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Symptom pre.e.tation and e.olution in the.first 48 hours afte. injury are.associate. with re.urn to play afte. concussion in e.ite.Rugby Union

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Journal of Sport and He.lth Scie.ce 2024年第3期13卷 387-397页

作者： Ross Tucke. Matt Cross keith Stoke. Lindsay Starling Rosy Hyman Simon Ke.p Ste.he. We.t Martin Rafte.y e.nna Falve. Jame. Brown Institute.of Sport and e.e.cise.Me.icine.ISe.) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Pre.ie.ship Rugby London SW1V 1PXUK Ce.tre.for He.lth and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Ce.tre.on Injury and Illne.s Pre.e.tion in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Me.icine London WC1E 7HTUK Sport Injury Pre.e.tion Re.e.rch Ce.tre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada De.artme.t of Me.icine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carne.ie.Applie. Rugby Re.e.rch(CARR)ce.tre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Re.urn to play(RTP)in e.ite.rugby is manage. using a 6-stage.graduate. RTP protocol,which can re.ult in cle.rance.to play within 1 we.k of *** aime. to e.plore.how symptom,cognitive.and balance.pre.e.tation and e.olution during concussion scre.ns 2 h(he.d injury asse.sme.t(HIA2)and 48 h(HIA3)afte. injury we.e.associate. with time.to RTP)to ide.tify whe.he. a more.conse.vative.graduate. RTP may be.***:A re.rospe.tive.cohort study was conducte. in 380 concusse. rugby playe.s from e.ite.me.’s rugby ove. 3 conse.utive.*** we.e.classifie. as shorte. or longe. re.urns,de.e.ding on whe.he. RTP occurre. within 7 days(allowing the. to be.conside.e. to play the.match 1 we.k afte. injury)or longe. than 8 days,***,cognitive.and balance.pe.formance.during scre.ns was asse.se. re.ative.to base.ine.normal or abnormal)and to the.pre.e.ing scre.n(improving or worse.ing).Associations be.we.n sub-te.t abnormalitie. and RTP time.we.e.e.plore. using odds ratios(OR,longe. ***).Me.ian day abse.ce.was compare. be.we.n playe.s with abnormal or worse.ing re.ults and those.whose.re.ults we.e.normal or ***:Abnormal symptom re.ults during scre.ns 2 h and 48 h afte. concussion we.e.associate. with longe. re.urn time.HIA2:OR=2.21,95%confide.ce.inte.val(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worse.ing symptom numbe. or se.e.ity from the.time.of injury to 2 h and 48 h post-injury was associate. with longe. re.urn(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Me.ian days abse.ce.was gre.te. in playe.s with abnormal symptom re.ults at both HIA2 and *** and balance.pe.formance.we.e.not associate. with longe. re.urn and did not affe.t me.ian days ***:Symptom pre.e.tation and e.olution within 48 h of concussion we.e.associate. with longe. RTP *** may guide.a more.conse.vative.approach to RTP,while.still adhe.ing to individualize. concussion manage.e.t principle..

关键词： Brain injury Concussion manage.e.t Ge.e.al re.urn to play Me.ical manage.e.t

e.H2 inhibitors promote.β-like.ce.l re.e.e.ation in young and adult type.1 diabe.e. donors

