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Solvent Reorganization Energy and Electronic Coupling for Intramolecular Electron Transfer in Biphenyi-Acceptor Anion Radicals

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Chinese Journal of Chemical Physics 2008年第1期21卷 45-54页

作者： Jing-bo Wang Jian-yi Ma Xiang-yuan Li Fu-cheng He ke-xiang Fu College of Chemical Engineering Sichuan University Chengdu 610065 China Institute for Nanobiomedical Technology and Membrane Biology 5ichuan University Chengdu510055 China

A novel algorithm was designed and implemented to realize the numerical calculation of the solvent reorganization energy for electron transfer reactions, on the basis of nonequilibrium solvation theory and the dielectric polarizable continuum model. Applying the procedure to the well-investigated intramoleeular electron transfer in biphenyl-androstane-naphthyl and biphenyl-androstane-phenanthryl systems, the numerical results of solvent reorganization energy were determined to be around 60 k J/mol, in good agreement with experimental data. Koopman＇s theorem was adopted for the calculation of the electron transfer coupling element, associated with the linear reaction coordinate approximation. The values for this quantity obtained are acceptable when compared with experimental results.

关键词： Nonequilibrium salvation Electron transfer Solvent reorganization energy Continuum model

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基于半导体桥芯片的钝感高瞬发底火设计

火工品 2025年第1期 7-12页

作者：牛惠媛任炜褚恩义李慧常英珂金豪杰陕西应用物理化学研究所瞬态化学效应与控制全国重点实验室陕西西安710061 杭州电子科技大学微电子研究院浙江杭州310018

针对超高速射武器弹药对高频高安全及高一致性点火的发展需求,基于半导体桥芯片点火技术,设计了一种新型钝感高瞬发底火。通过对比研究4种半导体桥芯片及其2种封装结构,选用斯蒂芬酸铅和亚铁氢化铅/高氯酸钾作为两级复合装药,优化形成... 详细信息

针对超高速射武器弹药对高频高安全及高一致性点火的发展需求,基于半导体桥芯片点火技术,设计了一种新型钝感高瞬发底火。通过对比研究4种半导体桥芯片及其2种封装结构,选用斯蒂芬酸铅和亚铁氢化铅/高氯酸钾作为两级复合装药,优化形成了模块化结构的半导体桥底火样机。该底火满足了与弹药接口的匹配要求,并达到1 A 1 W 5 min不发火的安全性要求。发火性能试验表明,所研制的半导体桥底火作用时间不大于200μs,散布不大于30μs,与传统桥丝电底火相比瞬发度和作用时间一致性显著提高,综合性能更好。

关键词：底火半导体桥模块化设计高瞬发高安全

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Allelochemical p-hydroxybenzoic acid inhibits root growth via regulating ROS accumulation in cucumber(Cucumis sativus L.)

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Journal of Integrative Agriculture 2020年第2期19卷 518-527页

作者： HUANG Cheng-zhen XU Lei Sun Jin-jing ZHANG Zhong-hua FU Mei-lan TENG Hui-ying yi ke-ke key Laboratory of Plant Nutrition and Fertilizer Ministry of Agriculture and Rural Affairs/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 10081P.R.China key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture Sino-Dutch Joint Laboratory of Horticultural GenomicsInstitute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 10081P.R.China The Semi-arid Agriculture Engineering&Technology Research Center of China Hebei 050051P.R.China

Allelopathy is prevalent in agricultural ecosystems and mediated by plant-derived secondary metabolites(allelochemicals).Allelochemicals are released by donor plants and affect the root growth and development of receptor *** is responsible for the continuous cropping obstacles in cucumber(Cucumis sativus L.).p-Hydroxybenzoic acid(pHBA),an autotoxin from root exudates of cucumber,has been proposed to be an important allelopathic ***,the molecular mechanism by which pHBA affect root growth and development in cucumber is ***,we found that pHBA treatment suppressed root growth of cucumber by reducing the meristem activity and cell *** root growth defect is caused by reduced reactive oxygen species(ROS)accumulation in root *** pHBA treatment,the expression levels of several ROS-scavenging-related genes were increased,including peroxidase(POD),catalase(CAT)and metallothionein(MT).Moreover,exogenously application of salicylhydroxamate(SHAM),a peroxidase inhibitor,can partially restore the pHBA treatment induced root growth ***,we found that there is natural variation for the inhibitory effect of pHBA on root *** also showed that pHBA treatment could maintain higher level of ROS accumulated in the pHBA less sensitive cucumber than that in the pHBA-sensitive *** results suggest that pHBA inhibits root growth by reducing root tip ROS level in cucumber.

关键词： allelopathy cucumber reactive oxygen species natural variation

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Industry 4.0： a way from mass customization to mass personalization production

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Advances in Manufacturing 2017年第4期5卷 311-320页

作者： yi Wang Hai-Shu Ma Jing-Hui Yang ke-Sheng Wang School of Business Plymouth University Plymouth UK Department of Production and Quality Engineering Norwegian University of Science and Technology S.P.Andersens Veg 5 7031 Trondheim Norway School of Business Management Shanghai PolytechnicUniversity Shanghai 201209 People's Republic of China

Although mass customization, which utilizes modularization to simultaneously increase product variety and maintain mass production （MP） efficiency, has become a trend in recent times, there are some limitations to mass customization. Firstly, customers do not participate wholeheartedly in the design phase. Secondly, potential combinations are predetermined by designers. Thirdly, the concept of mass customization is not necessary to satisfy individual requirements and is not capable of providing personalized services and goods. Industry 4.0 is a collec- tive term for technologies and concepts of value chain organization. Based on the technological concepts of radio frequency identification, cyber-physical system, the Inter- net of things, Internet of service, and data mining, Industry 4.0 will enable novel forms of personalization. Direct customer input to design will enable companies to increasingly produce customized products with shorter cycle-times and lower costs than those associated with standardization and MP. The producer and the customer will share in the new value created. To overcome the gaps between mass customization and mass personalization, this paper presents a framework for mass personalization production based on the concepts of Industry 4.0. Several industrial practices and a lab demonstration show how we can realize mass personalization.

