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mechanical Characterisation of Densified Hardwood with Regard to Structural Applications

Journal of Renewable materials 2020年第9期8卷 1091-1109页

作者： katharina müller Walter Sonderegger Oliver Kläusler michael Klippel Edwin Zea Escamilla Institute of Structural Engineering(IBK) Chair of Structural Engineering–Timber StructuresSwiss Federal Institute of Technology ZurichZurich8093Switzerland Swiss Wood Solutions AG 8600 DübendorfSwitzerlandPreviously at Institute for Building Materials(IfB)Chair of Wood Materials ScienceSwiss Federal Institute of Technology ZurichZurich8093Switzerland College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Sustainable Building Center for Corporate Responsibility and SustainabilityUniversity of ZurichZurich8001Switzerland

The demand for high-performance,yet eco-friendly materials is increasing on all scales from small applications in the car industry,instrument or furniture manufacturing to greater dimensions like floorings,balcony furnishings and even *** offers a good choice on all of these scales and can be modified and improved in many different *** this study,two common European hardwood species,Beech(Fagus sylvatica L.)and Ash(Fraxinus excelsior L.)were densified in radial direction by thermo-mechanical treatment and the densified product was investigated in an extensive characterisation series to determine all relevant mechanical *** in the three main directions(longitudinal,tangential,radial)and tension perpendicular to the grain(tangential,radial)were tested and compared to reference specimens with native *** and modulus of elasticity were determined in all *** addition,a Life Cycle Assessment was carried out to evaluate the environmental impact associated to the densification *** experimental investigations showed that strength and stiffness of hardwood in the longitudinal and tangential directions improve significantly by radial densification,whereas some properties in the radial direction *** Life Cycle Assessment showed that artificial wood drying has higher impact than wood ***,the transport distance of the raw material highly influences the environmental impact of the final densified *** paper then also offers an overview of possible applications in structural timber *** hardwood is a viable option as local reinforcement,where high compressive or tensile strength is *** wood densification process offers an alternative to the use of carbon-intense steel components or hardwoods from tropical forests.

关键词： Hardwood densification high-performance construction materials thermo-mechanical treatment mechanical characterisation life cycle assessment timber structures

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Outcome after early mobilization following hip reconstruction in children with developmental hip dysplasia and luxation

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World Journal of Pediatrics 2018年第2期14卷 176-183页

作者： katharina Susanne Gather Eva von Stillfried Sebastien Hagmann Sebastian müller Thomas Dreher Center of Orthopaedic and Trauma Surgery/Spinal Cord Injury Center Heidelberg University HospitalSchlierbacher Landstr.200a69118 HeidelbergGermany

Background most orthopedic surgeons prefer spica cast immobilization in children for 4 to 12 weeks after surgical hip reconstruction in children with developmental hip *** challenging treatment may be associated with *** are lacking that focus on early mobilization without casting for postoperative care after hip *** Twenty-seven children(3.4±2.0 years),including 33 hips with developmental hip dysplasia(DDH)and dislocation of the hip(Tonnis grade 1 to 4),who underwent hip reconstruction(Dega acetabuloplasty,varisation-derotation osteotomy and facultative open reduction)were retrospectively included in this *** the patients were placed in an individual foam shell with 30 degrees of hip abduction,hip extension,and neutral *** mobilization physiotherapy was performed within the first few days after the surgery under epidural *** weight bearing was allowed after 3-4 *** children received a clinical examination and radiographic evaluation before and after surgical *** follow-up period was 12.3±2.9 *** On average,the postoperative acetabular index decreased significantly from 36.9 to 21.7 degrees and the center-edge angle increased from 9.9 to 28.6 *** hips had reached Tonnis grade 1 at the time of the last *** complications such as dislocation of the bone wedge,avascular necrosis of the acetabulum or femur,lack of non-union,or nerve injury,were *** In this cohort study,hip reconstruction was successful according to clinical and radiographic outcome param-eters after early mobilization without cast *** mobilization may be used as an alternative treatment option after hip reconstruction in DDH.

关键词： Dega acetabuloplasty Developmental hip dysplasia Early mobilization Spica cast Varisation-derotation osteotomy

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A Time-Space Adaptive method for the Schrodinger Equation

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Communications in Computational Physics 2016年第6期20卷 60-85页

作者： katharina Kormann Technische Universitat munchen Zentrum MathematikBoltzmannstr.385747 GarchingGermany

In this paper,we present a discretization of the time-dependent Schrodinger equation based on a magnus-Lanczos time integrator and high-order Gauss-Lobatto finite elements in space.A truncated Galerkin orthogonality is used to obtain dualitybased a posteriori error estimates that address the temporal and the spatial error *** on this theory,a space-time adaptive solver for the Schrodinger equation is *** efficient matrix-free implementation of the differential operator,suited for spectral elements,is used to enable computations for realistic *** demonstrate the performance of the algorithm for the example of matter-field interaction.

