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Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance,neuroinflammation and Alzheimer’s disease

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Translational Neurodegeneration 2022年第1期11卷 931-948页

作者： Alessandro Dario Confettura Eleonora Cuboni mohamed Rafeet Ammar Shaobo Jia Guilherme m.Gomes PingAn Yuanxiang Rajeev Raman Tingting Li katarzyna m.grochowska Robert Ahrends Anna Karpova Alexander Dityatev michael R.Kreutz RG Neuroplasticity Leibniz-Institute for Neurobiology39118 Magde-burgGermany German Center for Neurodegenerative Diseases(DZNE) 39120 MagdeburgGermany Center for Behavioral Brain Sciences Otto Von Guericke University39120 MagdeburgGermany Leibniz-Institut Für Analytische Wissenschaften-ISAS-e.V. 44227 DortmundGermany Leibniz Group‘Dendritic Organelles and Synaptic Function’ Center for Molecular NeurobiologyZMNHUniversity Medical Center Hamburg-Eppendorf20251 Ham-burgGermany Department of Analytical Chemistry Faculty of ChemistryUniversity of Vienna1090 WienAustria medical Faculty Otto-von-Guericke University39120 MagdeburgGermany.

Background:The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer’s *** has been proposed that neuroinflammation might be an intervening variable,but the underlying mechanisms are currently ***:We utilized primary neurons to induce synaptic insulin resistance as well as a mouse model of high-risk aging that includes a high amyloid load,neuroinflammation,and diet-induced obesity to test hypotheses on underly-ing ***:We found that neddylation and subsequent activation of cullin-RING ligase complexes induced synaptic insulin resistance through ubiquitylation and degradation of the insulin-receptor substrate IRS1 that organizes synap-tic insulin ***,inhibition of neddylation preserved synaptic insulin signaling and rescued memory deficits in mice with a high amyloid load,which were fed with a’western diet’.Conclusions:Collectively,the data suggest that neddylation and degradation of the insulin-receptor substrate is a nodal point that links high amyloid load,neuroinflammation,and synaptic insulin resistance to cognitive decline and impaired synaptic plasticity in high-risk aging.

关键词： metabolic syndrome Alzheimer’s disease Neddylation Cullins mLN-4924 Insulin IRS1 Amyloid-β TNFα

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Use of endoscopic ultrasound-guided gallbladder drainage as a rescue approach in cases of unsuccessful biliary drainage

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World Journal of Gastroenterology 2024年第1期30卷 70-78页

作者： Alessandro Fugazza Kareem Khalaf katarzyna m Pawlak marco Spadaccini matteo Colombo marta Andreozzi marco Giacchetto Silvia Carrara Chiara Ferrari Cecilia Binda Benedetto mangiavillano Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSRozzano 20089MilanoItaly Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8ONCanada Department of Anesthesia Humanitas Research Hospital-IRCCSRozzano 20089MilanoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsRomagna 47121Italy Gastrointestinal Endoscopy Unit Humanitas Mater DominiCastellanza 21100Italy Gastroenterology and Digestive Endoscopy Unit Fondazione IRCCS Policlinico San MatteoPavia 27100Italy

This narrative review provides an overview of the utilization of endoscopic ultrasound-guided gallbladder drainage(EUS-GBD)as a salvage approach in cases of unsuccessful conventional ***-GBD is a minimally invasive and effective technique for drainage in patients with acute cholecystitis with high risk of *** procedure has demonstrated impressive technical and clinical success rates with low rates of adverse events,making it a safe and effective option for appropriate ***,EUS-GBD can also serve as a rescue option for patients who have failed endoscopic retrograde cholangiopancreatography or EUS biliary drainage for relief of jaundice in malignant biliary ***,patient selection is critical for the success of EUS-GBD,and proper patient selection and risk assessment are important to ensure the safety and efficacy of the *** the field continues to evolve and mature,ongoing research will further refine our understanding of the benefits and limitations of EUS-GBD,ultimately leading to improved outcomes for patients.

