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Comparison of ope. and close. hype.the.mic intrape.itone.l che.othe.apy: Re.ults from the.Unite. State. hype.the.mic intrape.itone.l che.othe.apy collaborative

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World Journal of Gastrointe.tinal Oncology 2020年第7期12卷 756-767页

作者： Je.nife. L Le.ting Jordan M Cloyd Ahme. Ahme. keith Fournie. Andre. J Le. Sophie.De.sure.ult Se.h Fe.de. Jula Ve.rapong Joe. M Baumgartne. Callisia Clarke.Harve.hp Mogal Charle. A Stale. Mohammad Y Zaidi Same.r H Pate. Sye. A Ahmad Ryan J He.drix Laura Lambe.t Danie. e.Abbott Courtne. Pokrzywa Mustafa Raoof Christophe. J LaRocca Fabian M Johnston Jonathan Gre.r Travis e.Grotz Division of He.atobiliary and Pancre.s Surge.y Mayo ClinicRochesterMN 55901United States Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States De.artme.t of Surgical Oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States De.artme.t of Gastrointe.tinal Oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical Oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical Oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States De.artme.t of Surge.y University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical Oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Pe.itone.l Surface.Malignancy Program Se.tion of Surgical Oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical Oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Christophe. La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States De.artme.t of Surge.y Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGROUND Cytore.uctive.surge.y(CRS)with hype.the.mic intrape.itone.l che.othe.apy(HIPe.)for pe.itone.l carcinomatosis can be.pe.forme. in two ways:Ope. or close. abdominal *** To e.aluate.the.impact of HIPe. me.hod on post-ope.ative.and long-te.m survival *** Patie.ts unde.going CRS with HIPe. from 2000-2017 we.e.ide.tifie. in the.Unite. State. HIPe. collaborative.***-ope.ative.re.urre.ce.and ove.all survival outcome. we.e.compare. be.we.n those.who re.e.ve. ope. vs close. *** Of the.1812 patie.ts unde.going curative.inte.t CRS and HIPe.,372(21%)patie.ts unde.we.t ope. HIPe. and 1440(79%)unde.we.t close. *** was no diffe.e.ce.in re.ope.ation or se.e.e.complications be.we.n the.two *** HIPe. had highe. rate. of 90-d re.dmission while.ope. HIPe. had a highe. rate.of 90-d *** multi-variable.analysis,close. HIPe. te.hnique.was not a significant pre.ictor for ove.all survival(hazards ratio:0.75,95%confide.ce.inte.val:0.51-1.10,P=0.14)or re.urre.ce.fre. survival(hazards ratio:1.39,95%confide.ce.inte.val:1.00-1.93,P=0.05)in the.e.tire.*** findings re.aine. consiste.t in the.appe.dice.l and the.colore.tal *** In this multi-institutional analysis,the.HIPe. me.hod was not inde.e.de.tly associate. with re.e.ant post-ope.ative.or long-te.m *** te.hnique.may be.le.t to the.discre.ion of the.ope.ating surge.n.

关键词： Mucinous appe.dice.l carcinoma Cytore.uctive.surge.y Multi-institutional

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Nucle.r Odontoge.ic Ame.oblast-Associate. Prote.n (ODAM) Corre.ate. with Me.anoma Se.tine. Lymph Node.Me.astasis

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Journal of Cance. The.apy 2013年第8期4卷 1283-1289页

作者： Sagar S. Gandhi Danie. P. Ke.tle. Charle. T. Bruke. Jame. M. McLaughlin Robe.t e. He.de. Sabina Siddiqui Jame. S. Foste. keith D. Gray John Be.l Alan Solomon Jame. Le.is De.artme.t of Pathology Boca Raton Regional Hospital Boca Raton De.artme.t of Surge.y University of Michigan School of Medicine Ann Arbor USA De.artme.t of Surge.y University of Tennessee Medical Center-Knoxville Knoxville USA Graduate.School of Me.icine University of Tennessee Medical Center-Knoxville Knoxville USA

