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中国新时代 2002年第14期 100-104页

作者： kathleen m.eisenhardt ,jeanl.kahwajy ,l.j.bourgeoisill

人际冲突较少的团队,通常能将实质议题与人身攻击区隔开来,而在处理人际冲突上,有6项相同的技巧,包括:专注于事实、选择多元化、创造共同目标、运用幽默、平衡权力结构、以及寻求有条件的共识。

关键词：管理团队高阶议题人身攻击安卓经理人人际冲突人际关系冲突

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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military medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu marina A.Gritsenko Young-mo Kim jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie munoz kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa l.Paurus Kent j.Bloodsworth Kelsey A.Allen lisa m.Bramer Fernando montes kathleen A.Clark Grant Tietje justin Teeguarden Kristin E.Burnum-johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： multi-omics analysis Intense exercise Human performance Biofluids metabolism Immunity

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别让观点冲突变成人际冲突

工程经济 2007年第8期23卷 8-8页

作者： kathleen m.eisenhardt jeanl.kahwajy l．j．BourgeoisIII

许多公司高管都自诩为理性人和理性决策者，事实果真如此吗？过去10年的研究令作者得出结论：情绪在商业决策中起到了很大作用，高级经理人的决策行为中有着情绪化、非理性的一面，高管团队内部的人际冲突往往阻碍了有效决策的达成。

关键词：人际冲突突变高级经理人非理性商业决策决策行为有效决策情绪化

Experimental and modeling Study of Forest Fire Effect on Soil Thermal Conductivity

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Pedosphere 2016年第4期26卷 462-473页

作者： kathleen m.SmITS Elizabeth KIRBY William j.mASSmAN larry Scott BAGGETT Center for the Experimental Study of Subsurface Environmental Processes Department of Civil and Environmental EngineeringColorado School of Mines USDA Forest Service Rocky Mountain Research Station

An understanding of soil thermal conductivity after a wildfire or controlled burn is important to land management and post-fire recovery efforts. Although soil thermal conductivity has been well studied for non-fire heated soils, comprehensive data that evaluate the long-term effect of extreme heating from a fire on the soil thermal conductivity are limited. The purpose of this study was to evaluate the long-term impact of fire on the effective thermal conductivity of soils by directly comparing fire-heated and no-fire control soils through a series of laboratory studies. The thermal conductivity was measured for ten soil samples from two sites within the manitou Experimental Forest, Colorado, USA, for a range of water contents from saturation to the residual degree of saturation. The thermal conductivity measured was compared with independent estimates made using three empirical models from literature, including the Campbell et al. （1994）, CSt~ and Konrad （2005）, and massman et al. （2008） models. Results demonstrate that for the test soils studied, the thermal conductivity of the fire-heated soils was slightly lower than that of the control soils for all observed water contents. modeling results show that the Campbell et al. （1994） model gave the best agreement over the full range of water contents when proper fitting parameters were employed. Further studies are needed to evaluate the significance of including the influence of fire burn on the thermal properties of soils in modeling studies.

关键词： controlled burn degree of saturation empirical model water content wildfire

Influence of supraphysiological cortisol manipulation on predator avoidance behaviors and physiological responses to a predation threat in a wild marine teleost fish

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Integrative Zoology 2018年第2期13卷 206-218页

作者： michael j.lAWRENCE Erika j.ElIASON jacob W.BROWNSCOmBE kathleen m.GIlmOUR john W.mANDElmAN lee F.G.GUTOWSKY Steven j.COOKE Fish Ecology and Conservation Physiology laboratory Department of BiologyCarleton UniversityOttawaOntarioCanada Department of Ecology Evolution&Marine BiologyUniversity of CaliforniaSanta BarbaraCaliforniaUSA Department of Biology University of OttawaOttawaOntarioCanada School for the Environment University of New EnglandBiddefordMaineUSA john H.Prescott marine laboratory New England AquariumBostonMassachusettsUSA

The stress axis in teleost fish attempts to maintain internal homeostasis in the face of allostatic ***,stress axis induction has been associated with a higher predation rate in *** date,the physiological and behavioral factors associated with this outcome are poorly *** purpose of the present study was to investigate the impact of experimental cortisol elevation on anti-predator behavior and physiological responses to predator *** hypothesized that semi-chronic cortisol elevation would increase susceptibility to predation by increasing stress-induced risk-taking *** test this hypothesis,schoolmaster snapper were given cocoa butter implants without cortisol(sham)or with cortisol(50 mg/kg body weight)and tethered to *** were exposed to either a lemon shark or control conditions for *** use and activity were recorded throughout and fish were terminally sampled for *** implantation,relative to shams,resulted in higher blood glucose and plasma cortisol concentrations with a lower plasma lactate *** exposure,relative to controls,elicited higher blood glucose and lactate concentrations but had no effect on plasma cortisol *** interactions were detected between shark exposure and cortisol treatment for any physiological *** metrics,including shelter use and activity,were unaffected by either cortisol implantation or shark *** responses to cortisol implantation likely resulted from enhanced gluconeogenic activity,whereas alterations under predator exposure may have been the product of catecholamine *** work should address context-specific influences of stress in mediating behavioral responses to predation.