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Signal Transduction and Targe.e. The.apy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwe.l Jun Okabe.Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam e.-Osta e.ige.e.ics in Human He.lth and Dise.se.Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia De.artme.t of Diabe.e. Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia e.ige.e.ics in Human He.lth and Dise.se.Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Scie.ce STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabe.e. Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia De.artme.t of Me.icine.and The.ape.tics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute.of Diabe.e. and Obe.ity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute.of He.lth Scie.ce. The Chinese University of Hong KongSha TinHong Kong SAR Biome.ical Laboratory Scie.ce Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-ce.ls are.a type.of e.docrine.ce.l found in pancre.tic isle.s that synthe.ize.store.and re.e.se.*** type.1 diabe.e.(T1D),T-ce.ls of the.immune.syste. se.e.tive.y de.troy the.insulin-producingβ-*** of the.e.ce.ls le.ds to a life.ong de.e.de.ce.on e.oge.ous insulin administration for ***,the.e.is an urge.t ne.d to ide.tify nove. the.apie. that stimulate.-ce.l growth and induce.-ce.l *** and othe.s have.shown that pancre.tic ductal proge.itor ce.ls are.a promising source.for re.e.e.atingβ-ce.ls for T1D owing to the.r inhe.e.t diffe.e.tiation *** transcriptional suppre.sion is re.ractory to e.ocrine.re.ction and tightly controls the.re.e.e.ative.pote.tial by the.e.H2 *** the.pre.e.t study,we.show that transie.t stimulation of e.ocrine.ce.ls,de.ive. from juve.ile.and adult T1D donors to the.FDAapprove. e.H2 inhibitors GSK126 and Taze.e.ostat(Taz)influe.ce.a phe.otypic shift towards aβ-like.ce.l *** transition from re.re.se. to pe.missive.chromatin state. are.de.e.de.t on bivale.t H3K27me. and H3K4me. chromatin *** e.H2 is fundame.tal toβ-ce.l re.e.e.ative.*** pancre.tic ductal ce.ls e.hibit insulin production and se.re.ion in re.ponse.to a physiological glucose.challe.ge.e. *** pre.clinical studie. unde.score.the.pote.tial of small mole.ule.inhibitors as nove. modulators of ductal proge.itor diffe.e.tiation and a promising ne. approach for the.re.toration ofβ-like.ce.l function.

关键词： e.H2 struction inhibitors

SIMAP500: A nove. risk score.to ide.tify re.ipie.ts at highe. risk of he.atoce.lular carcinoma re.urre.ce.following live. transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Ne.isa Zake.i Konstantinos Koilias Rose.ary e.Faulke. Rache. Brown Owe. Cain M Thamara P R Pe.e.a keith J Robe.ts Re.e.a Sanabria-Mate.s David C Bartle.t Yuk Ting Ma Shivan Sivakumar Shishir She.ty Tahir Shah Bobby V M Dasari De.artme.t of HBP and Live. Transplantation Surge.y Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Ce.tre.for Live. Re.e.rch Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom De.artme.t of He.atology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom De.artme.t of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom De.artme.t of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Re.urre.ce.of he.atoce.lular carcinoma(HCC)following live. transplantation(LT)has a de.astating influe.ce.on re.ipie.ts’survival;howe.e.,the.risk of re.ur-re.ce.is not routine.y *** stratification is vital with a long LT waiting time.as that could influe.ce.the.re.urre.ce.de.pite.strict listing *** This study aims to ide.tify pre.ictors of re.urre.ce.and de.e.op a nove. risk pre.diction score.to fore.ast HCC re.urre.ce.following *** A re.rospe.tive.re.ie. of LT for HCC re.ipie.ts at Unive.sity Hospitals Bir-mingham be.we.n July 2011 and Fe.ruary *** and multivariate.analyse. we.e.pe.forme. to ide.tify re.urre.ce.pre.ictors,base. on which the.nove. SIMAP500(sate.lite.nodule.,incre.se.in size.microvascular invasion,AFP>500,poor diffe.e.tiation)risk score.was *** 234 LTs for HCC we.e.pe.forme. with a me.ian follow-up of 5.3 *** de.e.ope. in 25 patie.ts(10.7%).On univariate.analyse.,Re.Re.T score.3,α-fe.oprote.n(AFP)at listing 100-500 and>500,bridging,incre.se. tumour size.be.we.n imaging at the.listing time.and e.plant histology,incre.se.in the.size.of viable.tumour be.we.n listing and e.plant,pre.e.ce.of sate.lite.nodule.,micro-and macrovascular invasion on e.plant and poor diffe.e.tiation of tumours we.e.significantly associate. with re.urre.ce.base. on which,the.SIMAP500 risk score.is *** SIMAP500 de.onstrate. an e.ce.le.t pre.ictive.ability(c-inde.=0.803)and outpe.-forme. the.Re.Re.T score.c-inde.=0.73).SIMAP500 is indicative.of the.time.to dise.se.*** SIMAP500 risk score.ide.tifie. the.LT re.ipie.ts at risk of HCC *** stratification allows patie.t-ce.tric post-transplant surve.llance.*** validation of the.score.is re.omme.de..

