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Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2537-2552页

作者： Chitra Karki Amod Athavale Vijay Abilash Gary Hantsbarger Parnia Geransar kate Lee Slobodan Milicevic Marko Perovic Leanne Raven Magdalena Sajak-Szczerba Abigail Silber Annabelle Yoon Phil Tozer Global Evidence and Outcomes-Gastroenterology Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Trinity Partners LLCWalthamMA 02451-7528United States Observational research Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Medical Affairs Takeda Pharmaceuticals International Co.Opfikon 8152ZurichSwitzerland research and Patient Programs Crohn’s and Colitis Canada600-60 St.Clair Avenue EastToronto M4T 1N5OntarioCanada Treasurer European Federation of Crohn’s&Ulcerative Colitis AssociationsBrussels B 1000Belgium Crohn’s and Colitis Australia Camberwell SouthVIC 3124Australia European Federation of Crohn’s&Ulcerative Colitis Associations Brussels B 1000Belgium Japan Medical Office Takeda Pharmaceutical Company LimitedTokyo 103-8668Japan Department of Colorectal Surgery St Mark’s Hospital and Academic InstituteLondon HA13UJUnited Kingdom

BACKGROUND Patients with Crohn’s disease(CD)are at risk of developing complications such as perianal *** with Crohn’s perianal fistulas(CPF)are affected by fecal incontinence(FI),bleeding,pain,swelling,and purulent perianal discharge,and METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries(April-August 2021).Patients were recruited into three cohorts:Cohort 1 included patients without perianal fistulas;cohort 2 included patients with perianal fistulas without fistula-related surgery;and cohort 3 included patients with perianal fistulas and fistula-related *** patient-reported outcome measures were used to assess quality of *** of treatment preferences were measured using a discrete choice experiment(DCE).RESULTS In total,929 patients were recruited(cohort 1,n=620;cohort 2,n=174;cohort 3,n=135).Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF(cohorts 2 and 3)than for those with CD without CPF(cohort 1):Mean score 3.8 and 3.7 vs 4.1,respectively,(P<0.001).Similarly,mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without *** of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery(cohorts 2 and 3):Mean score 41 and 42,*** the DCE,postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice:Mean relative importance 35.7 and 24.7,*** The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.

关键词： Burden of illness Crohn’s disease Discrete choice experiment Perianal fistulas Patient-reported outcomes Treatment preferences

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Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA

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World Journal of Gastroenterology 2019年第48期25卷 6939-6948页

作者： Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik Centre for Applied Genomics of Solid Tumors Genomac Research InstitutePrague CZ 16100Czech Republic Surgery Department 2nd Faculty of Medicine of Charles University Prague and Military University HospitalPrague CZ 16902Czech Republic Surgery Department 1st Faculty of MedicineCharles University Prague and Thomayer HospitalPrague CZ 14059Czech Republic Surgery Department 2nd Faculty of Medicine of Charles University Prague and Motol University HospitalPrague CZ 15006Czech Republic Institute of Biostatistics and Analyses of the Masaryk University Brno CZ 62500Czech Republic Elphogene Prague CZ 16100Czech Republic

BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative *** referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be *** is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or *** To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal *** total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical *** postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA *** addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month *** presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the *** Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 *** 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive dur

关键词： Circulating tumor DNA Metastatic colorectal cancer Postoperative Radicality of resection Follow-up Recurrence

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超高效合相色谱技术在中药研究和质量控制中的应用

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世界科学技术-中医药现代化 2014年第3期16卷 543-548页

作者：徐永威黄静孙庆龙潭晓杰 kate Yu 沃特世科技(上海)有限公司上海201206 Waters Corporation MilfordMA USA

中药质量不仅关系到患者的身心健康,同时涉及到药品生产企业的稳健发展。面对中药体系的复杂性,现有以单(多)指标成分进行中药质量控制的方法不能客观反映中药的实际质量。因此,国内研究者开展了大量的研究工作,以期弄清中药的效用物质... 详细信息

中药质量不仅关系到患者的身心健康,同时涉及到药品生产企业的稳健发展。面对中药体系的复杂性,现有以单(多)指标成分进行中药质量控制的方法不能客观反映中药的实际质量。因此,国内研究者开展了大量的研究工作,以期弄清中药的效用物质基础,提升中药的质量,进而实现中药的现代化。本文基于对超高效合相色谱的特点和应用进行简介,以期为众多中药研究者提供技术帮助,有利于开展中药研究和质量控制工作。

关键词：超高效合相色谱中药研究质量控制应用

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Modeling of genetic gain for single traits from marker-assisted seedling selection in clonally propagated crops

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Horticulture research 2016年第1期3卷 257-266页

