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Photo-induced Alignment Behavior of Azobenzene-containing Polymer Films with Different Cross-linking Degree

Chinese Journal of Chemical Physics 2008年第5期21卷 493-499页

作者： Jing Shena Jin-tang Huang Yan-hua Luoa Qi-jin Zhang ke-yi wang CAS key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering Key Laboratory of Optoelectronic Science and Technology Anhui Province University of Science and Technology of China Hefei 230025 China Department of Precision Machinery and Precision Instrumentation University of Science and Tech- nology of China Hefei 230025 China

Three series of amorphous copolymers containing azobenzene groups with various substituents and certain amounts of crosslinkable acrylic groups were prepared. The cross-linked polymer films were obtained by thermal polymerization of the acrylic groups in the copolymers, during which, by controlling the time of cross-linking reaction, the films can be made with different cross-linking degree （from 0 to 32%, which was monitored by FT-IR spectra measurement）. Photo-induced alignment process of the films was performed under irradiation with linearly polarized light at 442 nm, and the effect of cross-linking degree on the photo-induced alignment rate was investigated. The dynamics of the photo-induced alignment was analyzed with biexponential curve fitting. The photo-induced alignment rate and the maximum transmittance of the films decreased because of the cross-linking. Furthermore, for the cross-linked samples, it was found that their saturated value of transmittances keep constant after repeated ＂writing＂ and ＂erasing＂ cycles. The findings reveal that the cross-linking of the film can effectively restrain the phototactic mass transport of azopolymer during irradiation by polarized light. The relationship between the cross-linking degree and the photo-induced alignment behavior of azopolymer is discussed in detail.

关键词： Azo polymer Cross-linking Photo-induced alignment Mass transport

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Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex,but not in the myocardium

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Neural Regeneration Research 2018年第7期13卷 1225-1230页

作者： Wen-Yuan Zhang ke-yi wang Yun-Jing Li ying-Ran Li Rong-Zhi Lu Department of Pharmacy Zhongshan Hospital of Sun Yat-sen University Department of Magnetic Resonance Imaging Zhongshan Hospital of Sun Yat-sen University

Chronic stress is strongly associated with the occurrence and development of depression and cardiovascular *** can induce altered mitochondrial function and activation of apoptosis in the cardio-cerebral ***,it is unknown whether the protein kinase C ε（PKCε）-aldehyde dehydrogenase 2（ALDH2） pathway is altered under chronic stress,and this study sought to address this question.A rat model of depression was established using a chronic unpredictable mild stress（CUMS） *** experiencing CUMS for 4 weeks,the sucrose preference test and the forced swim test verified depressive-like *** linked immunosorbent assays showed that ALDH2 activity was decreased in the rat hippocampus and prefrontal cortex,but was not altered in the *** blot assays demonstrated reduced levels of ALDH2 and PKCε,but increased levels of 4-hydroxy-2-nonenal（4 HNE） ***-3 expression did not obviously alter,but active forms of caspase-3 were increased in the hippocampus and prefrontal *** the myocardium,expression of ALDH2,PKCε and 4 HNE adducts did not remarkably alter;while caspase-3 expression was reduced and the active forms of caspase-3 were ***＇s correlation test demonstrated that expression of 4 HNE adducts was positively correlated with levels of the active forms of caspase-3 in the hippocampus and prefrontal cortex,but not in the *** conclusion,chronic stress can damage the PKCε-ALDH2 signaling pathway in the hippocampus and prefrontal cortex,but not in the ***,4 HNE is associated with active forms of caspase-3 in the hippocampus and prefrontal cortex.

关键词： nerve regeneration stress depression protein kinase C ε aldehyde dehydrogenase 2 4-hydroxy-2-nonenal apoptosis hippocampus prefrontal cortex myocardium neural regeneration

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Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第3期10卷 193-202页

作者： Xi-ping ZHANG Guang-hua FENG Jie ZHANG Yang CAI Hua TIAN Xiao-feng ZHANG yi-feng ZHOU Zhi-wei wang ke-yi wang Department of General SurgeryHangzhou First People 's Hospital Hangzhou 310006 China The First College of Clinical Medicine Zhejiang University of Traditional Chinese Medicine Hangzhou 310053 China Department of General Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Digest Hangzhou First People 's Hospital Hangzhou 310006 China Centralab Hangzhou First People's Hospital Hangzhou 310006 China