关键词： Live. transplantation He.atoce.lular carcinoma Re.urre.ce Survival

Surface.Drive. High-Pre.sure.Proce.sing

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e.gine.ring 2018年第3期4卷 311-320页

作者： keith e. Gubbins Kai Gu Liangliang Huang Yun Long J. Matthe. Manse.l e.ik e. Santiso Kaihang Shi Malgorzata Sliwifiska-Bartkowiak De.pti Srivastava De.artme.t of Che.ical and Biomole.ular e.gine.ring North Carolina State University Raleigh NC 27695-7905 USA De.artme.t of Che.istry Zhejiang University Hangzhou 310027 China School of Che.ical Biological and Materials Engineering The University of Oklahoma Norman OK 73019 USA De.artme.t of Che.ical and Biomole.ular e.gine.ring National University of Singapore Singapore 117585 Singapore Faculty of Physics Adam Mickiewicz University in Poznan Poznaan 61-614 Poland

许多化学过程都要在高压下进行,因为高压状态能提高产率,加快化学反应的速率,在分离过程中提高溶剂的溶解率,并通过增加分子能量和分子碰撞率来克服活化作用的障碍。在实验室中可以通过使用金刚石砧室使压力达到数百万巴(1 bar=1×10~5P... 详细信息

许多化学过程都要在高压下进行,因为高压状态能提高产率,加快化学反应的速率,在分离过程中提高溶剂的溶解率,并通过增加分子能量和分子碰撞率来克服活化作用的障碍。在实验室中可以通过使用金刚石砧室使压力达到数百万巴(1 bar=1×10~5Pa),因此为利用热力学、输运和电子性质来进行化学合成以及新材料的合成提供了新的途径。然而,在工业规模上,高压工艺目前正受到成本压缩和材料有限的约束,因此很少有工业过程能够在压力超过25 MPa的情况下进行。本文提出了一种高压工艺的替代方法,即利用来自固体底物的表面驱动的相互作用产生极高的局部压力。近期的实验和分子模拟表明,这种相互作用可以产生高达数万巴的局部压力,在某些情况下甚至可以达到数百万巴。由于活跃的高压区域分布不均匀,压力在不同方向上存在差异。在许多情况下,增大最多的是平行于底物表面的压力(切向压力)。这种压力是施加在要加工的分子上的,而不是施加在固体底物或容器上。本文综述了现阶段对这种增压的认识,并讨论了一种基于表面驱动力的可行方法来达到高压处理的效果。与传统的整体相位工艺相比,这种表面驱动高压工艺能达到更高的压力,因为它不需要机械压缩。此外,处理过程中没有对容器施加更大的压力,因此不用担心材料受损。

关键词：限制高压高压相高压反应高压制造高压化学工艺

Se.arations of Me.al Ions Using Ionic Liquids: The.Challe.ge. of Multiple.Me.hanisms

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Tsinghua Scie.ce.and Te.hnology 2006年第2期11卷 188-193页

作者： Violina A. Cocalia John D. Holbre. keith e. Gutowski Nicholas J. Bridge. Robin D. Roge.s De.artme.t of Che.istry and Ce.te. for Gre.n Manufacturing The University of Alabama Tuscaloosa AL 35487 USA

Ionic liquids are.a distinct sub-se. of liquids, comprising only of cations and anions, ofte. with ne.ligible.vapor pre.sure. As a re.ult of the.low or non-volatility of the.e.fluids, ionic liquids are.ofte. conside.e. in liquid/liquid se.aration sche.e. whe.e.the.goal is to re.lace.volatile.organic solve.ts. Unfortunate.y, it is ofte. not ye. re.ognize. that the.ionic nature.of the.e.solve.ts can re.ult in a varie.y of e.traction me.hanisms, including solve.t ion-pair e.traction, ion e.change. and simultane.us combinations of the.e. This pape. discusse. curre.t ionic liquid-base. se.arations re.e.rch whe.e.the.e.fe.ts of the.nature.of the.solve.t ions, ligands, and me.al ion spe.ie. we.e.studie. in orde. to be.able.to unde.stand the.nature.of the.challe.ge. in utilizing ionic liquids for practical applications.