关键词： Industry 4.0 Smart manufacturing Mass customization production (MCP) Mass personalization production

Nanopore techniques as a potent tool in the diagnosis and treatment of endophthalmitis:a literature review

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2009-2016页

作者： Zi-Yue Li ke-yi-Zhi Xu Wei Jin Eye Center Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina The Computer School of Wuhan University Wuhan 430072Hubei ProvinceChina

Endophthalmitis is a serious ophthalmic disease characterized by changes in the eye's posterior segment,such as hypopyon and intraocular inflammation,vitritis being a ***-caused endophthalmitis can lead to irreversible vision loss,accompanied by eye pain or eye distention,and in the most severe cases the removal of the *** such as bacteria,fungi,viruses,and parasites typically account for the disease and the entry pathways of the microbial can be divided into either endogenous or exogenous approaches,according to the origin of the etiological *** endophthalmitis can be derived from various occasions(such as postoperative complications or trauma)while endogenous endophthalmitis results from the bloodstream which carries pathogens to the *** review aims to summarize the application of new technology in pathogen identification of endophthalmitis so as to prevent the disease and better guide clinical diagnosis and treatment.

关键词： postoperative endophthalmitis high-throughput sequencing metagenomics long-read nanopore targeted sequencing pathogen identification

The synthesis of B,N-carbon dots by a combustion method and the application of fluorescence detection for Cu^2+

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Chinese Chemical Letters 2017年第5期28卷 1119-1124页

作者： Ming-Cong Rong ke-Xin Zhang yi-Ru Wang Xi Chen Department of Chemistry and the MOE key Laboratory of Spectrochemical Analysis&Instrumentation College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China key Laboratory of Global Change and Marine-Atmospheric Chemistry Third Institute of OceanographyState Oceanic AdministrationXiamen 361005China

Heteroatom doping is an efficient approach to regulate the fluorescence properties of carbon *** aminophenylboronic acid as the raw material,a combustion method was developed for the synthesis of boron,nitrogen-doped carbon dots（B,N-carbon dots）.The B,N-carbon dots emitted green fluorescence and displayed high resistance to both photo bleaching and ionic strength.A facile fluorescence sensing approach for Cu^2＋ was fabricated via static fluorescence *** optimal conditions,a rapid detection of Cu^2＋ could be completed in 2 min with a linearity ranging from 1 μmol/L to 25 μmol/L and a detection limit of 0.3 μmol/L Furthermore,the proposed method showed potential applications for the detection of Cu^2＋ in natural water samples.

关键词： Combustion method B N-carbon dots Fluorescence method Cu^2+ Static fluorescence quenching

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

A bioartificial transgenic porcine whole liver expressing human proteins alleviates acute liver failure in pigs

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Hepatobiliary & Pancreatic Diseases International 2023年第3期22卷 270-281页

作者： Wei-Song Xue Hao-Jie Zhang Jing-Jing ke Yu Fu Qing Peng Li Li yi Gao ke-Bo Zhong General Surgery Center Department of Hepatobiliary SurgeryⅡGuangdong Provincial Research Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Department of General Surgery&Guangdong Provincial key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang HospitalThe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515China People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine Fuzhou 350000China State key Laboratory of Organ Failure Research Southern Medical UniversityGuangzhou 510280China

Background:Preventing heterologous protein influx in patients is important when using xenogeneic bioartificial livers(BALs)to treat liver *** development of transgenic porcine livers synthesizing human proteins is a promising approach in this ***,we evaluated the safety and efficacy of a transgenic porcine liver synthesizing human albumin(h ALB)and coagulation factor VII(h FVII)within a bioartificial ***:Tibetan miniature pigs were randomly subjected to different interventions after surgeryinduced partially ischemic liver *** A(n=4)was subjected to basic treatment;group B(n=4)was to standard medical treatment and wild-type porcine BAL perfusion,and group C(n=2)was to standard medical treatment and transgenic BAL *** parameters,coagulation status,survival time,and pathological changes were *** of h ALB and h FVII were detected using immunohistochemistry and enzyme-linked immunosorbent ***:The survival time in group A was 9.75±1.26 days;this was shorter than that in both perfused groups,in which all animals reached an endpoint of 12 days(P=0.006).Ammonia,bilirubin,and lactate levels were significantly decreased,whereas albumin and fibrinogen levels were increased after perfusion(all P<0.05).h ALB and h FVII were detected in transgenic BAL-perfused pig serum and ex vivo in the liver ***:The humanized transgenic pig livers could synthesize and secrete h ALB and h FVII ex vivo in a whole organ-based bioartificial system,while maintaining their metabolism,detoxification,transformation,and excretion functions,which were comparable to those observed in wild-type porcine ***,the use of transgenic bioartificial whole livers is expected to become a new approach in treating acute liver failure.

关键词： Acute liver failure Transgenic pig Bioartificial liver Xenotransplantation