作者： Sushan Ru Craig Hardner Patrick A Carter kate Evans Dorrie Main Cameron Peace Department of Horticulture Washington State UniversityPO Box 646414Pullman99164-6414WAUSA Queensland Alliance for Agriculture and Food Innovation University of QueenslandSt Lucia4072BrisbaneAustralia School of Biological Sciences Washington State UniversityPullman99164-4236WAUSA Department of Horticulture Washington State University Tree Fruit Research and Extension CenterWenatchee98801WAUSA

Seedling selection identifies superior seedlings as candidate cultivars based on predicted genetic potential for traits of ***,genetic potential is determined by phenotypic *** the availability of DNA tests for some agronomically important traits,breeders have the opportunity to include DNA information in their seedling selection operations—known as marker-assisted seedling selection.A major challenge in deploying marker-assisted seedling selection in clonally propagated crops is a lack of knowledge in genetic gain achievable from alternative *** models based on additive effects considering seed-propagated crops are not directly relevant for seedling selection of clonally propagated crops,as clonal propagation captures all genetic effects,not just *** study modeled genetic gain from traditional and various marker-based seedling selection strategies on a single trait basis through analytical derivation and stochastic simulation,based on a generalized seedling selection scheme of clonally propagated *** trait-test scenarios with a range of broad-sense heritability and proportion of genotypic variance explained by DNA markers were simulated for two populations with different segregation *** derived and simulated results indicated that marker-based strategies tended to achieve higher genetic gain than phenotypic seedling selection for a trait where the proportion of genotypic variance explained by marker information was greater than the broad-sense *** from this study provides guidance in optimizing genetic gain from seedling selection for single traits where DNA tests providing marker information are available.

关键词： seedling crops cultivar

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On the potential of documenting decadal-scale avifaunal change from before-and-after comparisons of museum and observational data across North America

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Avian research 2022年第1期13卷 1-10页

作者： Fernando Machado-Stredel Benedictus Freeman Daniel Jiménez-Garcia Marlon E.Cobos Claudia Nunez-Penichet Laura Jiménez Ed Komp Utku Perktas Ali Khalighifar kate Ingenloff Walter Tapondjou Thilina de Silva Sumudu Fernando Luis Osorio-Olvera A.Townsend Peterson Biodiversity Institute and Department of Ecology and Evolutionary Biology University of KansasLawrenceKSUSA Centro de Agroecología y Ambiente Instituto de CienciasBenemérita Universidad Autónoma de PueblaPueblaPueblaMexico Information and Telecommunication Technology Center(ITTC) University of KansasLawrenceKSUSA Department of Biology(Zoology Section-Biogeography research Lab.) Faculty of ScienceHacettepe UniversityBeytepeAnkaraTurkey Department of Ornithology American Museum of Natural HistoryCentral Park West at 79th StreetNew YorkNYUSA Departamento de Ecología de la Biodiversidad Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico

Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of decades to ***-scale biodiversity information resources now available offer opportunities to fill this gap for many parts of the world via detailed,quantitative comparisons of assemblage composition,particularly for regions without rich time series *** explore the possibility that such changes in avifaunas across the United States and Canada before and after the first three decades of marked global change(i.e.,prior to 1980 versus after 2010)can be reconstructed and characterized from existing primary biodiversity *** an illustration of the potential of this methodology for sites even in regions not as well sampled as the United States and Canada,we also explored changes at a single site in Mexico(Chichén-Itzá).We analyzed two large-scale datasets:one summarizing bird records in the United States and Canada before 1980,and one for the same region after *** used probabilistic inventory completeness analyses to identify sites that have avifaunas that have likely been inventoried more or less *** prepared detailed comparisons between the two time periods to analyze species showing distributional changes over the time period *** identified 139 sites on a 0.05°grid that were demonstrably well-inventoried before 1980 in the United States and Canada,of which 108 were also well-inventoried after *** presence/absence patterns between the two time periods for 601 bird species,we found significant spatial autocorrelation in overall avifaunal turnover(species gained and lost),but not in numbers of species *** noted potential northward retractions of ranges of several species with high-latitude(boreal)distributions,while other species showed dominant patterns of population loss,either rangewide(e.g.,Tympanuchus cupido)or regionally(e.g.,Thryomanes bewickii).We dev

关键词： Biodiversity dynamics Birds Climate change Inventory completeness Time scale Turnover

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3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease

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Bone research 2021年第4期9卷 521-536页