关键词： Endoscopic ultrasound-guided gallbladder drainage Gallbladder drainage Acute cholecystitis malignant obstruction Interventional endoscopic ultrasound Lumen-apposing metal stents

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Fabrication and Significant Photoelectrochemical Activity of Titania Nanotubes modified with Thin Indium Tin Oxide Film

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Acta metallurgica Sinica(English Letters) 2017年第12期30卷 1210-1220页

作者： katarzyna Siuzdak mariusz Szkoda Jakub Karczewski Jacek Ryl Kazimierz Darowicki katarzyna grochowska Centre for Plasma and Laser Engineering The Szewalski Institute of Fluid-Flow Machinery Polish Academy of Sciences Fiszera 14 80-231 Gdansk Poland Department of Chemistry and Technology of Functional materials Chemical Faculty Gdańsk University of Technology Narutowicza 11/12 80-233 Gdansk Poland Faculty of Applied Physics and mathematics Gdansk University of Technology Narutowicza 11/12 80-233 Gdafisk Poland Department of Electrochemistry Corrosion and Materials Engineering Gdansk University of Technology Narutowicza 11/12 80-233 Gdafisk Poland

Ordered titanium dioxide nanotubes （TiOaNTs） modified with indium tin oxide （ITO） films were obtained via magnetron sputtering, in which ITO plate was used as a target, onto the as-anodized titania support followed by the calcination process. The morphology of fabricated material with deposited oxide was investigated using scanning electron microscopy. Raman and UV-Vis spectroscopies were utilized to characterize crystalline phase and optical properties of prepared samples, whereas X-ray photoelectron spectroscopy allowed determining the binding energy of present elements. In the case of titanium, three various oxidation states were identified and also the presence of indium and tin was confirmed. The electrochemical test carried out when the sample was exposed to light allows for selection of the most photoactive material. The highest photocurrent was registered when only 5-nm ITO layer was sputtered, and it equals 256 and 133 μA cm^-2 for the electrode material immersed in 0.5 m KOH and K2SO4 electrolytes, respectively, that is accordingly 3.5 and 4.4 times higher than the one observed for pristine titania. Furthermore, ITO-modified titania exhibits excellent photostability upon prolonged illumination that is of key importance for possible application in light-driven processes.

关键词： Titania nanotubes Indium tin oxide Photoactivity Anodization magnetron sputtering Electrochemical activity

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Dormancy heterogeneity among Arabidopsis thaliana seeds is linked to individual seed size

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Plant Communications 2024年第2期5卷 215-227页

作者： michal Krzyszton Sebastian P.Sacharowski Veena Halale manjunath katarzyna muter Grzegorz Bokota Ce Wang Dariusz Plewczynski Tereza Dobisova Szymon Swiezewski Laboratory of Seeds molecular Biology Institute of Biochemistry and BiophysicsPAS02-106 WarsawPoland Laboratory of Functional and Structural Genomics Centre of New TechnologiesUniversity of WarsawWarsawPoland Laboratory of Bioinformatics and Computational Genomics Faculty of Mathematics and Information ScienceWarsaw University of TechnologyWarsawPoland Labdeers Ltd. 680-01 BoskoviceCzech Republic

Production of morphologically and physiologically variable seeds is an important strategy that helps plants to survive in unpredictable natural ***,the model plant Arabidopsis thaliana and most agronomically essential crops produce visually homogenous *** automated phenotype analysis,we observed that small seeds in Arabidopsis tend to have higher primary and secondary dormancy levels than large *** analysis revealed distinct gene expression profiles between large and small *** seeds have higher expression of translation-related genes implicated in germination *** contrast,small seeds have elevated expression of many positive regulators of dormancy,including a key regulator of this process,the DOG1 *** in DOG1 expression are associated with differential production of its alternative cleavage and polyadenylation isoforms;in small seeds,the proximal poly(A)site is selected,resulting in a short mRNA ***,single-seed RNA sequencing analysis demonstrated that large seeds resemble DOG1 knockout mutant ***,on the single-seed level,expression of genes affected by seed size is correlated with expression of genes that position seeds on the path toward *** results demonstrate an unexpected link between seed size and dormancy phenotypes in a species that produces highly homogenous seed pools,suggesting that the correlation between seed morphology and physiology is more widespread than initially assumed.

关键词： seed size dormancy DOG1 Arabidopsis

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Identification of modal Loss Factor of a Sandwich Composite Structure with Polyethylene Terephthalate Core in the Aspect of Core Properties Determination

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materials Sciences and Applications 2015年第6期6卷 473-488页

作者： Krzysztof marynowski katarzyna grochowska Division of Dynamics Lodz University of Technology Lodz Poland

Comparison of the loss factor determination methods of the sandwich composite structure with polyethylene terephthalate core in the aspect of core material rheological parameters identification was the purpose of the study. Three frequency bandwidths n dB: 1 dB, 2 dB, 3 dB methods, the resonant amplitude method and the fit method of the response of the one degree of freedom model system are taken into considerations. Identification procedure, according to ASTm E756-2005 [1] based on experimental studies of the forced vibrations of the composite structure was presented in the paper. To determine the function of the complex shear modulus of the core material, the Nelder-mead method is applied. Shear modulus and loss factor identification results were presented on the plots in the frequency domain. The results in a quantitative manner set the applied methods and their practical utility in order.

