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Extramedullary plasmacytoma with the uvula as first affected site:A case report

World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-ke Tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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Influence of Hot-Rolling Deformation on Microstructure,Crystalline Orientation,and Texture Evolution of the Ti6Al4v-5Cu Alloy

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Acta Metallurgica Sinica(English Letters) 2023年第8期36卷 1261-1280页

作者： solomon kerealme Yeshanew Chunguang Bai Qing Jia Tong Xi Zhiqiang Zhang Diaofeng Li Zhizhou Xia Rui Yang ke Yang Shi-Changxu Innovation Center for Advanced Materials Institute of Metal Research(IMR)Chinese Academy of Sciences(CAS)Shenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

The influence of hot-deformation on the microstructure,crystalline orientation,and texture evolution of Ti6Al4v-5Cu,an antibacterial(α+β)titanium alloy,was *** alloy was deformed using a hot rolling process in 15%,58%,and 73%thickness reduction *** was found that the basaland pyramidaltype slip planes could be activated in theαphase,which dominated the deformation behavior of Ti6Al4v-5Cu *** various deformation conditions,the alloy revealed different microstructure *** the 15%hot rolled alloy,the deformation was performed by the breakdown of priorβgrain boundaries(GBβ),which was attributed to the formation of coarseαgrains,rotated nearly 45°with respect to the transversal and rolling *** presence of different sub-structure geometries made the interior grain size distribution *** the 58%hot rolled alloy,Ti2Cu intermetallic compound was found at theα/β***-resolution transmission electron microscopy investigation showed the occurrence of grain rotation in different crystallographic *** room temperature,the percentage elongation(El)of the alloy reached 23.15%on the 58%hot rolled *** the 73%deformed alloy,refined and randomly oriented characteristics of grains were obtained due to higher thickness reduction,which resulted from the segregation of very fine *** influence of grain rotation during a hot rolling process revealed that theα/βtexture fiber separation angle to maintain the Burger orientation relationship of{0001}α//{110}βplanes decreased with increase of the thickness reduction ratio when Ti6Al4v-5Cu alloy was deformed by a hot rolling *** of tensile{1012}and compressive{1122}twins on the deformation of the alloy was also studied.

关键词： Ti6Al4v-5Cu Hot rolling Microstructure Texture evolution Twining

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Ming-ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients vitamins Minerals

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Adenosine-treated bioprinted muscle constructs prolong cell survival and improve tissue formation

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Bio-Design and Manufacturing 2021年第3期4卷 441-451页

作者： Dongxu ke Adam M.Jorgensen Sang J.Lee James J.Yoo Sean v.Murphy Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Novaprint Therapeutics Suzhou Co. LtdSuzhouJiangsuChina

It is crucial to maintaining the viability of biofabricated human-sized tissues to ensure their successful survival and function after *** is a purine nucleoside that has the function to suppress cellular metabolism and has been previously proposed as a method to prolong cell viability under *** this study,we optimized the dose concentration of adenosine for incorporation into bioprinted constructs to preserve long-term cell viability in *** results showed that muscle cells(C2C12)containing 6,7,or 8 mM adenosine maintained high cell viability for 20 days under hypoxic conditions(0.1%O2),whereas cells without adenosine treatment showed 100%cell death after 11 *** 20 days under hypoxic conditions,muscle cells treated with adenosine proliferated and differentiated when transferred to normoxic *** these adenosine concentrations,6 mM was picked as the optimized adenosine concentration for further investigations due to its most effective results on improving cell *** bioprinted muscle constructs containing adenosine(6 mM)maintained high cell viability for 11 days under hypoxic conditions,while the control constructs without adenosine had no live *** in vivo validation,the bioprinted constructs with adenosine implanted under the dorsal subcutaneous space in mice,showed the enhanced formation of muscle tissue with minimal central necrosis and apoptosis,when compared to the constructs without *** positive in vitro and in vivo results demonstrate that the use of adenosine is an effective approach to preventing the challenge of hypoxia-induced necrosis in bioprinted tissues for clinical translation.

关键词： Bioprinting Hypoxia Adenosine Cell viability In vivo

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Obesity paradox in patients with community-acquired pneumonia:Have you fully considered the confounding factors?

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World Journal of Clinical Cases 2025年第9期13卷 53-55页

作者： Jin-ke Sun Hui Tian Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000Shandong ProvinceChina Department of Critical Care Medicine Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

There exists a notion that there is an obesity paradox in the prognosis of community-acquired *** other words,obese individuals with communityacquired pneumonia have a better *** study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.