作者： Erika Kague Francesco Turci Elis Newman Yushi Yang kate Robson Brown Mona S.Aglan Ghada A.Otaify Sarnia A.Temtamy Victor L.Ruiz-Perez Stephen Cross C.Patrick Royall P.Eckhard Witten Chrissy L.Hammond School of Physiology Pharmacology and NeuroscienceBiomedical SciencesUniversity of BristolBristolUK School of Physics HH Wills Physics LaboratoryUniversity of BristolBristolUK Centre for Nanoscience and Quantum Information University of BristolBristolUK Bristol Centre for Functional Nanomaterials University of BristolBristolUK Department of Anthropology and Archaeology University of BristolBristolUK Department of Mechanical Engineering University of BristolBristolUK clinical Genetics Department Human Genetics and Genome Research DivisionCenter of Excellence for Human GeneticsNational Research CentreCairoEgypt lnstituto de Investigaciones Biomedicas de Madridand Ciber de Enfermedades Raras(CIBERER)MadridSpain Wolfson Bioimaging Facility Biomedical SciencesUniversity of BristolBristolUK School of Chemistry University of BristolBristolUK Evolutionary Developmental Biology Department of BiologyGhent UniversityGhentBelgium

Back pain is a common condition with a high social impact and represents a global health *** disc disease(IVDD)is one of the major causes of back pain;no therapeutics are currently available to reverse this *** impact of bone mineral density(BMD)on IVDD has been controversial,with some studies suggesting osteoporosis as causative for IVDD and others suggesting it as protective for *** studies to evaluate the influence of genetic components of BMD in IVDD could highlight opportunities for drug development and *** taking a holistic 3D approach,we established an aging zebrafish model for spontaneous *** BMD in aging,detected by automated computational analysis,is caused by bone deformities at the ***,aged zebrafish spines showed changes in bone morphology,microstructure,mineral heterogeneity,and increased fragility that resembled *** of the discs recapitulated IVDD symptoms found in humans:the intervertebral ligament(equivalent to the annulus fibrosus)showed disorganized collagen fibers and herniation,while the disc center(nucleus pulposus equivalent)showed dehydration and cellular *** manipulated BMD in young zebrafish by mutating sp7 and cathepsin K,leading to low and high BMD,***,we detected IVDD in both groups,demonstrating that low BMD does not protect against IVDD,and we found a strong correlation between high BMD and *** learning was applied to high-resolution synchrotron\iCJ image data to analyze osteocyte 3D lacunar distribution and morphology,revealing a role of sp7 in controlling the osteocyte lacunar 3D *** findings suggest potential avenues through which bone quality can be targeted to identify beneficial therapeutics for IVDD.

关键词： intervertebral degeneration protective

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Retrograde jejunogastric intussusception following Braun's jejunojejunostomy

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World Journal of clinical Cases 2014年第1期2卷 24-26页

作者： Raj Gopal Thirthar Palanivelu Elamurugan Sunny Hage Rajakannu Muthukumarassamy Vikram kate Department of Surgery Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry 605006 India

Jejunogastric intussusception is a rare long term complication of Billroth Ⅱ gastrectomy. The case reported here is a 50 year old man with history of a Billroth Ⅱ gastrectomy and Braun's side-to-side jejunojejunal anastomosis who presented with hematemesis. On abdominal examination, there was a mass in the left iliac fossa. Computed tomography scan showed a retrograde jejunogastric intussusception across the gastrojejunostomy. On laparotomy, a retrograde intussusception of the distal jejunum through the jejunojejunal anastomosis and across the gastrojejunostomy with a gangrenous intussusceptum was found. The jejunojejunal anastomosis was taken down, the gangrenous segment was resected and bowel continuity was restored with two jejunojejunal anastomoses, proximal and distal to the gastrojejunostomy. The gastrojejunostomy was preserved. This case brings out an unusual type of retrograde gangrenous intussusception which occurred at two points of a previous anastomosis, i.e., jejunojejunostomy and gastrojejunostomy simultaneously, which could be managed with jejunal resection.

关键词： Retrograde Intussusception BillrothⅡgastrectomy Jejunojejunostomy

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Risk factors for the development of colorectal carcinoma:A case control study from South India

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World Journal of Gastrointestinal Oncology 2016年第2期8卷 207-214页

作者： Santhana Krishnan Iswarya Kariyarath Cheriyath Premarajan Sitanshu Sekhar Kar Sathasivam Suresh Kumar Vikram kate departments of preventive and social medicine jawaharlal institute of postgraduate medical education and researchPondicherry 605006India department of surgery jawaharlal institute of postgraduate medical education and researchPondicherry 605006India

