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A Room-Temperature Chloride-Conducting Metal-Organic Crystal[Al(dMSO)_(6)]Cl_(3) for Potential Solid-State Chloride-Shuttle Batteries

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Energy & Environmental Materials 2024年第1期7卷 107-113页

作者： Bing Wu Jan Luxa Jiří Šturala Shuangying Wei lukáš d.k.novský Abhilash karuthedath Parameswaran Min Li Zdenek Sofer department of Inorganic Chemistry University of Chemistry and Technology PragueTechnická 516628Prague Czech Republic

The growing demand for substitutes of lithium chemistries in battery leads to a surge in budding novel anion-based electrochemical energy storage,where the chloride ion batteries(CIBs)take over the *** application of CIBs is limited by the dissolution and side reaction of chloride-based electrode materials in a liquid *** the flipside,its solid-state electrolytes are scarcely reported due to the challenge in realizing fast Cl^(-)*** present study reports[Al(dMSO)_(6)]Cl_(3),a solid-state metal-organic material,allows chloride ion *** strong Al-Cl bonds in AlCl_(3)are broken down after coordinating of Al^(3+)by ligand dMSO,and Cl^(-)in the resulting compound is weakly bound to complexions[Al(dMSO)_(6)]^(3+),which may facilitate Cl^(-)*** partial replacement of Cl^(-)with PF_(6)^(-),the room-temperature ionic conductivity of as-prepared electrolyte is increased by one order of magnitude from 2.172×10^(-5)S cm^(-1)to 2.012×10^(-4)S cm^(-1).When they are assembled with Ag(anode)/Ag-AgCl(cathode)electrode system,reversible electrochemical redox reactions occur on both sides,demonstrating its potential for solid-state chloride ion *** strategy by weakening the bonding interaction using organic ligands between Cl^(-)and central metallic ions may provide new ideas for developing solid chloride-ion conductors.

关键词： [Al(dMSO)_(6)]Cl_(3) chloride-ion batteries ionic conductivity metal-organic solid-state electrolytes

支点弯曲位X线片对运用椎弓根螺钉固定治疗脊柱侧凸中的可预测性

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中华骨科杂志 2010年第6期30卷 I0037-I0042页

作者： kenneth M.C. Cheung deepa Natarajan dino Samartzis Yat-Wa Wong Wai-Yuen Cheung keith d.k. luk 宋跃明(译) Investigation performed at the department of Orthopaedics arid Traumatology Duchess of Kent Children's Hospital Hong Kong China 四川大学华西医院骨科 610041

背景：支点弯曲位X线片在运用钩棒系统治疗青少年特发性脊柱侧凸时能准确预测术后弯曲矫正情况。本研究拟探讨支点弯曲位x线片在运用交替椎弓根螺钉固定治疗脊柱侧凸中的预测性价值。方法：我们对在同一机构内运用交替椎弓根螺钉固定方... 详细信息

背景：支点弯曲位X线片在运用钩棒系统治疗青少年特发性脊柱侧凸时能准确预测术后弯曲矫正情况。本研究拟探讨支点弯曲位x线片在运用交替椎弓根螺钉固定治疗脊柱侧凸中的预测性价值。方法：我们对在同一机构内运用交替椎弓根螺钉固定方法进行手术治疗的胸椎特发性脊柱侧凸患者进行前瞻性放射学分析。测量术前和术后1周时站立后前位脊柱x线片上侧凸的Cobb角。计算支点柔韧百分比和支点弯曲矫正指数百分比。结果：42例患者纳入本研究。实施手术时患者的平均年龄是14．6岁，平均融合节段数为9．4个。术前站立位X线片Cobb角、支点弯曲位Cobb角、支点柔韧度分别为57．9°．21．8°和62．7％。术后1周X线片，平均Cobb角为15．4°，弯曲的平均矫正度为73.4％，支点弯曲的平均矫正指数为122．1％。支点弯曲位x线片的角度与支点弯曲矫正指数呈显著正相关，表明支点弯曲化X线片能预测支点弯曲的术后矫正情况。然而，对于僵硬型的脊柱侧凸，椎弓根螺钉固定能为患者带来比支点弯曲位X线片所预测的更理想的矫正效果。结论：据我们所知，本研究是证实支点弯曲位X线片在运用交替椎弓根螺钉固定治疗脊柱侧凸中的预测性价值的首次研究。弯曲的柔韧性能反映支点弯曲矫正指数的程度，即柔韧性差的侧凸畸形能获得一个更大的矫正指数。支点弯曲位x线片具有潜在的预测价值。此外．与钩棒及其他系统相比，椎弓根螺钉固定表现出更好的矫正能力。

