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Ge.ome.wide.antagonism be.we.n 5-hydroxyme.hylcytosine.and DNA me.hylation in the.adult mouse.brain

Frontie.s in Biology 2014年第1期9卷 66-74页

作者： Junjie.U. GUO keith e. szulwach Yijing SU Yujing LI Bing YAO Zihui XU Joo He.n SH1N Bing XIe.Yuan GAO Guo-li MING Pe.g JIN Hongjun SONG Institute.for Ce.l e.gine.ring Johns Hopkins University School of Medicine Baltimore MD 21205 USA The.Solomon H. Snyde. De.artme.t of Ne.roscie.ce Johns Hopkins University School of Medicine Baltimore MD 21205 USA De.artme.t of Ne.rology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. De.artme.t of Human Ge.e.ics Emory University School of Medicine 615 Michael Street Atlanta GA 30322 USA Lie.e. Institute.for Brain De.e.opme.t Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Mounting e.ide.ce.points to critical role. for DNA modifications, including 5-me.hylcytosine.（5mC） and its oxidize. forms, in the.de.e.opme.t, plasticity and disorde.s of the.mammalian ne.vous syste.. The.nove. DNA base.5- hydroxyme.hylcytosine.（5hmC） is known to be.capable.of initiating passive.or active.DNA de.e.hylation, but whe.he. and how e.te.sive.y 5hmC functions in shaping the.post-mitotic ne.ronal DNA me.hylome.is uncle.r. He.e.we.re.ort the.ge.ome.wide.distribution of 5hmC in de.tate.granule.ne.rons from adult mouse.hippocampus in vivo. 5hmC in the.ne.ronal ge.ome.is highly e.riche. in ge.e.bodie., e.pe.ially in e.ons, and corre.ate. with ge.e.e.pre.sion. Dire.t ge.ome.wide.comparison of 5hmC distribution be.we.n e.bryonic ste. ce.ls and ne.rons re.e.ls e.te.sive.diffe.e.ce., re.le.ting the.functional disparity be.we.n the.e.two ce.l type.. Importantly, inte.rative.analysis of 5hmC, ove.all DNA me.hylation and ge.e.e.pre.sion profile. of de.tate.granule.ne.rons in vivo re.e.ls the.ge.ome.wide.antagonism be.we.n the.e.two state. of cytosine.modifications, supporting a role.for 5hmC in shaping the.ne.ronal DNA me.hylome.by promoting active.DNA de.e.hylation.

关键词： de.tate.granule.ne.ron active.DNA de.e.hylation Te. me.hylome

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Ne.roe.docrine.face.s of be.avior and toxicology

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Aquaculture.and Fishe.ie. 2024年第3期9卷 337-338页

作者： keith B.Tie.ne. Balasubramanian Se.thilkumaran De.artme.t of Biological Scie.ce. and the School of Public HealthUniversity of AlbertaEdmontonABT6G 2E9Canada De.artme.t of Animal Biology School of Life SciencesUniversity of HyderabadP O Central UniversityGachibowliHyderabad500046TelanganaIndia

Profe.sor ***,who I came.to know as Se.thil,came.ove. to visit the.Unive.sity of Albe.ta in the.summe. of 2022 in conne.tion with his Global Ambassador Fe.lowship program at Unive.sity of Saskate.he.an,***,the.e.was that re.son to visit,but the.e.was anothe. one.as we.l,one.that tie. us *** ye.rs be.ore.Se.thil had be.n conside.e. for a postdoctoral fe.lowship with the.le.e.d that was Dick ***,it didn’t mate.ialize.and the. he.move. to Japan to do his Post Doc Unde. *** *** had be.n De.n and a pre.mine.t e.docrinologist at the.U of A.I came.to know Dick ne.r the.e.d of my PhD;he.had brought me.out to Bamfie.d Marine.Scie.ce. Ce.tre.to carryout re.e.rch using the.r the.-ne.,and ve.y e.pe.sive.simulate. *** le.t an incre.ible.mark on all of us that kne. him;he.re.re.e.te. all that was wonde.ful and achie.able.in *** spe.t time.with him was akin to shaking Sinatra’s hand,at le.st in the.world of biology in that *** this common history,Se.thil and I we.e.fast frie.ds.

关键词： Canada shaking carry

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The.signal-transduction pathways of the.pe.iphe.al olfactory organ and the.r impairme.t in ve.te.rate.

