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Journal of Animal Science and Biotechnology 2019年第2期10卷 435-448页

作者： kathleen R.Walter Xi Lin Sheila K.Jacobi Tobias Kaser Debora Esposito Jack Odle Department of Animal Science Plants for Human Health InstituteNorth Carolina State UniversityKannapolisNorth CarolinaUSA Department of Animal Science North Carolina State UniversityRaleighNorth CarolinaUSA Department of Animal Science Ohio State UniversityColumbusOhioUSA Department of Population Health and Pathobiology College of Veterinary MedicineNorth Carolina State UniversityRaleighNorth CarolinaUSA.

Background: Respiratory infections challenge the swine industry, despite common medicinal practices. The dual signaling nature of PGE2(supporting both inflammation and resolution) makes it a potent regulator of immune cell function. Therefore, the use of dietary long chain n-6 PUFA to enhance PGE2 effects merits ***: Day-old pigs(n = 60) were allotted to one of three dietary groups for 21 d(n = 20/diet), and received either a control diet(CON, arachidonate = 0.5% of total fatty acids), an arachidonate(ARA)-enriched diet(LC n-6,ARA = 2.2%), or an eicosapentaenoic(EPA)-enriched diet(LC n-3, EPA = 3.0%). Alveolar macrophages and lung parenchymal tissue were collected for fatty acid analysis. Isolated alveolar macrophages were stimulated with LPS in situ for 24 h, and m RNA was isolated to assess markers associated with inflammation and eicosanoid *** media were collected to assess PGE2 secretion. Oxidative burst in macrophages was measured by: 1)oxygen consumption and extracellular acidification(via Seahorse), 2) cytoplasmic oxidation and 3) nitric oxide production following 4, 18, and 24 h of LPS ***: Concentration of ARA(% of fatty acids, w/w) in macrophages from pigs fed LC n-6 was 86% higher than CON and 18% lower in pigs fed LC n-3(P mulation, abundance of COX-2 and TNF-α mRNA(P m vs. CON. However, ALOX5 abundance was1.6-fold lower than CON. macrophages from CON and LC n-6 groups were 4-fold higher in ALOX12/15 abundance(P mpared to LC n-3. Oxygen consumption and extracellular acidification rates increased over 4 h following LPS stimulation(P ment. Similarly, increases in cytoplasmic oxidation(P mulation but were unaffected by ***: We infer that enriching diets with arachidonic acid may be an ef

关键词： Arachidonic acid Cyclooxygenase Eicosanoid Eicosapentaenoic acid Inflammation Lipid mediator class switch LPS Lipoxin Porcine alveolar macrophage

WONCA研究论文摘要汇编——全科医疗特点和非日间全科医疗合作机构利用的关系

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中国全科医学 2015年第17期18卷 2116-2116页

作者：本刊编辑部 smits m Peters Y Broers S 本刊编辑部

背景非日间非紧急医疗服务与日间初级医疗组织相关,但是其中的潜在机制尚不明确。本研究旨在发现日间全科医疗特点和非日间全科医疗合作机构利用的关系。方法对荷兰5个全科医疗合作机构所属的100个全科医疗诊所进行横断面研究。在每个... 详细信息

背景非日间非紧急医疗服务与日间初级医疗组织相关,但是其中的潜在机制尚不明确。本研究旨在发现日间全科医疗特点和非日间全科医疗合作机构利用的关系。方法对荷兰5个全科医疗合作机构所属的100个全科医疗诊所进行横断面研究。在每个全科医疗合作机构中分别抽取10个非日间医疗利用量最多和10个非日间医疗利用量最少的家庭医学诊所。通过问卷、访谈、病人注册系统的数据抽取和电话可及性测量,对行医和人口特点进行调查。为了明确非日间医疗利用量的行医组织影响因素,进行Logistic回归分析(较少的非日间医疗利用量和较多的非日间医疗利用量),并校正人口特点误差。结果非日间医疗利用量较多组的平均非日间医疗利用量是非日间医疗利用量较少组的1.8倍。日间初级医疗对象中儿童和外国人口越多,距离全科医学合作机构越近,则全科医疗诊所的非日间初级医疗利用量越大。电话等待时间越长,日间缓和的病人个人服务可利用性越差,则非日间初级医疗利用量越大。非日间进行诊断测试、治疗程序越多,且每1000名病人的助手雇佣时间越长,则非日间医疗利用量越大。行医管理的其他方面出现了一些不太显著的趋势:高度利用的全科医学诊所的非紧急预约等待时间更长、电话询问时间的可及性更低、下午5点之后的咨询可及性更低、假日诊所开放率更低。结论除了患者人群特点,全科医疗诊所的结构性特点使非日间医疗利用量降低。提高日间初级医疗服务的可及性和可利用性也许能够促进非日间医疗服务的有效利用。