关键词： me.al ion liquid-liquid se.aration ionic liquid solve.t e.traction

Cloud computing for inte.rate. stochastic groundwate. unce.tainty analysis

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Inte.national Journal of Digital e.rth 2013年第4期6卷 313-337页

作者： Yong Liu Ale.ande. Y.Sun keith Ne.son We.le. e.Hipke National Ce.te. for Supe.computing Applications University of Illinois at Urbana-ChampaignUrbanaILUSA Bure.u of e.onomic Ge.logy University of Texas at AustinAustinTXUSA Arizona De.artme.t of Wate. Re.ource. PhoenixAZUSA

One.of the.major scie.tific challe.ge. and socie.al conce.ns is to make.informe. de.isions to e.sure.sustainable.groundwate. availability whe. facing de.p unce.taintie..A major computational re.uire.e.t associate. with this is on-de.and computing for risk analysis to support time.y *** pape. pre.e.ts a scie.tific mode.ing se.vice.calle.‘ModflowOnAzure.which e.able. large.scale.e.se.ble.runs of groundwate. flow mode.s to be.e.sily e.e.ute. in paralle. in the.Windows Azure.*** te.hnical issue. we.e.addre.se.,including the.conjunctive.use.of de.ktop tools in MATLAB to avoid lice.se.issue. in the.cloud,inte.ration of Dropbox with Azure.for improve. usability and‘Drop-and-Compute.’and automate. file.e.change. be.we.n de.ktop and the.*** scie.tific use.case. are.pre.e.te. in this pape. using this se.vice.with significant computational *** case.is from Arizona,whe.e.six plausible.alte.native.conce.tual mode.s and a stre.mflow stochastic mode. are.use. to e.aluate.the.impacts of diffe.e.t groundwate. pumping *** case.is from Te.as,whe.e.a global se.sitivity analysis is pe.forme. on a re.ional groundwate. availability *** of both case. show informe. unce.tainty analysis re.ults that can be.use. to assist the.groundwate. planning and sustainability study.

关键词： MODFLOW groundwate.sustainability unce.taintyanalysis global se.sitivity analysis cloudcomputing WindowsAzure Dropbox alte.native.conce.tual mode. cybe.infrastructure e.cie.ce

Association of Acid-Base.Balance.in the.Re.al Proximal Tubule.and Blood Pre.sure.Alte.ations: Pote.tial Role.of Local Me.iators

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Journal of Bioscie.ce. and Me.icine. 2020年第4期8卷 26-44页

作者： Dine.h Aryal keith e. Jackson School of Basic Pharmace.tical and Toxicological Scie.ce. College of Pharmacy University of Louisiana at Monroe Monroe LA USA

Disturbance. in acid-base.balance.le.ding to the.de.e.opme.t of hype.te.sion are.curre.tly gaining incre.se. atte.tion among re.e.rche.s. Pe.turb acid-base.balance.characte.ize. by me.abolic acidosis has be.n de.onstrate. in hype.te.sive.animals and humans. Re.e.rch sugge.ts that acid-base.change. are.not only the.conse.ue.ce. of e.e.ate. blood pre.sure.but can pre.e.e.the.de.e.opme.t of hype.te.sion. Howe.e., no e.act me.hanism has be.n ide.tifie. to link acid-base.imbalance.with alte.ations in blood pre.sure. The.kidne. proximal tubule.is the.major site.for maintaining normal bicarbonate.conce.trations which is an important compone.t of acid-base.balance. Acid-base.transporte. prote.ns in the.re.al proximal tubule.such as Na+/HCO-3?cotransporte.s, Na+/H+ e.change.s, and anion-e.change.s play important role. in controlling acid se.re.ion, ammonia production and bicarbonate.re.bsorption for maintaining acid-base.balance. It is we.l known that sodium re.e.tion in the.re.al tubule. le.ds to incre.se.in blood volume.and conse.ue.tly incre.se. in blood pre.sure. The.e.ore. it is the.purpose.of this re.ie. to discuss the.role.of sodium-couple. acid-base.transporte.s in re.ulating proximal tubular sodium re.e.tion and controlling blood pre.sure.home.stasis. We.will also focus on the.capacity of local me.iators;angiote.sin II, cortisol, prosta-glandin and aldoste.one. to re.ulate.acid-base.and blood pre.sure.home.stasis.

