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Open Journal of Gastroenterology 2011年第2期1卷 13-22页

作者： Bronislaw l. Slomiany Amalia Slomiany 不详

Gastric mucosal inflammatory responses to H. pylori lipopolysaccharide (lPS), are characterized by the excessive NO and prostaglandin (PGE2) generation due to the disturbances in nitric oxide synthase (NOS) and cyclooxygenase (cox) systems. Here, we report that the lPS-induced enhancement in gastric mucosal inducible (i) iNOS) activity and up-regulation in PGE2 production was associated with the suppression in Akt kinase activity and the impairment in constitutive (c) cNOS activation. The stimulatory effect of the lPS on PGE2 production, furthermore, was susceptible to suppression by cox-2 inhibitor, NS-398, and iNOS inhibitor, 1400 W. Further, we show that the countering effect of peptide hormone, ghrelin, on the lPS-induced changes was reflected in up-regu- lation in Akt activity and the increase in cNOS activation through phosphorylation, and accompanied by the suppression in iNOS expression and the reduction in cox-2 activity associated with the loss in cox-2 protein S-nitrosylation. Moreover, the effect of ghre-lin on the lPS-induced cox-2 S-nitrosylation was subject to repression by Akt inhibition. Our findings demonstrate that induction in iNOS with H. pylori in- fection leads to cox-2 activation through S-nitro- sylation and up-regulation in PGE2 generation, and that ghrelin counters these untoward consequences of the lPS through Akt-mediated up-regulation in cNO- S activation required for the iNOS gene repression.

关键词： H. pylori Gastric Mucosa iNOS Induction cox-2 Activation S-nitrosylation Ghrelin

New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract

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Natural Products and Bioprospecting 2015年第6期5卷 277-285页

作者： Daniela Batista Pedro l.Falé Maria l.Serralheiro Maria E.Araújo Paulo J.A.Madeira Carlos Borges Isabel Torgal Margarida Goulart Jorge Justino Alice Martins Amélia P.Rauter Centro de Química e Bioquímica Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisbonPortugal Institute of Pharmaceutical Science King’s College London150 Stamford StreetLondon SE19NHUK Escola Superior Agrária de Santarém Quinta do Galinheiro2001-904 SantarémPortugal

The inhibition of a-glucosidase and glucose-6-phosphatase,two enzymes involved in the carbohydrate metabolism,is an important target to control glycaemia on individuals with type 2 *** this work we report for the first time the inhibition of both enzymes by the antihyperglycemic n-butanol extract from Genista tenera(Fabaceae).This extract decreased a-glucosidase and glucose-6-phosphatase activities to 0.97 and 80.25%,respectively,being more effective than acarbose,and phlorizin,the positive controls,which reduced enzymes activities only to 17.39 and 96.06%.Once inflammation and oxidative stress are related to diabetic impairments,the anti-inflammatory activity of the extract was also evaluated,through its inhibitory activity over cox-1 enzyme(47.5%inhibition).Moreover,after induction of oxidative stress by UV radiation,the viability of irradiated rat liver hepatoma cells exposed to the extract was significantly higher(67.82%)than that promoted by ascorbic acid,the positive control(45.05%).In addition,the stability of the extract under gastrointestinal conditions was evaluated by HPlC–DAD-ESI–MS/*** diglycosides were identified as the main constituents of the extract,and no alterations in the chemical composition nor in the antioxidant activity were observed after in vitro digestion with artificial gastric and pancreatic juices.

关键词： a-Glucosidase inhibition In vitro digestion HPlC-DAD-ESI-MS/MS Antioxidant activity Flavonoid glycosides

增加日粮中小麦的比例对荷斯坦奶牛生产性能和瘤胃发酵的影响

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饲料与畜牧（新饲料） 2009年第8期 62-62页

作者：刘冰 l.Doepel A.cox A.Hayirli

12头处于第二次泌乳的荷斯坦奶牛，采用拉丁方设计研究增加日粮巾小麦比例对泌乳性能、瘤胃发酵和全肠养分消化率的影响。供试奶牛随机分为3组，分别饲喂0％、10％、20％蒸汽压片小麦（在干物质基础上替代等量蒸汽压片大麦）。每天饲喂... 详细信息

