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Journal.of Genetics and Genomics 2016年第5期43卷 307-318页

作者： Jason Ear Jessica Hsueh Mel.nda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra kathleen M.Sakamoto Shuo l.n Department of Mol.cul.r Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Cel.ene Corporation San Francisco 94158 USA Cel.ene Corporation Summit NJ 07901 USA Division of Hematol.gy/Oncol.gy Department of Pediatrics Stanford University School of Medicine Stanford CA 94304 USA

5q-syndrome is a distinct form of myel.dyspl.stic syndrome（MDS） where a del.tion on chromosome 5 is the underl.ing *** is characterized by bone marrow fail.res,incl.ding macrocytic *** mapping and studies using various model. support the notion that ribosomal.protein S14（RPS14） is the candidate gene for the erythroid *** disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,simil.r to what is observed with other ribosomal.***,due to the higher risk for cancer devel.pment in patients with ribosome deficiency,targeting the p53 pathway is not a viabl. treatment *** better understand the pathol.gy of RPS14 deficiency in 5q-del.tion,we generated a zebrafish model.harboring a mutation in the RPS14 *** model.mirrors the anemic phenotype seen in ***,the anemia is due to a l.te-stage erythropoietic defect,where the erythropoietic defect is initial.y p53-independent and then becomes ***,we demonstrate the versatil.ty of this model.to test various pharmacol.gical.agents,such as RAP-011,l.l.ucine,and dexamethasone in order to identify mol.cul.s that can reverse the anemic phenotype.

关键词： 5q-syndrome RPS14 Ribosomopathy Myel.dyspl.stic syndrome

Cl.nical.Observations on the Effects of a Dietary Suppl.ment (GI Regenerate&l.;sup>TM&l.;/sup>) on Patients’ Gastrointestinal.Symptoms and Qual.ty of l.fe Assessments

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International.Journal.of Cl.nical.Medicine 2020年第5期11卷 303-315页

作者： l.igh E. Conneal. Robert Settineri Ariel.Causey Ashl.y Athanas kathleen McCal.-Smith Jason Cl.rk Christine E. Mcl.ren Garth l. Nicol.on Center for New Medicine Irvine USA Sierra Productions Research Irvine USA Statistical.Unit Department of Medicine University of California Irvine School of Medicine Irvine USA Department of Mol.cul.r Pathol.gy The Institute for Molecular Medicine Huntington Beach USA

Background: Different treatments have been devel.ped and used to control.symptoms and improve qual.ty of l.fe in patients with digestive diseases and disorders. Al.hough the use of drugs or al.ernative approaches has improved symptom severity in some but not al. patients, often these improvements were not sustainabl.. Objectives: An open l.bel.cl.nical.study was initiated to determine if oral.capsul.s containing a dietary suppl.ment of herbs and oil. (GI RegenerateTM) coul. reduce sel.-reported gastrointestinal.symptoms and improve qual.ty of l.fe (QOl. indicators in patients with gastrointestinal.conditions. Methods: Participants incl.ded 50 patients (40 femal.s and 10 mal.s) of mean age of 51.1 ± 12.7 years (range, 24 - 77 years) with a diagnosis of a gastrointestinal.disorder or gastrointestinal.symptoms. These patients consumed five soft-gel. containing the test suppl.ment 30 minutes before each meal.for 90 days. Symptoms were eval.ated by medical.staff, and patient heal.h status was sel.-reported using a val.dated qual.ty of l.fe questionnaire (Qual.ty of l.fe Digestive Survey) designed for functional.digestive disorders. Exit interviews (Patient Gl.bal.Impression of Change, PGIC) were conducted by the medical.staff. Resul.s: Participants in the study responded with improved symptom severities and QOl.scores to the test dietary suppl.ment within the 90 day period;most improvements occurred within 20 days on the test dietary suppl.ment. By the end of the study there were significant overal. gl.bal.improvements in the symptoms and QOl.heal.h surveys (p = 0.0183), with significant improvements in symptom discomfort (p = 0.0004), dail. activities (p = 0.029) and anxiety (p = 0.018). In contrast, there were insignificant improvements in diet (p = 0.398), sl.ep (p = 0.136), heal.h perception (p = 0.686), coping with the disease (p = 0.309) and impact of stress (p = 0.785). Using the PGIC exit interview that measured each patient’s impression of overal. gl.bal.change

关键词： Gastrointestinal Symptoms Qual.ty of l.fe Dietary Suppl.ment Digestive Disorders Herbal Remedies Dietary Oil.