关键词： a posteriori error estimate adaptive mesh refinement finite/spectral elements timedependent Schrodinger equation

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makeHub:Fully Automated Generation of UCSC Genome Browser Assembly Hubs

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Genomics, Proteomics & Bioinformatics 2019年第5期17卷 546-549页

作者： katharina Jasmin Hoff University of Greifswald Institute for Mathematics and Computer Science17489 GreifswaldGermany University of Greifswald Center for Functional Genomics of Microbes17489 GreifswaldGermany

Novel genomes are today often annotated by small consortia or individuals whose background is not from *** audience requires tools that are easy to *** need has been addressed by several genome annotation tools and *** resulting annotation is a crucial step of quality *** UCSC Genome Browser is a powerful and popular genome visualization *** Hubs,which can be hosted on any publicly available web server,allow browsing genomes via UCSC Genome Browser *** steps for creating custom Assembly Hubs are well documented and the required tools are publicly ***,the number of steps for creating a novel Assembly Hub is *** some cases,the format of input files needs to be adapted,which is a difficult task for scientists without programming ***,we describe make Hub,a novel command line tool that generates Assembly Hubs for the UCSC Genome Browser in a fully automated *** pipeline also allows extending previously created Hubs by additional *** Hub is freely available for downloading at https://***/Gaius-Augustus/make Hub.

关键词： Genome annotation Annotation visualization RNA-seq Genome browser

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Running‑In Behavior of Wet multi‑plate Clutches:Introduction of a New Test method for Investigation and Characterization

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Chinese Journal of mechanical Engineering 2020年第2期33卷 152-160页

作者： katharina Voelkel Hermann Pflaum Karsten Stahl Gear Research Centre(FZG) Technical University of MunichGarchingGermany

Wet multi-plate clutches are relevant components of modern drivetrain applications,not only in terms of function but also safety and *** at the beginning of their lifetime,distinct changes of the friction behavior may occur and make the actuation of the clutch *** transcript describes the typical running-in behavior of wet multi-plate clutches and gives a general definition for running-in of ***,a new test method to systematically investigate the running-in behavior of clutches is *** test method contains a test procedure to characterize the running-in behavior on different load ***,a multi-stage procedure to evaluate and characterize the running-in behavior of clutches with mathematical approaches and new characteristic values is *** quality of the test method is demonstrated on the example of three different tribological systems from dual clutch transmissions(DCT)and automatic transmissions(AT)application using paper friction linings.

关键词： Clutch Running-in Test method Paper friction lining

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Leaf thermal tolerance and sensitivity of temperate tree species are correlated with leaf physiological and functional drought resistance traits

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Journal of Forestry Research 2023年第1期34卷 63-76页

作者： Ines katharina münchinger Peter Hajek Berivan Akdogan Astor Torano Caicoya Norbert Kunert Department of Integrative Biology and Biodiversity Research Institute of BotanyUniversity of Natural Resources and Life Sciences ViennaGregor-Mendel Str.331190 ViennaAustria Geobotany University of FreiburgSchanzlestr.179104 FreiburgGermany TUm School of Live SciencesChair of Forest Growth and Yield ScienceTechnical University of MunichGermanyHans-Carl-Von-Carlowitz 285354 FreisingGermany

Climate change is causing more frequent and severe climatic events,such as extreme heat and co-occurring drought,potentially accelerating tree *** tree species will cope better with those extreme events is still being *** study focuses on heat as a physiological stress factor and interspecifi c variation of thermal tolerance and sensitivity traits in 15 temperate coniferous and broad-leaved tree *** investigate(1)whether thermal tolerance and sensitivity traits correlate with a droughtrelated physiological trait,particularly the leaf turgor loss point(πtlp,wilting point),and(2)how thermal tolerance and sensitivity traits co-vary within diff erent tree-functional types classifi ed by morphological and physiological traits of the leaf,i.e.,leaf mass per area(LmA)and percentage loss of area(PLA).The study was carried out in the Traunstein Forest Dynamics Plot of the ForestGEO network in *** temperature response of the maximum quantum yield of photosystem II(F_(v)/F_(m))on leaf discs was determined,from which various physiological leaf traits were estimated,one of which is the breaking point temperature(T_(5)),the temperature at which F_(v)/F_(m)declines by 5%.Additionally,the temperature of 50%(T_(50))and 95%(T_(95))decline in F_(v)/F_(m)was *** decline width between T_(50)and T 5(DW T_(50)−T_(5))was taken as an indicator of the species’thermal *** breaking point temperature ranged from 35.4±3.0 to 47.9±3.9℃among the investigated tree species and T 50 ranged between 46.1±0.4 and 53.6±0.7℃.A large interspecifi c variation of thermal tolerance and sensitivity was *** ash(Fraxinus excelsior L.)was the most heat-sensitive species,while Wild cherry(Prunus avium L.)was the least heat-sensitive *** with a more negativeπtlp tended to have a higher breaking point temperature than species with a less negativeπtlp.A lower thermal sensitivity characterized species with a higher LmA,and high PLA was

