检索结果-南通市图书馆

Neuropeptide Y receptor Y8b(npy8br)regulates feeding and digestion in Japanese medaka(Oryzias latipes)larvae:evidence from gene knockout

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 605-616页

作者： Xiaodan JIA ke lu Xufang LIANG College of Fisheries Chinese Perch Research CenterHuazhong Agricultural UniversityWuhan 430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt Ministry of EducationWuhan 430070China

Neuropeptide Y receptor Y8(NPY8R)is a fish-specific receptor with two subtypes,NPY8AR and *** in expression levels during physiological processes or in vivo regulation after ventricular injection suggest that NPY8BR plays an important role in feeding regulation;this has been found in only a few fish,at *** order to better understand the physiological function of npy8br,especially in digestion,we used clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology to generate npy8br-/-japanese medaka(Oryzias latipes).We found that the deletion of npy8br in medaka larvae affected their feeding and digestion ability,ultimately affecting their ***,npy8br deficiency in medaka larvae resulted in decreased feed intake and decreased expression levels of orexigenic genes(npy and agrp).npy8br-/-medaka larvae fed for 10 d(10th day of feeding)still had incompletely digested brine shrimp(Artemia nauplii)in the digestive tract 8 h after feeding,the messenger RNA(mRNA)expression levels of digestion-related genes(amy,lpl,ctra,and ctrb)were significantly decreased,and the activity of amylase,trypsin,and lipase also significantly *** deletion of npy8br in medaka larvae inhibited the growth and significantly decreased the expression of growth-related genes(gh and igf1).Hematoxylin and eosin(H&E)sections of intestinal tissue showed that npy8br-/-medaka larvae had damaged intestine,thinned intestinal wall,and shortened intestinal *** far,this is the first npy8br gene knockout model established in fish and the first demonstration that npy8br plays an important role in digestion.

关键词： Neuropeptide Y receptor Y8b(npy8br) Japanese medaka(Oryzias latipes) Knockout Feeding Digestion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-Perspective Data Fusion Framework Based on Hierarchical BERT: Provide Visual Predictions of Business Processes

引用

Computers, Materials & Continua 2024年第1期78卷 1227-1252页

作者： Yongwang Yuan Xiangwei Liu ke lu School of Mathematics and Big Data Anhui University of Science and TechnologyHuainan232001China School of Economics and Management Anhui University of Science and TechnologyHuainan232001China The key Laboratory of Embedded System and Service Computing Ministry of Education Tongji UniversityShanghai201804China

Predictive Business Process Monitoring(PBPM)is a significant research area in Business Process Management(BPM)aimed at accurately forecasting future behavioral *** present,deep learning methods are widely cited in PBPM research,but no method has been effective in fusing data information into the control flow for multi-perspective process ***,this paper proposes a process prediction method based on the hierarchical BERT and multi-perspective data ***,the first layer BERT network learns the correlations between different category attribute ***,the attribute data is integrated into a weighted event-level feature vector and input into the second layer BERT network to learn the impact and priority relationship of each event on future predicted ***,the multi-head attention mechanism within the framework is visualized for analysis,helping to understand the decision-making logic of the framework and providing visual ***,experimental results show that the predictive accuracy of the framework surpasses the current state-of-the-art research methods and significantly enhances the predictive performance of BPM.

关键词： Business process prediction monitoring deep learning attention mechanism BERT multi-perspective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Early prediction and prevention of infected pancreatic necrosis

引用

World Journal of Gastroenterology 2024年第9期30卷 1005-1010页

作者： Cheng Lv Zi-Xiong Zhang lu ke Department of Critical Care Medicine Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210000Jiangsu ProvinceChina Research Institute of Critical Care Medicine and Emergency Rescue Nanjing UniversityNanjing 210000Jiangsu ProvinceChina