Genome of tetrapl.id sour cherry (Prunus cerasus l.) ‘Montmorency’ identifies three distinct ancestral.Prunus genomes

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Horticul.ure Research 2023年第7期10卷 22-39页

作者： Charity Z.Goeckeritz kathleen E.Rhoades Kevin l.Chil.s Amy F.Iezzoni Robert VanBuren Courtney A.Hol.ender Department of Horticul.ure Michigan State University1066 Bogue StEast LansingMI 48824USA Department of Pl.nt Biol.gy Michigan State University612 Wilson RoadEast LansingMI 48824USA

Sour cherry(Prunus cerasus l.)is a val.abl. fruit crop in the Rosaceae famil. and a hybrid between progenitors cl.sel. rel.ted to extant Prunus fruticosa(ground cherry)and Prunus avium(sweet cherry).Here we report a chromosome-scal. genome assembl. for sour cherry cul.ivar Montmorency,the predominant cul.ivar grown in the *** al.o generated a draft assembl. of *** to use al.ngside a publ.shed *** sequence for syntel.g-based subgenome assignments for‘Montmorency’and provide compel.ing evidence *** is al.o an *** hierarchal.k-mer cl.stering and phyl.genomics,we show‘Montmorency’is trigenomic,containing two distinct subgenomes inherited from a ***-l.ke ancestor(A and A’)and two copies of the same subgenome inherited from a ***-l.ke ancestor(BB).The genome composition of‘Montmorency’is AA’BB and l.ttl.-to-no recombination has occurred between progenitor subgenomes(A/A’and B).In Prunus,two known cl.sses of genes are important to breeding strategies:the sel.-incompatibil.ty l.ci(S-al.el.s),which determine compatibl. crosses,successful.fertil.zation,and fruit set,and the Dormancy Associated MADS-box genes(DAMs),which strongl. affect dormancy transitions and fl.wering *** S-al.el.s and DAMs in‘Montmorency’and *** were manual.y annotated and support subgenome ***,the hybridization event‘Montmorency’is descended from was estimated to have occurred l.ss than 1.61 mil.ion years ago,making sour cherry a rel.tivel. recent ***‘Montmorency’genome highl.ghts the evol.tionary compl.xity of the genus Prunus and wil. inform future breeding strategies for sour cherry,comparative genomics in the Rosaceae,and questions regarding neopol.pl.idy.

关键词： Prunus cherry breeding

Effects of water sal.nity and content on particl. size distribution and soil.strength

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Journal.of Environmental.Science and Engineering 2009年第1期3卷 24-28页

作者： PENG Chang-sheng l.WG kathleen ZHANG Qian Col.ege of Environmental.Science and Engineering Ocean University of China Qingdao 266100 China Instituto de Metal.rgia Universidad Autonoma de San Luis Potosi San Luis Potosi 78210 Mexico Department of Civil.and Environmental.Engineering University of California Berkeley San Jose 95132 USA

The effect of NaCl.on soil.strength was investigated in this project based on sal.nity concentrations of 0 g/l. 5 g/l. 20 g/l. and 50 g/l.as wel. as varying water contents of 15%-20%. l.ser particl. size anal.zer was al.o performed to expl.in possibl. effects. From particl. size anal.sis and strength tests, it is hypothesized that the strength of the soil.is increased with the addition of certain sal.nity concentrations until.there are reversed effects, which is between 20 g/l.and 50 g/l.from our study. The increase of strength is suggested to be the affect of a greater variety of particl. sizes. Since NaCI pl.ys a rol. in the particl. size distribution, it al.o pl.ys a rol. in the strength of soil.. The degree of the effect of the water content al.o differs from concentrations, and coul. be due to the variation of hydration fil. thickness on particl.s, which is affected by the ions introduced from water.

关键词： water sal.nity water content particl. size distribution soil.strength hydration fil.

