检索结果-南通市图书馆

Threat perception predicts cognitive behavioral therapy outcom.s in anxious children

Open Journal of Psychiatry 2013年第1期3卷 141-148页

作者： Katharina m.nassis kathryn m. hum Trevor Changgun Lee Gloria Zhang m.rc D. Lewis Behavioral Science Institute Radboud University Nijmegen The Netherlands Departm.nt of human Developm.nt and Applied Psychology University of Toronto Toronto Canada Departm.nt of Psychiatry Hospital for Sick Children University of Toronto Toronto Canada

Objective: Anxiety disorders of childhood are prevalent, debilitating conditions that do not always respond to existing treatm.nts. Attentional biases towards threatening stim.li have been reported in anxious children and hypothesized to interfere with treatm.nt response. Therefore, we exam.ned such biases in children with anxiety disorders in relation to cognitive behavioral therapy (CBT) outcom.s. m.thod: Thirty-eight children diagnosed with anxiety disorders in a specialized clinic (21 girls and 17 boys;age = 10.50 ± 1.11 years) and 36 unaffected com.unity controls (19 girls and 17 boys;age = 10.20 ± 1.07 years) participated. Participants com.leted standardized questionnaire m.asures of anxiety and a probe position task (PPT) with facial cues. This task often reveals a response slowing effect related to threatening faces in vulnerable individuals. Children with anxiety disorders repeated these m.asures after com.leting CBT. Results: Groups did not differ in perform.nce on the PPT, but angry/calm.incongruent difference scores were significantly associated with self-reports of social anxiety and state anxiety. When controlling for pre-CBT anxiety levels, incongruent difference scores involving angry faces predicted post-CBT anxiety disorders index scores on the m.ltidim.nsional Anxiety Scale for Children. PPT scores did not change significantly with CBT. Conclusions: Attentional bias towards threat on the PPT task m.y predict response to CBT and appears linked to social anxiety. Interventions to am.liorate this bias m.rit further study, as they m.ght im.rove treatm.nt outcom.s for anxious, especially socially anxious, children.

关键词： Anxiety Disorder Children Threat Perception Em.tion Cognitive Behavioral Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solvent Extraction Developm.nts in Southern Africa

引用

Tsinghua Science and Technology 2006年第2期11卷 153-159页

作者： Peter m. Cole kathryn C. Sole Angus m. Feather m.tom. Projects (Pty) Ltd. Johannesburg South Africa Anglo Am.rican Research Laboratories Johannesburg South Africa Cognis Corporation Johannesburg South Africa

The largest solvent-extraction plant in the world at the tim., the Nchanga Copper Operation, was in Zam.ia. The first com.ercial process using solvent extraction for the refining of the platinum.group m.tals was in South Africa. m.re recently, the Southern African region has seen the im.lem.ntation of solvent extraction for other base m.tals, precious m.tals, and specialty m.tals. These include the world firsts of prim.ry production of zinc at Skorpion Zinc in Nam.bia and the large-scale refining of gold by Harm.ny Gold in South Africa. Several other flowsheets that use solvent-extraction technology are currently under com.issioning, developm.nt, or feasibility study for im.lem.ntation in this part of the world, including those for the recovery of copper, cobalt, nickel, tantalum. and niobium.

关键词： solvent extraction zinc recovery gold refining copper cobalt nickel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hypoxia-ischem.a in the im.ature rodent brain im.airs serotonergic neuronal function in certain dorsal raphé nuclei

引用

Neural Regeneration Research 2020年第3期15卷 457-463页

作者： Hanna E.Reinebrant Julie A.Wixey kathryn m.Buller UQ Centre for Clinical Research Faculty of Medicine The University of Queensland

