The ubiquitin carboxyl-terminal esterase L1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced by promoter methylation in breast cancer
作者单位：Chongqing Medical University
会议名称：《中华医学会肿瘤学分会第七届全国中青年肿瘤学术会议——中华医学会肿瘤学分会“中华肿瘤 明日之星”大型评选活动暨中青年委员全国遴选》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Breast cancer(BrCa) is a complex disease driven by aberrent gene alterations and environmental factors. Recent studies reveal that abnormal epigenetic gene regulation also plays an important role in its *** carboxyl-terminal esterase L1(UCHL1) is a tumor suppressor silenced by promoter methylation in multiple cancers,but its role and alterations in breast tumorigenesis remains *** found that UCHL1 was frequently downregulated or silenced in breast cancer cell lines and tumor tissues,but readily expressed in normal breast tissues and mammary epithelial *** methylation of UCHL1