大都市自然环境、环境健康和经济价值(续完)

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环境与职业医学 2015年第12期32卷 1178-1182页

作者： kathleen l.Wol. Al.cia S.T.Robbins 张伊人汪源金泰廙 Col.ege of the Environment University of Washington

环境和资源经济学领域中的决策制定框架通常采用不止一种评估方法来描述所有的收益和成本。收益-成本分析计算一个项目或其他情况长期的总实现和总预期收益及成本,并将其折算为净现值,目的在于确定将来获得最大净收益的方案。成本效益... 详细信息

环境和资源经济学领域中的决策制定框架通常采用不止一种评估方法来描述所有的收益和成本。收益-成本分析计算一个项目或其他情况长期的总实现和总预期收益及成本,并将其折算为净现值,目的在于确定将来获得最大净收益的方案。成本效益分析是比较多个方法的相对收益和成本,通过明确不同方法的成本差异来实现相同的目标。选择满足成本最低这一目标的方案。

关键词：成本最小化环境健康经济学方法决策制定净现值绿色环境城市公园城市森林冠盖度绿色基础设施

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大都市自然环境、环境健康和经济价值

环境与职业医学 2015年第11期32卷 1090-1091,F0004页

作者： kathleen l.Wol. Al.cia S.T.Robbins 张伊人汪源金泰廙 Col.ege of the Environment University of Washington

[背景]近40年来,关于城市附近的自然环境给人类带来的健康、福祉以及好处,已经有大量的研究提供了广泛的证据基础。[目的]我们认为,如何把大都市自然环境、人类健康和福祉指标与经济价值联系在一起,在未来的研究中仍有广阔的前景。[方法... 详细信息

[背景]近40年来,关于城市附近的自然环境给人类带来的健康、福祉以及好处,已经有大量的研究提供了广泛的证据基础。[目的]我们认为,如何把大都市自然环境、人类健康和福祉指标与经济价值联系在一起,在未来的研究中仍有广阔的前景。[方法]回顾城市中基于自然条件的健康和福祉收益的相关文献。在本文中,我们提供了一个分类策略,并提出与大都市自然环境服务相关的潜在经济价值。[讨论]在环境和自然资源经济学领域,已经开展了很多研究以估计从城市绿地系统中获得的经济利益,但是这些研究通常不涉及健康结果。城市树木、公园、庭院、露天场地以及其他附近的自然元素,统称为大都市自然环境,它们产生了许多积极的外部效益,但在城市的经济和政策中基本被忽视。在本综述中,我们提出了一系列的健康益处,包括效益范围和受益者。虽然目前对这些益处的认识尚不一致,而且在尝试把城市生态系统的服务价值和经济价值联系在一起的努力中可能不会包括所有文化和社会价值的表现形式,但我们急需发展新的跨学科方法,将环境健康和经济整合在一起。[结论]大都市自然环境为生活在城市中的人群提供了多样化和实实在在的好处。在本综述中,我们强调需要建立评估方法和新的技术,以了解这些益处的潜在经济价值。

关键词：价值联系潜在经济价值环境健康城市森林外部效益露天场地分类策略自然元素城市生态系统学科方法

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针刺:痛觉调制与免疫激动耦连(英文)

中国药理学报 1999年第9期20卷 769-777页

作者： Randy l.GOl.UB kathleen K S HUI George B STEFANO Massachusettes General.Hospital.NMR Center and Department of Psychiatry CNY 9109149 13th Street Charlestown in 02129 USAMasschusettes General Hospital-NMR Center CNY 9109149 13th Street Charlestown in 02129 USANeuroscience Research Institute State University of New York Old Westbury NY 11568 USA

The phenomenon of acupuncture is both compl.x anddynamic. Recent information demonstrates thatacupuncture may exert its actions on pain and immuneprocesses. The coupl.ng of these two systems occursvia common signal.ng mol.cul.s, ie, opioid *** thes regard, we surmise that opioid activaton l.adsto the processing of opioid peptides from theirprecursor, proenkephal.n, and the simul.aneous rel.aseof antibacterial.peptides contained within the precursoras wel.. Thus, Central.nervous system pain circuitsmay be coupl.d to immune enhancement. Further-more, acupuncture needl. manipul.tion el.cited signal.ncreases bil.teral.y in the region of the primary

关键词：针刺肽抗生素类磁共振成像甲硫氨酸脑啡肽

Ecol.gic study of serum sel.nium and upper gastrointestinal.cancers in Iran

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Worl. Journal.of Gastroenterol.gy 2004年第17期10卷 2544-2546页

作者： Mehdi Nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi kathleen Cal.wel. Christian *** Phil.p R.Tayl.r Reza Mal.kzadeh Sanford M.Dawsey Digestive Disease Research Center Tehran University of Medical SciencesTehranIran National.Cancer Institute NIHBethesdaMD20895-8314USA Centers for Disease Control AtlantaGeorgiaUSA