12头处于第二次泌乳的荷斯坦奶牛，采用拉丁方设计研究增加日粮巾小麦比例对泌乳性能、瘤胃发酵和全肠养分消化率的影响。供试奶牛随机分为3组，分别饲喂0％、10％、20％蒸汽压片小麦（在干物质基础上替代等量蒸汽压片大麦）。每天饲喂2次，挤奶2次。其中6头试验牛安装瘤胃瘘管，试验结束前2d采瘤胃液样本共计18次。不同处理的试验牛干物历摄入量（20．9kg／d）、产奶量（36．1kg／d）、乳成分（脂肪、蛋白、乳糖含量分别为1．25kg／d、1．10kg／d、1．67kg／d）差异不品著。

关键词：小麦奶牛消化率发酵

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凯·瑞安诗歌中的“老调新谈”

当代外国文学 2015年第1期36卷 19-27页

作者：吕爱晶湖南科技大学外国语学院

被称为"当代狄金森"、荣膺2011年普利策诗歌奖、2012年度"国家人文奖章"的美国诗人凯·瑞安认为诗歌多为游戏,倡议以一种游戏式的姿态建构诗歌,在一种貌似游戏娱乐的轻松氛围中作出思想的审视和批判。她的诗歌蕴含了当代知识分子的游戏... 详细信息

被称为"当代狄金森"、荣膺2011年普利策诗歌奖、2012年度"国家人文奖章"的美国诗人凯·瑞安认为诗歌多为游戏,倡议以一种游戏式的姿态建构诗歌,在一种貌似游戏娱乐的轻松氛围中作出思想的审视和批判。她的诗歌蕴含了当代知识分子的游戏精神。本文主要借助游戏批评,兼容日常生活批判视角审视诗歌中习语的"老调新谈"游戏主题,探讨瑞安如何从最平凡、最俗套的习语引入富有哲理性的思考,探讨当代知识分子在主流文化圈外寻求自我的独特艺术,从而揭示诗人对历史、社会、人生等诸多方面游戏元素的思考和强烈情感的表达。

关键词：凯·瑞安老调新谈游戏精神

锥形束CT血管成像对肝转移瘤病人偶发富血供微小结节的预后价值

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国际医学放射学杂志 2018年第1期 116-116页

作者： B.C.Odisio V.l.cox S.C.Faria S.Yamashita X.Shi J.Ensor 毛凡 Department of Interventional Radiology Division of Diagnostic ImagingThe University of Texas MD Anderson Cancer Center

摘要目的探讨锥形束CT血管成像(CBCTA)检出经过肝动脉(化学)栓塞术(TACE/TAE)后的肝转移瘤病人偶然发现富血供微小结节(IHM)的临床相关性。材料与方法此单

关键词：肝转移瘤微小结节血管成像锥形束 CT

Antihypertensive prescribing patterns in non-dialysis dependent chronic kidney disease:Findings from the Salford Kidney Study

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World Journal of Nephrology 2023年第5期12卷 168-181页

作者： Rajkumar Chinnadurai Henry H l Wu Jones Abuomar Sharmilee Rengarajan David I New Darren Green Philip A Kalra Donal O’Donoghue Renal Research Centre&Department of Renal Medicine Northern Care Alliance NHS Foundation TrustSalford M68HDUnited Kingdom Department of Renal Research Kolling Institute of Medical ResearchRoyal North Shore Hospital&The University of SydneySt.Leonards(Sydney)2065New South WalesAustralia Faculty of Biology Medicine&HealthThe University of ManchesterManchester M17HRUnited Kingdom

BACKGROUND Hypertension is commonly observed in patients living with chronic kidney disease(CKD).Finding an optimal treatment regime remains challenging due to the complex bidirectional cause-and-effect relationship between hypertension and *** remains variability in antihypertensive treatment *** To analyze data from the Salford Kidney Study database in relation to antihypertensive prescribing patterns amongst CKD *** The Salford Kidney Study is an ongoing prospective study that has been recruiting CKD patients since *** patients are followed up annually,and their medical records including the list of medications are updated until they reach study endpoints[starting on renal replacement therapy or reaching estimated glomerular filtration rate(eGFR)expressed as ml/min/1.73 m2≤10 ml/min/1.73 m2,or the last follow-up date,or data lock on December 31,2021,or death].Data on antihypertensive prescription practices in correspondence to baseline eGFR,urine albumin-creatinine ratio,primary CKD aetiology,and cardiovascular disease were *** between patients who were prescribed three or more antihypertensive agents and their clinical outcomes were studied by cox regression ***-Meier analysis demonstrated differences in survival *** Three thousand two hundred and thirty non-dialysis-dependent CKD patients with data collected between October 2002 and December 2019 were *** median age was 65 years.A greater proportion of patients were taking three or more antihypertensive agents with advancing CKD stages(53%of eGFR≤15 ml/min/1.73 m2 vs 26%of eGFR≥60 ml/min/1.73 m2,Plasses of antihypertensive agents was observed as the urine albumin-creatinine ratio category increased(category A3:62%vs category A1:40%,Plarly noticeable in the number of individuals prescribed renin angiotensin system *** pr