We.have.e.amine. primary tumor se.tions from me.anoma patie.ts by immunohistochmistry (IHC) for the.pre.e.ce.of the.odontoge.ic ame.oblast-associate. prote.n (ODAM). Within the.e.patie.t tissue. we.have.obse.ve. a corre.ation of nucle.r ODAM staining in the.primary tumors with se.tine. lymph node.(SLN) me.astasis. Surgically, SLN invasion in me.anoma is conside.e. an important indicator of more.aggre.sive. invasive.me.anoma and to date.the.e.are.limite. biomarke.s which strongly corre.ate.with me.astatic dise.se. The.obse.vation that ODAM staining in me.anoma associate. with SLN invasion may have.important prognostic implications which could assist in the.manage.e.t of me.anoma. Notably, ODAM e.pre.sion may corre.ate.with pathway-signaling we.have.pre.iously re.orte. to be.affe.te. by e.topic ODAM e.pre.sion in culture. me.anoma and bre.st cance. ce.l line..

关键词： Me.anoma Se.tine. Lymph Node Me.astase. ODAM Immunohistoche.istry

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Se. diffe.e.ce. in cognitive.impairme.t in Alzhe.me.'s dise.se

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World Journal of Psychiatry 2016年第1期6卷 54-65页

作者： keith R Laws Kare. Irvine.Tim M Gale School of Life.and Me.ical Scie.ce. University of Hertfordshire He.tfordshire.Partne.ship Unive.sity NHS Foundation Trust

Se. diffe.e.ce. in ne.rocognitive.abilitie. have.be.n e.te.sive.y e.plore. both in the.he.lthy population andin many disorde.s. Until re.e.tly, howe.e., little.work has e.amine. such diffe.e.ce. in pe.ple.with Alzhe.me.'s dise.se.AD). This is de.pite.cle.r e.ide.ce.that AD is more.pre.ale.t in wome., and conve.ging line. of e.ide.ce.from brain imaging, post-morte. analyse., hormone.the.apy and ge.e.ics sugge.ting that AD affe.ts me. and wome. diffe.e.tly. We.provide.an ove.vie. of e.ide.ce.atte.ting to the.poore. cognitive.profile. in wome. than in me. at the.same.stage.of AD. Inde.d, me. significantly outpe.form wome. in se.e.al cognitive.domains, including: Language.and se.antic abilitie., visuospatial abilitie. and e.isodic me.ory. The.e.diffe.e.ce. do not appe.r to be.attributable.to any diffe.e.ce. in age. e.ucation, or de.e.tia se.e.ity. Re.sons posite. for this fe.ale.disadvantage.include.a re.uction of e.troge. in postme.opausal wome., gre.te. cognitive.re.e.ve.in me., and the.influe.ce.of the.apolipoprote.n e.ε4 alle.e. Asse.sme.t of cognitive.abilitie. contribute. to the.diagnosis of the.condition and thus, it is crucial to ide.tify the.role.of se. diffe.e.ce. if pote.tially more.accurate.diagnose. and tre.tme.ts are.to e.e.ge.

关键词： De.e.tia Ge.de. Se. diffe.e.ce. Cognition

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High school sports programs diffe.e.tially impact participation by se.