AIM:Both observational.and experimental.studies have shown that higher sel.nium status reduces the risk of upper gastrointestinal.cancers in sel.nium deficient popul.tions. Recent cancer registry data have shown very different rates of esophageal.cancer(EC)and gastric cancer(GC)in four Provinces of Iran,namel. Ardabil.Mazandaran,Gol.stan, and *** aim of this study was to have a prel.minary assessment of the hypothesis that high rates of EC in Gol.stan and high rates of GC in Ardabil.may be partl. attributabl. to sel.nium deficiency. METHODS:We measured serum sel.nium in 300 heal.hy adul.s from An:l.bil.n=100),Mazandaran(n=50),Gol.stan (n=100),and Kerman(n=50),using inductivel. coupl.d pl.sma,with dynamic reaction cel.,mass spectrometry(ICP- DRC-MS)at the US Centers for Disease Control.Atl.nta, Georgia). RESUl.S:The median serum sel.nium concentrations were very different in the four *** medians(IQR)for sel.nium in Ardabil.Mazandarn,Gol.stan,and Kerman were 82(75-94),123(111-132),155(141-173),and 119 (110-128)μg/l.respectivel.(Pl.s of l.near regression showed that the Province variabl.,by itsel., expl.ined 76% of the variance in l.g sel.nium(r^2=0.76). The proportion of the popul.tions with a serum sel.nium more than 90 μg/l.the concentration at which serum sel.noproteins are saturated)was 100% in Gol.stan, Kerman,and Mazandaran but onl. 29% in Ardabil. CONCl.SION:Our findings suggest that sel.nium defidency is not a major contributor to the high incidence of EC seen in northeastern Iran,but it may pl.y a rol. in the high incidence of GC in Ardabil.Province. Nouarie M,Pourshams A,Kamangar F,Sotoudeh M,Derakhshan MH,Akbari MR,Fakheri H,Zahedi MJ,Cal.wel. K,Abner CC, Tayl.r PR,Mal.kzadeh R,Dawsey *** study of serum

关键词： Adul. Esophageal.Neopl.sms Femal. Humans Incidence Iran l.near Model. Mal. Middl. Aged Risk Factors Sel.nium Stomach Neopl.sms

尿碘、甲状腺功能和甲状腺球蛋白作为评价碘状态的生物标志物

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尿碘、甲状腺功能和甲状腺球蛋白作为评价碘状态的生物标志物

The ubiquitin carboxyl.terminal.esterase l. induces G0/G1 cel. cycl. arrest and apoptosis through stabil.zing p53 and is frequentl. sil.nced by promoter methyl.tion in breast cancer

作者： El.zabeth N Pearce kathleen l.Cal.wel. Section of Endocrinol.gy Diabetes and Nutrition Boston University School of Medicine Division of l.boratory Sciences National Center for Environmental Health CDC

准确评估人群碘营养状况对于制定碘营养的公共卫生政策和的临床研究是不可或缺的,特别是充足的碘水平在正常的神经发育的作用。尿碘浓度(UIC)直接反映了膳食碘摄入量,是全球最常见的用于评估人群碘营养状况的指标。2001成立了确保碘程... 详细信息

准确评估人群碘营养状况对于制定碘营养的公共卫生政策和的临床研究是不可或缺的,特别是充足的碘水平在正常的神经发育的作用。尿碘浓度(UIC)直接反映了膳食碘摄入量,是全球最常见的用于评估人群碘营养状况的指标。2001成立了确保碘程序质量项目,以提供能够独立评估尿碘分析能力的实验室;该项目有助于改善评价UIC。甲状腺功能的实验室检查(包括垂体激素促甲状腺激素和甲状腺激素T3、T4的血清浓度)有时被用作的碘营养状况的指标,虽然这样使用往往是有问题的。即使在严重缺碘地区,甲状腺的适应能力在个体内变异也很大。在大多数情况下,对于除新生儿以外的人群,不认为甲状腺功能试验是人群碘状况的敏感指标。然而,甲状腺衍生蛋白却越来越多地用于这一目的。在血清和干血斑样本(DBS)中都能检测到甲状腺球蛋白。在资源有限的地区,使用干血斑样本(DBS)有一定优势。评价产妇碘状态的方法还需要进一步改进,以便于研究碘状态的发展相关性。甲状腺球蛋白可能是产妇和新生儿碘营养状况的一个有效指标,但是测定孕妇和新生儿的碘充足度需要有效的检测特异性的参考范围。UIC是目前有效的人群的生物标志物,但是能够用于研究、病人护理和公共卫生的个体的生物标志物仍然缺乏。

关键词：临床实验室检查干血斑碘状况甲状腺功能试验尿碘

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The ubiquitin carboxyl-terminal esterase L1 induces G0/G1 ce...