关键词： Water stress Heat stress Physiological limitations Climate change ForestGEO

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Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.Lange katharina m.Lange Yukiko Nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge *** symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the *** potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of *** mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical ***,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are *** epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these *** clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea.

关键词： Green tea Epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

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Food intolerance and the few-foods(or oligoantigenic)diet in children with attention-deficit hyperactivity disorder

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Food Science and Human Wellness 2024年第4期13卷 1729-1738页

作者： Klaus W.Lange Andreas Reissmann Yukiko Nakamura katharina m.Lange Faculty of Human Sciences University of RegensburgRegensburg 93040Germany Department of Psychology University of BathBath BA27AYUnited Kingdom

The hypothesis that some children with attention-deficit hyperactivity disorder(ADHD)may show sensitivity or allergic reactions to various food items has led to the development of the the few-foods(or oligoantigenic)*** rationale of the diet is to eliminate certain foods from the diet in order to exclude potential allergens contained either naturally in food or in artificial ingredients with allergenic *** oligoantigenic diet attempts to identify individual foods to which a person might be ***,ADHD symptoms are monitored while multiple foods are excluded from the ***,if symptoms remit,foods are re-introduced,while observing the individual for the return of *** advantage of the oligoantigenic diet is that it can be tailored to the individual.A growing body of evidence suggests that behavioral symptoms of subgroups of children with ADHD may benefit from the elimination of certain *** effect sizes of an oligoantigenic diet regarding improvement of ADHD symptoms have been found to be medium to *** evidence suggests that the investigation of the role of food hypersensitivities in ADHD is a promising avenue worthy of further *** large-scale,randomized controlled studies including assessment of long-term outcome are therefore warranted.

关键词： Attention-deficit hyperactivity disorder Food intolerance Few-foods diet Etiology Treatment

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Using multispectral landsat and sentinel-2 satellite data to investigate vegetation change at mount St. Helens since the great volcanic eruption in 1980

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Journal of mountain Science 2018年第9期15卷 1851-1867页

作者： katharina TELTSCHER Fabian Ewald FASSNACHT Institute of Geography and Geoecology Karlsruhe Institute of Technology

Long-term analyses of vegetation succession after catastrophic events are of high interest for an improved understanding of succession dynamics. However, in many studies such analyses were restricted to plot-based measurements. Contrarily, spatially continuous observations of succession dynamics over extended areas and timeperiods are sparse. Here, we applied a change vector analysis(CVA) to investigate vegetation succession dynamics at mount St. Helens after the great volcanic eruption in 1980 using Landsat. We additionally applied a supervised random forest classification using Sentinel-2 data to map the currently prevailing vegetation types. Change vector analysis was performed with the normalized difference vegetation index(NDVI) and the urban index(UI) for three subsequent decades after the eruption as well as for the whole observation time between 1984 and 2016. The influence of topography on the current vegetation distribution was examined by comparing altitude, slope angles and aspect values of vegetation classes derived by the random forest classification. WilcoxRank-Sum test was applied to test for significant differences between topographic properties of the vegetation classes inside and outside of the areas affected by the eruption. For the full time period, a total area of 516 km2 was identified as re-vegetated, whereas the area and magnitude of re-growing vegetation decreased during the three decades and migrated closer to the volcanic crater. Vegetation losses were mainly observed in regions unaffected by the eruption and related mostly to timber harvesting. The vegetation type classification reached a high overall accuracy of approximately 90%. 36 years after the eruption, coniferous and deciduous trees have established at formerly devastated areas dominating with a proportion of 66%, whereas shrubs are more abundant in riparian zones. Sparse vegetation dominates at regions very close to the crater. Elevation was found to have a great influence on th

关键词： mount St. Helens Vegetation change Remote sensing Change vector analysis (CVA) Supervised classification Topography Density-plots

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Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach Tobias Claff Alexandra Hingst katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa E.müller michael Gütschow Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(m^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active m^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of m^(pro),including a prototypical,internally quenched Dabcyl-EDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the m^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

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