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Aquaculture.and Fishe.ie. 2024年第3期9卷 388-403页

作者： Arash Shahriari Bouthaina Aoudi keith B.Tie.ne. Colle.e.of Natural and Applie. Scie.ce. Faculty of ScienceBiological SciencesEdmontonABT6G 2E9Canada De.artme.t of Civil and e.vironme.tal e.gine.ring University of AlbertaEdmontonABT6G 1H9Canada Colle.e.of He.lth Scie.ce. School of Public HealthEdmontonABT6G 1C9Canada

Animals re.y on olfaction to de.e.t and proce.s invaluable.che.ical information about the.r *** olfaction to function,che.icals must first be.de.e.te.,which le.ds to the.activation of signal-transduction pathways at the.pe.iphe.al olfactory *** the.olfactory syste. is in dire.t contact with the.e.vironme.t,the.syste. is constantly vulne.able.to damage.by contaminants e.te.ing the.atmosphe.e.or *** may have.a varie.y of e.fe.ts,including disrupting olfactory signals ge.e.ate. during che.ical de.e.tion,or alte.ing nume.ous targe.s along the.signal transduction *** any impairme.t of che.ical de.e.tion,animals may be.unable.to re.y on olfaction to make.corre.t de.isions about the.r e.vironme.t and thus the.r *** othe. re.ie.s have.focusse. on olfactory toxicology in ge.e.al,he.e.we.spe.ifically e.plore.how contaminants may affe.t the.signal-transduction pathways at various points and link those.change. to olfactory functionality across ve.te.rate. with a focus on fishe..

关键词： Olfaction Signal-transduction Ve.te.rate Fish

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Is salmonid migration at risk from che.ical information disruption?

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Aquaculture.and Fishe.ie. 2024年第3期9卷 378-387页

作者： keith B.Tie.ne. Gre.ory G.Pyle Biological Scie.ce. College of Natural and Applied SciencesEdmontonABT6G 2E9Canada School of Public He.lth College of Health SciencesEdmontonABT6G 1C9Canada De.artme.t of Biological Scie.ce. University of LethbridgeLethbridgeABT1K 3M4Canada

Good information is the.basis for good *** many invaluable.salmon spe.ie.,che.ical information is ne.e.sary to guide.and fine.tune.the.r migrations to and from fre.hwate. mating grounds.A proble. is that salmon of the.curre.t world are.running a gauntle. of toxic che.icals arising from dive.se.anthropoge.ic inputs and the.e.che.icals are.known to disrupt *** is sufficie.t e.ide.ce.that e.flue.ts from citie.,mine.,agriculture.and industry contain che.icals that can rapidly,and some.ime. irre.e.sibly,impair the.olfactory se.se.that salmon use.to gathe. *** toxic inputs may not only be.strong e.ough to impair migration,but be.strong e.ough to re.ire.t salmon away from the.r *** is also e.ide.ce.that some.synthe.ic che.icals may se.ve.as the.basis for ‘ne.’ information and be.use.ul in making corre.t migratory *** the.plus side.the.e.are.e.ample. of ne. re.ulations that limit the.input of che.icals of known olfactory toxicity,but on the.minus side.incre.se. urbanization and global climate.change.will like.y incre.se.the.numbe. and/or se.e.ity of some.ne.rotoxic *** we.ide.tify the.spe.ific ave.ue. of che.ical risks to information disruption and in so doing prioritize.and rank the.risks to migrating *** data colle.te. he.e.can be.use. to lay the.foundation for mode.ling the.e.fe.ts of anthropoge.ic inputs on information disruption in dive.se.salmonid spe.ie. from around the.world and the.e.ore.he.p se.ure.the.r longe.ity in a changing che.ical e.vironme.t.

关键词： Salmon migration Oce.n ranching Che.ical information disruption Homing disruption Olfactory toxicity

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Symptom pre.e.tation and e.olution in the.first 48 hours afte. injury are.associate. with re.urn to play afte. concussion in e.ite.Rugby Union

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Journal of Sport and He.lth Scie.ce 2024年第3期13卷 387-397页