关键词：青少年特发性脊柱侧凸椎弓根螺钉固定支点弯曲位可预测性固定治疗 X线片 Cobb角预测价值

Comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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Journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek J.dittrich M.knapek F.lukáˇc d.k.utný J.Jaroš R.král Faculty of Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the Czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(SPS)and selective laser melting(SLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SLM material and unmeasurably low porosity in the SPS *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion *** materials showed comparable strength of∼110 MPa in tension and compression and relatively good deformability of∼9%and∼21%for the SLM and SPS materials,*** corrosion resistance of the SPS material in 0.1 M NaCl solution was superior to the SLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SLM *** the other hand,one of the primary outcomes of this study is that the SPS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium Powder metallurgy Microstructure Mechanical strength Corrosion resistance

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt Cross keith Stokes Lindsay Starling Rosy Hyman Simon kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK Uk Collaborating Centre on Injury and Illness Prevention in Sport(UkCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP *** may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play Medical management

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan kaipananickal Scott Maxwell Jun Okabe Ishant khurana Thomas karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas kay Assam El-Osta Epigenetics in Human Health and disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia department of diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong kong Institute of diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1d),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1d owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1d donors to the FdAapproved EZH2 inhibitors GSk126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3k27me3 and H3k4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

Tree structure and diversity shape the biomass of primary temperate mountain forests

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Forest Ecosystems 2024年第4期11卷 568-579页

作者： dheeraj Ralhan Ruffy Rodrigo Heather keith Annemiek Irene Stegehuis Jakob Pavlin Yumei Jiang Milos Rydval Juliana Nogueira Alexandre Fruleux Marek Svitok Martin Mikolas daniel kozak Martin dusatko Pavel Janda Oleh Chaskovsky Catalin-Constantin Roibu Miroslav Svoboda Czech University of Life Sciences Prague Faculty of Forestry and Wood SciencesKamycka 129Suchdol16521 Praha 6Czech Republic department of Forest Science Biliran Province State UniversityBiliran6549Philippines Griffith Climate Action Beacon Griffith UniversityParklands DriveSouthportGold CoastQueensland4222Australia Laboratoire de Geologie IPSLCNRSUMR 8538Ecole Normale SuperieurePSL UniversityParisFrance Univ.Lille Institut Mines-TelecomUniv.ArtoisJuniaULR 4515LGCgELaboratoire de Genie Civil et Geo-EnvironnementF-59000LilleFrance department of Biology and General Ecology Faculty of Ecology and Environmental SciencesTechnical University in ZvolenMasaryka 2496001ZvolenSlovakia Institute of Forest Management Ukrainian National Forestry UniversityLvivUkraine Forest Biometrics Laboratory–Faculty of Forestry Stefan Cel Mare University of SuceavaUniversitații Street Number.13Suceava720229Romania

Primary forests are spatially diverse terrestrial ecosystems with unique characteristics,being naturally regenerative and heterogeneous,which supports the stability of their carbon storage through the accumulation of live and dead ***,little is known about the interactions between biomass stocks,tree genus diversity and structure across a temperate montane primary ***,we investigated the relationship between tree structure(variability in basal area and tree size),genus-level diversity(abundance,tree diversity)and biomass stocks in temperate primary mountain forests across Central and Eastern *** used inventory data from726 permanent sample plots from mixed beech and spruce across the Carpathian *** used nonlinear regression to analyse the spatial variability in forest biomass,structure,and genus-level diversity and how they interact with plot-level tree age,disturbances,temperature and *** found that the combined effects of genus and structural indices were important for addressing the variability in biomass across different spatial *** processes in disturbance regimes and uneven tree age support forest hete rogeneity and the accumulation of live and dead biomass through the natural regeneration,growth and decay of the forest *** complexities in basal area index,supporte d by genus-level abundance,positively influence total biomass stocks,which was modulated by tree age and *** forests showed higher tree density and basal area than mixed beech forests,though mixed beech still contributes significantly to biomass across *** heterogeneity was strongly influenced by complexities in forest composition(tree genus diversity,structure).We addressed the importance of primary forests as stable carbon stores,achieved through structure and *** such ecosystems is critical for ensuring the stability of the primary forest,carbon store and biodiversity into the future.

关键词： Biodiversity indicators Biomass carbon stock Ecosystem functioning Forest composition Primary forest structure Tree size distribution

Engineered polycaprolactone–magnesium hybrid biodegradable porous scaffold for bone tissue engineering

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Progress in Natural Science:Materials International 2014年第5期24卷 561-567页

作者： Hoi Man Wong Paul k.Chu Frankie k.L.Leung kenneth M.C.Cheung keith d.k.luk kelvin W.k.Yeung department of Orthopaedics and Traumatology The University of Hong Kong Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital department of Physics and Materials Science City University of Hong Kong Peking University Shenzhen Institution