Approximately 20%-30%of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis(IPN),a highly morbid and potentially lethal *** identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical *** the past two decades,several markers and predictive tools have been proposed and evaluated for this *** biomarkers like C-reactive protein,procalcitonin,lymphocyte count,interleukin-6,and interleukin-8,and newly developed biomarkers like angiopoietin-2 all showed significant association with *** the other hand,scoring systems like the Acute Physiology and Chronic Health Evaluation II and Pancreatitis Activity Scoring System have also been tested,and the results showed that they may provide better *** early prevention of IPN,several new therapies were tested,including early enteral nutrition,anti-biotics,probiotics,immune enhancement,etc.,but the results *** together,several evidence-supported predictive markers and scoring systems are readily available for predicting ***,effective treatments to reduce the incidence of IPN are still lacking apart from early enteral *** this editorial,we summarize evidence concerning early prediction and prevention of IPN,providing insights into future practice and study design.A more homo-geneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN,thereby achieving individualized treatment.

关键词： Acute pancreatitis Infected pancreatic necrosis Biomarker Scoring system Nutrition therapy Selective digestive decontamination Probiotics Antibiotics Immune enhancement therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneous acceleration of sulfur reduction and oxidation on bifunctional electrocatalytic electrodes for quasi-solid-state Zn–S batteries

引用

Science China Chemistry 2024年第5期67卷 1531-1538页

作者： Mingli Wang Hong Zhang Tianhang Ding Fangjun Wu Lin Fu Bin Song Pengfei Cao ke lu Institutes of Physical Science and Information Technology School of Materials Science and EngineeringKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei 230601China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China State key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

The incomplete sulfur reduction and high ZnS re-oxidation energy barrier along with severe side reactions during the battery cycling compromise the practical application of Zn–S electrochemistry. Herein, a bifunctional electrocatalytic sulfur matrix that simultaneously accelerates the sulfur reduction and ZnS oxidation is proposed to realize a highly-efficient Zn–S cell. It is revealed that the N-heteroatom hotspots are more favorable for facilitating the conversion of S to ZnS while the CoO nanocrystal substantially lowers the ZnS activation energy barrier thereby suppressing the formation of disproportionation species(e.g.,SO_(4)^(2-)) and accumulation of inactive ZnS. Accordingly, the Co O anchored on the N-doped carbon-supported sulfur cathode delivers a high Zn^(2+)storage capacity of 1,172 m Ahg^(-1)and outstanding cycling stability with a capacity retention of 71.6% after500 cycles with a high average Coulombic efficiency of 97.8%. Simultaneously, the stable cycling of solid-state Zn–S pouch cells with an energy density of 585 Whkg^(-1)sulfuris also demonstrated. Moreover, the postmortem analysis reveals that the degradation of Zn–S cells is mainly attributed to the limited reversibility of Zn anodes rather than the ZnS decomposition and/or accumulation. The approach to the bidirectional catalysis manipulated the sulfur redox provides a new perspective to realize the theoretical potentials of Zn–S cells.

关键词： Zn–S battery bifunctional catalysts solid-state battery sulfur redox degradation mechanism

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early systemic anticoagulation reduces hospital readmission in acute necrotizing pancreatitis patients:A retrospective cohort study

引用

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 77-82页

作者： Wen-Jian Mao Jing Zhou Guo-Fu Zhang Fa-Xi Chen Jing-Zhu Zhang Bai-Qiang Li lu ke Wei-Qin Li Department of Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjing 210002China Department of Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China National Institute of Healthcare Data Science Nanjing UniversityNanjing 210010China

Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been ***,whether it affects long-term outcomes is *** study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP ***:During January 2013 and December 2018,ANP patients admitted within 7 days from the onset of abdominal pain were *** primary outcome was 90-day readmission after *** proportional-hazards regression model and mediation analysis were used to define the relationship between early SAC and 90-day ***:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospitalization and 98 did *** who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95%CI:0.26-0.60,P<0.01]and lower 90-day readmission with an RR of 0.61(95%CI:0.41-0.91,P=0.02)than those who did *** the quality of life,patients who received early SAC had a significantly higher score in the subscale of vitality(P=0.03)while the other subscales were all comparable between the two *** Cox regression model showed that early SAC was an independent protective factor for 90-day readmission after adjusting for potential confounders with a hazard ratio of 0.57(95%CI:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0%of the early SAC-90-day readmission ***:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.