关键词： Community-acquired pneumonia Mortality Body mass index Overweight Obesity paradox

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Co-oxidation of arsenic(Ⅲ) and iron(Ⅱ) ions by pressurized oxygen in acidic solutions

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 181-189页

作者： ke-zhou Song Ping-chao ke Zhi-yong Liu Zhi-hong Liu School of Metallurgy and Environment Central South University

The co-oxidation of As(Ⅲ) and Fe(Ⅱ) in acidic solutions by pressured oxygen was studied under an oxygen pressure between 0.5 and 2.0 MPa at a temperature of 150℃. It was confirmed that without Fe(Ⅱ) ions, As(Ⅲ) ions in the solutions are virtually non-oxidizable by pressured oxygen even at a temperature as high as 200℃ and an oxygen pressure up to 2.0 MPa. Fe(Ⅱ) ions in the solutions did have a catalysis effect on the oxidation of As(Ⅲ), possibly attributable to the production of such strong oxidants as hydroxyl free radicals (OH ) and Fe(Ⅳ) in the oxidation process of Fe(Ⅱ). The effects of such factors as the initial molar ratio of Fe(Ⅱ)/As(Ⅲ), initial pH value of the solution, oxygen pressure, and the addition of radical scavengers on the oxidation efficiencies of As(Ⅲ) and Fe(Ⅱ) were studied. It was found that the oxidation of As(Ⅲ) was limited in the co-oxidation process due to the accumulation of the As(Ⅲ) oxidation product, As(Ⅴ), in the solutions.

关键词： co-oxidation As As(Ⅲ)oxidation Fe(Ⅱ) pressured oxygen radical scavenger

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Structure of High Temperature Phase α-Ba_3Y(BO_3)_3 Crystal

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Chinese Journal of Structural Chemistry 2003年第5期22卷 550-552页

作者： PANShang-ke WANGGuo-Fu StatekeyLaboratoryofStructuralChemistry FujianInstituteofResearchontheStructureofMatterTheChineseAcademyofSciencesFuzhouFujian350002China GraduateSchooloftheChineseAcademyofSciences Beijing100039China

The high temperature phase a-Ba3Y(BO3)3 was synthesized by Czochralski method, and its crystal structure has been determined by single-crystal X-ray diffraction. It crystallizes in the trigonal system, space group 3R with a = 13.028(2), c = 9.4992(2) ? v = 1396.1(5) ?, Ba3YB3O9, Mr = 677.36, Z = 6, Dc = 4.834 g/cm3, l(MoKa) = 0.71073 ? m = 18.721 mm-1, F(000) = 1764, the final R = 0.0718 and wR = 0.1640 for 1199 observed reflections with I > 2s(I). In this structure two alternate nonequivalent Y atoms form one-dimensional chains bridged by the Ba atoms with BO3 triangles which link Y(1) and Y(2), respectively. The Ba atom is surrounded by nine O atoms belonging to six BO3 triangles.

关键词： synthesis crystal structure double borate

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A new dihydrobenzofuran lignanoside from Selaginella moellendorffii Hieron

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Chinese Chemical Letters 2008年第1期19卷 79-81页

作者： Xiao ke Zheng ke ke Li Yan Zhi Wang Wei Sheng Feng Henan College of Traditional Chinese Medicine Zhengzhou 450008 China

A new lignanoside, （7R,8S）-7,8-dihydro-7-（4-hydroxy-3,5-dimethoxyphenyl）-1＇-formyl-3＇-y-methoxyl-8-hydroxymethylbenzo- furan-4-O-β-D-glucopyranoside （moellenoside A）, was isolated from Selaginella moellendorffii Hieron. Its structure was determined by spectroscopic evidences. 2007 Wei Sheng Feng. Published by Elsevier B.v. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Selaginella moellendorffii Hieron Lignanoside Moellenoside A

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Parallel DNA Constrained by“CC^+Clamps”

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Chemical Research in Chinese Universities 1999年第2期15卷 42-47页

作者： LIU ke-liang H.Todd Miles Frank B.Howard Joe Frazier v.Sasisekharan Laboratory of Molecular Biology NIDDKNational Institutes of HealthBethesdaMaryland20892USA

Parallel DNA helices with reverse WatsonCrick pairing have been described in several *** has been pointed out,however,that the parallel structures may also be in equilibrium with antiparallel WatsonCrick helices due to their closely similar *** avoid the problem we have prepared and characterized DNA helices which are constrained to possess parallel polarity by two dC residues,or CC+clamps,at both the ends of AT oligomer *** residues are hemiprotonated below neutral pH,forming two stable CC+base pairs with three hydrogen bonds at each end of the *** physical properties of these constructs can then be used to calibrate those of duplexes having the same sequences but lacking the terminal C *** recent studies indicate that dC acid selfstructures are fourstranded with intercalated bases,gel electrophoresis indicates that these structures are not present in the molecules described here.

关键词： Parallel DNA helices Reverse Watson-Crick pairing CC+ base pair Oligonucleotide helices, Reverse WatsonCrick pairing, CC+ base pair, Oligonucleotide

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