关键词： Composite material Rheological Fractional model Viscoelasticity Loss Factor Shear modulus

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Practical approach to linear endoscopic ultrasound examination of the gallbladder

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World Journal of Radiology 2024年第6期16卷 184-195页

作者： Hussein Hassan Okasha Eyad Gadour Hassan Atalla Omar AbdAllah AbdEl-Hameed Reem Ezzat Ahmed Elsayed Alzamzamy Elsayed Ghoneem Rasha Ahmad matar Zeinab Hassan Bogdan miutescu Ayman Qawasmi katarzyna m Pawlak Ahmed Elmeligui Department of Internal medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt Department of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Department of medicine School of MedicineZamzam University CollegeKhartoum 11113Sudan Department of Internal medicine Hepatology and Gastroenterology UnitFaculty of MedicineMansoura UniversityMansoura 35516Egypt Department of Internal medicine Faculty of MedicineAssiut UniversityAssiut 71511Egypt Department of Gastroenterology and Heptology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11728Egypt Department of Gastroenterology and Advance Endoscopy Sultant Qaboos Comprehensive Cancer Care and Research CentreMuscat 0961Oman Department of Internal medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Centre in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Department of Gastroenterology Al-Makassed Islamic Charitable Society HospitalCairo 11124Egypt Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8Canada Department of Gastroenterology Southend University HospitalEssex SS26XTUnited Kingdom

The gallbladder(GB)is a susceptible organ,prone to various pathologies that can be identified using different imaging *** ultrasound(TUS)is typically the initial diagnostic method due to its numerous well-established ***,in cases of uncertainty or when a definitive diagnosis cannot be established,computed tomography(CT)or magnetic resonance imaging may be employed to provide more detailed ***,CT scans may sometimes offer inadequate spatial resolution,which can limit the differentiation of GB lesions,particularly when smaller yet clinically relevant abnormalities are ***,endoscopic ultrasound(EUS)provides higher frequency compared to TUS,superior spatial resolution,and the option for contrast-enhanced harmonic imaging,enabling a more comprehensive ***,EUS can serve as a supplementary tool when conventional imaging methods are *** review will describe the standard EUS examination of the GB,focusing on its endosonographic characteristics in various GB path-ologies.

关键词： Endoscopic ultrasound Linear endoscopic ultrasound Gallbladder anatomy Gallbladder pathologies Therapeutic endoscopic ultrasound

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Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer

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World Journal of Gastroenterology 2014年第29期20卷 9759-9774页

作者： magorzata muc-Wierzgoń Ewa Nowakowska-Zajdel Sylwia Dziegielewska-Gesiak Teresa Kokot katarzyna Klakla Edyta Fatyga Elzbieta grochowska-Niedworok Dariusz Waniczek Janusz Wierzgoń Department of Internal Diseases Medical University of Silesia Department of Human Nutrition Medical University of Silesia Department of Gastrointestinal Surgery Medical University of Silesia Department of Oncological and Reconstructive Surgery Center of Oncology Maria Skodowska-Curie Memorial Institute in Warsaw

Advances in genomics,molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical *** and biological studies suggest a role for adiposity,dyslipidaemia,hyperinsulinemia,altered glucose homeostasis,and elevated expression of insulin-like growth factor(IGF)axis members in the risk and prognosis of *** review discusses some recent past and current approaches being taken by researches in obesity and metabolic *** authors describe three main systems as the most studied metabolic candidates of carcinogenesis:dyslipidemias,adipokines and insulin/IGF ***,each of these components is unsuccessful in defining the diseases risk and progression,while their co-occurrence increases cancer incidence and mortality in both men and women.