关键词： Anticoagulation Splanchnic venous thrombosis Acute necrotizing pancreatitis Readmission Long-term outcomes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 2977-2991页

作者： ke lu Ming Zhang Hongyu Qin Siyu Shen Haiqing Song Hua Jiang Chunxiang Zhang Guozhi Xiao Liping Tong Qing Jiang Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyShenzhen 518055China Oncology Department Johns Hopkins University School of MedicineBaltimoreMD 21205USA Division of Spine Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolState Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210008China fWenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China Department of Cardiology Basic Medicine Innovation Center for Cardiometabolic Diseases of Ministry of EducationInstitute of Cardiovascular Researchthe Affiliated HospitalSouthwest Medical UniversityLuzhou 646000China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of ***,we demonstrated that cyclin D1 is SUMOylated,and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating SUMO-induced ubiquitination and proteasome degradation of cyclin *** generated cyclin D1 mutant mice with mutations in the SUMOylation site,phosphorylation site,or both sites of cyclin D1,and found that double mutant mice developed a Mantle cell lymphoma(MCL)-like *** showed that arsenic trioxide(ATO)enhances cyclin D1 SUMOylation-mediated degradation through inhibition of cyclin D1 deSUMOylation enzymes,leading to MCL cell *** of severe combined immunodeficiency(SCID)mice grafted with MCL cells with ATO resulted in a significant reduction in tumor *** this study,we provide novel insights into the mechanisms of MCL tumor development and cyclin D1 regulation and discover a new strategy for MCL treatment.

关键词： Cyclin D1 SUMOylation Mantle cell lymphoma Arsenic trioxide SENP2 Proteasome degradation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

供给短缺下考虑消费异质性的零售商定价策略

引用

中国管理科学 2024年第7期32卷 201-211页

作者：杜恒卢珂南京工程学院经济与管理学院江苏南京211167 南京信息工程大学管理工程学院江苏南京210044

销售多种产品变体的零售商有时会遭遇某些单品的供给短缺,为此,零售商会采用一些定价策略来缓解这种缺货问题。为了分析零售商在供给风险环境下的最优定价策略,首先,基于数学优化方法,建立一个包含零售商和消费者的市场模型,理论上比较... 详细信息

销售多种产品变体的零售商有时会遭遇某些单品的供给短缺,为此,零售商会采用一些定价策略来缓解这种缺货问题。为了分析零售商在供给风险环境下的最优定价策略,首先,基于数学优化方法,建立一个包含零售商和消费者的市场模型,理论上比较两种定价模式:统一定价和差异定价,结果表明,当产品变体存在竞争关系,零售商应该选择差异定价策略,但存在不同的定价行为;若产品局部垄断市场,则使用统一定价策略。其次,在数理模型的基础上,考虑更多的现实复杂因素,基于计算实验方法,进一步探索零售商的定价机制。对比理论模型发现,估值差异可以改变零售商的定价策略选择,特别是当低估值产品缺货且两种产品市场估值差异不大时,应该选择统一定价策略;面对不确定的市场需求,零售商在市场竞争和市场局部垄断两种情境下的订货行为有所不同。

关键词：产品变体定价策略供给短缺数学优化计算实验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

卡夫卡中短篇小说中的非人类叙事

引用

学习与探索 2024年第1期 135-143页

作者：曾艳兵鲁珂中国人民大学文学院天津师范大学跨文化与世界文学研究院

近年来非人类叙事已成为学术界关注的热点和前沿话题。20世纪最杰出的预言和寓言作家卡夫卡,不仅是人类叙事的卓越代表,也是非人类叙事的探险者和领路人。卡夫卡的非人类叙事主要涉及他的中短篇小说。卡夫卡的非人类叙事主要通过动物叙... 详细信息