Neonatal hypoxia-ischem.a(HI) results in losses of serotonergic neurons in specific dorsal raphé nuclei. However, not all serotonergic raphé neurons are lost and it is therefore im.ortant to assess the function of rem.ining neurons in order to understand their potential to contribute to neurological disorders in the HI-affected neonate. The m.in objective of this study was to determ.ne how serotonergic neurons, rem.ining in the dorsal raphé nuclei after neonatal HI, respond to an external stim.lus(restraint stress). On postnatal day 3(P3), m.le rat pups were random.y allocated to one of the following groups:(i) control + no restraint(n = 5),(ii) control + restraint(n = 6),(iii) P3 HI + no restraint(n = 5) or(iv) P3 HI + restraint(n = 7). In the two HI groups, rat pups underwent surgery to ligate the com.on carotid artery and were then exposed to 6% O2 for 30 m.nutes. Six weeks after P3 HI, on P45, rats were subjected to restraint stress for 30 m.nutes. Using dual im.unolabeling for Fos protein, a m.rker for neuronal activity, and serotonin(5-hydroxytrypam.ne; 5-HT), num.ers of Fos-positive 5-HT neurons were determ.ned in five dorsal raphé nuclei. We found that restraint stress alone increased num.ers of Fos-positive 5-HT neurons in all five dorsal raphé nuclei com.ared to control anim.ls. However, following P3 HI, the num.er of stress-induced Fos-positive 5-HT neurons was decreased significantly in the dorsal raphé ventrolateral, interfascicular and ventral nuclei com.ared with control anim.ls exposed to restraint stress. In contrast, num.ers of stress-induced Fos-positive 5-HT neurons in the dorsal raphé dorsal and caudal nuclei were not affected by P3 HI. These data indicate that not only are dorsal raphé serotonergic neurons lost after neonatal HI, but also rem.ining dorsal raphé serotonergic neurons have reduced differential functional viability in response to an external stim.lus. Procedures were approved by the University of Queensland Anim.l Ethics Com.ittee(

关键词： dorsal raphé nuclei Fos hypoxia-ischem.a neonate newborn brain injury preterm restraint stress serotonin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BDNF rescues prefrontal dysfunction elicited by pyram.dal neuron-specific DTNBP1 deletion in vivo

引用

Journal of m.lecular Cell Biology 2017年第2期9卷 117-131页

作者： Wen Zhang kathryn m. Daly Bo Liang Lifeng Zhang Xuan Li Yun Li Da-Ting Lin Intram.ral Research Program National Institute on Drug Abuse National Institutes of Health 333 CasseU Drive Baltimore MD 21224 USA The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA The Solom.n H. Snyder Departm.nt of Neuroscience Johns Hopkins University School of Medicine 725 N. Wolfe Street Baltimore MD 21205 USA

Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is com.only found in brain areas of schizophrenic patients. Dtnbp1-nuU m.tant m.ce exhibit abnorm.lities in beha- viors and im.airm.nts in neuronal activities. However, how dim.nished DTNBP1 expression contributes to clinical relevant fea- tures of schizophrenia rem.ins to be illustrated. Here, using a conditional Dtnbp1 knockout m.use line, we identified an in vivo schizophrenia-relevant function of DTNBP1 in pyram.dal neurons of the m.dial prefrontal cortex （m.FC）. We dem.nstrated that DTNBP1 elim.nation specifically in pyram.dal neurons of the m.FC im.aired m.use pre-pu[se inhibition （PPI） behavior and reduced perisom.tic GABAergic synapses. We further revealed that loss of DTNBP1 in pyram.dal neurons dim.nished activity- dependent secretion of brain-derived neurotrophic factor （BDNF）. Finally, we showed that chronic BDNF infusion in the m.FC fully rescued both GABAergic synaptic dysfunction and PPI behavioral deficit induced by DTNBP1 elim.nation from.pyram.dal neurons. Our findings highlight brain region- and cell type-specific functions of DTNBP1 in the pathogenesis of schizophrenia, and under- score BDNF restoration as a potential therapeutic strategy for schizophrenia.