关键词：医疗合作医疗特点 WONCA 论文摘要汇编医疗组织医疗服务医疗诊所

WONCA研究论文摘要汇编——全科医生的非工作时间全科医生合作项目的经历:荷兰的调查研究

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中国全科医学 2015年第4期 432-432页

作者： smits m Keizer E Huibers L 本刊编辑部

背景自2000年以来,荷兰全科医生合作项目一直在提供工作时间外的初级保健服务。具有类似组织机构的国家的早期研究也说明了全科医生合作项目的正性经验。然而大家普遍认为在合作项目中全科医生经历了高负荷的工作量,外包成为他们工作的... 详细信息

背景自2000年以来,荷兰全科医生合作项目一直在提供工作时间外的初级保健服务。具有类似组织机构的国家的早期研究也说明了全科医生合作项目的正性经验。然而大家普遍认为在合作项目中全科医生经历了高负荷的工作量,外包成为他们工作的相当大的一部分。目的对全科医生在工作时间外提供初级保健服务的利与弊、频次及外包工作的理由进行了解。方法以网络问卷方式,对荷兰6个全科医生合作项目的 688名全科医生进行了横截面调查。结果问卷的回收率为55%(378/688)。全科医生合作项目工作的主要理由:作为全科医生要保持挂号(79%);处理急症经历(74%)。全科医生认为峰值工作量(81%)和患者数目众多(73%)为最负性的经历。大多数全科医生自己选择提供非工作时间的外包服务:85%的全科医生外包服务时间最高超过了他们工作时间的25%。外包服务比例随着年龄增长而上升。外包服务的主要理由是希望有更多的私人时间(76%);白天工作时间高工作负荷(71%);非工作时间低工作负荷(46%)。结论鼓励全科医生参加非工作时间的全科医生合作项目,减少外包工作。全科医生认为最负性的经历是峰值工作量及大数目(非急症)帮助需求。为了激励更多全科医生提供7 d×24 h的初级保健服务,对他们的工作负荷进行界定显得更为重要。

关键词： WONCA 合作项目工作时间工作负荷保健服务问卷方式组织机构性经验

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世界哲学简史

milk Replacer Acidification for Free-Access Feeding: Effects on the Performance and Health of Veal Calves

作者： (美)罗伯特·C. 所罗门(Robert C. Solomon) 凯瑟琳·m. 希金斯(kathleen m. Higgins)

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Open Journal of Animal Sciences 2016年第3期6卷 234-246页

作者： Cynthia G. Todd Ken E. Leslie Suzanne T. millman Jan m. Sargeant Heather migdal kathleen Shore Neil G. Anderson Trevor J. DeVries Department of Population medicine Ontario Veterinary College University of Guelph Guelph ON Canada Department of Veterinary Diagnostic & Production Animal medicine Iowa State University Ames IA USA Centre for Public Health and Zoonoses University of Guelph Guelph ON Canada Department of Animal Biosciences University of Guelph Guelph ON Canada Grober Nutrition Cambridge ON Canada Ontario ministry of Agriculture Food and Rural Affairs Veterinary Science and Policy Unit Elora ON Canada

Objectives of this study were to investigate the effects of milk replacer (mR) acidification for free- access feeding on pre- and post-weaning performance, morbidity and mortality of calves. Calves were randomly assigned to free-access feeding of acidified (ACID, n = 31) or non-acidified (NON, n = 31) mR, and weaned at 42 days. ACIDmR was prepared to pH 4.0 - 4.5 using formic acid. Intakes were measured daily and weights weekly. Samples of ACID and NON mR were analyzed for coliform and aerobic bacterial growth. After weaning, calves transitioned to a grain-fed veal diet, weighed every 2 weeks. At slaughter (approximately 6 months of age), lungs were evaluated for gross pathological changes and dressed carcass weights were obtained. Generalized linear mixed models were constructed to examine the effects of mR acidification. Differences by treatment group for pre- and post-weaning morbidity and mortality were tested using Pearson’s χ2 and Fisher’s exact tests. ACID calves consumed less mR than NON (10.6 vs. 11.7 L/d, P = 0.02). Acidification tended to promote earlier onset of starter ration consumption (32.0 vs. 39.5 d, hazard ratio = 1.5, P = 0.07), but did not affect average daily starter ration or water intakes across the pre-weaning period. ACID and NON calves did not differ for BW at weaning, pre- or post-weaning ADG or dressed carcass weight. ACID mR had less coliform (P mR, but odds of disease treatment and mortality did not differ. ACID calves tended to have lower odds of pulmonary lesions during post-mortem inspection than NON calves (OR = 0.3, P = 0.07). These results indicate that under free-access feeding conditions, acidification limited bacterial growth and mR intake, but there were no long-term impacts of acidification on calf performance or health. In conclusion, acidification to pH 4.0 - 4.5 will significantly reduce bacterial growth in milk fed to calves.