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Journal of Sport and He.lth Scie.ce 2015年第3期4卷 282-288页

作者： keith M. Drake.Me.han R. Longacre.Todd MacKe.zie.Linda J. Titus Michae. L. Be.ch Andre. G. Rundle.Made.ine.A. Dalton Hood Ce.te. for Childre. and Familie. Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA De.artme.t of Pe.iatrics Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA De.artme.t of Community and Family Me.icine Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA De.artme.t of Me.icine Dartmouth-Hitchcock Medical Center Lebanon NH 03756 USA De.artme.t of Ane.the.iology Dartmouth--Hitcheock Medical Center Lebanon NH 03756 USA De.artme.t of e.ide.iology Mailman School of Public Health Columbia University New York NY 10032 USA

背景:研究表明,参加体育活动可降低儿童和青少年肥胖的风险。学校是促进儿童和青少年参加体育活动的理想环境,但目前尚不清楚体育活动的"获得"和"选择"如何影响学生的参与度,也不清楚学校体育课的特点对学生参与体育的影响是否存在性别... 详细信息

背景:研究表明,参加体育活动可降低儿童和青少年肥胖的风险。学校是促进儿童和青少年参加体育活动的理想环境,但目前尚不清楚体育活动的"获得"和"选择"如何影响学生的参与度,也不清楚学校体育课的特点对学生参与体育的影响是否存在性别差异。本研究旨在评价高中体育运动项目的特点,并确定这些体育课程对男女生参与运动队的影响程度。方法:用电话采访的方式纵向调查了1,244名新罕布什尔州和佛蒙特州的学生。学生自述他们小学至高中阶段参与运动队的情况。通过调查高中职员了解体育机会。在本研究中,"体育机会"是指每100名学生所对应的学校提供的体育项目种类《选择)和学校提供的体育种类中不限制参加人数的体育项目的比例(获得)。结果:约70%的儿童参加了至少一个体育运动队,男生为73%,女生为66%。研究发现在性别和两个体育机会变量之间存在显著交互影响。控制小学生参与体育活动和其他协变量后,发现如果学校不限制最受欢迎的体育项目的参与人数,男生会参加更多的体育运动队(RR=1.12,p<0.01)。相反,如果学校提供广泛的体育项目,女生会参加更多的体育运动队(RR=1 47,p<0.001)。结论:前人研究表明,参加体育活动能带来许多健康效益。对公共卫生工作包括预防肥胖而言,学校体育课可能是一个重要而有效但未被充分利用的对象。要使青少年参加更多的体育活动,就应综合考虑学校体育项目的获得和选择。学校可运用不同策略,促使男生和女生更多地参加体育活动。

关键词：体育节目高中差异性体育运动体育项目体育活动工作人员公共卫生

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油锯噪音的现代研究

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国外林业 1987年第4期 52-54页

作者： S.e.keith 许其春

由一些锯和锯链制造商、森林工业协会和加拿大林业部门发起的油锯噪声研究计划始于1983年7月1日,其目的如下: 1、对油锯切削木材时传到操作者耳旁的最大噪声源进行确定和分级; 2、与制造商合作对选定的油锯进行研

关键词：油锯模拟手制造商链锯排气噪声噪声源试验台试验设备计权声级声级测功计力学测试仪器剩余噪声锯链

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Se.f-Diffusion of Fluids Confine. in Orde.e. and Disorde.e. Microporous Carbons

Self-Diffusion of Fluids Confined in Ordered and Disordered ...

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第十届全国计算(机)化学学术会议

作者： Joshua D.Moore.Je.e.y C.Palme. Thomas J.Rousse. keith e.Gubbins Institute.for Computational Scie.ce.& e.gine.ring and De.artme.t of Che.ical and Biomole.ular e.gine.ring North Carolina State UniversityRaleighNC 27695 U.S.A Institut de.Cie.cia de.Mate.ials Consejo Superior de Investigaciones CientificasCampus de la UAB 08193 BellaterraBarcelonaSpain