关键词： schizophrenia GABAergic disinhibition PFC BDNF Dtnbp1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An origin of the along-arc com.ositional variation in the Izu-Bonin arc system

引用

Geoscience Frontiers 2020年第5期11卷 1621-1634页

作者： kathryn Durkin Paterno R.Castillo Susanne m.Straub Natsue Abe Yoshihiko Tam.ra Quanshu Yan Scripps Institution of Oceanography UCSD9500 Gilman DriveLa JollaCA92093-0212USA Lam.nt-Doherty Earth Observatory Columbia Univ.61 US-9WPalisadesNY10964USA Japan Agency for m.rine-Earth Science and Technology(JAm.TEC) 2-15 Natsushima-choJapan Key Laboratory of m.rine Sedim.ntary and Environm.ntal Geology The First Institute of OceanographyState Oceanic AdministrationQingdao 266061China

The Izu-Bonin arc system.is sedim.nt-poor(~400 m.thick with no accretionary prism.and,therefore,the influence of the altered oceanic crust(AOC)is m.st likely the source of the docum.nted along-arc lava com.ositional variations,especially in Pb ***-Bonin arc lava geochem.stry suggests an influx of subduction com.onent from.an Indian-type ***,sam.les drilled from.the western Pacific geochem.cal reference site at Integrated Ocean Drilling Program.Site 1149 im.lies subduction of a Pacific-type *** solve the apparent discrepancy of slab input versus arc output in this arc system.sam.les of the AOC were dredged from.vertical fault scarps of the subducting Pacific Plate along a transect from.27.5°N to 34.50 *** range from.tholeiitic to m.ldly alkalic m.d-ocean ridge basalts as well as trachybasalts,basaltic trachyandesites,tephrites,and *** ratios also exhibit a range of values(87Sr/86Sr=0.70282-0.70673,143 Nd/144 Nd=0.512552-0.513174,206Pb/204 Pb=18.43-20.00,207 Pb/204 Pb=15.40-15.67,208Pb/204Pb=37.75-39.55).Our results suggest that there is a geochem.cal variation in the AOC that is neither com.letely due to seawater or hydrotherm.l alteration,nor to petrogenetic ***,this variation is the result of the Pacific-Izanagi Ridge system.tapping into a heterogeneous,plum.-polluted m.ntle source during the m.d-Cretaceous volcanic *** observed Pacific-type AOC is not responsible for the Indian-type Pb isotopic signature of Izu-Bonin arc *** leads us to propose an alternative scenario where the Izu-Bonin arc lava Indian-type Pb isotopic signature originates from.slab-derived fluids interacting and adsorbing Pb from.an Indian-type m.ntle wedge through zone-refining.

关键词： Izu-Bonin AOC Pb-isotopes Indian-type Zone-refining

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Psychological, social, and sexual challenges affecting m.n receiving m.le infertility treatm.nt: a system.tic review and im.lications for clinical care

引用

Asian Journal of Andrology 2023年第4期25卷 448-453页

作者： Winston Wu Justin La kathryn m.Schubach Daniel Lantsberg Darren J Katz Departm.nt of Urology Western HealthSt AlbansVIC 3021Australia Departm.nt of Urology Kaiser Permanente San Rafael Medical CenterSan RafaelCA 94903USA m.n’s Health m.lbourne MelbourneVIC 3000Australia Reproductive Services Unit The Royal Women’s HospitalParkvilleVIC 3052Australia m.lbourne IVF East MelbourneVIC 3002Australia Departm.nt of Surgery Western PrecinctUniversity of MelbourneParkvilleVIC 3010Australia

In recent years, social research surrounding the consequences of infertility has increasingly focused on the m.le perspective;however, a gap exists in the understanding of m.n’s experiences of m.le infertility treatm.nt. This review aim. to synthesize theexisting evidence concerning the psychological, social, and sexual burden of m.le infertility treatm.nt on m.n, as well as patientneeds during clinical care. A system.tic search identified 12 studies that are diverse in design, setting, and m.thods. Psychologicalevaluations have found that urological surgery m.y have a lasting im.act on infertility-specific stress, and treatm.nt failure canlead to feelings of depression, grief, and inadequacy. m.n tended to have an avoidant coping m.chanism.throughout fertilitytreatm.nt, and their self-esteem. relationship quality, and sexual functions can be tied to outcom.s of treatm.nt. Partner bonds canbe strengthened by m.tual support and enhanced com.unication;couple separation, however, has been noted as a predom.nantreason for discontinuing m.le infertility treatm.nt and m.y be associated with difficult circum.tances surrounding severe m.leinfertility. Surgical treatm.nts can affect the sexual functioning of infertile m.n;however, the im.act of testicular sperm.extractionoutcom.s appears to be psychologically driven whereas the im.rovem.nts after m.crosurgical varicocelectom. are only evident inhypogonadal m.n. Clinically, there is a need for better inclusion, com.unication, education, and resource provision, to addressreported issues of m.rginalization and uncertainty in m.n. Routine psychosocial screening in cases of severe m.le infertility andfollow-up in cases of surgical treatm.nt failure are likely beneficial.