Objective： To investigate the therapeutic effects and mechanisms of Salvia miltiorrhizae （Danshen） in the treatment of severe acute pancreatitis （SAP）- or obstructive jaundice （OJ）-induced heart injury. Methods： A total of 288 rats were used for SAP- （n= 108） and O J-associated （n= 180） experiments. The rats were randomly divided into sham-operated, model control, and Salvia miltiorrhizae-treated groups. According to the difference of time points after operation, SAP rats in each group were subdivided into 3, 6 and 12 h subgroups （n=12）, whereas OJ rats were subdivided into 7, 14, 21, and 28 d subgroups （n=lS）. At the corresponding time points after operation, the mortality rates of the rats, the contents of endotoxin and phospholipase A2 （PLA：） in blood, and pathological changes of the hearts were investigated. Results： The numbers of dead SAP and OJ rats in the treated groups declined as compared with those in the model control group, but not significantly （P〉0.05）. The contents ofendotoxin （at 6 and 12 h in SAP rats and on 7, 14, 21, and 28 d in OJ rats, respectively） and PLA2 （at 6 and 12 h in SAP rats and on 28 d in OJ rats, respectively） in the treated group were significantly lower than those in the model control group （P〈0.01 and P〈0.001, respectively）. Besides, myocardial pathological injuries were mitigated in SAP and OJ rats. Conclusion： In this study, we found that Salvia rniltiorrhizae improved myocardial pathological changes, reduced the content of PLA2 in blood, and decreased the mortality rates of SAP and OJ rats, exerting protective effects on the hearts of the rats.

关键词： Salvia miltiorrhizae Traditional Chinese medicine Severe acute pancreatitis (SAP) Obstructive jaundice (O J) Heart

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Laparoscopic resection of an obturator schwannoma： a case report

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Chinese Medical Journal 2010年第13期123卷 1804-1806页

作者： yi ke wang Yu-mei CHEN Jie Department of Gynecology West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China

Schwannomas are usually benign tumors that arise from a nerve supporting the Schwann cells, those are mostly associated with the cranial or main peripheral nerves. The occurrence of retroperitoneal schwannoma is quite rare, and in such a case, surgical excision is the first option for treatment. In 1996, Melvin confirmed the feasibility of the complete resection of a retroperitoneal schwannoma using laparoscopy for the first time. Until recently, only few cases of laparoscopic resection of retroperitoneal schwannoma have been reported.

关键词： laparoscopy obturator schwannomas

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Ureaplasma urealyticum-derived lipid-associated membrane proteins introduce IL-6, IL-8, and TNF-α cytokines into human amniotic epithelial cells via Toll-like receptor 2

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第8期19卷 654-661页

作者： Guang-yong YE ke-yi wang Qiao-di GUI Min wang Women's Hospital Zhejiang University School of Medicine Central Laboratory Hangzhou First People's Hospital Department of Clinical Laboratory Shaanxi Provincial People's Hospital

Objective： The purpose of this study was to determine the role of Ureaplasma urealyticum-derived lipidassociated membrane proteins （LAMPs） in the host innate immune system, specifically their effect on Toll-like receptors （TLRs）. Methods： LAMPs were derived from U. urea/yticum strains, and human amniotic epithelial cells （HAECs） were isolated from healthy full-term placentas. Cytokine concentrations were determined by enzyme-linked immunosorbent assay （ELISA） and TLR2 mRNA by real-time PCR. Expression of TLR2 was confirmed by Western blotting and immunohistochemistry. Results： LAMPs induced HAECs to produce inflammatory cytokines interleukin （IL）-6, IL-8, and tumor necrosis factor （TNF）-α. Cytokine production was reduced after blocking TLR2 using TLR2 inhibitor （anti-hTLR2-IgA）. Conclusions： LAMPs isolated from U. urealyticum induced TLR2-dependent up-regulation of inflammatory genes and cytokines in HAECs.

关键词： Ureaplasma urealyticum Lipid-associated membrane protein Human amniotic epithelial cell Toll-like receptor 2

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Mazabraud’s syndrome in female patients:Two case reports

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World Journal of Orthopedics 2024年第6期15卷 593-601页

作者： Xiu-Mao Li Ze-Hao Chen ke-yi wang Jun-Nan Chen Zhao-Nong Yao Yu-Hong Yao Xiao-Wei Zhou Nong Lin Department of Orthopedics The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Orthopedics Research Institute Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina State key Laboratory of Transvascular Implantation Devices Hangzhou 310009Zhejiang ProvinceChina Songyang Branch of the Second Affiliated Hospital School of MedicineZhejiang UniversityLishui 331124Zhejiang ProvinceChina