AIM:To study the association of colorectal carcinoma(CRC) with diet,smoking,alcohol,physical activity,body mass index,family history and ***: All consecutive patients with CRC confirmed by histopathology diagnosis were included. Age(±5 years) and gender matched controls were selected among the patients admitted in surgery ward for various conditions without any co-existing malignancy. Food frequency questionnaire(FFQ) was developed and validated after pretesting by investigator trained in data col ection techniques. Cases and controls were interviewed ensuring privacy,in similar interview setting,with same duration of time for both cases and controls without any leading question. Biological variables like family history of CRC in first degree relatives,history of diabetes mellitus; behavioral factors like tobacco use both smoking and smokeless form,alcohol consumption and physical activity were recorded. Dietary details were recorded using a FFQ consisting 29 food items with seven categories. Analysis was done using appropriate statistical ***: Ninety-four histopathologically confirmed cases of CRC and equal number of age and gender matched controls treated over a period of two years were studied. Age distribution,mean age,male to female ratio,education level and socioeconomic status were similar in cases and controls. Intake of food items was categorized into tertile due to skewed distribution of subjects as per recommended cut off for consumption of food item. On univariate analysis red meat [OR=7.4(2.935-18.732)],egg [OR=5.1(2.26-11.36)],fish,fried food and oil consumption were found to be risk factors for CRC. On multivariate analysis red meat consumption of more than 2-3 times a month(OR=5.4; 95%CI:1.55-19.05) and egg consumption of more than 2-3 times a week(OR = 3.67; 95%CI:1.23-9.35) were found to be independent risk factors for the development of ***: Egg and red meat consumption found to be independent risk factors for C

关键词： Dietary factors Smoking Rectal cancer Redmeat Colorectal malignancy

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基于纤毛鹅观草特异的卫星重复序列开发寡核苷酸探针

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南京农业大学学报 2022年第3期45卷 442-452页

作者：程梦豪 Miroslava Karafiatova 孙昊杰 kate Arina Holušva Jaroslav Dolezel 宋新颖王海燕王秀娥南京农业大学作物遗传与种质创新国家重点实验室/细胞遗传研究所/现代作物生产省部共建协同创新中心江苏南京210095 捷克科学院实验植物学研究所/哈纳地区生物技术和农业研究中心捷克共和国奥洛穆茨77900

[目的]本文旨在开发纤毛鹅观草特异的寡核苷酸(oligonucleotide,oligo)探针,进一步完善纤毛鹅观草染色体鉴定技术。[方法]利用前期选育的普通小麦-纤毛鹅观草异附加系DA2S^(c)L和DA6S^(c),通过流式分拣和基因组二代测序获得纤毛鹅观草... 详细信息

[目的]本文旨在开发纤毛鹅观草特异的寡核苷酸(oligonucleotide,oligo)探针,进一步完善纤毛鹅观草染色体鉴定技术。[方法]利用前期选育的普通小麦-纤毛鹅观草异附加系DA2S^(c)L和DA6S^(c),通过流式分拣和基因组二代测序获得纤毛鹅观草染色体6S^(c)和染色体臂2S^(c)长臂的基因组序列,利用Repeatexplorer2/TAREAN软件从中鉴定出卫星重复序列并设计成oligo探针,通过荧光原位杂交(fluorescence in situ hybridization,FISH)分析所开发oligo探针的应用价值。[结果]从6S^(c)和2S^(c)L基因组序列中共鉴定出11个卫星重复序列并开发成11个oligo探针,oligo-FISH结果表明,其中6个探针可以在纤毛鹅观草染色体上产生明显杂交信号,而在小麦染色体上未产生明显杂交信号,可用于特异鉴定小麦背景中的纤毛鹅观草染色体或片段。对1套普通小麦-纤毛鹅观草异附加系oligo-FISH分析发现,oligo-2S^(c)L^(-1)63和oligo-6S^(c)-111仅在S^(c)基因组染色体上产生明显信号,可作为纤毛鹅观草S^(c)组特异探针;将oligo-2S^(c)L-161和oligo-2S^(c)L-163组合,对1整套二体异附加系进行双色oligo-FISH,构建了纤毛鹅观草染色体的oligo-FISH核型。[结论]本研究提供了纤毛鹅观草重复序列组成的初步信息,开发的探针能特异鉴定纤毛鹅观草染色体,阐明纤毛鹅观草2个基因组的来源和分化,对推动纤毛鹅观草优异基因的转移和利用有重要意义。

关键词：纤毛鹅观草普通小麦-纤毛鹅观草异附加系染色体分拣卫星重复序列寡聚核苷酸探针荧光原位杂交

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Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D<sup>+</sup>CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus

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Open Journal of Immunology 2017年第1期7卷 1-17页

作者： Satoru Hamada Andrea Caballero-Benitez kate L. Duran Anne M. Stevens Thomas Spies Veronika Groh clinical research Division Fred Hutch Seattle WA USA Department of Pediatrics Ryukyus University Okinawa Prefecture Nishihara Japan Division of Rheumatology Department of Pediatrics University of Washington Medicine Seattle WA USA Center for Immunity and Immuno Therapies Seattle Children’s Research Institute Seattle WA USA

Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus (SLE). This study’s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands MICA and MICB, suggesting that kidney and/or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.

关键词： NKG2D Ligands NKG2D+ CD4 T Cells Juvenile-Onset Systemic Lupus Erythematosus B Cells Monocytes

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