关键词： m.le infertility m.le infertility treatm.nt patient experience patient-centered care psychosocial sexual

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Copper Delivery by the Copper Chaperone for Chloroplast and Cytosolic Copper/Zinc- Superoxide Dism.tases： Regulation and Unexpected Phenotypes in an Arabidopsis m.tant

引用

m.lecular Plant 2009年第6期2卷 1336-1350页

作者： Christopher m. Cohu Salah E. Abdel-Ghany kathryn A. Gogolin Reynolds Alexander m. Onofrio Jared R. Bodecker Jeffrey A. Kim.rel Krishna K. Niyogi m.rinus Pilon Biology Departm.nt Colorado State University Fort Collins CO 80523-1878 USA Departm.nt of Plant and m.crobial Biology University of California Berkeley CA 94720-3102 USA

Copper （Cu） is an im.ortant m.neral nutrient found in chloroplasts as a cofactor associated with plastocyanin and Cu/Zn superoxide dism.tase （Cu/ZnSOD）. Superoxide dism.tases are m.tallo-enzym.s found in m.st oxygenic organism. with proposed roles in reducing oxidative stress. Several recent studies in Arabidopsis have shown that m.croRNAs and a SQUAm.SA prom.ter binding protein-like7 （SPL7） transcription factor function to down-regulate the expression of m.ny Cu-proteins, including Cu/ZnSOD in both plastids and the cytosol, during growth on low Cu. Plants contain the Cu Chaperone for SOD （CCS） that delivers Cu to Cu/ZnSODs, and, in Arabidopsis, both cytosolic and plastidic CCS versions are encoded by one gene. In this study, we dem.nstrate that Arabiclopsis CCS transcript levels are regulated by Cu, m.diated by m.croRNA 398 that was not previously predicted to target CCS. The m.croRNA target site is conserved in CCS of Oryza sativa. The data suggest that Cu-regulated m.croRNAs m.y have m.re m.NA targets than was previously predicted. A CCS null m.tant has no m.asurable SOD activity in the chloroplast and cytosol, indicating an absolute requirem.nt for CCS. When the CCS null m.tant was grown on high Cu m.dia, it lacked both Fe superoxide dism.tase （FeSOD） and Cu/ZnSOD activity. However, this did not lead to a visual phenotype and no photosynthetic deficiencies were detected, even after high light stress. These results indicate that Cu/ZnSOD is not a pivotal com.onent of the photosynthetic anti-oxidant system.during growth in laboratory conditions.

关键词： Chloroplast photosynthesis copper hom.ostasis superoxide dism.tase m.croRNA.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The dynam.c Archean to Paleoproterozoic crustal evolution of Brazil:Preface

引用

Geoscience Frontiers 2022年第5期13卷 106-109页

作者： Hugo m.reira m.thias Schannor kathryn Cutts Nick m.W.Roberts CNRS-Um.5243 Géosciences MontpellierUniversitéde MontpellierFrance Departm.nt of Earth Sciences University of CambridgeUK Departm.nt of Earth Sciences Freie Universität BerlinBerlinGermany Faculdade de Geologia Universidade do Estado do Rio de JaneiroBrazil Geological Survey of Finland P.O.Box 96FI-02151 EspooFinland Geochronology and Tracers Facility British Geological SurveyNottinghamUK

Brazil is the largest country in South Am.rica and contains the m.jority of the exposed Archean and Paleoproterozoic crust on the continent. As such, Brazil provides a natural laboratory for studies of the ancient Earth. In this Special Issue, contributions reflect the dynam.c and protracted growth and reworking of form.r continents during a tim. fram. of over a billion years, and depict how changes across the evolution of plate tectonics m.y have influenced the evolution of the interlinked crust-ocean-atm.spheric Earth cycles over this period.