BACKGROUND Mazabraud’s syndrome(MS)is a rare and slowly progressive benign disease characterized by the concurrent presence of fibrous dysplasia of bone and intramuscular myxoma,and is thought to be associated with mutations of the GNAS *** date,only about 100 cases of MS have been reported in the literature,but its standard treatment strategy remains *** SUMMARY We report two cases of MS in young women who underwent different treatments based on their symptoms and disease *** first patient,aged 37,received internal fixation and intravenous bisphosphonate for a pathological fracture of the right femoral neck,excision of a right vastus medialis myxoma was subsequently performed for pain control,and asymptomatic psoas myxomas were monitored without *** testing confirmed a GNAS gene mutation in this *** second patient,aged 24,underwent right vastus intermedius muscle myxoma resection,and conservative treatment for fibrous dysplasia of the *** patients were followed-up for 17 months and 3 years,respectively,and are now in a stable *** Various treatments have been selected for MS patients who suffer different *** main treatment for myxomas is surgical resection,while fibrous dysplasia is selectively treated if the patient experiences pathological fracture or severe ***,given the documented instances of malignant transformation of fibrous dysplasia in individuals with MS,close follow-up is necessary.

关键词： Mazabraud's syndrome Fibrous dysplasia Intramuscular myxoma Bisphosphonate Case report

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Analysis of sex chromosome aneuploidy by non-invasive prenatal testing in singleton pregnancies: a systematic review and meta-analysis

Analysis of sex chromosome aneuploidy by non-invasive prenat...

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2019年浙江省检验医学学术大会

作者： Hai wang ke yi wang XiaoTing Gong Lei Huai Yong Le Zhang Tongde Hospital of Zhejiang Province Central Laboratory Hangzhou First People's Hospital

Objectives: This study aims to review clinical implementation or validation articles on maternal blood cellfree DNA(cfDNA) testing and to evaluate its ability of fetal sex chromosome aneuploidies(SCA) screening.

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糖、糖、“糖”——什么是糖?

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生命的化学 2008年第6期28卷 665-668页

作者：王克夷中国科学院上海生命科学研究院生物化学与细胞生物学研究所上海200031

糖类是自然界中最常见的一类生物分子,但是糖类因不同的人群可以有三种不同的理解。一是科学上的糖类,二是生活中的糖类,三是作为甜味剂的"糖"类。因为甜味是一个生理上的感觉,凡能与甜味受体相互作用的均是甜味剂,其中有些是糖的"糖",... 详细信息

糖类是自然界中最常见的一类生物分子,但是糖类因不同的人群可以有三种不同的理解。一是科学上的糖类,二是生活中的糖类,三是作为甜味剂的"糖"类。因为甜味是一个生理上的感觉,凡能与甜味受体相互作用的均是甜味剂,其中有些是糖的"糖",也有不是糖的"糖"。

关键词：糖类糖甜味剂糖科学

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糖类是包罗万象的分子

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生命的化学 2008年第6期28卷 669-672页

作者：王克夷中国科学院上海生命科学研究院生物化学与细胞生物学研究所上海200031

糖类是自然界中,类型最多样、结构最复杂、生物质量最丰富的有机分子。糖类是完全不同于核酸和蛋白质的、包罗万象的"另类",因此,研究糖类应该使用独特的、包罗万象的思维模式。

关键词：糖类核酸蛋白质思维模式

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细胞外的“组”和“组学”

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生命的化学 2008年第5期28卷 527-530页

作者：王克夷中国科学院上海生命科学研究院生物化学与细胞生物学研究所上海200031

总的说来,细胞是蛋白质组研究的热点。除了血浆,细胞外的蛋白质几乎是被遗忘了。然而,细胞外的蛋白质形成了细胞外基质,它们是细胞功能所必需的。在某些情况中,细胞外基质能对细胞产生许多效应。除了基质蛋白质组,细胞外还有很多"组"。... 详细信息

总的说来,细胞是蛋白质组研究的热点。除了血浆,细胞外的蛋白质几乎是被遗忘了。然而,细胞外的蛋白质形成了细胞外基质,它们是细胞功能所必需的。在某些情况中,细胞外基质能对细胞产生许多效应。除了基质蛋白质组,细胞外还有很多"组"。糖组是细胞外的另一个组。在许多生理和病理过程中,细胞外基质中的蛋白质和糖被降解。被降解的产物是化合物,它们是降解物组的对象。现在一个大的组——人类蛋白质组——正在启动。在这个大的组中,细胞外基质应该被捡起,并从冷点转化为热点。

关键词：细胞外基质基质蛋白质组糖组降解物组

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