Microporous carbons have.found nume.ous applications in the.are.s of che.istry, che.ical e.gine.ring and mate.ials scie.ce.due.to the.r pote.tial for use.in se.aration and storage.of *** activate. carbons are.an e.ample.of a disorde.e. microporous *** have.found wide.pre.d use.in industry due.to the.r low production cost and high adsorption *** Co.’s bituminous coal-base. carbon(BPL) is among the.most wide.y studie. and has be.n use. e.te.sive.y in e.vironme.tal applications as an adsorbe.t for the.re.oval of toxic and odorous industrial *** the.Hybrid Re.e.se.Monte.Carlo me.hod,Palme. e. *** re.e.tly de.e.ope. a morphologically re.listic mode. of BPL,that succe.sfully pre.icts the.adsorptive.prope.tie. of the.re.l mate.ial. A se.ond class of mate.ials which has had re.e.t inte.e.t are.carbon te.plate. of silica mate.ials such as MCM-41,SBA-15 or various *** type.of mate.ial is inhe.e.tly highly orde.e..A carbon re.lica of the.ze.lite.Faujasite.C-FAU) has shown pote.tial application in the.are.s of hydroge. storage.and in the.de.e.opme.t of hydroge. fue. ce.ls. Using a mime.ic Grand Canonical Monte.Carlo te.plating proce.s,Rousse. e. *** mode.e. C-FAU and compare. its structural and adsorptive.prope.tie. with e.pe.ime.t. Using microcanonical mole.ular dynamics simulations,we.compare.the.se.f-diffusion of fluids confine. in the.mode. BPL and C-FAU and show that the.microporous fe.ture. of the.mate.ials le.d to multi-modal diffusion *** also compare.to the.diffusion of fluids in a carbon nanotube.CNT) bundle.which has distinct bimodal diffusion,with Fickian diffusion occurring inside.the.CNTs and single.file.diffusion occurring in *** show that the.diffusion of fluids in the.orde.e.(C-FAU) and disorde.e.(BPL) microprous carbons posse.s both slowe.(quasi-single.file. and faste.(Fickian) diffusion mode..

关键词： bituminous coal-base. carbon BPL bimodal diffusion carbon re.lica Faujasite carbon nanotube.bundle single.file.diffusion Fickian diffusion

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急倾斜层状矿床下盘边坡稳定性分析的计算机程序

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露天采矿技术 1987年第4期 35-36+26页

作者： Brian Stimpson,keith e.Robinson,王天金北京钢铁学院加拿大加拿大研究生

引言如图1所示,在倾斜的沉积岩层中,边坡可能沿沉积面和不连续面或软弱夹层滑动而破坏。这种破坏模式可以称为“双线性” 破坏,因为破坏面是两个线性或近似线性的平面。这种类型的破坏称为加拿大阿尔白塔著名的弗朗克滑坡(由Crude...

引言如图1所示,在倾斜的沉积岩层中,边坡可能沿沉积面和不连续面或软弱夹层滑动而破坏。这种破坏模式可以称为“双线性” 破坏,因为破坏面是两个线性或近似线性的平面。这种类型的破坏称为加拿大阿尔白塔著名的弗朗克滑坡(由Crude. and Krahn 在1973年提出)。在这次滑坡中大约90Mt (8.97×10～5MN)的岩石从泰特山滑下, 埋没了弗朗克镇。由于露天矿深度的增加以及公路通道穿过倾斜岩层,这种破坏模式也

关键词：计算机程序边坡水压分布楔体

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The.pote.tial of a ye.r-round school cale.dar for maintaining childre.’s we.ght status and fitne.s:Pre.iminary outcome. from a natural e.pe.ime.t

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Journal of Sport and He.lth Scie.ce 2020年第1期9卷 18-27,102页

作者： r.gle.n we.ve. e.han hunt aaron raffe.ty michae. w.be.ts keith braze.dale.gabrie.le.tume.-mcgrie.y russe.l r.pate.albe.to mayde.-olivare. brian sae.e.s shawn youngste.t Se.artme.t of e.e.cise.scie.ce university of south carolinacolumbiasc 29208usa De.artme.t of he.lth promotion educationand behavioruniversity of south carolinacolumbiasc 29208usa De.artme.t of psychology university of south carolinacolumbiasc 29208usa Ce.te. for child he.lth be.avior and de.e.opme.t seattle children's hospitalseattlewa 98105usa De.artme.t of nursing and he.lth innovation arizona state universitytempeaz 85281usa

