersin University Medical Faculty Mersin Turkey Child and Adolescent Psychiatry Department Ege University Medical Faculty Izmir Turkey

Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.

关键词： Attention Deficit Hyperactivity Disorder Synapsin III Association Cognitive Function

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Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats

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Asian pacific Journal of Reproduction 2021年第4期10卷 168-175页

作者： Sevil Kiremitli Tunay Kiremitli Umit Nayki Nesrin Yilmaz Can Turkler kemal Dinc Renad Mammadov Gulce Naz yazici Mine Gulaboglu Nihal Cetin Erzincan Binali Yildirim University Faculty of Medicine Department of Obstetrics and GynaecologyErzincanTurkey Erzincan Binali Yildirim University Faculty of Medicine Department of PharmacologyErzincanTurkey Erzincan Binali Yildirim University Faculty of Medicine Department of Histology and EmbryologyErzincanTurkey Ataturk University Faculty of Pharmacy Department of BiochemistryErzurumTurkey Selcuk University Faculty of Medicine Department of PharmacologyKonyaTurkey

Objective:To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in ***:A total of 18 female Wistar albino rats were randomly and equally divided into three groups:the sham group,the ovarian ischemia reperfusion group,and the 50 mg/kg taxifolin+ovarian ischemia reperfusion *** ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion *** and histopathologic examinations were performed on the extracted ***:Levels of malondialdehyde and cyclooxygenase-2 were increased,while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion ***,these values were reversed in the taxifolin+ovarian ischemia reperfusion ***,the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group,while they were within normal range in the taxifolin+ovarian ischemia reperfusion ***:Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury,and taxifolin may be useful for protecting ovarian tissue from such injury.

关键词： Antioxidants Ischemia-reperfusion Ovarian damage Rat Taxifolin Oxidative stress Ovarian torsion

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Effect of age on computed tomography findings:Specificity and sensitivity in coronavirus disease 2019 infection

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World Journal of Virology 2022年第5期11卷 331-340页

作者： Erdal Karavas Edhem Unver Sonay Aydın Gonul Seven Yalcin Erdem Fatihoglu Ufuk Kuyrukluyildiz Yusuf kemal Arslan Mustafa yazici Department of Radiology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Pulmonology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Anesthesiology and Reanimation Erzincan Binali Yıldırım UniversityErzincan 24100Turkey Department of Biostatistics Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Dermatology Erzincan Binali Yildirim UniversityErzincan 24100Turkey

BACKGROUND Coronavirus disease 2019(COVID-19)is a pandemic caused by the severe acute respiratory syndrome coronavirus in *** the real-time reverse transcription PCR test for viral nucleic acids is the gold standard for COVID-19 diagnosis,computed tomography(CT)has grown in *** To evaluate the sensitivity and specificity of thoracic CT findings of COVID-19 pneumonia according to age *** PCR and CT results from 411 patients were *** diagnosis of COVID-19 pneumonia was made by three ***,pericardial effusion,pleurisy,pleural thickening,pleural effusion,location features of the lesions,ground glass,consolidation,air bronchogram,vascular enlargement,bronchial dilatation,halo finding,inverted halo sign,nodularity,air bubble,subpleural band(curvilinear density),reticular density,crazy paving pattern,and fibrosis findings were *** patients were divided into nine groups by decades while calculating the sensitivity,specificity,and diagnostic efficacy for CT *** The mean age of the cases was 48.1±22.7 *** CT finding with the highest diagnostic power was ground *** enlargement and bronchial dilatation followed ground *** effusion was the finding with the lowest diagnostic *** incidence of lymphadenopathy,pleurisy,pleural thickening,peripheral localization,bilateral,ground glass,vascular enlargement,bronchial dilatation,subpleural band,reticular density,crazy paving appearance,and fibrosis all increased increase significantly with age in patients with positive real-time reverse transcription PCR *** There are few publications comparing sensitivity and specificity of thoracic CT findings according to *** cases of COVID-19 pneumonia,there is an increase in the variety and frequency of CT findings with age,and parallel to this the sensitivity and specificity of the findings ***-19 cases in the pediatric age group have fewer lung

关键词： Thoracic computerized tomography SARS-CoV-2 COVID-19 Diagnosis Pediatric age

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