关键词： homeostatic overload lemon shark predation refuging stress axis teleost physiology

Comparison of hepatitis C virus testing recommendations in high-income countries

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World journal of Hepatology 2018年第10期10卷 743-751页

作者： Risha Irvin kathleen Ward Tracy Agee Noele P Nelson Claudia Vellozzi David l Thomas Alexander j millman Division of Infectious Diseases Johns Hopkins University School of Medicine Division of Viral Hepatitis Centers for Disease Control and Prevention

AIm To investigate hepatitis C virus(HCV) testing recommendations from the United States and other high-income *** A comprehensive search for current HCV testing recommendations from the top quartile of United Nations Human Development Index(HDI) countries(very high HDI) was performed using Google and reviewed from may 1-October 30, 2014 and re-reviewed April 1-October 2, 2017. RESUlTS Of the 51 countries identified, 16 had HCV testing recom-mendations from a government body or recommendations issued collaboratively between a government and a medical organization. Of these 16 countries, 15 had HCV testing recommendations that were primarily risk-based and highlight behaviors, exposures, and conditions that are associated with HCV transmission in that region. In addition to risk-based testing, the HCV Guidance Panel(United States) incorporates recommendations for aone-time test for individuals born during 1945-1965(the birth cohort) without prior ascertainment of risk into their guidance. In addition to the United States, six other countries either have an age-based testing recommendation or recommend one-time testing for all adults independent of risk factors typical of the region. CONClUSION This review affirmed the similarities of the HCV Guidance Panel's guidance with those of recommendations from very high HDI countries.

关键词： Hepatitis C Testing Recommendations mass screening Guidelines

mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

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World journal of Gastroenterology 2010年第2期16卷 217-224页

作者： Ursula m Gehling marc Willems kathleen Schlagner Ralf A Benndorf maura Dandri jrg Petersen martina Sterneck joerg-matthias Pollok Dieter K Hossfeld Xavier Rogiers Department of Hepatobiliary Surgery and Transplant Surgery University Hospital Hamburg-Eppendorf20246 HamburgGermany Department of medicine University Hospital Hamburg-Eppendorf20246 HamburgGermany Institute of Experimental and Clinical Pharmacology and Toxicology University Hospital Hamburg-Eppendorf20246 HamburgGermany Gent University Hospital and medical School 9000 GentBelgium

AIm:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. mETHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow *** progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent ***:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th *** 1%and 26%of the peripheral bloo mononuclear cells(mNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the mNCs)could b detected in 91%of the ***,18% of the patients showed a population of progenito cells(between 1%and 68%of the mNCs)that wa characterized by expression of breast cancer resistanc *** phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for *** line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells.

关键词： CD133 antigen CD14 antigen c-kit protein Breast cancer resistance protein-1 protein Progenitor cells CXC chemokine receptor 4 Stromal cell-derived factor-1 liver cirrhosis

Weight loss Impact on Change in Depression in Type 2 Diabetes mellitus: Study to Help Improve Early Evaluation and management of Risk Factors leading to Diabetes (SHIElD)

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journal of Diabetes mellitus 2014年第3期4卷 216-224页

作者： Susan Grandy Andrew j. Green kathleen m. Fox AstraZeneca lP Wilmington DE USA midwestern Endocrinology Overland Park KS USA Strategic Healthcare Solutions LLC Baltimore MD USA

Objectives: This study evaluated the association between weight loss and change in depression among patients with type 2 diabetes mellitus (T2Dm). methods: Weight change from 2008 to 2009 among respondents (with and without T2Dm) in the Study to Help Improve Early evaluation and management of risk factors leading to Diabetes (SHIElD) was calculated. Change in depression was calculated as change from 2008 to 2009 in Patient Health Questionnaire-9 (PHQ-9) scores. Respondents with weight loss (>1%, >3%, >5%) were compared with respondents with weight gain (≥1%). multivariate regression adjusted for baseline characteristics. Results: Among those with T2Dm, more respondents with weight loss (n = 779) improved their depression scores, compared with respondents with weight gain (n = 731): 32.9%, 36.9%, 39.8% for >1%, >3%, and >5% weight loss, respectively, vs. 28.7% for weight gain (pmore respondents with weight loss improved the severity level of depression compared with respondents with weight gain (p justment, T2Dm respondents with weight loss had significantly greater improvement in depression scores (p mes higher odds of improving depression severity than T2Dm respondents with weight gain (OR: 2.22 for >1%, 2.96 for >3%, and 3.31 for >5% weight loss, p milar improvement in depression scores and severity of depression related to weight loss was observed among all SHIElD respondents (with and without T2Dm). Conclusions: Our findings demonstrate an association between weight loss and improvement in depression over a 1-year period in adults with T2Dm, and suggest the need for further investigation with respect to causality.