关键词： Colorectal cancer metabolic biomarkers Risk Prognosis Dyslipidemias Adipokines Insulin-like growth factor-system

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Highly Porous Crosslinked Poly(ester-anhydride) microspheres with High Loading Efficiency

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Chinese Journal of Polymer Science 2015年第9期33卷 1271-1282页

作者： katarzyna Jaszcz Department of Physical Chemistry and Technology of Polymers Silesian University of Technology

microparticles with diameter within the range of Dn = 26-38 μm were prepared from functional poly（ester- anhydride）s with different amount of allyl groups in the side chains, using emulsion solvent evaporation technique. Porous structure was obtained as the effect of photocrosslinking of aUyl groups. 2,2-Dimetoxy-2-phenylacetophenone （DmPA）（0.5 wt%-10 wt%） was used as a photoinitiator. The crosslinking was carried out by UV irradiation during the solvent evaporation. Effectiveness of the crosslinking was characterized by the content of insoluble part of samples and it was in the range of 18%-75%. Porosity of microparticles （in the range of 76%-88%） depended on the functionality of poly（ester- anhydride）s and amount of the photoinitiator used. The most porous particles were obtained with use of 0.5 wt% of DmPA. Their flow ability expressed by Carr＇s index was excellent, and their theoretical mass mean aerodynamic diameters were acceptable for use in pulmonary drug delivery. The most porous particles were loaded with p-nitroaniline, theophilline or doxycycline. The loading efficiencies of drugs in porous microspheres were higher compared to nonporous ones. The porosity of loaded microparticles was slightly decreased, however their flow ability was still very good.

关键词： Functional poly(ester-anhydride) Crosslinkable microspheres Allyl groups Photocurring Porous structure.

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Propolis modulates vitronectin,laminin,and heparan sulfate/heparin expression during experimental burn healing

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 932-941页

作者： Pawe OLCZYK katarzyna KOmOSINSKA-VASSEV katarzyna WINSZ-SZCZOTKA Ewa m.KOZmA Grzegorz WISOWSKI Jerzy STOJKO katarzyna KLImEK Krystyna OLCZYK Department of Clinical Chemistry and Laboratory Diagnostics Medical University of Silesia41-200 SosnowiecPoland Center of Experimental medicine Medical University of Silesia40-752 KatowicePoland Department of Statistics Medical University of Silesia41-200 SosnowiecPoland

Objective:This study was aimed at assessing the dynamics of vitronectin (VN), laminin (LN), and heparan sulfate/heparin (HS/HP) content changes during experimental burn healing. methods:VN, LN, and HS/HP were isolated and purified from normal and injured skin of domestic pigs, on the 3rd, 5th, 10th, 15th, and 21st days following thermal damage. The wounds were treated with apitherapeutic agent (propolis), silver sulfadiazine (SSD), physiological salt solution, and propolis vehicle. VN and LN were quantified using an immunoenzymatic assay and HS/HP was estimated by densitometric analysis. Results:Propolis treatment stimulated significant increases in VN, LN, and HS/HP contents during the initial phase of study, followed by a reduction in the estimated extracellular matrix molecules. Similar patterns, although less extreme, were observed after treatment with SSD. Conclusions:The beneficial effects of propolis on experimental wounds make it a potential apitherapeutic agent in topical burn management.

关键词： Apitherapeutic agent Silver sulfadiazine Laminin Vitronectin Heparan sulfate/heparin Wound healing

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Experimental evolution of personality traits: open-field exploration in bank voles from a multidirectional selection experiment

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Current Zoology 2019年第4期65卷 375-384页

作者： Uttaran mAITI Edyta T. SADOWSKA katarzyna m. CHRZASCIK Pawet KOTEJA Institute of Environmental Sciences Jagiellonian University Gronostajowa Krakow Poland

Evolution of complex physiological adaptations could be driven by natural selection acting on behavioral traits. Consequently, animal personality traits and their correlation with physiological traits have become an engaging research area. Here, we applied a unique experimental evolution model lines of bank voles selected for (A) high exercise-induced aerobic metabolism,(H) ability to cope with low-quality herbivorous diet, and (P) intensity of predatory behavior, that is, traits shaping evoluti on ary path and diversity of mammals and asked how the selecti on affected the voles' personality traits, assessed in an open field test. The A- and P-line voles were more active, whereas the H-line voles were less active, compared those from unselected control lines (C). H-line voles moved slower but on more meandering trajectories, which indicated a more thorough explorati on, whereas the A- and P-line voles moved faster and on straighter trajectories. A-line voles showed also an increased escape propensity, whereas P-line voles tended to be bolder. The remarkable correlated responses to the selectio n indicate a comm on gen etic un derlying mecha nism of behavioral and physiological traits, and support the paradigm of evoluti on ary physiology built around the concept of correlated evolution of behavior and physiology.

关键词： evolution behavior physiology selection rodents myodes glareolus

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