关键词： Acidified milk Feeding Free-Access milk Feeding Health Growth Veal Calves

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管理团队如何化冲突为力量

中国新时代 2002年第14期 100-104页

作者： kathleen m.Eisenhardt ,JeanL.Kahwajy ,L.J.BourgeoisIll

人际冲突较少的团队,通常能将实质议题与人身攻击区隔开来,而在处理人际冲突上,有6项相同的技巧,包括:专注于事实、选择多元化、创造共同目标、运用幽默、平衡权力结构、以及寻求有条件的共识。

关键词：管理团队高阶议题人身攻击安卓经理人人际冲突人际关系冲突

Nonlinear optical properties of integrated GeSbS chalcogenide waveguides

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Photonics Research 2018年第5期6卷 I0062-I0067页

作者： SAmUEL SERNA HONGTAO LIN CARLOS ALONSO-RAmOS ANUPAmA YADAV XAVIER LE ROUX kathleen RICHARDSON ERIC CASSAN NICOLAS DUBREUIL JUEJUN HU LAURENT VIVIEN Centre de Nanosciences et de Nanotechnologies (C2N) CNRS Univ.Paris-Sud Université Paris SaclayC2N Orsay Laboratoire Charles Fabry Institut d'Optique Graduate SchoolCNRS Université Paris Saclay Department of materials Science and Engineering Massachusetts Institute of Technology-MIT College of Optics and Photonics-CREOL University of Central Florida

In this paper, we report the experimental characterization of highly nonlinear GeSbS chalcogenide glass waveguides. We used a single-beam characterization protocol that accounts for the magnitude and sign of the real and imaginary parts of the third-order nonlinear susceptibility of integrated Ge23Sb7S70 （GeSbS） chalcogenide glass waveguides in the near-infrared wavdength range at λ = 1580 nm. We measured a waveguide nonlinear parameter of 7.0 4- 0.7 W-1 · m-1, which corresponds to a nonlinear refractive index of n2 =（0.93 ± 0.08） ×10-18 m2/W, comparable to that of silicon, but with an 80 times lower two-photon absorption coefficient βTPA = （0.010± 0.003） cm/GW, accompanied with linear propagation losses as low as 0.5 dB/cm. The outstanding linear and nonlinear properties of GeSbS, with a measured nonlinear figure of merit FOm TPA = 6.0 ± 1.4 at λ = 1580 nm, ultimately make it one of the most promising integrated platforms for the realization of nonlinear functionalities.

关键词： Nonlinear optical properties integrated GeSbS chalcogenide waveguides

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经肝动脉^90Y放射性栓塞治疗的新进展

中华核医学与分子影像杂志 2018年第8期38卷 573-581页

作者：李莉(译) 冯对平(译) 李思进(审校) Arthur J.A.T. Braat maarten L.J. smits manon N.G.J.A. Braat Andor F. van den Hoven Jip F. Prince Hugo W.A.m. de Jong maurice A.A.J. van den Bosch marnix G.E.H. Lam 山西医科大学第一医院核医学科太原030001 山西医科大学第一医院介入科太原030001

放射性栓塞治疗（RE）是经过10余年探索而建立起来的一种治疗模式，发展迅速。该文对RE领域新进展进行综述，就RE患者选择、疗效判断以及将来的临床应用进行探讨。

关键词：放射性栓塞剂量学肝脏恶性肿瘤肝血管系统 ^90Y

Targeting TGF-beta to suppress： metastasis

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中国药理通讯 2013年第2期30卷 43-44页

作者： Yu-an Yang Jia Weng michael Welsh Douglas Weinberg Dror Luger Nancy Guan Lucy Shan Josh Webster kathleen C. Flanders Xin Chen Joe Oppenheim Scott m. Lonning JohnmcPherson Latage m. Wakefield Lab of Cancer Biology and Genetics Center for Cancer ResearchNational Cancer Institute Bethesda MD Genzyme Corp. Framingham MA.

TGF-betas are pleiotropic growth factors with important roles in normal homeostasis and complex roles in tumorigenesis. In general TGF-betas function as tumor suppressors early in the tumorigenic process and as pro-metastatic factors later. metastasis-promoting activities include the enhancement of invasion and migration, the promotion of angiogenesis, and the suppression of immune surveillance. Overexpression of TGF-beta in many advanced human tumors correlates with metastasis and poor prognosis, and there is considerable interest in developing TGF-beta antagonists for cancer therapy. However, the complexity of TGF-beta action, involving the context-dependent interplay of many cellular targets, means that preclinical animal models are critical for evaluating such agents.

关键词： c-met抑制剂药效监控标志物肿瘤治疗