Purpose. To e.aluate.the.pote.tial of a ye.r-round school cale.dar (180-day school ye.r distribute. across 12 months) as an inte.ve.tion compare.to a traditional school cale.dar (180-day school ye.r distribute. across 9 months) for mitigating childre.'s we.ght gain and fitne.s loss viaa natural ***. He.ght, we.ght, and cardiore.piratory fitne.s (CRF) (i.e., Fitne.sgram Progre.sive.Ae.obic Cardiovascular e.durance.Run) we.e.me.sure. inchildre. (5—12 ye.rs old) in 3 schools (2 traditional, 1 ye.r-round, n = 990 stude.ts, age.= 8.6 土 2.4 ye.rs, 53.1% male. 68.9% African Ame.ican) from1 school district. Structure.(re.re.e.te. by the.pre.e.ce.of a school day) was the.inde.e.de.t variable. Change. in body mass inde. (BMI), age. andse.-spe.ific BMI z-score. (zBMI), BMI pe.ce.tile. pe.ce.t of ove.we.ght or obe.e.childre., and CRF (Progre.sive.Ae.obic Cardiovascular e.durance.un laps comple.e.) we.e.asse.se. for summe. 2017 (May—August 2017), school ye.r 2017/2018 (August 2017—May 2018), and summe. 2018(May—August 2018). Primary analyse. e.amine. the.ove.all change.in we.ght and CRF from summe. 2017 until summe. 2018 via multile.e. mixe.e.fe.ts re.re.sion, with group (traditional vs. ye.r-round cale.dar), time. and a group-by-time.inte.action as the.inde.e.de.t variable.. Se.ondaryre.re.sion analyse. e.timate. diffe.e.ce. in change.within and be.we.n groups during e.ch time.pe.iod, ***. Ye.r-round stude.ts gaine. le.s BMI (diffe.e.ce.in A = —0.44, 95% confide.ce.inte.val (CI): —0.67 to —0.03) and le.s CRF (diffe.e.ce.n △ = — 1.92, 95%CI: —3.56 to —0.28) than stude.ts atte.ding a traditional school ove.all. Compare. with traditional stude.ts, during both sum・me.s, ye.r-round stude.ts gaine. le.s BMI (summe. 2017 diffe.e.ce.in A = —0.15, 95%CI: —0.21 to —0.08;summe. 2018 diffe.e.ce.in△ = —0.16, 95%CI: —0.24 to —0.07) and zBMI (summe. 2017 diffe.e.ce.in A = —0.032, 95%CI: —0.050 to —0.010;summe. 2018 diffe.e.ce.in△ = —0.033, 95%CI: —0.056 to —0.009

关键词： Childre. Inte.ve.tion Obe.ity Ove.we.ght Policy School cale.dar

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JnCML-like.lt;/i>, an e.-hand motif-containing ge.e.se.sonally upre.ulate. in the.transition zone.of black walnut (Juglans nigraL.)

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Ame.ican Journal of Mole.ular Biology 2011年第3期1卷 140-155页

作者： Zhonglian Huang Priyanka Surana Daisuke.Kihara Richard Me.lan keith Woe.te 不详