关键词： Hypertension Chronic kidney disease Antihypertensive agents Prescribing patterns Cardiovascular complications Renin angiotensin system blockers

Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic ***

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Journal of Animal Science and Biotechnology 2017年第1期8卷 143-153页

作者： Jae Cheol Kim Bruce P. Mullan John l. Black Robert J. E. Hewitt Robert J. van Barneveld John R. Pluske School of Veterinary and life Sciences Murdoch University Murdoch WA 6150 Australia Department of Agriculture and Food Pork Innovation South Perth WA 6151 Australia John l Black Consulting Warrimoo NSW 2774 Australia SunPork Farms Solutions Loganholme QLD 4129 Australia Barneveld Nutrition Pry ltd Loganholme QLD 4129 Australia

Background： This experiment was conducted to test the hypothesis that vitamin E（Vit E） and acetylsalicylic acid（ASA）, a cyclooxygenase-2（cox-2） inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E_2（PGE_2） and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. ***： The experiment was conducted in a research facility with 192 individually-housed male weaner pigs（landrace × large White） weighing 6.6 ± 0.04 kg（mean ± SEM）. The pigs were experimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels of Vit E supplementation（50, 100 or 200 IU/kg diet, dl-α-tocopheryl acetate）.Results： Acetylsalicylic acid supplementation improved average daily gain（P 〈 0.05） and tended to improve feed：gain ratio（P 〈 0.10） during the first 14 d after weaning. Acetylsalicylic acid supplementation also improved（P 〈 0.001） amino acid utilization efficiency（as assessed by plasma urea level） and tended to decrease（P 〈 0.10） PGE2 production in the liver without affecting smal intestinal histology and tight junction protein mR NA expression in the jejunal epithelium. Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration（P 〈 0.001） and plasma haptoglobin content（P 〈 0.001） after weaning. However, there was no additive effects of the combined supplementation of ASA and Vit E on performance, intestinal barrier function and inflammatory responses of weaned ***： Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses, ASA and vitamin E did not additively reduce production of PGE2 and inflammatory responses in weaner pigs experimental y infected with an enterotoxigenic strain of E. coli.

关键词： Acetylsalicylic acid E.coli infection PGE_2 Vitamin E Weaner pigs

日粮小麦对荷斯坦奶牛生产性能和瘤胃发酵的影响

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饲料博览 2009年第9期19卷 43-43页

作者： Doepel l.cox A Hayirli A 张树金（摘译）

试验旨在研究探讨日粮小麦对荷斯坦奶牛泌乳性能、瘤胃发酵和总营养物质消化率的影响。试验采用拉丁方设计,选择奶牛12头,随机分为3个处理组,分别添加蒸汽压片小麦0、10%、20%。奶牛每天饲喂和挤奶2次。选择6头奶牛安装瘤胃瘘管,瘤胃液... 详细信息

试验旨在研究探讨日粮小麦对荷斯坦奶牛泌乳性能、瘤胃发酵和总营养物质消化率的影响。试验采用拉丁方设计,选择奶牛12头,随机分为3个处理组,分别添加蒸汽压片小麦0、10%、20%。奶牛每天饲喂和挤奶2次。选择6头奶牛安装瘤胃瘘管,瘤胃液样来自每个时期前2d的瘤胃液。试验结果表明,干物质采食量为20.9kg·d-1,产奶量为36.1kg·d-1,乳脂肪、乳蛋白、乳糖分别为1.25、1.10和1.67kg·d-1,对其无显著影响。各处理间的乳脂率无显著差异,乳蛋白含量减少,10%组乳蛋白较20%组少(6.36,6.44)。与对照组相比,饲喂小麦组瘤胃pH降低(6.36,6.44),氨氮浓度和总挥发性脂肪酸升高(11.49,8.10mg·d-1·l-1,121,113mM),醋酸盐和丙酸盐比率降低(3.21,3.36),但10%组和20%组无显著差异。饲喂小麦不影响总表观消化率、粗蛋白质、酸性洗涤纤维和中性洗涤纤维。试验结果显示,如果日粮有合适的配比及提供足够的纤维,20%的蒸汽压片小麦不降低生产,但会导致亚急性瘤胃酸中毒。