In this paper, we describe the fabrication of a new biodegradable porous scaffold composed of polycaprolactone(PCL) and magnesium(Mg)micro-particles. The compressive modulus of PCL porous scaffold was increased to at least 150% by incorporating 29% Mg particles with the porosity of 74% using Micro-CT analysis. Surprisingly, the compressive modulus of this scaffold was further increased to at least 236% when the silane-coupled Mg particles were added. In terms of cell viability, the scaffold modified with Mg particles significantly convinced the attachment and growth of osteoblasts as compared with the pure PCL scaffold. In addition, the hybrid scaffold was able to attract the formation of apatite layer over its surface after 7 days of immersion in normal culture medium, whereas it was not observed on the pure PCL scaffold. This in vitro result indicated the enhanced bioactivity of the modified scaffold. Moreover, enhanced bone forming ability was also observed in the rat model after 3 months of implantation. Though bony in-growth was found in all the implanted scaffolds. High volume of new bone formation could be found in the Mg/PCL hybrid scaffolds when compared to the pure PCL scaffold. Both pure PCL and Mg/PCL hybrid scaffolds were degraded after 3 months. However, no tissue inflammation was observed. In conclusion, these promising results suggested that the incorporation of Mg micro-particles into PCL porous scaffold could significantly enhance its mechanical and biological properties. This modified porous bio-scaffold may potentially apply in the surgical management of large bone defect fixation.

关键词： Magnesium Polycaprolactone Biodegradability Biocompatibility Mechanical properties

Clinical features and management of primary sclerosing cholangitis

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World Journal of Gastroenterology 2008年第21期14卷 3338-3349页

作者： Marina G Silveira keith d Lindor division of Gastro-enterology and Hepatology Miles and Shirley Fiterman Center for Digestive DiseasesMayo Clinic and FoundationRochesterMinnesotaUnited States

Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts,resulting in cirrhosis and need for liver transplantation and reduced life *** majority of cases occur in young and middle-aged men,often in association with inflammatory bowel *** etiology of primary sclerosing cholangitis includes immune-mediated components and elements of undefined *** effective medical therapy has been *** multiple complications of primary sclerosing cholangitis include metabolic bone disease,dominant strictures,bacterial cholangitis,and malignancy,particularly cholangiocarcinoma,which is the most lethal complication of primary sclerosing *** transplantation is currently the only life-extending therapeutic alternative for patients with end-stage disease,although recurrence in the allografted liver has been described.A PSC-like variant attracting attention is cholangitis marked by raised levels of the immunoglobulin G4 subclass,prominence of plasma cells within the lesions,and steroid responsiveness.

关键词： Sclerosing cholangitis diagnosis Therapy Cholestasis Cholangiocarcinoma Liver transplantation

The significance of cherts as markers of Ocean Plate Stratigraphy and paleoenvironmental conditions:New insights from the Neoproterozoic-Cambrian Blovice accretionary wedge,Bohemian Massif

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Geoscience Frontiers 2023年第1期14卷 162-180页

作者： lukášAckerman Jirízák Václav kachlík Jan Pašava karelZák Andreas Pack František Veselovsky Ladislav Strnad Institute of Geology of the Czech Academy of Sciences Rozvojová269CZ-16500 Prague 6Czech Republic Czech Geological Survey Klárov3CZ-11821 Prague 1Czech Republic Institute of Geology and Paleontology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Geowissenschaftliches Zentrum Universität GöttingenGoldschmidtstraβe 1D-37077 GöttingenGermany Laboratories of the Geological Institutes Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic

The Ediacaran to early Cambrian Blovice accretionary complex,Bohemian Massif,hosts abundant chert bodies that formed on an oceanic plate and were involved in subduction beneath the northern margin of *** relationships of cherts to their host,their microstructure and elemental as well as isotopic compositions revealed diverse processes of chert petrogenesis reflecting depositional environment and position on the oceanic *** deep-water cherts formed through a hydrothermal precipitation of silica-rich gels on outer trench swell of the subducted slab with none or only minor addition of terrigenous *** the contrary,the shallow-water cherts formed in lagoons on seamount slopes,and at least some of them represent a product of hydrothermal replacement of former carbonate and/or evaporite *** both chert types,the hydrothermal fluids were of low temperature and continuous pervasive hydrothermal alteration of oceanic crust,together with an elevated Si content in Neoproterozoic seawater,served as the major source of *** the other hand,minor carbon enrichment in chert is mostly linked to variable incorporation of organic matter that was deposited on the *** earth element(REE)systematics of the cherts indicate predominantly oxygenated environment for the shallow-water cherts whereas the deep-water cherts were deposited in diverse redox conditions,depending on their distance from hydrothermal *** these data,we demonstrate that the cherts once formed a part of Ocean Plate Stratigraphy(OPS)now dismembered and mixed with terrigenous siliciclastic material to form OPS mé*** our data with those from the existing literature,we show that cherts can serve as significant markers of OPS since the Archean,recording a complex interplay between seafloor-related volcanic(production of MORB-and OIB-like magmas)and sedimentary processes,hydrothermal activity at mid-ocean ridges and seamount chains as well as at outer slopes o

关键词： Chert Accretionary wedge Ediacaran Triple oxygen isotopes Strontium isotopes Ocean Plate Stratigraphy