近年来非人类叙事已成为学术界关注的热点和前沿话题。20世纪最杰出的预言和寓言作家卡夫卡,不仅是人类叙事的卓越代表,也是非人类叙事的探险者和领路人。卡夫卡的非人类叙事主要涉及他的中短篇小说。卡夫卡的非人类叙事主要通过动物叙事来完成,变形叙事也是卡夫卡的重要叙事方式和手段,物叙事则是卡夫卡的卓越创造和独特贡献。鉴于以往我们对卡夫卡的人类叙事作品关注和研究较多,对非人类叙事作品重视和研究尚显不足,尤其对这类作品的叙事特征和价值研究不够,因此,集中探讨和分析卡夫卡的非人类叙事艺术无疑丰富和拓展了有关卡夫卡的研究领域,对于叙事学理论研究也有一定的积极意义。

关键词：卡夫卡非人类叙事动物叙事变形叙事物叙事

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

体质量管理在糖尿病防治中的利与弊

引用

实用医学杂志 2024年第16期40卷 2219-2223页

作者：鲁可陈小燕广州医科大学附属第一医院广州510145

随着人民生活水平的提高及生活方式的改变,我国肥胖及糖尿病人群数量不断激增,造成了极大的疾病负担。近年来,循证证据越来越强调体质量管理在糖尿病防治中的重要地位。尽管在理论和实践层面有诸多问题有待进一步阐明,但新形势下迫切需... 详细信息

随着人民生活水平的提高及生活方式的改变,我国肥胖及糖尿病人群数量不断激增,造成了极大的疾病负担。近年来,循证证据越来越强调体质量管理在糖尿病防治中的重要地位。尽管在理论和实践层面有诸多问题有待进一步阐明,但新形势下迫切需要医患双方转变思维方式。减重是一把“双刃剑”,让伴有超重或肥胖的糖尿病患者获益最大化的减重策略应建立在正确理解体质量管理内涵的基础上。长期维持减重成效仍面临许多的挑战,需要准确评估病情,权衡减重利弊,实施合理可行的减重方案,坚持长期的专业化管理。

关键词：体质量管理减重糖尿病肥胖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于行为轮廓矩阵增强的业务流程结果预测方法

引用

计算机应用研究 2024年第6期41卷 1762-1768页

作者：刘恒方贤文卢可安徽理工大学数学与大数据学院安徽淮南232001 安徽省煤矿安全大数据分析与预警技术工程实验室安徽淮南232001

预测性过程监控依赖于预测效果,针对如何增强预测性过程监控预测效果的问题,提出了一种基于行为轮廓矩阵增强的业务流程结果预测方法。首先,通过分析活动间的行为关系提取行为轮廓矩阵,并将其与事件序列一同输入到模型中。随后,结合卷... 详细信息

预测性过程监控依赖于预测效果,针对如何增强预测性过程监控预测效果的问题,提出了一种基于行为轮廓矩阵增强的业务流程结果预测方法。首先,通过分析活动间的行为关系提取行为轮廓矩阵,并将其与事件序列一同输入到模型中。随后,结合卷积神经网络(CNN)和长短期记忆网络(LSTM)分别学习矩阵图像特征和序列特征。最后,引入注意力机制以整合图像特征和序列特征进行预测。通过真实事件日志进行验证,在预测事件日志结果方面,提出的增强方法对比基准的LSTM预测方法提高了预测效果,验证了方法的可行性。该方法结合行为轮廓矩阵增强了预测模型对事件日志中行为之间关系的理解,进而提升了预测效果。

关键词：行为轮廓预测性过程监控业务流程结果预测

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：