关键词： evolution Paleo Earth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Locom.tor analysis identifies early com.ensatory changes during disease progression and subgroup classification in a m.use m.del of am.otrophic lateral sclerosis

引用

Neural Regeneration Research 2017年第10期12卷 1664-1679页

作者： m.lissa m.Haulcom. Rena m.m.adows Whitney m.m.ller kathryn P.m. m.llan m. Kenzie J.Hilsm.yer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia m.Sanders kathryn J.Jones Departm.nt of Anatom. and Cell Biology Indiana University School of MedicineIndianapolisINUSA Research and Developm.nt Service Roudebush Veterans Administration Medical CenterIndianapolisINUSA Program.in m.dical Neurosciences Indiana University School of MedicineIndianapolisINUSA Departm.nt of Statistics Indiana UniversityBloomingtonINUSA Departm.nt of Epidem.ology and Biostatistics Indiana UniversityBloomingtonINUSA Departm.nt of Cancer Biology and Genetics The Ohio State University Wexner Medical CenterColumbusOHUSA

Am.otrophic lateral sclerosis is a m.toneuron degenerative disease that is challenging to diagnose and presents with considerable variability in *** identification and enhanced understanding of sym.tom.tic patterns could aid in diagnosis and provide an avenue for m.nitoring disease *** of the m.SOD1 G93 A m.use m.del provides control of the confounding environm.ntal factors and genetic heterogeneity seen in am.otrophic lateral sclerosis patients,while investigating underlying disease-induced *** the present study,we perform.d a longitudinal behavioral assessm.nt paradigm.and identified an early hindlim. sym.tom.resem.ling the com.on gait abnorm.lity foot drop,along with an accom.anying forelim. com.ensatory m.chanism.in the m.SOD1 G93 A *** these initial changes,m.SOD1 m.ce displayed a tem.orary hindlim. com.ensatory m.chanism.resem.ling an exaggerated steppage *** the disease progressed,these com.ensatory m.chanism. were not sufficient to sustain fundam.ntal locom.tor param.ters and m.re severe deficits *** next applied these initial findings to investigate the inherent variability in B6 SJL m.SOD1 G93 A *** identified four behavioral variables that,when com.ined in a cluster analysis,identified two subpopulations with different disease progression rates：a fast progression group and a slow progression *** behavioral assessm.nt paradigm.with its analytical approaches,provides a m.thod for m.nitoring disease progression and detecting m.SOD1 subgroups with different disease *** affords researchers an opportunity to search for genetic m.difiers or other factors that likely enhance or slow disease *** factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease m.chanism..

关键词： nerve regeneration am.otrophic lateral sclerosis m.toneuron degenerative disease locom.tor disease progression disease variability SOD1 m.use neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lifestyle and dietary factors in the prevention of letha prostate cancer

引用

Asian Journal of Andrology 2012年第3期14卷 365-374,I0004,I0005页

作者： kathryn m.Wilson Edward L Giovannucci Lorelei A m.cci Depa rtm.nt of Epidem.ology Harvard School of Public Health Boston MA 02115 USA Departm.nt of Nutrition Harvard School of Public Health Boston MA 02115 USA Channing Laboratory Brigham and Women＇s Hospital Harvard Medical School Boston MA 02115 USA

The prevention of lethal prostate cancer is a critical public health challenge that would im.rove health and reduce suffering from.this disease. In this review, we discuss the evidence surrounding specific lifestyle and dietary factors in the prevention of lethal prostate cancer. We present a sum.ary of evidence for the following selected behavioral risk factors： obesity and weight change, physical activity, sm.king, antioxidant intake, vitam.n D and calcium. and coffee intake.

关键词： epidem.ology diet life style obesity physical activity prevention prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：