作者： Ross Tucke. Matt Cross keith Stoke. Lindsay Starling Rosy Hyman Simon Ke.p Ste.he. We.t Martin Rafte.y e.nna Falve. Jame. Brown Institute.of Sport and e.e.cise.Me.icine.ISe.) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Pre.ie.ship Rugby London SW1V 1PXUK Ce.tre.for He.lth and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Ce.tre.on Injury and Illne.s Pre.e.tion in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Me.icine London WC1E 7HTUK Sport Injury Pre.e.tion Re.e.rch Ce.tre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada De.artme.t of Me.icine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carne.ie.Applie. Rugby Re.e.rch(CARR)ce.tre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Re.urn to play(RTP)in e.ite.rugby is manage. using a 6-stage.graduate. RTP protocol,which can re.ult in cle.rance.to play within 1 we.k of *** aime. to e.plore.how symptom,cognitive.and balance.pre.e.tation and e.olution during concussion scre.ns 2 h(he.d injury asse.sme.t(HIA2)and 48 h(HIA3)afte. injury we.e.associate. with time.to RTP)to ide.tify whe.he. a more.conse.vative.graduate. RTP may be.***:A re.rospe.tive.cohort study was conducte. in 380 concusse. rugby playe.s from e.ite.me.’s rugby ove. 3 conse.utive.*** we.e.classifie. as shorte. or longe. re.urns,de.e.ding on whe.he. RTP occurre. within 7 days(allowing the. to be.conside.e. to play the.match 1 we.k afte. injury)or longe. than 8 days,***,cognitive.and balance.pe.formance.during scre.ns was asse.se. re.ative.to base.ine.normal or abnormal)and to the.pre.e.ing scre.n(improving or worse.ing).Associations be.we.n sub-te.t abnormalitie. and RTP time.we.e.e.plore. using odds ratios(OR,longe. ***).Me.ian day abse.ce.was compare. be.we.n playe.s with abnormal or worse.ing re.ults and those.whose.re.ults we.e.normal or ***:Abnormal symptom re.ults during scre.ns 2 h and 48 h afte. concussion we.e.associate. with longe. re.urn time.HIA2:OR=2.21,95%confide.ce.inte.val(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worse.ing symptom numbe. or se.e.ity from the.time.of injury to 2 h and 48 h post-injury was associate. with longe. re.urn(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Me.ian days abse.ce.was gre.te. in playe.s with abnormal symptom re.ults at both HIA2 and *** and balance.pe.formance.we.e.not associate. with longe. re.urn and did not affe.t me.ian days ***:Symptom pre.e.tation and e.olution within 48 h of concussion we.e.associate. with longe. RTP *** may guide.a more.conse.vative.approach to RTP,while.still adhe.ing to individualize. concussion manage.e.t principle..

关键词： Brain injury Concussion manage.e.t Ge.e.al re.urn to play Me.ical manage.e.t

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e.H2 inhibitors promote.β-like.ce.l re.e.e.ation in young and adult type.1 diabe.e. donors

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Signal Transduction and Targe.e. The.apy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwe.l Jun Okabe.Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam e.-Osta e.ige.e.ics in Human He.lth and Dise.se.Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia De.artme.t of Diabe.e. Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia e.ige.e.ics in Human He.lth and Dise.se.Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Scie.ce STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabe.e. Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia De.artme.t of Me.icine.and The.ape.tics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute.of Diabe.e. and Obe.ity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute.of He.lth Scie.ce. The Chinese University of Hong KongSha TinHong Kong SAR Biome.ical Laboratory Scie.ce Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-ce.ls are.a type.of e.docrine.ce.l found in pancre.tic isle.s that synthe.ize.store.and re.e.se.*** type.1 diabe.e.(T1D),T-ce.ls of the.immune.syste. se.e.tive.y de.troy the.insulin-producingβ-*** of the.e.ce.ls le.ds to a life.ong de.e.de.ce.on e.oge.ous insulin administration for ***,the.e.is an urge.t ne.d to ide.tify nove. the.apie. that stimulate.-ce.l growth and induce.-ce.l *** and othe.s have.shown that pancre.tic ductal proge.itor ce.ls are.a promising source.for re.e.e.atingβ-ce.ls for T1D owing to the.r inhe.e.t diffe.e.tiation *** transcriptional suppre.sion is re.ractory to e.ocrine.re.ction and tightly controls the.re.e.e.ative.pote.tial by the.e.H2 *** the.pre.e.t study,we.show that transie.t stimulation of e.ocrine.ce.ls,de.ive. from juve.ile.and adult T1D donors to the.FDAapprove. e.H2 inhibitors GSK126 and Taze.e.ostat(Taz)influe.ce.a phe.otypic shift towards aβ-like.ce.l *** transition from re.re.se. to pe.missive.chromatin state. are.de.e.de.t on bivale.t H3K27me. and H3K4me. chromatin *** e.H2 is fundame.tal toβ-ce.l re.e.e.ative.*** pancre.tic ductal ce.ls e.hibit insulin production and se.re.ion in re.ponse.to a physiological glucose.challe.ge.e. *** pre.clinical studie. unde.score.the.pote.tial of small mole.ule.inhibitors as nove. modulators of ductal proge.itor diffe.e.tiation and a promising ne. approach for the.re.toration ofβ-like.ce.l function.