关键词：小麦奶牛消化率发酵

New perspectives on robotic pancreaticoduodenectomy:An analysis of the National Cancer Database

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 60-71页

作者： Aleksandr Kalabin Vishnu R Mani Robin l Kruse Chase Schlesselman Kai Yu li Kevin F Staveley-O'Carroll Eric T Kimchi Department of Surgery University of MissouriColumbiaMO 65212United States Department of Surgery The Johns Hopkins HospitalBaltimoreMD 21287United States

BACKGROUND Pancreatic ductal adenocarcinoma is a common *** all advancements,the prognosis remains,poor with an overall 5-year survival of only 10.8%.Recently,a robotic platform has become an attractive tool for treating pancreatic cancer(PC).While recent studies indicated improved lymph node(lN)harvest during robotic pancreaticoduodenectomy(PD),data on long-term outcomes are *** To evaluate absolute lN harvest during *** outcomes included evaluating the association between lN harvest and short-and long-term oncological outcomes for three different surgical *** We conducted an analysis of the National Cancer Database,including patients diagnosed with PC who underwent open,laparoscopic,or robotic PD in ***-way analysis of variance was used to compare continuous variables,chi-square test-for *** survival was defined as the time between surgery and *** survival time was estimated with the Kaplan-Meier method,and groups were compared with the Wilcoxon test.A cox proportional hazards model was used to assess the association of covariates with survival after controlling for patient characteristics and procedure *** 17169 patients were included,8859(52%)males;mean age 65;14509(85%)white.13816(80.5%)patients had an open PD,2677(15.6%)and 676(3.9%)-laparoscopic and robotic PD *** comorbidity index(Charlson-Deyo Score)*** average,18.84 lNs were *** lN harvest during open,laparoscopic and robotic PD was 18.59,19.65 and 20.70 respectively(PlNs were positive for cancer and did not differ by the procedure type(P=0.26).Vascular invasion was noted in 42.6%of lNs and did differ by the approach:42.1%for open,44.0%for laparoscopic and 47.2%for robotic PD(P=0.015).Median survival for open PD was 26.1 mo,laparoscopic-27.2 mo,robotic-29.1 mo(P=0.064).Survival was associated with higher lN harvest,while higher number of positive lNs was assoc

关键词： Pancreatic cancer Pancreaticoduodenectomy Robotic surgery National Cancer Database

Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer:A population-based study

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1461-1474页

作者： Jiao Jiang Xiao-Wei Tang Shu Huang Nan Hu Yuan Chen Bei luo Wen-Sen Ren Yan Peng Wei-Xing Yang Mu-Han lü Department of Gastroenterology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology the People’s Hospital of LianshuiHuaian 223400Jiangsu ProvinceChina

BACKGROUND Mucinous adenocarcinoma(MC)has attracted much attention as a distinct histologic subtype of colorectal cancer in recent ***,data about its epidemiologic and prognostic characteristics are ***,patient data extracted from the National Cancer Institute’s Surveillance,Epidemiology,and End Results Program were collected to analyze the epidemiologic and clinicopathological characteristics of *** To determine the epidemiologic and clinicopathological characteristics of *** The incidence trend of MC was calculated through the Joinpoint Regression *** regression analyses were performed to identify prognostic factors associated with overall survival(OS).A nomogram was established to predict the survival probability of individual patients with *** We found that rates of MC decreased from 4.50/100000 in 2000 to 1.54/100000 in *** of MCs in patients aged≤50 years decreased 2.27%/year during *** incidence of appendiceal MCs increased from 0.14/100000 in 2000 to 0.24/100000 in 2018,while the incidence in other anatomic subsites continued to *** multivariable cox analyses,age,race,tumor site,T stage,N stage,M stage,surgery,and chemotherapy were associated with OS.A nomogram was developed based on these factors,and the area under the curve for 1-year,3-year,and 5-year OS in the training cohort was 0.778,0.778,and 0.768,*** Our results demonstrated that MC incidence decreased in almost all anatomic subgroups except for the appendix.A nomogram predicting the survival probability of patients with MCs showed good performance.

关键词： Mucinous adenocarcinoma Colorectal cancer Epidemiology Prognostic factor Nomogram Surveillance epidemiology and end results database