关键词： Acid-Base Transporte.s Hype.te.sion Proximal Tubule Angiote.sin II

De.pe.ing e.change. and Mutual Le.rning Among Civilizations

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China Today 2023年第11期72卷 45-47页

作者： keith Be.Ne.T Frie.ds of Socialist China base. in London

HUMANITY has a history of civilization dating back *** civilizations arose.and de.e.ope. on die.e.t conti-ne.ts and at die.e.t time.,the. pros-pe.e. and innovate. through mutual e.change. and mutual le.rning.e.ancie...

关键词： mutual dating De.p

e.fe.ts of gibbe.e.lin A_(4/7), 6-be.zylaminopurine.and chlorme.uat chloride.on the.numbe. of male.and fe.ale.strobili and immature.cone. in Chine.e.Pine.(Pinus tabuliformis) with foliar sprays

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Journal of Fore.try Re.e.rch 2011年第3期22卷 353-359页

作者： ZHAO Pe.g keith e. Woe.te.ZHANG Shuo-xin YANG Pe.hua FAN Jun-fe.g HUANG Zhong-lian MA Zhe.-hua Colle.e.of Fore.try Northwest A＆F University Yangling Shaanxi 712100 P. R. China USDA Fore.t Se.vice Hardwood Tree Improvement and Re-generation Center Department of Forestry and Natural Resources PurdueUniversity 715 West State Street West Lafayette IN 47907 USA. QinlingNational Fore.t e.osyste. Re.e.rch Station Ningshan Shaanxi 711600 P. R. China Donald Danforth Plant Scie.ce.Ce.te. St. Louis MO 63132 USA Northwe.t Fore.try e.ploring Institute.of China State.Fore.try Administra-tion Xi＇an Shaanxi 710048 P. R. China

Thre. kinds of plant growth re.ulators, gibbe.e.linA 4/7 （GA 4/7 ）, 6-be.zylaminopurine.（BA）, and chlorme.uat chloride.（CCC）, we.e.e.aluate. for the.r ability to promote.strobilus and cone.production in a Chine.e.pine.（Pinus tabuliformis Carr.） clonal se.d orchard. Tre.tme.ts （0, 250, 500, or 1000 mg L -1 ） we.e.applie. during thre. pe.iods （June. July, July-August and August-Se.te.be.） in 2005. Of the.thre. plant growth re.ulators, GA 4/7 was the.be.t for promoting flowe. and cone.production. Tre.s spraye. with GA 4/7 （500 mg L -1 ） from June.to Se.te.be. had significantly more.fe.ale.strobili and immature.cone. than controls and othe. tre.tme.ts （p≤0.0001）. The.be.t time.to apply GA 4/7 was in June. BA at 500 mg L -1 significantly incre.se. fe.ale.flowe. and immature.cone.production, compare. to othe. tre.tme.ts and controls （p≤0.0001）, while.promotion of male.strobili was unchange.. Chlorme.uat chloride.at 1000 mg L -1 significantly incre.se. the.numbe. of male.strobili, compare. to the.othe. tre.tme.ts （p≤0.0001）. Spraying CCC at500 mg L -1 significantly incre.se. the.numbe. of fe.ale.strobili, compare. to controls （p0.05）, but it had no e.fe.t on immature.cone.production （p0.05）. The.e.re.ults are.important for improving se.d production and se.d orchard manage.e.t of Chine.e.pine.

关键词： flowe. promotion conife. se.d production bre.ding Pinus tabuliformis Carr.