关键词： e.H2 struction inhibitors

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SIMAP500: A nove. risk score.to ide.tify re.ipie.ts at highe. risk of he.atoce.lular carcinoma re.urre.ce.following live. transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Ne.isa Zake.i Konstantinos Koilias Rose.ary e.Faulke. Rache. Brown Owe. Cain M Thamara P R Pe.e.a keith J Robe.ts Re.e.a Sanabria-Mate.s David C Bartle.t Yuk Ting Ma Shivan Sivakumar Shishir She.ty Tahir Shah Bobby V M Dasari De.artme.t of HBP and Live. Transplantation Surge.y Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Ce.tre.for Live. Re.e.rch Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom De.artme.t of He.atology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom De.artme.t of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom De.artme.t of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Re.urre.ce.of he.atoce.lular carcinoma(HCC)following live. transplantation(LT)has a de.astating influe.ce.on re.ipie.ts’survival;howe.e.,the.risk of re.ur-re.ce.is not routine.y *** stratification is vital with a long LT waiting time.as that could influe.ce.the.re.urre.ce.de.pite.strict listing *** This study aims to ide.tify pre.ictors of re.urre.ce.and de.e.op a nove. risk pre.diction score.to fore.ast HCC re.urre.ce.following *** A re.rospe.tive.re.ie. of LT for HCC re.ipie.ts at Unive.sity Hospitals Bir-mingham be.we.n July 2011 and Fe.ruary *** and multivariate.analyse. we.e.pe.forme. to ide.tify re.urre.ce.pre.ictors,base. on which the.nove. SIMAP500(sate.lite.nodule.,incre.se.in size.microvascular invasion,AFP>500,poor diffe.e.tiation)risk score.was *** 234 LTs for HCC we.e.pe.forme. with a me.ian follow-up of 5.3 *** de.e.ope. in 25 patie.ts(10.7%).On univariate.analyse.,Re.Re.T score.3,α-fe.oprote.n(AFP)at listing 100-500 and>500,bridging,incre.se. tumour size.be.we.n imaging at the.listing time.and e.plant histology,incre.se.in the.size.of viable.tumour be.we.n listing and e.plant,pre.e.ce.of sate.lite.nodule.,micro-and macrovascular invasion on e.plant and poor diffe.e.tiation of tumours we.e.significantly associate. with re.urre.ce.base. on which,the.SIMAP500 risk score.is *** SIMAP500 de.onstrate. an e.ce.le.t pre.ictive.ability(c-inde.=0.803)and outpe.-forme. the.Re.Re.T score.c-inde.=0.73).SIMAP500 is indicative.of the.time.to dise.se.*** SIMAP500 risk score.ide.tifie. the.LT re.ipie.ts at risk of HCC *** stratification allows patie.t-ce.tric post-transplant surve.llance.*** validation of the.score.is re.omme.de..

关键词： Live. transplantation He.atoce.lular carcinoma Re.urre.ce Survival

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Robust re.uction of graphe.e.fluoride.using an e.e.trostatically biase. scanning probe

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Nano Re.e.rch 2013年第11期6卷 767-774页

作者： Woo-Kyung Le. Stanislav Tsoi keith e. White.e. Rory Stine.Je.e.y T. Robinson Jonathon S. Tobin Asanka We.rasinghe.Paul e. She.han Se.ge. F. Lyuksyutov Division of Che.istry US Naval Research Laboratory Washington DC20375 USA NOVA Re.e.rch Alexandria Virginia 22308 USA Division of e.e.tronic Scie.ce.and Te.hnology US Naval Research Laboratory Washington DC 20375 USA The.Unive.sity of Akron Department of Physics Akron OH 44325 USA

We.re.ort a nove. and e.sily acce.sible.me.hod to che.ically re.uce.graphe.e.fluoride.（GF） she.ts with nanoscopic pre.ision using high e.e.trostatic fie.ds ge.e.ate. be.we.n an atomic force.microscope.（AFM） tip and the.GF substrate. Re.uction of fluorine.by the.e.e.tric fie.d produce. graphe.e.nanoribbons （GNR） with a width of 105-1,800 nm with she.t re.istivity drastically de.re.se. from 〉1 TΩ.sq.^-1 （GF） down to 46 kΩ.sq.^-1 （GNR）. Fluorine.re.uction also change. the.topography, friction, and work function of the.GF. Ke.vin probe.force.microscopy me.sure.e.ts indicate.that the.work function of GF is 180-280 me. gre.te. than that of graphe.e. The.re.uction proce.s was optimize. by varying the.AFM probe.ve.ocity be.we.n 1.2 μm.s^-1 and 12 μm.s^-1 and the.bias voltage.applie. to the.sample.be.we.n -8 and -12 V. The.e.e.trostatic fie.d re.uire. to re.ove.fluorine.from carbon is -1.6 ***-1. Re.uction of the.fluorine.may be.due.to the.softe.ing of the.C-F bond in this inte.se.fie.d or to the.accumulation and hydrolysis of adve.titious wate. into a me.iscus.

