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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding Pan Pan li Bo Peng Hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng Cai Shengjun Miao Yuan li Yu Wang key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

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Science China Technological Sciences 2025年

作者： Sisi CHEN jiemin ZHANG Nan CHENG Wenbo li Jing liU Hongfei XIE jie ZHANG Yueying CHENG Xiaotong ZHAO Meng SU Yanlin SONG key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (ICCAS) University of Chinese Academy of Sciences Weiyang College Tsinghua University Department of Cardiovascular Surgery First Medical Center PLA General Hospital AECC Beijing Institute of Aeronautical Materials Beijing Institute of Graphene Technology Beijing Engineering Research Centre of Graphene Application School of Integrated Circuit & Beijing National Research Center for Information Science and Technology (BNRist) Tsinghua University

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors, optical and mechanical bi-modal sensors provide improved precision, enhanced safety,and robustness of human-machine interaction systems. Here, the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing capabilities. The printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition functionality. The combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing capabilities. Thus, the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor, as well as contact mechanical sensing capabilities to detect touch force applied by the hand. It provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

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基于结晶过程的分子动理论优化算法

计算机工程与科学 2017年第9期39卷 1774-1780页

作者：易灵芝朱彪明范朝冬任柯李杰肖乐意智能计算与信息处理教育部重点实验室(湘潭大学) 湖南湘潭411105 湖南省"风电装备与电能变化"2011协同创新中心湖南湘潭411105 湘潭大学艺术学院湖南湘潭411105

针对分子动理论优化算法(KMTOA)存在易陷入局部最优、寻优精度低等问题,提出一种基于结晶过程的分子动理论优化算法(C-KMTOA)。该算法通过模拟结晶过程设计了一种分离算子,该算子将种群分为最优个体、优秀个体、较差个体三个子群,并通... 详细信息

针对分子动理论优化算法(KMTOA)存在易陷入局部最优、寻优精度低等问题,提出一种基于结晶过程的分子动理论优化算法(C-KMTOA)。该算法通过模拟结晶过程设计了一种分离算子,该算子将种群分为最优个体、优秀个体、较差个体三个子群,并通过引导操作使较差个体向优秀个体附近移动、优秀个体向最优个体附近移动,从而使搜索范围快速缩小到最优解附近。实验结果表明,该算法在优化精度、动态性能等方面均优于GA、DE、QPSO和KMTOA。

关键词：函数优化分子动理论优化算法最优解分离算子

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Reversible li2C2O4 product regulation in li–CO2 batteries using single-atom alloy engineering

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Science China Chemistry 2025年

作者： Xinxin Zhang Yu Wang Yafei li Jiangsu key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University

The efficiency of lithium-carbon dioxide （li–CO2） batteries is limited by the sluggish generation/decomposition kinetics of the discharge products （i.e.,li2CO3and carbon） despite the use of state-of-the-art noble metal （NM） ***2C2O4has emerged as a promising alternative product;however,the thermodynamic instability of li2C2O4causes it to generally appear as an intermediate in li2CO3pathways rather than a product during ***,using comprehensive first-principles calculations,we report tailoring the discharge products of li–CO2batteries to li2C2O4via single-atom alloy （SAA） engineering,in which NM-doped copper SAAs （NM1Cu） are constructed for *** NM1Cu catalysts display a free-atom-like narrow d-band state and unique charge distribution over the solute NM1atom and the surrounding matrix Cu *** an optimized electronic structure is substantial in Ru1Cu and Ir1Cu,which is conducive to the co-activation and coupling of *** lithiation of*CO2intermediate that breaks the charge symmetry of the central C species can further reduce the kinetic barriers of the C–C *** advantages promote li2C2O4generation on Ru1Cu and Ir1Cu while suppress its subsequent ***,they exhibit low theoretical overpotentials and enable facile delithiation under normal charging *** work proposes a universal principle of manipulating electronic structures to achieve li2C2O4product,which provides practical guidance for the development of li–CO2batteries.

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Zinc alloys

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Distributed Observer for Full-Measured Nonlinear Systems Based on Knowledge of FMCF

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 69-85页

作者： Haotian Xu Shuai liu Yueyang li ke li the School of Control Science and Engineering Shandong University and also with Key Laboratory of Machine Intelligence and System Control Ministry of Education IEEE the School of Electrical Engineering University of Jinan

Driven by practical applications, the achievement of distributed observers for nonlinear systems has emerged as a crucial advancement in recent years. However, existing theoretical advancements face certain limitations: They either fail to address more complex nonlinear phenomena, rely on hard-to-verify assumptions, or encounter difficulties in solving system ***, this paper aims to address these challenges by investigating distributed observers for nonlinear systems through the full-measured canonical form(FMCF), which is inspired by full-measured system(FMS) theory. To begin with, this study addresses the fact that the FMCF can only be obtained through the observable canonical form(OCF) in existing FMS *** paper demonstrates that a class of nonlinear systems can directly obtain FMCF through state space equations, independent of OCF. Also, a general method for solving FMCF in such systems is provided. Furthermore, based on the FMCF, A distributed observer is developed for nonlinear systems under two scenarios: lipschitz conditions and open-loop bounded *** paper establishes their asymptotic omniscience and demonstrates that the designed distributed observer in this study has fewer design parameters and is more convenient to construct than existing approaches. Finally, the effectiveness of the proposed methods is validated through simulation results on Van der Pol oscillators and microgrid systems.

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认知空间映射及其神经机制

心理科学进展 2025年第1期33卷 62-76页

作者：吴际李会杰南宁师范大学教育科学学院南宁530001 中国科学院行为科学重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生... 详细信息

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生成、将信息与背景结构捆绑,以及海马体与其它脑区的协同。未来研究应关注预测性的认知空间地图、海马体对不同精度和层级信息的表征、认知空间映射微观和介观层面的研究空缺以及物理空间和认知空间映射的共同机制和特异性机制等问题。

关键词：认知地图网格细胞位置细胞海马体

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