SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis
作者机构：Human Epigenetics ProgramDepartment of DiabetesCentral Clinical SchoolMonash UniversityMelbourneVICAustralia Cardiovascular Disease ProgramMonash Biomedicine Discovery Institute and Department of PharmacologyMonash UniversityClaytonVICAustralia Infrared Microspectroscopy BeamlineANSTO-Australian SynchrotronClaytonVICAustralia Department of Medicine and TherapeuticsThe Chinese University of Hong Kong(CUHK)Hong Kong SARHong Kong Institute of Diabetes and ObesityCUHKHong Kong SARPrince of Wales HospitalLi Ka Shing Institute of Health SciencesCUHKShatinHong KongChina University College CopenhagenFaculty of HealthDepartment of TechnologyBiomedical Laboratory ScienceCopenhagenDenmark
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第5期
页 面：1429-1432页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：A.E-O.dedicates this article to his late grandmother.Professor Sam El-Osta is a National Health and Medical Research Council(NHMRC)Senior Research Fellow(1154650) Funded by NSFC(81561128017)and NHMRC(1113188)International Joint Programme
主 题：SAHA Takotsubo protective
摘 要：Dear Editor,Takotsubo syndrome(TS)is a stress-induced non-ischaemic cardiomyopathy that is more common in women,but is associated with higher morbidity and mortality in *** known as broken-heart syndrome,TS is characterised by transient left ventricular(LV)dysfunction independent of obstructive coronary artery *** is a polygenic condition and nowhere is this more evident than the use of positive inotropes,such as isoprenaline(ISO)in pre-clinical models.1 There is no standard therapy for broken-heart syndrome because the mechanisms underlying the condition remain ***,there is no consensus on predisposition for Takotsubo2 and our goal was to better understand the regulatory mechanism as a first step towards improved treatment *** acid or SAHA,a drug approved for cancer treatment by the US Food and Drug Administration has previously been shown to improve cardiopulmonary function.3 We tested the hypothesis that the cardioprotective benefit of SAHA in a pre-clinical model of Takotsubo is conferred by an epigenetic acetylation/deacetylation(Ac/Dc)axis.
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