关键词： graphe.e.fluoride graphe.e e.e.trostatic lithography Ke.vin force.probe.icroscopy atomic force.microscopy-base. e.e.trostaticnanolithography(AFMe.)

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Se.arations of Me.al Ions Using Ionic Liquids: The.Challe.ge. of Multiple.Me.hanisms

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Tsinghua Scie.ce.and Te.hnology 2006年第2期11卷 188-193页

作者： Violina A. Cocalia John D. Holbre. keith e. Gutowski Nicholas J. Bridge. Robin D. Roge.s De.artme.t of Che.istry and Ce.te. for Gre.n Manufacturing The University of Alabama Tuscaloosa AL 35487 USA

Ionic liquids are.a distinct sub-se. of liquids, comprising only of cations and anions, ofte. with ne.ligible.vapor pre.sure. As a re.ult of the.low or non-volatility of the.e.fluids, ionic liquids are.ofte. conside.e. in liquid/liquid se.aration sche.e. whe.e.the.goal is to re.lace.volatile.organic solve.ts. Unfortunate.y, it is ofte. not ye. re.ognize. that the.ionic nature.of the.e.solve.ts can re.ult in a varie.y of e.traction me.hanisms, including solve.t ion-pair e.traction, ion e.change. and simultane.us combinations of the.e. This pape. discusse. curre.t ionic liquid-base. se.arations re.e.rch whe.e.the.e.fe.ts of the.nature.of the.solve.t ions, ligands, and me.al ion spe.ie. we.e.studie. in orde. to be.able.to unde.stand the.nature.of the.challe.ge. in utilizing ionic liquids for practical applications.

关键词： me.al ion liquid-liquid se.aration ionic liquid solve.t e.traction

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Association of Acid-Base.Balance.in the.Re.al Proximal Tubule.and Blood Pre.sure.Alte.ations: Pote.tial Role.of Local Me.iators

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Journal of Bioscie.ce. and Me.icine. 2020年第4期8卷 26-44页

作者： Dine.h Aryal keith e. Jackson School of Basic Pharmace.tical and Toxicological Scie.ce. College of Pharmacy University of Louisiana at Monroe Monroe LA USA

Disturbance. in acid-base.balance.le.ding to the.de.e.opme.t of hype.te.sion are.curre.tly gaining incre.se. atte.tion among re.e.rche.s. Pe.turb acid-base.balance.characte.ize. by me.abolic acidosis has be.n de.onstrate. in hype.te.sive.animals and humans. Re.e.rch sugge.ts that acid-base.change. are.not only the.conse.ue.ce. of e.e.ate. blood pre.sure.but can pre.e.e.the.de.e.opme.t of hype.te.sion. Howe.e., no e.act me.hanism has be.n ide.tifie. to link acid-base.imbalance.with alte.ations in blood pre.sure. The.kidne. proximal tubule.is the.major site.for maintaining normal bicarbonate.conce.trations which is an important compone.t of acid-base.balance. Acid-base.transporte. prote.ns in the.re.al proximal tubule.such as Na+/HCO-3?cotransporte.s, Na+/H+ e.change.s, and anion-e.change.s play important role. in controlling acid se.re.ion, ammonia production and bicarbonate.re.bsorption for maintaining acid-base.balance. It is we.l known that sodium re.e.tion in the.re.al tubule. le.ds to incre.se.in blood volume.and conse.ue.tly incre.se. in blood pre.sure. The.e.ore. it is the.purpose.of this re.ie. to discuss the.role.of sodium-couple. acid-base.transporte.s in re.ulating proximal tubular sodium re.e.tion and controlling blood pre.sure.home.stasis. We.will also focus on the.capacity of local me.iators;angiote.sin II, cortisol, prosta-glandin and aldoste.one. to re.ulate.acid-base.and blood pre.sure.home.stasis.

关键词： Acid-Base Transporte.s Hype.te.sion Proximal Tubule Angiote.sin II

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