关键词： Depression Type 2 Diabetes mellitus Weight loss

Effects of metoclopramide on gastric motility measured by short-term bio-impedance

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World journal of Gastroenterology 2009年第38期15卷 4763-4769页

作者： maría-Raquel Huerta-Franco miguel Vargas-luna kathleen m Capaccione Etna Yaez-Roldán Ulises Hernández-ledezma Ismael morales-mata Teodoro Córdova-Fraga Department of Applied Science and labor Research DCS-Campus LeónUniversity of Guanajuato Department of Physical Engineering DCI-Campus LeónUniversity of Guanajuato Robert Wood johnson medical School The University of Medicine and Dentistry of New Jersey

AIm:To analyze the accuracy of short-term bio-impedance as a means of measuring gastric ***: We evaluated differences in the short-term electrical bio-impedance signal from the gastric region in the following conditions: (1) fasting state, (2) after the administration of metoclopramide (a drug that induces an increase in gastric motility) and (3) after food ingestion in 23 healthy volunteers. We record-ed the real component of the electrical impedance signal from the gastric region for 1000 s. We performed a Fast Fourier Transform (FFT) on this data and then compared the signal among the fasting, medicated, and postprandial conditions using the median of the area under the curve, the relative area under the curve and the main peak ***: The median of the area under the curve of the frequency range in the region between 2-8 cycles per minute (cpm) decreased from 4.7 cpm in the fasting condition to 4.0 cpm in the medicated state (t=3.32, P=0.004). This concurred with the decrease seen in the relative area under the FFT curve in the region from 4 to 8 cpm from 38.3% to 26.6% (t=2.81, P=0.012) and the increase in area in the region from 2 to 4 cpm from 22.4% to 27.7%, respectively (t=-2.5, P=0.022). Finally the main peak position also decreased in the region from 2 to 8 cpm. main peak activity in the fasting state was 4.72 cpm and declined to 3.45 cpm in the medicated state (t=2.47, P=0.025). There was a decrease from the fasting state to the postprandial state at 3.02 cpm (t=4.0, P=0.0013). CONClUSION: Short-term electrical bio-impedance can assess gastric motility changes in individuals experiencing gastric stress by analyzing the area medians and relative areas under the FFT curve.

关键词： Bio-impedance Fast Fourier Transform Gastric motility metoclopramide Postprandial

Effect of Human Insulin on the Formation of Catheter-Associated <i>E. coli</i>Biofilms

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Open journal of Urology 2014年第5期4卷 49-56页

作者： Balbina j. Plotkin Zijian Wu kathleen Ward Shaven Nadella jacalyn m. Green Benny Rumnani Department of Biochemistry Midwestern University Downers Grove USA Department of microbiology and Immunology Midwestern University Downers Grove USA

Biofilm formation is essential for the survival and growth of Escherichia coli?in catheter-associated infections. Individuals with type 2 diabetes mellitus can excrete insulin and/or glucose in their urine. This population also has an increased incidence of urinary tract infections. The focus of this study was to determine if the composition of Foley catheter material affects biofilm formation by E. coli in a model system for type 2 diabetes mellitus. Rubber (lubricious-coated), silicon-coated, silver-coated and nitrofurazone-coated catheter segments (5 mm;n = 6) were tested. Catheter segments were added to E. coli ATCC25922 (104 CFU/ml, final concentration) in artificial urine alone, or with insulin (40 μU/ml) and/or glucose (0.1%). After incubation (18 h, 37?C, in air and anaerobically) the level of catheter-associated biofilm was determined by crystal violet staining (Abs550nm). Statistical analysis was done by ANOVA with post-hoc analysis (Tukey). Neither nitrofurazone-coated nor silver-coated catheters supported the formation of E. coli biofilm, regardless of growth condition tested. In contrast, under aerobic biofilm formation on silicon catheters was significantly higher (p E. coli controls. Biofilm formation was also significantly increased

关键词： Escherichia coli Insulin Catheters Diabetes mellitus Biofilm Electronegativity