The.e.onomic value.of a black walnut (Juglans nigra L.) tre. is strongly de.e.mine. by the.quality and quantity of darkly colore. he.rtwood in its ste.. To unde.stand the.re.ulation of he.rtwood formation, we.analyze. the.re.ion of he.rtwood formation in walnut ste.s (i.e., the.transition zone. TZ) for the.e.pre.sion of 80 e.Ts. Se.i-quantitative.RT-PCR and re.l-time.PCR was pe.forme. to de.e.t e.pre.sion change. of candidate.ge.e. in the.TZ and sapwood of tre.s harve.te. in summe. and fall. Re.ults re.e.le. that the.transcript of a clone.containing two pre.ume. e.-hand motifs was e.pre.se. at highe. le.e.s in the.TZ than in othe. xyle. tissue.. Analysis of the.full-le.gth coding se.ue.ce.re.e.le. that the.black walnut ge.e.JnCML-like.is similar to grancalcin-like.calcium-binding e. hand prote.ns in Arabidopsis thaliana (At3g10300) and Ze. mays (NM 001153810). A mode. of the.pre.icte. structure.of JnCML-like.showe. it is similar to grancalcin and m-calpain, pe.ta-e.-hand family prote.ns associate. with ce.l prolife.ation, diffe.e.tiation and programme. ce.l de.th. JnCML-like.transcript was de.e.te. in tissue.from the.re.ion of the.pith me.iste., and in roots, e.bryoge.ic callus, vascular cambium, fe.ale.flowe.s, male.flowe.s, gre.n le.ve., and partially and fully se.e.ce.t le.ve. of black walnut, although transcript abundance.varie. conside.ably among the.e.tissue..

关键词： Transition Zone M-Calpain Juglans Nigra Grancalcin

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SAHA atte.uate. Takotsubo-like.myocardial injury by targe.ing an e.ige.e.ic Ac/Dc axis

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Signal Transduction and Targe.e. The.apy 2021年第5期6卷 1429-1432页

作者： Ishant Khurana Scott Maxwe.l Simon Royce.Prabhu Mathiyalagan Tom Karagiannis Nadia Mazarakis Jitraporn Vongsvivut Harikrishnan K.N. Jun Okabe.keith Al-Hasani Chrishan Samue. Assam e.-Osta Human e.ige.e.ics Program Department of DiabetesCentral Clinical SchoolMonash UniversityMelbourneVICAustralia Cardiovascular Dise.se.Program Monash Biomedicine Discovery Institute and Department of PharmacologyMonash UniversityClaytonVICAustralia Infrare. Microspe.troscopy Be.mline ANSTO-Australian SynchrotronClaytonVICAustralia De.artme.t of Me.icine.and The.ape.tics The Chinese University of Hong Kong(CUHK)Hong Kong SARHong Kong Institute of Diabetes and ObesityCUHKHong Kong SARPrince of Wales HospitalLi Ka Shing Institute of Health SciencesCUHKShatinHong KongChina Unive.sity Colle.e.Cope.hage. Faculty of HealthDepartment of TechnologyBiomedical Laboratory ScienceCopenhagenDenmark

De.r e.itor,Takotsubo syndrome.TS)is a stre.s-induce. non-ischae.ic cardiomyopathy that is more.common in wome.,but is associate. with highe. morbidity and mortality in *** known as broke.-he.rt syndrome.TS is characte.ise. by transie.t le.t ve.tricular(LV)dysfunction inde.e.de.t of obstructive.coronary arte.y *** is a polyge.ic condition and nowhe.e.is this more.e.ide.t than the.use.of positive.inotrope.,such as isopre.aline.ISO)in pre.clinical mode.s.1 The.e.is no standard the.apy for broke.-he.rt syndrome.be.ause.the.me.hanisms unde.lying the.condition re.ain ***,the.e.is no conse.sus on pre.isposition for Takotsubo2 and our goal was to be.te. unde.stand the.re.ulatory me.hanism as a first ste. towards improve. tre.tme.t *** acid or SAHA,a drug approve. for cance. tre.tme.t by the.US Food and Drug Administration has pre.iously be.n shown to improve.cardiopulmonary function.3 We.te.te. the.hypothe.is that the.cardioprote.tive.be.e.it of SAHA in a pre.clinical mode. of Takotsubo is confe.re. by an e.ige.e.ic ace.ylation/de.ce.ylation(Ac/Dc)axis.

关键词： SAHA Takotsubo prote.tive

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